Article
Food Science & Technology
Manizheh Sarikhani, Mahla Deylam, Effat Alizadeh, Marzie Hejazy, Saeideh Alizadeh-Salteh, Hassan Moeini, Masoumeh Firouzamandi
Summary: The study found that extracts from peppermint and Shirazi thyme can promote anti-aging effects in rat mesenchymal stem cells, including anti-apoptosis and increased expression of the anti-aging related gene Nanog.
Article
Nutrition & Dietetics
Manoel Miranda Neto, Ana Carolina Freitas Meireles, Maristela Alves Alcantara, Angela Maria Tribuzy de Magalhaes Cordeiro, Alexandre Sergio Silva
Summary: This study demonstrates that peppermint essential oil can improve the physical performance of runners in endurance running, increasing the time to exhaustion without affecting body temperature, thermal sensation, thermal comfort, or hydration status.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Editorial Material
Parasitology
Yohann Le Govic, Benjamin Gourbal, Jerome Boissier
Summary: Researchers have decoded the functions of genes necessary for worm survival and pathogenesis using postgenomic technologies, paving the way for the development of innovative parasite-targeted therapies in the effort to eliminate schistosomiasis, which is hindered by the incomplete efficacy of the only FDA-approved anti-schistosomal drug, praziquantel.
TRENDS IN PARASITOLOGY
(2021)
Article
Polymer Science
Marcin Maslowski, Andrii Aleksieiev, Justyna Miedzianowska, Magdalena Efenberger-Szmechtyk, Krzysztof Strzelec
Summary: This research aimed to investigate the influence of Urtica dioica L. and Mentha piperita L. extracts on the properties of natural rubber-based vulcanizates before and after aging processes. The findings showed that the extracts had antioxidant activity and protective effects, which extended the materials' lifespan.
Article
Biotechnology & Applied Microbiology
Alyaa Farid
Summary: In many tropical regions, schistosomiasis is a major parasitic disease that causes significant morbidity and mortality, second only to malaria. Diagnostic methods include microscopy, radiography, and serology. Proteases have been investigated as targets for immunological or chemotherapeutic anti-Schistosoma agents due to their importance in the parasitic life cycle.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Horticulture
Hao Wei, Shuai Kong, Vanitha Jayaraman, Dhivya Selvaraj, Prabhakaran Soundararajan, Abinaya Manivannan
Summary: Mentha arvensis L. and Mentha x piperita L. are herbal plants that are cultivated for their essential oils and culinary uses. They have been used in traditional medicine to treat various disorders and have beneficial effects on the digestive, nervous, and respiratory systems.
Article
Food Science & Technology
Osman Taylan, Nur Cebi, Osman Sagdic
Summary: Mentha piperita essential oil is economically important due to its wide usage area and health-beneficial properties. Adulteration of high-valued essential oils can deteriorate the quality of authentic essential oil, harm consumers, and affect the entire supply chain. ATR-FTIR spectroscopy coupled with chemometrics is effective for monitoring various adulterants in essential oils.
Article
Immunology
Franziska Winkelmann, Anne Rabes, Cindy Reinholdt, Nicole Koslowski, Dirk Koczan, Emil C. Reisinger, Martina Sombetzki
Summary: This study reveals that adult schistosomes trigger sex-specific immune responses independent of parasite eggs. By identifying genes regulated by adult female or male worms, potential targets for schistosome elimination can be identified.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Sevde Nur Biltekin, Ayse Esra Karadag, Fatih Demirci, Betul Demirci
Summary: This study evaluated the anti-inflammatory and anticancer effects of the pharma-grade essential oils from Spearmint and German chamomile in vitro. The essential oils showed selective inhibition of COX-2 enzyme and promotion of apoptosis. Further in vivo experiments are needed to validate these findings.
Article
Agricultural Engineering
Jian Li, Jie Xu, Xinping Yang, Lili Ren, Yi Wang, Di Ma, Ping Fan, Haifeng Wang, Longxiang Liu, Bin Dong, Qingfeng Chen, Tao Wu
Summary: This study investigates the effects of polycyclic aromatic hydrocarbons (PAHs) on the chemical composition of essential oils and metabolic responses within aromatic plants. The results suggest that PAH stress has little effect on the primary characteristics of peppermint essential oils, but it does induce dynamic changes in metabolic pathways within peppermint leaves. The findings provide new insights into the responses of aromatic plants toward PAH stress and have implications for the phytoremediation of PAH-contaminated soils.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Veterinary Sciences
Amany M. Ramez, Ehab Kotb Elmahallawy, Gehad E. Elshopakey, Amira A. Saleh, Samar M. Moustafa, Ashraf Al-Brakati, Walied Abdo, Dina M. M. El-Shewehy
Summary: The combined treatment with Spirulina platensis and matcha green tea showed effective therapeutic effects in Schistosoma mansoni-infected mice. It reduced liver damage, enhanced antioxidant capacity, suppressed inflammatory response, and improved tissue structure. Further research is recommended to explore the mechanisms of this combined treatment for developing novel therapies against the disease.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Chemistry, Physical
Livia Bandici, Alin Cristian Teusdea, Vasile Darie Soproni, Francisc Ioan Hathazi, Mircea Nicolae Arion, Carmen Otilia Molnar, Simona Ioana Vicas
Summary: Microwave extraction is used to extract bioactive compounds from peppermint, resulting in a significant increase in phenols, flavonoids, and pigments.
Article
Engineering, Biomedical
Yu-Hsiu Chiu, Yan-Wei Wu, Jui- Hung, Mei-Chin Chen
Summary: The study shows that poly-gamma-glutamate microneedles can efficiently deliver epigallocatechin gallate into the skin to ameliorate symptoms of atopic dermatitis. This formulation not only protects EGCG from oxidation, but also modulates immune response to relieve allergic reactions, presenting a promising therapeutic option for AD treatment.
ACTA BIOMATERIALIA
(2021)
Review
Medicine, General & Internal
Adriana Marques, Carla Torre, Rui Pinto, Bruno Sepodes, Joao Rocha
Summary: Sepsis is a life-threatening condition caused by a dysregulated host response to infection, affecting over 25 million people annually. Septic shock, a severe subset of sepsis, is characterized by persistent low blood pressure, with hospital mortality rates exceeding 40%. Despite advances in early sepsis mortality, long-term complications such as secondary infection remain a significant cause of death, and there are currently no sepsis-specific therapies. Immunostimulatory therapy, including cytokines, growth factors, immune checkpoint inhibitors, and cellular therapies, holds promise in addressing this unmet medical need.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Plant Sciences
Peter Beatrice, Gabriella Saviano, Marcella Reguzzoni, Fabio Divino, Francesca Fantasma, Donato Chiatante, Antonio Montagnoli
Summary: Investigating the morphological and molecular mechanisms of plants under artificial biophilic lighting is important for implementing biophilic approaches. Studying the essential oil composition in aromatic plants can help unravel the influence of light on plant metabolism. Plants grown under the CoeLux(R) lighting system showed suppressed growth and changes in leaf characteristics, possibly related to shade avoidance syndrome. The essential oil composition was minimally affected by the CoeLux(R) light type, with major differences observed compared to plants grown under natural sunlight. Overall, O. basilicum showed better performance in terms of morphology and essential oil composition. Higher light intensity may be necessary to enhance biomass production and essential oil quality.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Immunology
Stephan Alberto Machado de Oliveira, Janayna Nunes Reis, Elisa Catao, Andre Correa Amaral, Ana Camila Oliveira Souza, Alice Melo Ribeiro, Lucia Helena Faccioli, Fabiana Pirani Carneiro, Clara Luna Freitas Marina, Pedro Henrique Burgel, Larissa Fernandes, Aldo Henrique Tavares, Anamelia Lorenzetti Bocca
Summary: The results of the study indicate that CD18(low) mice infected with Pb18 survived with fewer granulomas, lower fungal burden, lower nitrate levels, and high IgG1 levels compared to WT mice. In addition, the in vitro macrophages from CD18(low) mice showed slower internalization of yeast cells and lower fungal burden, suggesting that beta 2 integrins play a crucial role in fungal survival within macrophages.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Camila O. S. Souza, Natalia Ketelut-Carneiro, Cristiane M. Milanezi, Lucia H. Faccioli, Luiz G. Gardinassi, Joao S. Silva
Summary: The NLR molecule NLRC4 has been found to promote susceptibility to experimental PCM by regulating cytokine production and protective effector mechanisms. It suppresses prostaglandin E-2 production early in infection, reducing IL-1 beta release and impacting IL-18 release later in the disease, ultimately affecting immune responses and mortality.
Article
Immunology
Ana Lucia Borges Starling, Silvio Roberto Souza Pereira, Vanessa Peruhype-Magalhaes, Jordana Grazziela Alves Coelho-dos-Reis, Kelly Alves Bicalho, Luciene Pimenta de Paiva, Julia Pereira Martins, Bruno Caetano Trindade, Ludimila Labanca, Lucia Helena Faccioli, Jose Roberto Lambertucci, Luciana Cristina dos Santos Silva, Carlos Mauricio de Figueiredo Antunes, Andrea Teixeira-Carvalho, Anna Barbara de Freitas Carneiro-Proietti, Denise Ustch Goncalves, Olindo Assis Martins-Filho
Summary: The impact of HIV co-infection on the plasma immunological biomarker profile of HTLV-1 infected patients was evaluated. The study found that plasma levels of immunological biomarkers in co-infected patients were closely related to the HTLV-1 associated neurological diseases.
IMMUNOLOGY LETTERS
(2021)
Article
Plant Sciences
Juliana C. Ferreira, Mouzarllem B. Reis, Giovanna D. P. Coelho, Gabriel H. Gastaldello, Ana Paula F. Peti, Debora M. Rodrigues, Jairo K. Bastos, Vanessa L. Campo, Carlos A. Sorgi, Lucia H. Faccioli, Luiz G. Gardinassi, Cristiane Tefe-Silva, Karina F. Zoccal
Summary: The compounds Bac and pCA from Baccharis dracunculifolia D.C. were found to inhibit cellular infiltration and oxidative stress induced by inflammation, with regulatory effects on the production of inflammatory mediators.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Physical
Camila Marcovicz, Guilherme dos Anjos Camargo, Bianca Scharr, Larissa Sens, Mariana Negrelli Levandowski, Thiago De Castro Rozada, Patricia Castellen, Juliana Inaba, Rosimeire Nunes De Oliveira, Julio Cesar Mine, Sheila de Andrade Penteado Correa, Silmara Marques Allegretti, Barbara Celnia Fiorin
Summary: This study synthesized Chalcones with nitro and bromo substituents in different positions and investigated their conformation and schistosomicidal effects. The results showed that Chalcones had a preference for s-cis geometry and exhibited significant effects on adult Schistosoma mansoni. Chalcones reduced the motor activity, caused mortality, and suppressed egg production in a concentration-dependent manner. These findings indicate the potential of Chalcones as schistosomicidal drugs and contribute to the understanding of the relationship between molecular conformation and biological effects.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Neurosciences
Bruno L. Santos-Lobato, Luiz Gustavo Gardinassi, Mariza Bortolanza, Ana Paula Ferranti Peti, Angela V. Pimentel, Lucia Helena Faccioli, Elaine A. Del-Bel, Vitor Tumas
Summary: Metabolomic analysis revealed a distinct metabolic profile associated with levodopa-induced dyskinesia (LID) in Parkinson's disease (PD), particularly characterized by dysregulation of the glycosphingolipid metabolic pathway and bile acid biosynthesis metabolites in plasma and CSF. These findings suggest a potential link between lipid metabolism dysregulation and LID in PD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Parasitology
Allan Daniel Ribeiro Sotelo Montanhaur, Estela de Oliveira Lima, Jeany Delafiori, Cibele Zanardi Esteves, Cesar Corat Ribeiro Prado, Silmara Marques Allegretti, Marlene Tiduko Ueta, Carlos Emilio Levy, Rodrigo Ramos Catharino
Summary: Strongyloidiasis, caused by Strongyloides stercoralis infection, is a common parasitic disease in tropical or subtropical areas. Due to the lack of a gold-standard diagnostic tool, this study used metabolomics to evaluate metabolic changes in stool samples and identified 5 potential biomarkers, indicating the involvement of microbiota remodeling, parasite constitution, and host response in the intestinal metabolism of S. stercoralis infection.
Article
Dentistry, Oral Surgery & Medicine
Francine Lorencetti da Silva, Giuliana de Campos Chaves Lamarque, Fernanda Maria Machado Pereira Cabral de Oliveira, Paulo Nelson-Filho, Lea Assed Bezerra da Silva, Raquel Assed Bezerra Segato, Lucia Helena Faccioli, Francisco Wanderley Garcia Paula-Silva
Summary: The study found that LTB4 can promote the differentiation of dental pulp stem cells and mineralization of teeth by regulating the expression of Ibsp and Runx2 genes. Microspheres loaded with LTB4 can continuously release LTB4 in long-term culture and achieve the differentiation and mineralization of dental pulp stem cells.
Article
Biochemistry & Molecular Biology
Pedro da Silva-Neto, Valeria B. do Valle, Carlos A. Fuzo, Talita M. Fernandes, Diana M. Toro, Thais F. C. Fraga-Silva, Patricia A. Basile, Jonatan C. S. de Carvalho, Vinicius E. Pimentel, Malena M. Perez, Camilla N. S. Oliveira, Lilian C. Rodrigues, Victor A. F. Bastos, Sandra O. C. Tella, Ronaldo B. Martins, Augusto M. Degiovani, Fatima M. Ostini, Marley R. Feitosa, Rogerio S. Parra, Fernando C. Vilar, Gilberto G. Gaspar, Jose J. R. da Rocha, Omar Feres, Eurico Arruda, Sandra R. Maruyama, Elisa M. S. Russo, Angelina L. Viana, Isabel K. E. M. Santos, Vania L. D. Bonato, Cristina R. B. Cardoso, Jose E. Tanus-Santos, Eduardo A. Donadi, Lucia H. Faccioli, Marcelo Dias-Baruffi, Ana P. M. Fernandes, Raquel F. Gerlach, Carlos A. Sorgi
Summary: This study found that excessive activity of matrix metalloproteinases (MMPs) contributes to extensive lung tissue damage in severe COVID-19. MMP-2 and MMP-8 play important roles in this process and are associated with the release of immunosuppressive mediators sHLA-G and sTREM-1.
Article
Parasitology
Paula Berna da Silva Medeiros, Tiago Manuel Fernandes Mendes, Vera Lucia Garcia, Rosimeire Nunes De Oliveira, Leticia Bastos Duart, Silmara Marques Allegretti
Summary: In this study, the ethanolic extract of Spondias mombin L. was tested for its in vitro effect against Strongyloides venezuelensis. The results showed that the extract and its fractions had a better in vitro effect than ivermectin. Fraction 4 exhibited the best results, causing 100% mortality in a short period of time. Scanning electron microscopy and gas chromatography analysis provided insights into the mechanism of action, suggesting that monoaromatic phenolic lipids may be responsible for the antiStrongyloides effect. The use of polyvinylpyrrolidone reduced the efficiency of the extract.
Article
Biochemistry & Molecular Biology
Jessica F. C. Cordeiro, Talita M. Fernandes, Diana M. Toro, Pedro da Silva-Neto, Vinicius E. Pimentel, Malena M. Perez, Jonatan C. S. de Carvalho, Thais F. C. Fraga-Silva, Camilla N. S. Oliveira, Jamille G. M. Argolo, Augusto M. Degiovani, Fatima M. Ostini, Enrico F. Puginna, Joao S. da Silva, Isabel K. F. M. Santos, Vania L. D. Bonato, Cristina R. B. Cardoso, Marcelo Dias-Baruffi, Lucia H. Faccioli, Eduardo A. Donadi, Carlos A. Sorgi, Ana P. M. Fernandes
Summary: The study evaluated the levels of plasma soluble HLA-G (sHLA-G) in COVID-19 patients and healthy controls. The results showed increased levels of sHLA-G in COVID-19 patients, which correlated with disease severity. However, the levels decreased in critically ill patients, possibly indicating immune exhaustion. sHLA-G also exhibited positive correlation with other disease mediators IL-6, IL-8, and IL-10.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Juliana Virginio da Silva, Carla Cristina Moreira, Elisandra de Almeida Montija, Karina Alves Feitosa, Ricardo de Oliveira Correia, Nelson Luis de Campos Domingues, Edson Garcia Soares, Silmara Marques Allegretti, Ana Afonso, Fernanda de Freitas Anibal
Summary: This study evaluated the efficacy of compounds C1 and C3 in treating schistosomiasis caused by Schistosoma mansoni. The results showed that these compounds can inhibit the release of cercariae and reduce the inflammatory response in mice. Therefore, they have potential anti-schistosomicidal effects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Jonatan C. S. de Carvalho, Pedro V. da Silva-Neto, Diana M. Toro, Carlos A. Fuzo, Viviani Nardini, Vinicius E. Pimentel, Malena M. Perez, Thais F. C. Fraga-Silva, Camilla N. S. Oliveira, Augusto M. Degiovani, Fatima M. Ostini, Marley R. Feitosa, Rogerio S. Parra, Jose J. R. da Rocha, Omar Feres, Fernando C. Vilar, Gilberto G. Gaspar, Isabel K. F. M. Santos, Ana P. M. Fernandes, Sandra R. Maruyama, Elisa M. S. Russo, Vania L. D. Bonato, Cristina R. B. Cardoso, Marcelo Dias-Baruffi, Lucia H. Faccioli, Carlos A. Sorgi
Summary: COVID-19 is associated with immune dysregulation, and glucocorticoids (GCs) have attracted attention for their role in inhibiting pro-inflammatory cytokines. The endocannabinoid (eCB) system also regulates immune response. However, the effect of GCs on the lipid pathway in COVID-19 therapy is still unknown.
Article
Cell Biology
Diana Mota V. Toro, Pedro V. da Silva-Neto, Jonatan C. S. A. de Carvalho, Carlos A. M. Fuzo, Malena M. Perez, Vinicius E. Pimentel, Thais F. C. Fraga-Silva, Camilla N. S. R. Oliveira, Glaucia R. Caruso, Adriana F. L. Vilela, Pedro V. Nobre-Azevedo, Thiago V. Defelippo-Felippe, Jamille G. M. M. Argolo, Augusto M. Degiovani, Fatima M. R. Ostini, Marley R. S. Feitosa, Rogerio S. C. Parra, Fernando C. G. Vilar, Gilberto G. Gaspar, Jose J. R. da Rocha, Omar P. Feres, Gabriel P. Costa, Sandra R. C. Maruyama, Elisa M. S. Russo, Ana Paula M. Fernandes, Isabel K. F. M. Santos, Adriana T. Malheiro, Ruxana T. Sadikot, Vania L. D. Bonato, Cristina R. B. Cardoso, Marcelo Dias-Baruffi, Atila A. Trape, Lucia H. A. Faccioli, Carlos A. Sorgi, ImmunoCovid Consortium Grp
Summary: SARS-CoV-2 infection leads to distinct disease patterns with significant changes in host regulatory responses. Severe cases suffer from lung inflammation and systemic effects, while critically ill patients experience a lipid storm that affects inflammation and tissue damage. Sphingolipids play critical roles in various cellular processes and may serve as potential biomarkers and therapeutic targets for COVID-19.
Meeting Abstract
Immunology
Camila O. S. Souza, Jefferson Elias-Oliveira, Caroline Fontanari, Vanderlei Rodriguez, Luiz Gardinassi, Lucia Faccioli
JOURNAL OF IMMUNOLOGY
(2021)
