Review
Medicine, General & Internal
Suncica Kapor, Juan F. Santibanez
Summary: This review discusses the main features of MDSCs and MSCs in myeloid malignancies, revealing that MDSCs are elevated in numbers and exhibit strong immunosuppressive capabilities, while MSCs not only have immunosuppressive properties but also regulate the growth, apoptosis, and chemotherapy resistance of myeloid leukemia cells.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Faten A. M. Abo-Aziza, Basma M. Wasfy, Sanaa M. R. Wahba, Sahar S. Abd-Elhalem
Summary: There is limited research on the biological relationship between myeloid-derived suppressor cells (MDSCs) and mesenchymal stem cells (MSCs). This study examined their cooperation in a rat model of adjuvant-induced arthritis (AIA). Results showed that MDSCs played various roles in autoimmunity and MSCs administration improved cytokine levels, suggesting their potential application in immunotherapy for arthritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Yin Celeste Cheuk, Shihao Xu, Dong Zhu, Yongsheng Luo, Tian Chen, Juntao Chen, Jiawei Li, Yi Shi, Yi Zhang, Ruiming Rong
Summary: The supernatant derived from myeloid-derived suppressor cells (MDSCs) inhibits the transforming growth factor beta 1 (TGF-beta 1)-induced myofibroblastic differentiation of mesenchymal stem cells (MSCs) through IL-15. This finding provides a new perspective for the development of treatment strategies for renal fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, General & Internal
Iosif Papafragkos, Efrosyni Markaki, Christina Kalpadakis, Panayotis Verginis
Summary: Myeloid-derived suppressor cells (MDSCs) are potent regulators of the immune system, playing a role in cancer but their specific contribution to lymphomas remains unclear. This review focuses on MDSCs in lymphomas, discussing literature and lessons learned from animal models, and highlights future research directions and challenges in understanding the immune system complexities in malignancies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Hui Zhang, Qi-Wei Li, Yuan-Yuan Li, Xue Tang, Ling Gu, Han-Min Liu
Summary: Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance and pressure, and the relationship between myeloid-derived suppressor cells (MDSCs) and PH has been studied. MDSCs are a group of cells that can suppress T-cell responses and potentially exacerbate the development of diseases. Understanding the relationship between MDSCs and PH can help identify potential therapeutic targets for the treatment of PH.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jingshan Cai, Yudan Cui, Jun Yang, Shengjun Wang
Summary: MDSCs play a crucial role in tumor immunity, closely linked to tumor EMT and possessing unique functions in an immunosuppressive environment.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Biochemistry & Molecular Biology
Ching-Chuan Hsieh, Cheng-Chih Chang, Yung-Chien Hsu, Chun-Liang Lin
Summary: In the development of diabetic kidney disease, the dysregulation of glomerular cell types is crucial, and MDSCs exhibit anti-inflammatory activities that help improve renal fibrosis in diabetic mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Zhenya Tan, Chen Kan, Mandy Wong, Minqiong Sun, Yakun Liu, Fan Yang, Siying Wang, Hong Zheng
Summary: The bone marrow microenvironment plays a crucial role in both normal hematopoietic stem cells and pathological leukemic stem cells. Mesenchymal stem cells (MSCs) are particularly involved in leukemia progression, chemoresistance, and relapse. The abnormal behavior of MSCs can contribute to the initiation and development of leukemia. This article summarizes the detailed relationship between MSCs and leukemia, including how MSCs actively and passively regulate leukemia progression through various mechanisms. The recent advances in therapy targeting MSCs are also discussed, aiming to provide new perspectives and therapeutic strategies for leukemia treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Yu Chen, Yanquan Xu, Huakan Zhao, Yu Zhou, Jiangang Zhang, Juan Lei, Lei Wu, Mingyue Zhou, Jingchun Wang, Shuai Yang, Xiao Zhang, Guifang Yan, Yongsheng Li
Summary: Cancer immunotherapy targeting myeloid-derived suppressor cells (MDSCs) is a promising anti-cancer strategy. This study explored the regulatory mechanisms of cholesterol metabolic reprogramming in MDSCs and found that cholesterol deficiency increased the immunosuppressive activity of MDSCs. Mechanistically, cholesterol elimination induced nuclear accumulation of LXR beta and enhanced the binding of LXR beta-RXR alpha on Arg1 promoter. Furthermore, itraconazole improved MDSC immunosuppressive activity and promoted tumor growth by inhibiting the RIPK3-AKT-mTORC1 pathway and impeding cholesterol synthesis.
Article
Oncology
Ru Li, Mousumi Beto Mukherjee, Jun Lin
Summary: In this review, the effects of cytokines and chemokines on myeloid-derived suppressor cells in cancer metastasis are summarized. Cytokines and chemokines in the tumor microenvironment alter the functional properties of MDSCs and are involved in their production, infiltration, and immunosuppressive functions. The manipulation of MDSCs by tumors through cytokine and chemokine signaling is discussed, as well as potential treatment strategies targeting these signaling pathways to combat the immunosuppressive activities of MDSCs and improve disease outcomes.
Article
Immunology
Yue Qiu, Yirui Cao, Guowei Tu, Jiawei Li, Ying Su, Fang Fang, Xuepeng Zhang, Jing Cang, Ruiming Rong, Zhe Luo
Summary: The study demonstrated that MDSCs can significantly alleviate renal fibrosis by promoting the interaction of the CCL5-CCR5 axis and inhibiting the TGF-beta 1/Smad/Snail signaling pathway. This leads to enhanced infiltration of MDSCs and Treg in the kidney, while reducing the levels of T(H)1 cells. The findings suggest an alternative treatment approach for renal fibrosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Mary M. Stevenson, Rajesh M. Valanparambil, Mifong Tam
Summary: The article suggests that immune suppression caused by helminth infections may be related to myeloid-derived suppressor cells (MDSC), and the data collected so far support this hypothesis. Future strategies targeting MDSC could enhance immune responses to eliminate adult worms and prevent reinfection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yang Zhao, Junfeng Du, Xiaofei Shen
Summary: Myeloid-derived suppressor cells (MDSCs) are a major negative regulator in tumor microenvironment (TME) by inhibiting immune response and promoting immunosuppression. This review focuses on the features of MDSCs in TME and potential targets for tumor immunotherapy. Therapies aiming to reprogram TME, prevent MDSC immunosuppression, promote MDSC differentiation, and impact MDSC recruitment and abundance in tumor site are discussed. Combinatorial strategies to improve clinical efficacy and outcomes of cancer patients through better understanding of MDSCs generation and suppression in TME are also summarized.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Lu Wang, Yun Li, Moyan Xu, Zihui Deng, Yan Zhao, Mengmeng Yang, Yuyan Liu, Rui Yuan, Yan Sun, Hao Zhang, Heming Wang, Zhirong Qian, Hongjun Kang
Summary: Mesenchymal stem cells (MSCs) show promising potential in treating sepsis and COVID-19 by regulating immune responses and anti-inflammatory effects. However, the mechanisms underlying the impact of stem cells on inflammation and immune regulation are still unclear. Future research should focus on understanding how MSCs mediate immune responses and inflammation to combat disease exacerbation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Samantha L. Tucker, Demba Sarr, Balazs Rada
Summary: Cystic Fibrosis is a genetic disease that causes chronic lung inflammation and infections, leading to high mortality rates. Immune system disruption in CF results in impaired immune responses, chronic infections with pathogens, and alterations in T cell and neutrophil functions. The role of P. aeruginosa and gMDSCs in T cell suppression and immune evasion in CF remains a subject of ongoing research.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thomas G. Baboolal, Gregory I. Mashanov, Tatiana A. Nenasheva, Michelle Peckham, Justin E. Molloy
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Multidisciplinary Sciences
Tatiana Nenasheva, Alexander Nikolaev, Daniar Diykanov, Anna Sukhanova, Evgenii Tcyganov, Alexander Panteleev, Irina Bocharova, Yana Serdyuk, Leonid Nezlin, Tatiana Radaeva, Nikolai Adrianov, Yuri Rubtsov, Irina Lyadova
Article
Immunology
Irina Yu. Nikitina, Alexander V. Panteleev, George A. Kosmiadi, Yana V. Serdyuk, Tatiana A. Nenasheva, Alexander A. Nikolaev, Lubov A. Gorelova, Tatiana V. Radaeva, Yana Yu. Kiseleva, Vladimir K. Bozhenko, Irina V. Lyadova
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Tatiana Nenasheva, Tatiana Gerasimova, Yana Serdyuk, Elena Grigor'eva, George Kosmiadi, Alexander Nikolaev, Erdem Dashinimaev, Irina Lyadova
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Physiology
Gregory I. Mashanov, Tatiana A. Nenasheva, Tatiana Mashanova, Catherine Maclachlan, Nigel J. M. Birdsall, Justin E. Molloy
Summary: Recent advances in light microscopy have enabled the visualization of individual biological macromolecules in live cells with nanometer precision and high time resolution. This allows for direct observation of molecular interactions without bulk averaging, leading to new discoveries. While most single-molecule imaging studies have been done in unicellular organisms or cultured mammalian cell lines, there is potential to apply this approach to studying dynamics in different tissue samples.
JOURNAL OF GENERAL PHYSIOLOGY
(2021)
Meeting Abstract
Biophysics
Gregory I. Mashanov, Tatiana A. Nenasheva, Francine Parker, Laura Knipe, Michelle Peckham, Justin E. Molloy
BIOPHYSICAL JOURNAL
(2020)
Meeting Abstract
Respiratory System
Irina Nikitina, Yana Serdyuk, Tatiana Nenasheva, Tatevik Bagdasaryan, Violetta Shorokhova, Irina Ly Adova
EUROPEAN RESPIRATORY JOURNAL
(2019)
Meeting Abstract
Immunology
T. Nenasheva, Y. Serdyuk, E. Grigorieva, A. Nikolaev, I. Lyadova
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Meeting Abstract
Immunology
I Nikitina, Y. Serdyuk, T. Nenasheva, T. Bagdasaryan, V Shorokhova, I Lyadova
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Biochemical Research Methods
Victor N. Morozov, Andrey Y. Mikheev, Yuri M. Shlyapnikov, Alexander A. Nikolaev, Irina V. Lyadova
JOURNAL OF BREATH RESEARCH
(2018)
Article
Biochemical Research Methods
Victor N. Morozov, Alexander A. Nikolaev, Yuri M. Shlyapnikov, Andrei Y. Mikheev, Elena A. Shlyapnikova, Tatevik R. Bagdasaryan, Irina A. Burmistrova, Tatyana G. Smirnova, Irina Y. Andrievskaya, Elena E. Larionova, Irina Y. Nikitina, Irina V. Lyadova
JOURNAL OF BREATH RESEARCH
(2018)
