Article
Agriculture, Dairy & Animal Science
Qiufang Zong, Huan Qu, Yahui Zhao, Haoyu Liu, Shenglong Wu, Shuai Wang, Wenbin Bao, Demin Cai
Summary: This study aims to investigate whether a histone deacetylase inhibitor, sodium butyrate (NaBu), can protect the porcine liver from deoxynivalenol (DON) exposure by modulating cholesterol metabolism. The results showed that NaBu effectively restored parameters associated with liver injury, cholesterol content, and key genes involved in the cholesterol biosynthesis pathway.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Signe Schultz Pedersen, Lars Roed Ingerslev, Mathias Olsen, Michala Prause, Nils Billestrup
Summary: Butyrate can prevent pancreatic islet dysfunction by modifying histone acetylation levels, which may have potential therapeutic effects on type 2 diabetes.
Article
Plant Sciences
Si-Wei Wang, Hao Sheng, Yong-Feng Bai, Yuan-Yuan Weng, Xue-Yu Fan, Fang Zheng, Jing-Qi Fu, Feng Zhang
Summary: The study found that flavanones and phytomedicine rich in flavanones play an important role in protecting pancreatic beta cells in advanced diabetes. Targeting histone acetylation by phytomedicine is a potential strategy to delay the development and progression of diabetes. The inhibition of histone acetylation through regulating AMPK-mediated p300 inactivation is critical for the protective role of naringenin and hesperetin.
Article
Oncology
Saira R. Ali, Ayla Orang, Shashikanth Marri, Ross A. McKinnon, Robyn Meech, Michael Z. Michael
Summary: High-fiber diets with butyrate can prevent colorectal cancer by modulating gene and microRNA expression, providing insights into potential novel drug targets for cancer prevention and treatment.
Article
Biochemistry & Molecular Biology
Ola Karmi, Yang-Sung Sohn, Sara Zandalinas, Linda Rowland, Skylar D. King, Rachel Nechushtai, Ron Mittler
Summary: The CISD2 protein plays a key role in regulating cellular homeostasis, aging, cancer, and neurodegenerative diseases. Inducible disruption of CISD2 function may result in disruption of mitochondrial labile iron and increased levels of mitochondrial ROS. Disrupting CISD2 function may also lead to enhanced expression of the tumor suppressor thioredoxin-interacting protein, dependent on alterations in mitochondrial labile iron levels.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Environmental Sciences
Zhenkun Guo, Jianping Tang, Junxiang Wang, Fuli Zheng, Chunchun Zhang, Yuan-Liang Wang, Ping Cai, Wenya Shao, Guangxia Yu, Siying Wu, Huangyuan Li
Summary: Cobalt-induced neurotoxicity is associated with the inhibition of histone acetylation, leading to dysfunction of key genes associated with neurodegenerative damages. Pre-treatment with HDAC inhibitor can partially attenuate the neurodegenerative damages induced by CoCl2 in SHSY5Y cells. This study provides insights into the connection between histone modification and cobalt-induced neurodegenerative damages.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Yi-Ching Lin, Yu-Chih Lin, Mei-Lan Tsai, Wei-Ting Liao, Chih-Hsing Hung
Summary: Researchers found that TSLP can regulate ROS production and mitophagy through AMPK activation and histone modification, thus affecting the expression of M1/M2 chemokines in human monocytes.
CELL AND BIOSCIENCE
(2022)
Article
Chemistry, Medicinal
Dmitry A. Skvortsov, Sophia K. Emashova, Marina A. Kalinina, Olga A. Dontsova
Summary: Delocalized lipophilic cations (DLCs) are molecules known to target mitochondria and may have antioxidant or anticancer properties. The novel cytotoxic fluorescent compound 62E2 exhibits cytotoxic and mitotoxic effects at low concentrations, with some selectivity against A549 cancer cells. Its closest analog, F16, has also been described as a potential anticancer agent.
ARCHIV DER PHARMAZIE
(2021)
Article
Biochemistry & Molecular Biology
Mingjing Hu, Bilal Alashkar Alhamwe, Brigitte Santner-Nanan, Sarah Miethe, Hani Harb, Harald Renz, Daniel P. Potaczek, Ralph K. Nanan
Summary: This study aimed to generate fully functional human iTregs in vitro using SCFAs and to identify potential phenotypic markers best characterizing human iTregs. The results showed that the addition of butyrate or propionate can potentiate the differentiation of human naive CD4(+) non-Tregs towards iTregs and enhance their suppressive capacity. GITR, ICOS, CD39, PD-1, and PD-L1 were proven to be potential markers of human iTregs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Jianqiong Yang, Ling Cao, Yamei Li, Hai Liu, Minhong Zhang, Huamou Ma, Biao Wang, Xiaoliang Yuan, Qian Liu
Summary: Gracillin, isolated from Reineckia carnea for the first time, showed significant antiproliferative effect on A549 cells and induced apoptosis through the mitochondrial pathway by regulating intracellular calcium concentration, mitochondrial membrane potential, and expression levels of apoptosis-related proteins.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Neurosciences
Yuta Kashiwagi, Hyun Yi, Shue Liu, Keiya Takahashi, Kentaro Hayashi, Daigo Ikegami, Xun Zhu, Jun Gu, Shuanglin Hao
Summary: Opioid use disorders (OUDs) have become epidemic in the United States, involving illicit use, prescription drugs, and counterfeit opioids. This study shows that spinal PGC-1 alpha can reduce morphine tolerance by decreasing mitochondria-targeted superoxide in the spinal cord dorsal horn.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Genetics & Heredity
Simeng Wang, Xinyu Zhang, Qinglian Wang, Rong Wang
Summary: This review summarizes the pathogenesis of podocyte injury in diabetic nephropathy (DN), focusing on the role of histone modification. It provides new insights for further molecular research, diagnosis, and treatment.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Biochemistry & Molecular Biology
Jasvinder Singh, Bindeshwar Sah, Yao Shen, Liang Liu
Summary: This study found that UNC0642 can induce breast cancer cell death by upregulating TXNIP expression and oxidative stress. This discovery could provide a new target for future breast cancer therapies.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Cell Biology
Hao Song, Juanli Chen, Jin Huang, Peng Sun, Yanming Liu, Li Xu, Chuanfei Wei, Xin Mu, Xianjie Lu, Wei Wang, Nan Zhang, Miwei Shang, Mei Mo, Wei Zhang, Hui Zhao, Fabin Han
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD. These epigenetic modifications include DNA methylation, post-translational histone modifications, chromatin remodeling, and RNA-based mechanisms, which regulate cellular functions in almost all cells. Epigenetic alterations are involved in multiple aspects of neuronal development and neurodegeneration in PD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Qingyun Yang, Yingxiao Gao, Xia Liu, Yihang Xiao, Mingxuan Wu
Summary: A new method for editing the N-tail of histone H3 using sortase mediated metathesis (SMM) is reported. This method expands the application scope of sortase and offers a strategy for precise editing of PTMs of cellular histone H3.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)