STIM and Orai1 Variants in Store-Operated Calcium Entry

Critical role for Orai1 C-terminal domain and TM4 in CRAC channel gating

(2015) Raz Palty et al.   CELL RESEARCH

Cooperative Binding of Stromal Interaction Molecule 1 (STIM1) to the N and C Termini of Calcium Release-activated Calcium Modulator 1 (Orai1)

(2015) Raz Palty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels

(2015) Anshul Rana et al.   JOURNAL OF CELL BIOLOGY

STIM1L traps and gates Orai1 channels without remodeling the cortical ER

(2015) S. Sauc et al.   JOURNAL OF CELL SCIENCE

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

Multiple types of calcium channels arising from alternative translation initiation of theOrai1message

(2015) Pooja N. Desai et al.   Science Signaling

Inside-out Ca2+ signalling prompted by STIM1 conformational switch

(2015) Guolin Ma et al.   Nature Communications

A STIM2 splice variant negatively regulates store-operated calcium entry

(2015) Anna-Maria Miederer et al.   Nature Communications

Multiple types of calcium channels arising from alternative translation initiation of theOrai1message

(2015) Pooja N. Desai et al.   Science Signaling

Dominant mutations in ORAI1 cause tubular aggregate myopathy with hypocalcemia via constitutive activation of store-operated Ca2+ channels

(2014) Yukari Endo et al.   HUMAN MOLECULAR GENETICS

Molecular Determinants Mediating Gating of Transient Receptor Potential Canonical (TRPC) Channels by Stromal Interaction Molecule 1 (STIM1)

(2014) Kyu Pil Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Coiled-coil Clamp Controls Both Conformation and Clustering of Stromal Interaction Molecule 1 (STIM1)

(2014) Marc Fahrner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1 and STIM2 Proteins Differently Regulate Endogenous Store-operated Channels in HEK293 Cells

(2014) Alexey Shalygin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex role of STIM1 in the activation of store-independent Orai1/3 channels

(2014) Xuexin Zhang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Inverse regulation of melanoma growth and migration by Orai1/STIM2-dependent calcium entry

(2014) Hedwig Stanisz et al.   Pigment Cell & Melanoma Research

Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis

(2014) V. Nesin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site

(2014) Xizhuo Wang et al.   Nature Communications

Urotensin-II promotes vascular smooth muscle cell proliferation through store-operated calcium entry and EGFR transactivation

(2013) María Rodríguez-Moyano et al.   CARDIOVASCULAR RESEARCH

The polybasic lysine-rich domain of plasma membrane-resident STIM1 is essential for the modulation of store-operated divalent cation entry by extracellular calcium

(2013) Isaac Jardin et al.   CELLULAR SIGNALLING

The STIM1/Orai signaling machinery

(2013) Marc Fahrner et al.   Channels

The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1

(2013) Isabella Derler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis of activation of the arachidonate-regulated Ca2+(ARC) channel, a store-independent Orai channel, by plasma membrane STIM1

(2013) Jill L. Thompson et al.   JOURNAL OF PHYSIOLOGY-LONDON

STIM2 drives Ca2+oscillations through store-operated Ca2+entry caused by mild store depletion

(2013) Markus Thiel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Alternative splicing: a pivotal step between eukaryotic transcription and translation

(2013) Alberto R. Kornblihtt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Orai Channel Pore Properties and Gating by STIM: Implications from the Orai Crystal Structure

(2013) B. S. Rothberg et al.   Science Signaling

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry

(2013) Peter B. Stathopulos et al.   Nature Communications

How Many Orai's Does It Take to Make a CRAC Channel?

(2013) Jill L. Thompson et al.   Scientific Reports

Different binding property of STIM1 and its novel splice variant STIM1L to Orai1, TRPC3, and TRPC6 channels

(2012) Takahiro Horinouchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Capacitative and non-capacitative signaling complexes in human platelets

(2012) Alejandro Berna-Erro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Alternative translation initiation gives rise to two isoforms of Orai1 with distinct plasma membrane mobilities

(2012) M. Fukushima et al.   JOURNAL OF CELL SCIENCE

Unraveling STIM2 function

(2012) Esther López et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

STIM proteins: dynamic calcium signal transducers

(2012) Jonathan Soboloff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Different agonists recruit different stromal interaction molecule proteins to support cytoplasmic Ca2+ oscillations and gene expression

(2012) P. Kar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)

(2012) X. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

(2012) X. Hou et al.   SCIENCE

STIM1 and STIM2 Are Located in the Acidic Ca2+Stores and Associates with Orai1 upon Depletion of the Acidic Stores in Human Platelets

(2011) Hanene Zbidi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1L is a new actin-binding splice variant involved in fast repetitive Ca2+release

(2011) Basile Darbellay et al.   JOURNAL OF CELL BIOLOGY

Stimulated association of STIM1 and Orai1 is regulated by the balance of PtdIns(4,5)P2 between distinct membrane pools

(2011) N. Calloway et al.   JOURNAL OF CELL SCIENCE

STIM1-dependent store-operated Ca2+ entry is required for pathological cardiac hypertrophy

(2011) Xiang Luo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry

(2011) L. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Kinase C-induced Phosphorylation of Orai1 Regulates the Intracellular Ca2+Level via the Store-operated Ca2+Channel

(2010) Takumi Kawasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Store-operated Ca2+ signaling in dendritic cells occurs independently of STIM1

(2010) Bidhan C. Bandyopadhyay et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Essential Role for the CRAC Activation Domain in Store-dependent Oligomerization of STIM1

(2010) Elizabeth D. Covington et al.   MOLECULAR BIOLOGY OF THE CELL

The Calcium Store Sensor, STIM1, Reciprocally Controls Orai and CaV1.2 Channels

(2010) Y. Wang et al.   SCIENCE

A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels

(2009) Takumi Kawasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Store-operated Ca2+ entry is sensitive to the extracellular Ca2+ concentration through plasma membrane STIM1

(2009) Isaac Jardín et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

(2009) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetrameric Orai1 Is a Teardrop-shaped Molecule with a Long, Tapered Cytoplasmic Domain

(2009) Yuusuke Maruyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular architecture of the arachidonate-regulated Ca2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits

(2009) Olivier Mignen et al.   JOURNAL OF PHYSIOLOGY-LONDON

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

STIMulating store-operated Ca2+ entry

(2009) Michael D. Cahalan   NATURE CELL BIOLOGY

Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2

(2008) Le Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

(2008) Peter B. Stathopulos et al.   CELL

Stromal Interaction Molecule (STIM) 1 and STIM2 Calcium Sensing Regions Exhibit Distinct Unfolding and Oligomerization Kinetics

(2008) Peter B. Stathopulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orai1 Mediates the Interaction between STIM1 and hTRPC1 and Regulates the Mode of Activation of hTRPC1-forming Ca2+Channels

(2008) Isaac Jardin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1 Gates TRPC Channels, but Not Orai1, by Electrostatic Interaction

(2008) Weizhong Zeng et al.   MOLECULAR CELL

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

(2008) Aubin Penna et al.   NATURE

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

(2008) Riina M. Luik et al.   NATURE

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

(2008) Masatsugu Oh-hora et al.   NATURE IMMUNOLOGY

STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation

(2007) Suhel Parvez et al.   FASEB JOURNAL

Orai1 subunit stoichiometry of the mammalian CRAC channel pore

(2007) Olivier Mignen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels

(2007) Olivier Mignen et al.   JOURNAL OF PHYSIOLOGY-LONDON