Dopamine D3 Receptor Antagonists as Potential Therapeutics for the Treatment of Neurological Diseases

1,2,4-Triazolyl octahydropyrrolo[2,3-b]pyrroles: A new series of potent and selective dopamine D3 receptor antagonists

(2016) Fabrizio Micheli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists

(2016) Fabrizio Micheli et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Improving selectivity of dopamine D3 receptor ligands

(2016) Marc Capet et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The dopamine D 3 -preferring D 2 /D 3 dopamine receptor partial agonist, cariprazine, reverses behavioural changes in a rat neurodevelopmental model for schizophrenia

(2016) David J.G. Watson et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Cariprazine in the treatment of schizophrenia

(2016) Suresh Durgam et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Polypharmacology of dopamine receptor ligands

(2016) S. Butini et al.   PROGRESS IN NEUROBIOLOGY

Role of iso-receptors in receptor-receptor interactions with a focus on dopamine iso-receptor complexes

(2016) Luigi F. Agnati et al.   REVIEWS IN THE NEUROSCIENCES

P.3.d.053 Cariprazine as monotherapy for the treatment of schizophrenia patients with predominant negative symptoms: a double-blind, active controlled trial

(2015) M. Debelle et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Dopamine D3 receptor agonists as pharmacological tools

(2015) S. Kassel et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Novel dimensions of D3 receptor function: Focus on heterodimerisation, transactivation and allosteric modulation

(2015) Roberto Maggio et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Cariprazine in Acute Exacerbation of Schizophrenia

(2015) Suresh Durgam et al.   JOURNAL OF CLINICAL PSYCHIATRY

High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice

(2015) Comfort A. Boateng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dopamine Receptors and Neurodegeneration

(2015) Claudia Rangel-Barajas et al.   Aging and Disease

The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components

(2014) Dasiel Borroto-Escuela et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Efficacy and Safety of Low- and High-Dose Cariprazine in Acute and Mixed Mania Associated With Bipolar I Disorder

(2014) Joseph R. Calabrese et al.   JOURNAL OF CLINICAL PSYCHIATRY

Tranylcypromine Substituted cis-Hydroxycyclobutylnaphthamides as Potent and Selective Dopamine D3 Receptor Antagonists

(2014) Jianyong Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Structure–Activity Relationship Studies of a Series of [4-(4-Carboxamidobutyl)]-1-arylpiperazines: Insights into Structural Features Contributing to Dopamine D3 versus D2 Receptor Subtype Selectivity

(2014) Subramaniam Ananthan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Dopamine D3 and Serotonin 5-HT1A and 5-HT2A Receptors for Developing Effective Antipsychotics: Synthesis, Biological Characterization, and Behavioral Studies

(2014) Margherita Brindisi et al.   JOURNAL OF MEDICINAL CHEMISTRY

The novel dopamine D3 receptor antagonist, SR 21502, reduces cocaine conditioned place preference in rats

(2014) P. Hachimine et al.   NEUROSCIENCE LETTERS

Discovery of GPCR ligands for probing signal transduction pathways

(2014) Simone Brogi et al.   Frontiers in Pharmacology

The Role of Dopamine in Schizophrenia from a Neurobiological and Evolutionary Perspective: Old Fashioned, but Still in Vogue

(2014) Ralf Brisch et al.   Frontiers in Psychiatry

The effects of the novel DA D3 receptor antagonist SR 21502 on cocaine reward, cocaine seeking and cocaine-induced locomotor activity in rats

(2013) E. Galaj et al.   PSYCHOPHARMACOLOGY

Discovery of cariprazine (RGH-188): A novel antipsychotic acting on dopamine D3/D2 receptors

(2012) Éva Ágai-Csongor et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor

(2012) Amy Hauck Newman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Higher Binding of the Dopamine D3 Receptor-Preferring Ligand [11C]-(+)-Propyl-Hexahydro-Naphtho-Oxazin in Methamphetamine Polydrug Users: A Positron Emission Tomography Study

(2012) I. Boileau et al.   JOURNAL OF NEUROSCIENCE

Cariprazine (RGH-188), a D3-preferring dopamine D3/D2 receptor partial agonist antipsychotic candidate demonstrates anti-abuse potential in rats

(2012) V. Román et al.   PSYCHOPHARMACOLOGY

The effects of the dopamine D3 receptor antagonist GSK598809 on attentional bias to palatable food cues in overweight and obese subjects

(2011) Pradeep J. Nathan et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Selective Blockade of Dopamine D3 Receptors Enhances while D2 Receptor Antagonism Impairs Social Novelty Discrimination and Novel Object Recognition in Rats: A Key Role for the Prefrontal Cortex

(2011) David JG Watson et al.   NEUROPSYCHOPHARMACOLOGY

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

(2011) J.-M. Beaulieu et al.   PHARMACOLOGICAL REVIEWS

Recent advances in the search for D3- and D4-selective drugs: probes, models and candidates

(2011) Stefan Löber et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Current perspectives on selective dopamine D3 receptor antagonists as pharmacotherapeutics for addictions and related disorders

(2010) Christian A. Heidbreder et al.   Annals of the New York Academy of Sciences

Triazolyl Azabicyclo[3.1.0]hexanes: a Class of Potent and Selective Dopamine D3 Receptor Antagonists

(2010) Giorgio Bonanomi et al.   ChemMedChem

Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors

(2010) Stefania Butini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploration of the Amine Terminus in a Novel Series of 1,2,4-Triazolo-3-yl-azabicyclo[3.1.0]hexanes as Selective Dopamine D3Receptor Antagonists

(2010) Fabrizio Micheli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cariprazine (RGH-188), a Dopamine D3 Receptor-Preferring, D3/D2 Dopamine Receptor Antagonist-Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile

(2010) B. Kiss et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

PG01037, a novel dopamine D3 receptor antagonist, inhibits the effects of methamphetamine in rats

(2010) Amanda E Higley et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The Tetrahydroisoquinoline Derivative SB269,652 Is an Allosteric Antagonist at Dopamine D3 and D2 Receptors

(2010) E. Silvano et al.   MOLECULAR PHARMACOLOGY

Dopamine receptor expression and distribution dynamically change in the rat nucleus accumbens after withdrawal from cocaine self-administration

(2010) K.L. Conrad et al.   NEUROSCIENCE

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

(2010) E. Y. T. Chien et al.   SCIENCE

Reward, dopamine and the control of food intake: implications for obesity

(2010) Nora D. Volkow et al.   TRENDS IN COGNITIVE SCIENCES

Getting specialized: presynaptic and postsynaptic dopamine D2 receptors

(2009) Claudia De Mei et al.   CURRENT OPINION IN PHARMACOLOGY

Regional specificity in the real-time development of phasic dopamine transmission patterns during acquisition of a cue-cocaine association in rats

(2009) Brandon J. Aragona et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

1,1′-Disubstituted Ferrocenes as Molecular Hinges in Mono- and Bivalent Dopamine Receptor Ligands

(2009) Daniela Huber et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-(4-(4-(2,3-Dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with Functionalized Linking Chains as High Affinity and Enantioselective D3 Receptor Antagonists∥⊥

(2009) Amy Hauck Newman et al.   JOURNAL OF MEDICINAL CHEMISTRY

1,2,4-Triazolyl Azabicyclo[3.1.0]hexanes: A New Series of Potent and Selective Dopamine D3Receptor Antagonists

(2009) Fabrizio Micheli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Using prepulse inhibition to detect functional D3 receptor antagonism: Effects of WC10 and WC44

(2009) Martin Weber et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Discovery of a New Class of Potential Multifunctional Atypical Antipsychotic Agents Targeting Dopamine D3and Serotonin 5-HT1Aand 5-HT2AReceptors: Design, Synthesis, and Effects on Behavior

(2008) Stefania Butini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of Dopamine in the Motivational and Cognitive Control of Behavior

(2008) Roshan Cools   NEUROSCIENTIST

Cognitive Impairment in Schizophrenia: a Review of Developmental and Genetic Models, and Pro-cognitive Profile of the Optimised D3 > D2 Antagonist, S33138

(2008) Mark J. Millan et al.   THERAPIE

Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues

(2007) Nora D. Volkow et al.   NEUROIMAGE