Targeted therapeutics for severe refractory asthma: monoclonal antibodies

‘Real-life’ effectiveness studies of omalizumab in adult patients with severe allergic asthma: systematic review

(2016) I. Abraham et al.   ALLERGY

What if we made stratified medicine work for patients?

(2016) Nicky Britten et al.   Lancet Respiratory Medicine

Direct Health Care Costs Associated with Asthma in British Columbia

(2016) Mohsen Sadatsafavi et al.   Canadian Respiratory Journal

Changes in asthma control, work productivity, and impairment with omalizumab: 5-year EXCELS study results

(2015) James L. Zazzali et al.   ALLERGY AND ASTHMA PROCEEDINGS

House Dust Mite Allergens and the Induction of Monocyte Interleukin 1β Production That Triggers an IκBζ-Dependent Granulocyte Macrophage Colony-Stimulating Factor Release from Human Lung Epithelial Cells

(2015) Kruthika Sundaram et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Dedicated Severe Asthma Services Improve Health-care Use and Quality of Life

(2015) David Gibeon et al.   CHEST

Airway IL-1β and Systemic Inflammation as Predictors of Future Exacerbation Risk in Asthma and COPD

(2015) Juan-juan Fu et al.   CHEST

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

(2015) Dominick E. Shaw et al.   EUROPEAN RESPIRATORY JOURNAL

Biomarkers to identify sputum eosinophilia in different adult asthma phenotypes

(2015) Guus A. Westerhof et al.   EUROPEAN RESPIRATORY JOURNAL

Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study

(2015) Walter Reinisch et al.   GUT

Discriminating sputum-eosinophilic asthma: Accuracy of cutoffs in blood eosinophil measurements versus a composite index, ELEN

(2015) Deepak B. Khatry et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers

(2015) Michelle L. Hernandez et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma phenotyping: a necessity for improved therapeutic precision and new targeted therapies

(2015) Kian Fan Chung   JOURNAL OF INTERNAL MEDICINE

Targeting the interleukin pathway in the treatment of asthma

(2015) Kian Fan Chung   LANCET

The INNs and outs of antibody nonproprietary names

(2015) Tim D. Jones et al.   mAbs

Inhibition of CD23-mediated IgE transcytosis suppresses the initiation and development of allergic airway inflammation

(2015) S Palaniyandi et al.   Mucosal Immunology

Adjusting prednisone using blood eosinophils reduces exacerbations and improves asthma control in difficult patients with asthma

(2015) Peter AB Wark et al.   RESPIROLOGY

Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies

(2015) Nicola A Hanania et al.   THORAX

Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials

(2015) Mario Castro et al.   Lancet Respiratory Medicine

Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial

(2015) Christopher E Brightling et al.   Lancet Respiratory Medicine

Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjects

(2014) J. P. Arm et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Rethinking the Role of Immunoglobulin E and Its High-Affinity Receptor: New Insights into Allergy and Beyond

(2014) Barbara Dema et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Efficacy and safety of an anti–IL-13 mAb in patients with severe asthma: A randomized trial

(2014) Erika H. De Boever et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of Functional Roles for Both IL-17RB and IL-17RA in Mediating IL-25-Induced Activities

(2014) E. A. Rickel et al.   JOURNAL OF IMMUNOLOGY

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

(2014) Elisabeth H. Bel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

(2014) Hector G. Ortega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Loss of asthma control after cessation of omalizumab treatment: real life data

(2014) Izabela Kupryś-Lipińska et al.   Postepy Dermatologii i Alergologii

Heterogeneity of phenotypes in severe asthmatics. The Belgian Severe Asthma Registry (BSAR)

(2014) F. Schleich et al.   RESPIRATORY MEDICINE

Distribution of airway smooth muscle remodelling in asthma: Relation to airway inflammation

(2014) John G. Elliot et al.   RESPIROLOGY

External validation of blood eosinophils, FENOand serum periostin as surrogates for sputum eosinophils in asthma

(2014) A H Wagener et al.   THORAX

NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation

(2014) S R Kim et al.   Cell Death & Disease

Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study

(2014) Mario Castro et al.   Lancet Respiratory Medicine

Randomized, Double-Blind, Placebo-controlled Study of Brodalumab, a Human Anti–IL-17 Receptor Monoclonal Antibody, in Moderate to Severe Asthma

(2013) William W. Busse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Exploring the Effects of Omalizumab in Allergic Asthma

(2013) Nicola A. Hanania et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy

(2013) Nicola A. Hanania et al.   ANNALS OF INTERNAL MEDICINE

Does Omalizumab Make a Difference to the Real-life Treatment of Asthma Exacerbations?

(2013) Lamiae Grimaldi-Bensouda et al.   CHEST

A Proof-of-Concept, Randomized, Controlled Trial of Omalizumab in Patients With Severe, Difficult-to-Control, Nonatopic Asthma

(2013) Gilles Garcia et al.   CHEST

The effects of lebrikizumab in patients with mild asthma following whole lung allergen challenge

(2013) H. Scheerens et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids

(2013) Michael Noonan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia

(2013) Michel Laviolette et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effects of Omalizumab in Non-Atopic Asthma: Results from a Spanish Multicenter Registry

(2013) Luis Pérez de Llano et al.   JOURNAL OF ASTHMA

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multidimensional assessment and tailored interventions for COPD: respiratory utopia or common sense?

(2013) Vanessa M McDonald et al.   THORAX

Distribution of sputum cellular phenotype in a large asthma cohort: predicting factors for eosinophilic vs neutrophilic inflammation

(2013) Florence N Schleich et al.   BMC Pulmonary Medicine

Omalizumab may decrease IgE synthesis by targeting membrane IgE+ human B cells

(2013) Marcia A Chan et al.   Clinical and Translational Allergy

A Large Subgroup of Mild-to-Moderate Asthma Is Persistently Noneosinophilic

(2012) Kelly Wong McGrath et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Exacerbations of severe asthma

(2012) V. M. McDonald et al.   CLINICAL AND EXPERIMENTAL ALLERGY

A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma

(2012) Edward Piper et al.   EUROPEAN RESPIRATORY JOURNAL

Eculizumab for treatment of asthma

(2012) Steven G Smith et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma

(2012) Philippe Gevaert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A 26-Week, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Effect of Omalizumab on Asthma Control in Patients with Persistent Allergic Asthma

(2012) Jose Bardelas et al.   JOURNAL OF ASTHMA

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

(2012) Ian D Pavord et al.   LANCET

IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction

(2012) Makoto Kudo et al.   NATURE MEDICINE

IgE and mast cells in allergic disease

(2012) Stephen J Galli et al.   NATURE MEDICINE

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

(2012) Kim A. Papp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reslizumab for Poorly Controlled, Eosinophilic Asthma

(2011) Mario Castro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Inflammatory biomarkers in severe asthma

(2011) Kian F. Chung   CURRENT OPINION IN PULMONARY MEDICINE

An anti-IgE monoclonal antibody that binds to IgE on CD23 but not on high-affinity IgE.Fc receptors

(2011) Yu-Yu Shiung et al.   IMMUNOBIOLOGY

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City Children

(2011) William W. Busse et al.   NEW ENGLAND JOURNAL OF MEDICINE

Monoclonal antibodies for the treatment of asthma

(2011) Matthew C. Catley et al.   PHARMACOLOGY & THERAPEUTICS

How to set up a severe asthma service

(2011) VANESSA M. MCDONALD et al.   RESPIROLOGY

The inductive effect of interleukin-4 on IgG4 and IgE synthesis in human peripheral blood lymphocytes

(2010) A. ISHIZAKA et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Efficacy and safety of etanercept in moderate-to-severe asthma: a randomised, controlled trial

(2010) S. T. Holgate et al.   EUROPEAN RESPIRATORY JOURNAL

MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function

(2010) Roland Kolbeck et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes

(2010) Annette T. Hastie et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Decreases in human dendritic cell–dependent TH2-like responses after acute in vivo IgE neutralization

(2010) John T. Schroeder et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma in older adults

(2010) Peter G Gibson et al.   LANCET

Efficacy of eculizumab in a patient with factor-H-associated atypical hemolytic uremic syndrome

(2010) Anne-Laure Lapeyraque et al.   PEDIATRIC NEPHROLOGY

Omalizumab-induced decrease of FcɛRI expression in patients with severe allergic asthma

(2010) Pascal Chanez et al.   RESPIRATORY MEDICINE

Refractory asthma in the UK: cross-sectional findings from a UK multicentre registry

(2010) L. G. Heaney et al.   THORAX

After 6 years with Xolair; a 3-year withdrawal follow-up

(2009) A. Nopp et al.   ALLERGY

A Randomized, Double-blind, Placebo-controlled Study of Tumor Necrosis Factor-α Blockade in Severe Persistent Asthma

(2009) Sally E. Wenzel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The importance of nurse-led home visits in the assessment of children with problematic asthma

(2009) M Bracken et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Relationship between omalizumab pharmacokinetics, IgE pharmacodynamics and symptoms in patients with severe persistent allergic (IgE-mediated) asthma

(2009) Philip J. Lowe et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Therapeutic antibodies: successes, limitations and hopes for the future

(2009) Patrick Chames et al.   BRITISH JOURNAL OF PHARMACOLOGY

Safety and tolerability of omalizumab

(2009) J. Corren et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Golimumab for severe asthma

(2009) Sabina A Antoniu   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Reduced FcεRI-Mediated Release of Asthma-Promoting Cytokines and Chemokines from Human Basophils during Omalizumab Therapy

(2009) Janet M. Oliver et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

TH17-associated cytokines (IL-17A and IL-17F) in severe asthma

(2009) Wisam Al-Ramli et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Omalizumab for the treatment of exacerbations in children with inadequately controlled allergic (IgE-mediated) asthma

(2009) Bob Lanier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

(2009) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

Omalizumab in patients with severe persistent allergic asthma in a real-life setting in Germany

(2009) S. Korn et al.   RESPIRATORY MEDICINE

Effect of omalizumab on peripheral blood eosinophilia in allergic asthma

(2009) M. Massanari et al.   RESPIRATORY MEDICINE

Efficacy and safety of omalizumab in an Asian population with moderate-to-severe persistent asthma

(2009) Ken OHTA et al.   RESPIROLOGY

Cluster Analysis and Clinical Asthma Phenotypes

(2008) Pranab Haldar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Daclizumab Improves Asthma Control in Patients with Moderate to Severe Persistent Asthma

(2008) William W. Busse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IgE receptor and signal transduction in mast cells and basophils

(2008) Donald MacGlashan   CURRENT OPINION IN IMMUNOLOGY

Increased sputum and bronchial biopsy IL-13 expression in severe asthma

(2008) Shironjit K. Saha et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Evaluation of the anti-inflammatory effect of infliximab in a mouse model of acute asthma

(2008) Figen DEVECI et al.   RESPIROLOGY

The role of a soluble TNF  receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial

(2008) J B Morjaria et al.   THORAX

Targeting TNF-α: A novel therapeutic approach for asthma

(2007) Christopher Brightling et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY