Article
Endocrinology & Metabolism
Tsung-Cheng Hsieh, Guang-Hong Deng, Yung-Ching Chang, Fang-Ling Chang, Ming-Shan He
Summary: This study aimed to investigate optical coherence tomography (OCT) biomarkers of diabetic macular edema (DME) refractory to anti-vascular endothelial growth factor (anti-VEGF) therapy. The results showed that partially continuous inner segment-outer segment (IS-OS) layers were predictive of better response, while epiretinal membrane (ERM) was a significant predictor of poor response.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Ophthalmology
Wei-Hsuan Huang, Chi-Chun Lai, Lan-Hsin Chuang, Jerry Chien-Chieh Huang, Cheng-Hsiu Wu, Yu-Tze Lin, Ling Yeung
Summary: Compromised foveal microvascular integrity, as indicated by lower FD-300 and more severe perifoveal fluorescein leakage, was associated with a suboptimal clinical course in anti-VEGF treatment for diabetic macular edema (DME). A negative correlation existed between FD-300 and perifoveal leakage.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Lu Yu, Xiaolin Hao, Jie Cheng, Yu Ling, Hong Ren, Bin Mo, Wu Liu
Summary: This study evaluated the predictive effect of TCED-HFV grading and imaging biomarkers on anti-VEGF treatment in diabetic macular edema (DME). The results showed that TCED-HFV grading enables a comprehensive assessment of DME severity, standardizes the grading of multiple imaging biomarkers, and predicts the anatomical and functional outcomes of anti-VEGF treatment.
Article
Pharmacology & Pharmacy
Thibaud Mathis, Batoul El Ameen, Cristina Vartin, Yasmine Serrar, Frederic Matonti, Aditya Sudhalkar, Alper Bilgic, Amina Rezkallah, Laurent Kodjikian
Summary: This study examined the validity of using anatomical criteria alone to make retreatment decisions in patients with DME, compared to the gold standard that incorporates visual acuity. The OCT-guided strategy yielded equivalent results to the gold standard in 82.7% of cases, with variations in sensitivity and specificity based on the patient's treatment regimen.
Article
Medicine, General & Internal
Sunjin Hwang, Mincheol Seong, Min Ho Kang, Zheng Xian Thng, Heeyoon Cho, Yong Un Shin
Summary: This study examined the association between bioimpedance profiles and optical coherence tomography features in patients with diabetic macular edema. The results suggest a connection between systemic fluid status, including extracellular water-to-total body water ratio and phase angle, and DME development.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Ayman G. Elnahry, Alia M. Noureldine, Ahmed A. Abdel-Kaderi, Osama A. Sorour, David J. Ramsey
Summary: This study aimed to identify biomarkers that can predict an early anatomical response to intravitreal bevacizumab (IVB) treatment in diabetic macular edema (DME) using optical coherence tomography angiography (OCTA). The study found that eyes with an early anatomical response had worse baseline visual acuity, larger central macular thickness, smaller foveal avascular zones, and higher vascular density in the foveal superficial and deep capillary plexuses compared to non-responding eyes. Starting central macular thickness, foveal avascular zone size, and vascular density were found to be predictive of early treatment response to IVB.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Biology
Ayumi Usui-Ouchi, Asaka Tamaki, Yoshihito Sakanishi, Kazunori Tamaki, Keitaro Mashimo, Toshiro Sakuma, Nobuyuki Ebihara
Summary: The study found that the response of DME patients to intravitreal anti-VEGF injections may be associated with baseline glycemic control and macular ischemia.
Article
Ophthalmology
Emilia Maggio, Maurizio Mete, Mauro Sartore, Francesco Bauci, Massimo Guerriero, Antonio Polito, Grazia Pertile
Summary: The longitudinal analysis of specific OCT features in eyes with DME treated with anti-VEGF showed that SND and HRF exhibited a consistent pattern in DME recurrences compared to baseline, indicating a specific recurring pattern of DME characterized by these OCT biomarkers. Furthermore, the study suggested that the persistence and recurrence of SND and HRF may contribute more to a decline in visual function than the baseline prevalence of these biomarkers.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Paola Marolo, Enrico Borrelli, Francesco Gelormini, Giacomo Boscia, Guglielmo Parisi, Matteo Fallico, Costanza Barresi, Giorgio Lari, Alessandro Berni, Francesco Bandello, Michele Reibaldi
Summary: This study aims to determine the retinal thickness deviation (RTD) in eyes with diabetic macular edema (DME) treated with intravitreal therapy and establish associations between RTD and best-corrected visual acuity (BCVA). Retrospective analysis was conducted on DME patients undergoing intravitreal therapy. Results showed that RTD had a moderate association with BCVA at different time points and could be used as a reference for visual outcomes in DME eyes treated with intravitreal therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Daniel Duck-Jin Hwang
Summary: This study explored the use of spectral-domain optical coherence tomography (OCT) biomarkers to predict short-term anatomical improvement in diabetic macular edema (DME) patients who did not respond to anti-vascular endothelial growth factor (anti-VEGF) treatment and received dexamethasone (DEX) injections. The results showed that OCT parameters such as optical density (ODN) and optical density ratio (ODR) of the outer nuclear layer (ONL) cysts were correlated with changes in central macular thickness (CMT) after DEX injection, suggesting that these biomarkers could be useful in predicting short-term CMT responses after DEX injection in anti-VEGF non-responders.
Article
Medicine, General & Internal
Fabao Xu, Shaopeng Liu, Yifan Xiang, Jiaming Hong, Jiawei Wang, Zheyi Shao, Rui Zhang, Wenjuan Zhao, Xuechen Yu, Zhiwen Li, Xueying Yang, Yanshuang Geng, Chunyan Xiao, Min Wei, Weibin Zhai, Ying Zhang, Shaopeng Wang, Jianqiao Li
Summary: This study utilizes generative adversarial network (GAN) to generate and evaluate individualized post-therapeutic optical coherence tomography (OCT) images based on pre-therapeutic images, aiming to predict the short-term response of anti-vascular endothelial growth factor (VEGF) therapy for diabetic macular edema (DME). Results show that the synthetic OCT images generated by the GAN model are comparable to the actual images and can accurately predict edema resorption.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Huiping Yao, Zijian Yang, Yu Cheng, Xi Shen
Summary: This study investigated the changes in macular status and choroidal thickness following phacoemulsification in patients with mild to moderate nonproliferative diabetic retinopathy. The results showed that the increase in SCP-VD, MT, and CT after surgery was significantly greater in diabetic retinopathy patients compared to the control group.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Carolina Arruabarrena, Antonio Rodriguez-Miguel, Fernando de Aragon-Gomez, Purificacion Escamez, Ingrid Rosado, Miguel A. Teus
Summary: The purpose of this study was to establish normative data for macular thickness and volume in a diabetic population. The researchers used spectral-domain optical coherence tomography (SD-OCT) to observe and compare macular thickness and volume between diabetic patients and a reference population. The results showed that diabetic patients had thinner macular thickness and volume compared to the reference population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Xue Bai, Rui Hua
Summary: The study found that fluorescein angiography had a higher accuracy in detecting the severity of diabetic retinopathy and macular leakages compared to optical coherence tomography. Central foveal thickness is not a sensitive parameter for detecting latent DMEs.
FRONTIERS IN MEDICINE
(2021)
Article
Ophthalmology
Jing Cao, Kun You, Kai Jin, Lixia Lou, Yao Wang, Menglu Chen, Xiangji Pan, Ji Shao, Zhaoan Su, Jian Wu, Juan Ye
Summary: A machine learning-based system was developed to predict the therapeutic response of diabetic macular oedema (DME) patients to anti-vascular endothelial growth factor (VEGF) treatment using optical coherence tomography (OCT) images. The random forest classifier showed high accuracy in predicting treatment outcomes, offering the potential for individualized therapeutic regimens based on OCT features.
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Karen M. Wai, Mehnaz Khan, Sunil Srivastava, Aleksandra Rachitskaya, Fabiana Q. Silva, Ryan Deasy, Andrew P. Schachat, Amy Babiuch, Justis P. Ehlers, Peter K. Kaiser, Alex Yuan, Rishi P. Singh
BRITISH JOURNAL OF OPHTHALMOLOGY
(2017)
Article
Ophthalmology
Adrian Au, Vishal S. Parikh, Rishi P. Singh, Justis P. Ehlers, Alex Yuan, Aleksandra V. Rachitskaya, Jonathan E. Sears, Sunil K. Srivastava, Peter K. Kaiser, Andrew P. Schachat, Daniel F. Martin, Yasha Modi
BRITISH JOURNAL OF OPHTHALMOLOGY
(2017)
Article
Ophthalmology
Ashleigh L. Levison, Kimberly M. Baynes, Careen Y. Lowder, Peter K. Kaiser, Sunil K. Srivastava
BRITISH JOURNAL OF OPHTHALMOLOGY
(2017)
Letter
Ophthalmology
W. Lloyd Clark, David S. Boyer, Peter K. Kaiser
JAMA OPHTHALMOLOGY
(2017)
Article
Ophthalmology
Mehnaz Khan, Karen M. Wai, Fabiana Q. Silva, Sunil Srivastava, Justis P. Ehlers, Aleksandra Rachitskaya, Amy Babiuch, Ryan Deasy, Peter K. Kaiser, Andrew P. Schachat, Alex Yuan, Rishi P. Singh
OPHTHALMIC SURGERY LASERS & IMAGING RETINA
(2017)
Article
Ophthalmology
Justis P. Ehlers, Yasha S. Modi, Paula E. Pecen, Jeff Goshe, William J. Dupps, Aleksandra Rachitskaya, Sumit Sharma, Alex Yuan, Rishi Singh, Peter K. Kaiser, Jamie L. Reese, Carmen Calabrise, Allison Watts, Sunil K. Srivastava
Article
Ophthalmology
Anne P. Runkle, Sunil K. Srivastava, Alex Yuan, Peter K. Kaiser, Rishi P. Singh, Jamie L. Reese, Justis P. Ehlers
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2018)
Article
Ophthalmology
Amy S. Babiuch, Mehnaz Khan, Ming Hu, Peter K. Kaiser, Sunil K. Srivastava, Rishi P. Singh, Allison Watts, Jamie L. Reese, Justis P. Ehlers
OPHTHALMOLOGY RETINA
(2018)
Article
Ophthalmology
Justis P. Ehlers, Mehnaz Khan, Daniel Petkovsek, Laura Stiegel, Peter K. Kaiser, Rishi P. Singh, Jamie L. Reese, Sunil K. Srivastava
OPHTHALMOLOGY RETINA
(2018)
Article
Oncology
Brian L. Samuels, Sant P. Chawla, Neeta Somaiah, Arthur P. Staddon, Keith M. Skubitz, Mohammed M. Milhem, Pamela E. Kaiser, David C. Portnoy, Dennis A. Priebat, Mark S. Walker, Edward J. Stepanski
Article
Ophthalmology
Rishi P. Singh, Karishma A. Habbu, Rumneek Bedi, Fabiana Q. Silva, Justis P. Ehlers, Andrew P. Schachat, Jonathan E. Sears, Sunil K. Srivastava, Peter K. Kaiser, Alex Yuan
BRITISH JOURNAL OF OPHTHALMOLOGY
(2017)
Article
Ophthalmology
Tiffany A. Chen, Peter K. Kaiser, Rainer Fasching, Darius M. Moshfeghi
OPHTHALMIC SURGERY LASERS & IMAGING RETINA
(2017)
Article
Ophthalmology
Anne P. Runkle, Peter K. Kaiser, Sunil K. Srivastava, Andrew P. Schachat, Jamie L. Reese, Justis P. Ehlers
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)
Article
Ophthalmology
Peter K. Kaiser, Michael Singer, Michael Tolentino, Robert Vitti, Kristine Erickson, Namrata Saroj, Alyson J. Berliner, Karen W. Chu, Xiaoping Zhu, Zinaria Williams Liu, W. Lloyd Clark
OPHTHALMOLOGY RETINA
(2017)
Article
Ophthalmology
Darius M. Moshfeghi
OPHTHALMIC SURGERY LASERS & IMAGING RETINA
(2016)