The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor

PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

(2017) Noel G. Faux et al.   JOURNAL OF ALZHEIMERS DISEASE

Passage Variation of PC12 Cells Results in Inconsistent Susceptibility to Externally Induced Apoptosis

(2016) Nihar Kinarivala et al.   ACS Chemical Neuroscience

Possible role of metal ionophore against zinc induced cognitive dysfunction in d-galactose senescent mice

(2016) Kanchan Bharti et al.   BIOMETALS

Synthetic fluorescent probes to map metallostasis and intracellular fate of zinc and copper

(2016) Giuseppe Trusso Sfrazzetto et al.   COORDINATION CHEMISTRY REVIEWS

Intracellular Bioinorganic Chemistry and Cross Talk Among Different -Omics

(2016) Diego La Mendola et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Gold and Silver Nanoparticles for Applications in Theranostics

(2016) Patrizia Di Pietro et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A Small Linear Peptide Encompassing the NGF N-Terminus Partly Mimics the Biological Activities of the Entire Neurotrophin in PC12 Cells

(2015) Alessio Travaglia et al.   ACS Chemical Neuroscience

The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin

(2015) G. Grasso et al.   CHEMICAL COMMUNICATIONS

Zinc: indications in brain disorders

(2015) Atish Prakash et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Different zinc(II) complex species and binding modes at Aβ N-terminus drive distinct long range cross-talks in the Aβ monomers

(2015) Adriana Pietropaolo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Insulin-like modulation of Akt/FoxO signaling by copper ions is independent of insulin receptor

(2014) Ingrit Hamann et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A novel fully water-soluble Cu(i) probe for fluorescence live cell imaging

(2014) Maria Laura Giuffrida et al.   CHEMICAL COMMUNICATIONS

PTEN-inhibition by zinc ions augments interleukin-2-mediated Akt phosphorylation

(2014) Laura Marie Plum et al.   Metallomics

Combinatorial Assembly of Small Molecules into Bivalent Antagonists of TrkC or TrkA Receptors

(2014) Fouad Brahimi et al.   PLoS One

Neuroprotective Copper Bis(thiosemicarbazonato) Complexes Promote Neurite Elongation

(2014) Laura Bica et al.   PLoS One

The Neurobiological Bases of Memory Formation: From Physiological Conditions to Psychopathology

(2014) Reto Bisaz et al.   PSYCHOPATHOLOGY

Local versus long-range neurotrophin receptor signalling: Endosomes are not just carriers for axonal transport

(2014) Dusan Matusica et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Copper: from neurotransmission to neuroproteostasis

(2014) Carlos M. Opazo et al.   Frontiers in Aging Neuroscience

Zinc(II) Interactions with Brain-Derived Neurotrophic Factor N-Terminal Peptide Fragments: Inorganic Features and Biological Perspectives

(2013) Alessio Travaglia et al.   INORGANIC CHEMISTRY

Dissecting the Roles of Tyrosines 490 and 785 of TrkA Protein in the Induction of Downstream Protein Phosphorylation Using Chimeric Receptors

(2013) Jordane Biarc et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of insulin fragments by insulin-degrading enzyme: the role of zinc(II) and cystine bridges

(2013) Francesco Bellia et al.   JOURNAL OF MASS SPECTROMETRY

Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease

(2013) Frank M. Longo et al.   NATURE REVIEWS DRUG DISCOVERY

Adsorption of NGF and BDNF derived peptides on gold surfaces

(2013) Giuseppe Forte et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide

(2013) Alessio Travaglia et al.   Soft Matter

CREB and neuronal selection for memory trace

(2013) Jieun Kim et al.   Frontiers in Neural Circuits

Charting the travels of copper in eukaryotes from yeast to mammals

(2012) Tracy Nevitt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Copper, BDNF and Its N-terminal Domain: Inorganic Features and Biological Perspectives

(2012) Alessio Travaglia et al.   CHEMISTRY-A EUROPEAN JOURNAL

Peptide Mimetics of Neurotrophins and their Receptors

(2012) S. D. Skaper   CURRENT PHARMACEUTICAL DESIGN

Hippocampal ProNGF Signaling Pathways and β-Amyloid Levels in Mild Cognitive Impairment and Alzheimer Disease

(2012) Elliott J. Mufson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neural Stem Cells Enhance Nerve Regeneration after Sciatic Nerve Injury in Rats

(2012) Lin Xu et al.   MOLECULAR NEUROBIOLOGY

Nerve Growth Factor and Alzheimer's Disease: New Facts for an Old Hypothesis

(2012) Antonino Cattaneo et al.   MOLECULAR NEUROBIOLOGY

Erratum: Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity

(2012) D Scarpi et al.   Cell Death & Disease

Current advances in using neurotrophic factors to treat neurodegenerative disorders

(2012) April M Weissmiller et al.   Translational Neurodegeneration

Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?

(2011) Sune Skeldal et al.   BIOESSAYS

A Versatile Strategy for Signal Amplification Based on Core/Shell Silica Nanoparticles

(2011) Enrico Rampazzo et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Inorganic Perspective of Nerve Growth Factor: Interactions of Cu2+ and Zn2+ with the N-Terminus Fragment of Nerve Growth Factor Encompassing the Recognition Domain of the TrkA Receptor

(2011) Alessio Travaglia et al.   CHEMISTRY-A EUROPEAN JOURNAL

The inorganic perspectives of neurotrophins and Alzheimer's disease

(2011) Alessio Travaglia et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A TSH-CREB1-microRNA Loop Is Required for Thyroid Cell Growth

(2011) Vincenza Leone et al.   MOLECULAR ENDOCRINOLOGY

Ligand-Dependent TrkA Activity in Brain Differentially Affects Spatial Learning and Long-Term Memory

(2011) T. Aboulkassim et al.   MOLECULAR PHARMACOLOGY

Nerve growth factor/p38 signaling increases intraepidermal nerve fiber densities in painful neuropathy of type 2 diabetes

(2011) Hsinlin T. Cheng et al.   NEUROBIOLOGY OF DISEASE

Modulation of Neuronal Signal Transduction and Memory Formation by Synaptic Zinc

(2011) Carlos Sindreu et al.   Frontiers in Behavioral Neuroscience

A Doppel α-Helix Peptide Fragment Mimics the Copper(II) Interactions with the Whole Protein

(2010) Diego La Mendola et al.   CHEMISTRY-A EUROPEAN JOURNAL

The HADDOCK web server for data-driven biomolecular docking

(2010) Sjoerd J de Vries et al.   Nature Protocols

Thermostat Artifacts in Replica Exchange Molecular Dynamics Simulations

(2009) Edina Rosta et al.   Journal of Chemical Theory and Computation

Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling

(2009) Patrick T. Redman et al.   JOURNAL OF PHYSIOLOGY-LONDON

Prolyl Hydroxylase Inhibitors Depend on Extracellular Glucose and Hypoxia-Inducible Factor (HIF)-2  to Inhibit Cell Death Caused by Nerve Growth Factor (NGF) Deprivation: Evidence that HIF-2  Has a Role in NGF-Promoted Survival of Sympathetic Neurons

(2009) D. J. Lomb et al.   MOLECULAR PHARMACOLOGY

Cardiovascular Actions of Neurotrophins

(2009) Andrea Caporali et al.   PHYSIOLOGICAL REVIEWS

Transcription Factors in Long-Term Memory and Synaptic Plasticity

(2009) Cristina M. Alberini   PHYSIOLOGICAL REVIEWS

Increasing Cu bioavailability inhibits A  oligomers and tau phosphorylation

(2009) P. J. Crouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A New Nerve Growth Factor-Mimetic Peptide Active on Neuropathic Pain in Rats

(2008) A. M. Colangelo et al.   JOURNAL OF NEUROSCIENCE

Unveiling the Role of Histidine and Tyrosine Residues on the Conformation of the Avian Prion Hexarepeat Domain

(2008) Adriana Pietropaolo et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

Selective Inhibition of Mitogen-Activated Protein Kinase Phosphatases by Zinc Accounts for Extracellular Signal-Regulated Kinase 1/2-Dependent Oxidative Neuronal Cell Death

(2008) Y. Ho et al.   MOLECULAR PHARMACOLOGY

Cholecystokinin-58 is more potent in inhibiting food intake than cholecystokinin-8 in rats

(2008) Joerg Glatzle et al.   NUTRITIONAL NEUROSCIENCE

High-dose dietary supplementation of vitamin A induces brain-derived neurotrophic factor and nerve growth factor production in mice with simultaneous deficiency of vitamin A and zinc

(2008) Sorayya Kheirvari et al.   NUTRITIONAL NEUROSCIENCE

Src and FAK are key early signalling intermediates required for neurite growth in NGF-responsive adult DRG neurons

(2007) Budd A. Tucker et al.   CELLULAR SIGNALLING

P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation

(2007) Berk Hess   Journal of Chemical Theory and Computation