Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17/Treg Balance

Cryopreserved vitamin D3-tolerogenic dendritic cells pulsed with autoantigens as a potential therapy for multiple sclerosis patients

(2016) María José Mansilla et al.   Journal of Neuroinflammation

Harnessing the integrated stress response for the treatment of multiple sclerosis

(2016) Sharon W Way et al.   LANCET NEUROLOGY

Anoctamin 2 identified as an autoimmune target in multiple sclerosis

(2016) Burcu Ayoglu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the Immunogenic and Tolerogenic Subsets of Dendritic Cells in Multiple Sclerosis

(2015) Zhong-Xiang Xie et al.   MEDIATORS OF INFLAMMATION

Tolerogenic dendritic cells modified by tacrolimus suppress CD4+ T-cell proliferation and inhibit collagen-induced arthritis in mice

(2014) Yana Ren et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Tolerogenic dendritic cells specific for β2-glycoprotein-I Domain-I, attenuate experimental antiphospholipid syndrome

(2014) Gisele Zandman-Goddard et al.   JOURNAL OF AUTOIMMUNITY

1,25-Dihydroxyvitamin D3 Promotes Tolerogenic Dendritic Cells with Functional Migratory Properties in NOD Mice

(2014) G. B. Ferreira et al.   JOURNAL OF IMMUNOLOGY

Investigation of the KIR4.1 potassium channel as a putative antigen in patients with multiple sclerosis: a comparative study

(2014) Adipong Brickshawana et al.   LANCET NEUROLOGY

Tofacitinib versus Methotrexate in Rheumatoid Arthritis

(2014) Eun Bong Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells

(2013) Satoshi Kubo et al.   ANNALS OF THE RHEUMATIC DISEASES

Tolerogenic dendritic cells as a therapy for treating lupus

(2013) Carolina Llanos et al.   CLINICAL IMMUNOLOGY

Vitamin D3Induces IDO+Tolerogenic DCs and Enhances Treg, Reducing the Severity of EAE

(2013) Alessandro S. Farias et al.   CNS Neuroscience & Therapeutics

Small molecular compounds in development for rheumatoid arthritis

(2013) Ronald F. van Vollenhoven   CURRENT OPINION IN RHEUMATOLOGY

Human Inflammatory Dendritic Cells Induce Th17 Cell Differentiation

(2013) Elodie Segura et al.   IMMUNITY

Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation

(2012) Hideyuki Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stable antigen-specific T-cell hyporesponsiveness induced by tolerogenic dendritic cells from multiple sclerosis patients

(2012) Dàlia Raϊch-Regué et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fulfilling the dream: tolerogenic dendritic cells to treat multiple sclerosis

(2012) Catharina C. Gross et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Midkine Inhibits Inducible Regulatory T Cell Differentiation by Suppressing the Development of Tolerogenic Dendritic Cells

(2012) Y. Sonobe et al.   JOURNAL OF IMMUNOLOGY

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

(2012) Moa Fransson et al.   Journal of Neuroinflammation

The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-γ and interleukin-17 production by human CD4+ T cells

(2011) Keisuke Maeshima et al.   ARTHRITIS AND RHEUMATISM

Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE

(2011) Veit Rothhammer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain

(2011) Niroshana Anandasabapathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chaperone Activity of α B-Crystallin Is Responsible for Its Incorrect Assignment as an Autoantigen in Multiple Sclerosis

(2011) Jonathan B. Rothbard et al.   JOURNAL OF IMMUNOLOGY

Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

(2011) Kamran Ghoreschi et al.   JOURNAL OF IMMUNOLOGY

Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses

(2010) Jeroen N. Stoop et al.   ARTHRITIS AND RHEUMATISM

Tolerogenic dendritic cells in autoimmune diseases

(2010) Honorio Torres-Aguilar et al.   AUTOIMMUNITY REVIEWS

Targeting dendritic cells to treat multiple sclerosis

(2010) Manuel Comabella et al.   Nature Reviews Neurology

Therapeutic effects of tolerogenic dendritic cells

(2010) Sarah Price   Nature Reviews Rheumatology

Tumour necrosis factor alpha blockade impairs dendritic cell survival and function in rheumatoid arthritis

(2009) H. M. Baldwin et al.   ANNALS OF THE RHEUMATIC DISEASES

Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial

(2009) J H Coombs et al.   ANNALS OF THE RHEUMATIC DISEASES

Jak3 Is Involved in Dendritic Cell Maturation and CCR7-Dependent Migration

(2009) Ana Rivas-Caicedo et al.   PLoS One