Glioma Stem Cells and Their Microenvironments: Providers of Challenging Therapeutic Targets

Tissue-resident versus monocyte-derived macrophages in the tumor microenvironment

(2016) Qods Lahmar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Cancer stem cells and their vascular niche: Do they benefit from each other?

(2016) Yi-Fang Ping et al.   CANCER LETTERS

Tumor vasculature and glioma stem cells: Contributions to glioma progression

(2016) Niyati Jhaveri et al.   CANCER LETTERS

Tumortropic monocyte-mediated delivery of echogenic polymer bubbles and therapeutic vesicles for chemotherapy of tumor hypoxia

(2015) Wen-Chia Huang et al.   BIOMATERIALS

Circulating biomarker panels for targeted therapy in brain tumors

(2015) Cristiana Tanase et al.   Future Oncology

Do relevant markers of cancer stem cells CD133 and Nestin indicate a poor prognosis in glioma patients? A systematic review and meta-analysis

(2015) Bin Wu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone

(2015) A. L. Ribeiro Xavier et al.   JOURNAL OF NEUROSCIENCE

Nanoparticle-loaded macrophage-mediated photothermal therapy: potential for glioma treatment

(2015) Steen J. Madsen et al.   LASERS IN MEDICAL SCIENCE

Transcriptional profiling of dividing tumor cells detects intratumor heterogeneity linked to cell proliferation in a brain tumor model

(2015) Berwini B. Endaya et al.   Molecular Oncology

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

(2015) Wenchao Zhou et al.   NATURE CELL BIOLOGY

After counterfeit Avastin®—what have we learned and what can be done?

(2015) Tim K. Mackey et al.   Nature Reviews Clinical Oncology

Intratumoral heterogeneity in glioblastoma: don't forget the peritumoral brain zone

(2015) Jean-Michel Lemée et al.   NEURO-ONCOLOGY

Discovery of Power-Law Growth in the Self-Renewal of Heterogeneous Glioma Stem Cell Populations

(2015) Michiya Sugimori et al.   PLoS One

Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity

(2015) Mona Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factors in cancer stem cells and inflammation

(2015) Gong Peng et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeted therapy against cancer stem cells

(2015) TAO YANG et al.   Oncology Letters

From the core to beyond the margin: a genomic picture of glioblastoma intratumor heterogeneity

(2015) Marc Aubry et al.   Oncotarget

Registered report: Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2015) Denise Chroscinski et al.   eLife

Combined Effects of Pericytes in the Tumor Microenvironment

(2015) Aline Lopes Ribeiro et al.   Stem Cells International

miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis

(2015)   Oncotarget

Neoplastic cells are a rare component in human glioblastoma microvasculature

(2015) Fausto J. Rodriguez et al.   Oncotarget

Pericyte contractility controls endothelial cell cycle progression and sprouting: insights into angiogenic switch mechanics

(2014) Jennifer T. Durham et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hypoxic signature of microRNAs in glioblastoma: insights from small RNA deep sequencing

(2014) Rahul Agrawal et al.   BMC GENOMICS

Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth

(2014) Alexander Pietras et al.   Cell Stem Cell

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

Endothelial cells promote stem-like phenotype of glioma cells through activating the Hedgehog pathway

(2014) Guang-Ning Yan et al.   JOURNAL OF PATHOLOGY

Pericyte Dynamics during Angiogenesis: New Insights from New Identities

(2014) Peter C. Stapor et al.   JOURNAL OF VASCULAR RESEARCH

Integrated analysis identifies different metabolic signatures for tumor-initiating cells in a murine glioblastoma model

(2014) I. Saga et al.   NEURO-ONCOLOGY

Glioblastoma cancer stem cells: Biomarker and therapeutic advances

(2014) Kelli B. Pointer et al.   NEUROCHEMISTRY INTERNATIONAL

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

Notch1 Stimulation Induces a Vascularization Switch With Pericyte-Like Cell Differentiation of Glioblastoma Stem Cells

(2014) Pierre-Olivier Guichet et al.   STEM CELLS

CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment

(2014) Roberto Würth et al.   Frontiers in Cellular Neuroscience

Tumor and Endothelial Cell Hybrids Participate in Glioblastoma Vasculature

(2014) Soufiane El Hallani et al.   Biomed Research International

Hypoxia-regulated microRNAs in human cancer

(2013) Guomin Shen et al.   ACTA PHARMACOLOGICA SINICA

Fibroblast growth factor-2 up-regulates the expression of nestin through the Ras–Raf–ERK–Sp1 signaling axis in C6 glioma cells

(2013) Kai-Wei Chang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of basic fibroblast growth factor in glioblastoma multiforme and glioblastoma stem cells and in their in vitro culture

(2013) Elizabeth M. Haley et al.   CANCER LETTERS

MicroRNA-218 Inhibits Glioma Invasion, Migration, Proliferation, and Cancer Stem-like Cell Self-Renewal by Targeting the Polycomb Group Gene Bmi1

(2013) Y. Tu et al.   CANCER RESEARCH

Glioblastoma Stem Cells Are Regulated by Interleukin-8 Signaling in a Tumoral Perivascular Niche

(2013) D. W. Infanger et al.   CANCER RESEARCH

Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth

(2013) Lin Cheng et al.   CELL

Initial Contact of Glioblastoma Cells with Existing Normal Brain Endothelial Cells Strengthen the Barrier Function via Fibroblast Growth Factor 2 Secretion: A New In Vitro Blood–Brain Barrier Model

(2013) Keisuke Toyoda et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Therapy targets in glioblastoma and cancer stem cells: lessons from haematopoietic neoplasms

(2013) Maria Linda Cruceru et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Increased nanoparticle-loaded exogenous macrophage migration into the brain following PDT-induced blood-brain barrier disruption

(2013) Steen J. Madsen et al.   LASERS IN SURGERY AND MEDICINE

Cytokine Patterns in Brain Tumour Progression

(2013) Radu Albulescu et al.   MEDIATORS OF INFLAMMATION

Brain tumor stem cells: Molecular characteristics and their impact on therapy

(2013) David L. Schonberg et al.   MOLECULAR ASPECTS OF MEDICINE

Expression of 19 microRNAs in glioblastoma and comparison with other brain neoplasia of grades I-III

(2013) Michela Visani et al.   Molecular Oncology

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

CD133 Is Essential for Glioblastoma Stem Cell Maintenance

(2013) Paola Brescia et al.   STEM CELLS

Mechanisms of Glioma-Associated Neovascularization

(2012) Matthew E. Hardee et al.   AMERICAN JOURNAL OF PATHOLOGY

The cancer stem cell niche(s): The crosstalk between glioma stem cells and their microenvironment

(2012) Alina Filatova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Self-Renewal Does Not Predict Tumor Growth Potential in Mouse Models of High-Grade Glioma

(2012) Lindy E. Barrett et al.   CANCER CELL

Cancer stem cells from a rare form of glioblastoma multiforme involving the neurogenic ventricular wall

(2012) Shengwen Li et al.   Cancer Cell International

Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin  6 1 in Glioblastoma

(2012) P. Huang et al.   CANCER RESEARCH

Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors

(2012) Yan Xia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications

(2012) Liuqi Yang et al.   EXPERIMENTAL CELL RESEARCH

miR-125b regulates the proliferation of glioblastoma stem cells by targeting E2F2

(2012) Ning Wu et al.   FEBS LETTERS

Intratumoral, not circulating, endothelial progenitor cells share genetic aberrations with glial tumor cells

(2012) Ping-Pin Zheng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Efficacy of clinically relevant temozolomide dosing schemes in glioblastoma cancer stem cell lines

(2012) Dagmar Beier et al.   JOURNAL OF NEURO-ONCOLOGY

Failure pattern following complete resection plus radiotherapy and temozolomide is at the resection margin in patients with glioblastoma

(2012) Kevin Petrecca et al.   JOURNAL OF NEURO-ONCOLOGY

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Functional Differences of miR-125b on the Invasion of Primary Glioblastoma CD133-Negative Cells and CD133-Positive Cells

(2012) Lei Shi et al.   NEUROMOLECULAR MEDICINE

c-Jun N-terminal kinase has a pivotal role in the maintenance of self-renewal and tumorigenicity in glioma stem-like cells

(2012) C-H Yoon et al.   ONCOGENE

CXCR4-Positive Subset of Glioma Is Enriched for Cancer Stem Cells

(2012) Xuesheng Zheng et al.   ONCOLOGY RESEARCH

miR-34a Repression in Proneural Malignant Gliomas Upregulates Expression of Its Target PDGFRA and Promotes Tumorigenesis

(2012) Joachim Silber et al.   PLoS One

Differential Proteomic Analysis of Human Glioblastoma and Neural Stem Cells Reveals HDGF as a Novel Angiogenic Secreted Factor

(2012) Cécile Thirant et al.   STEM CELLS

Potential CanonicalWntPathway Activation in High-Grade Astrocytomas

(2012) Rebecca Schüle et al.   TheScientificWorldJOURNAL

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry

(2012) J S Tchorz et al.   Cell Death & Disease

MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10

(2011) Lihua Sun et al.   BRAIN RESEARCH

Targeting SDF-1/CXCR4 to inhibit tumour vasculature for treatment of glioblastomas

(2011) D Tseng et al.   BRITISH JOURNAL OF CANCER

Angiogenesis and immunity: a bidirectional link potentially relevant for the monitoring of antiangiogenic therapy and the development of novel therapeutic combination with immunotherapy

(2011) Eric Tartour et al.   CANCER AND METASTASIS REVIEWS

Endothelial Cells Create a Stem Cell Niche in Glioblastoma by Providing NOTCH Ligands That Nurture Self-Renewal of Cancer Stem-Like Cells

(2011) T. S. Zhu et al.   CANCER RESEARCH

EGFR-AKT-Smad Signaling Promotes Formation of Glioma Stem-like Cells and Tumor Angiogenesis by ID3-Driven Cytokine Induction

(2011) X. Jin et al.   CANCER RESEARCH

HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells

(2011) J. Mathieu et al.   CANCER RESEARCH

Glioma Stem Cell Proliferation and Tumor Growth Are Promoted by Nitric Oxide Synthase-2

(2011) Christine E. Eyler et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Identification of cancer stem cells from human glioblastomas: growth and differentiation capabilities and CD133/prominin-1 expression

(2011) Federica Gambelli et al.   CELL BIOLOGY INTERNATIONAL

Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential

(2011) J M Heddleston et al.   CELL DEATH AND DIFFERENTIATION

HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway

(2011) L Qiang et al.   CELL DEATH AND DIFFERENTIATION

CD133+ Glioblastoma Stem-Like Cells Induce Vascular Mimicry in Vivo

(2011) Ming-Tsang Chiao et al.   CURRENT NEUROVASCULAR RESEARCH

Glioma Stem Cell Maintenance: The Role of the Microenvironment

(2011) John M. Heddleston et al.   CURRENT PHARMACEUTICAL DESIGN

Secreted factors from brain endothelial cells maintain glioblastoma stem-like cell expansion through the mTOR pathway

(2011) Eva Maria Galan-Moya et al.   EMBO REPORTS

The role of microRNAs in glioma initiation and progression

(2011) Ying Zhang   Frontiers in Bioscience-Landmark

Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas

(2011) Yuji Guo et al.   HISTOPATHOLOGY

Glioma-initiating Cells Retain Their Tumorigenicity through Integration of the Sox Axis and Oct4 Protein

(2011) Hiroaki Ikushima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pro-inflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma

(2011) Marco Tafani et al.   Journal of Neuroinflammation

Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model

(2011) Shu-Chi Wang et al.   LABORATORY INVESTIGATION

Survivin promotes glioma angiogenesis through vascular endothelial growth factor and basic fibroblast growth factor in vitro and in vivo

(2011) Peng Wang et al.   MOLECULAR CARCINOGENESIS

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(2011) Ilya Ulasov et al.   MOLECULAR MEDICINE

Antiangiogenic therapy, hypoxia and metastasis: risky liaisons, or not?

(2011) Katrien De Bock et al.   Nature Reviews Clinical Oncology

Identification of a SOX2-dependent subset of tumor- and sphere-forming glioblastoma cells with a distinct tyrosine kinase inhibitor sensitivity profile

(2011) Daniel Hägerstrand et al.   NEURO-ONCOLOGY

EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway

(2011) R Bonavia et al.   ONCOGENE

Expression of NANOG in human gliomas and its relationship with undifferentiated glioma cells

(2011) Chao-Shi Niu   ONCOLOGY REPORTS

Correlation between glioblastoma stem-like cells and tumor vascularization

(2011) Chao Niu   ONCOLOGY REPORTS

Direct In Vivo Evidence for Tumor Propagation by Glioblastoma Cancer Stem Cells

(2011) Justin D. Lathia et al.   PLoS One

Characteristics of the Alternative Phenotype of Microglia/Macrophages and its Modulation in Experimental Gliomas

(2011) Konrad Gabrusiewicz et al.   PLoS One

Transdifferentiation of glioblastoma cells into vascular endothelial cells

(2011) Y. Soda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth hormone-releasing hormone: not only a neurohormone

(2011) Hippokratis Kiaris et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hypoxia induces tumor and endothelial cell migration in a Semaphorin 3F- and VEGF-dependent manner via transcriptional repression of their common receptor Neuropilin 2

(2011) Silvia Coma et al.   Cell Adhesion & Migration

Hypoxia Increases the Expression of Stem-Cell Markers and Promotes Clonogenicity in Glioblastoma Neurospheres

(2010) Eli E. Bar et al.   AMERICAN JOURNAL OF PATHOLOGY

Sox2 is translationally activated by eukaryotic initiation factor 4E in human glioma-initiating cells

(2010) Yuqing Ge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Potential therapeutic implications of cancer stem cells in glioblastoma

(2010) Lin Cheng et al.   BIOCHEMICAL PHARMACOLOGY

Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells

(2010) Sridhar Reddy Chirasani et al.   BRAIN

A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry

(2010) S. El Hallani et al.   BRAIN

A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma

(2010) Ruihuan Chen et al.   CANCER CELL

TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma

(2010) Judit Anido et al.   CANCER CELL

Transcriptional Profiles of CD133+ and CD133- Glioblastoma-Derived Cancer Stem Cell Lines Suggest Different Cells of Origin

(2010) C. Lottaz et al.   CANCER RESEARCH

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

(2010) John M. Heddleston et al.   CELL CYCLE

Growth hormone-releasing hormone: Extrapituitary effects in physiology and pathology

(2010) Nektarios Barabutis et al.   CELL CYCLE

Acidic stress promotes a glioma stem cell phenotype

(2010) A B Hjelmeland et al.   CELL DEATH AND DIFFERENTIATION

Integrin Alpha 6 Regulates Glioblastoma Stem Cells

(2010) Justin D. Lathia et al.   Cell Stem Cell

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

(2010) Nikki Charles et al.   Cell Stem Cell

MiRNA-196 Is Upregulated in Glioblastoma But Not in Anaplastic Astrocytoma and Has Prognostic Significance

(2010) Y. Guan et al.   CLINICAL CANCER RESEARCH

NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

(2010) Marie Zbinden et al.   EMBO JOURNAL

The use of hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma

(2010) Feng Zhi et al.   EUROPEAN JOURNAL OF CANCER

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

(2010) Johanna Chiche et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

(2010) Mitomu Kioi et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy

(2010) Jonathan M. Weiss et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD133+ niches and single cells in glioblastoma have different phenotypes

(2010) Karina Christensen et al.   JOURNAL OF NEURO-ONCOLOGY

Glioma-initiating cells: A predominant role in microglia/macrophages tropism to glioma

(2010) Liang Yi et al.   JOURNAL OF NEUROIMMUNOLOGY

BMI1 Confers Radioresistance to Normal and Cancerous Neural Stem Cells through Recruitment of the DNA Damage Response Machinery

(2010) S. Facchino et al.   JOURNAL OF NEUROSCIENCE

Genome-wide expression profiling identifies deregulated miRNAs in malignant astrocytoma

(2010) Soumya AM Rao et al.   MODERN PATHOLOGY

MicroRNA-451 Regulates LKB1/AMPK Signaling and Allows Adaptation to Metabolic Stress in Glioma Cells

(2010) Jakub Godlewski et al.   MOLECULAR CELL

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

Glioma cancer stem cells induce immunosuppressive macrophages/microglia

(2010) Adam Wu et al.   NEURO-ONCOLOGY

Intratumoral Hypoxic Gradient Drives Stem Cells Distribution and MGMT Expression in Glioblastoma

(2010) Francesca Pistollato et al.   STEM CELLS

MicroRNAs: new players in the DNA damage response

(2010) H. Hu et al.   Journal of Molecular Cell Biology

Identification and Functional Characterization of microRNAs Involved in the Malignant Progression of Gliomas

(2009) Bastian Malzkorn et al.   BRAIN PATHOLOGY

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis and Vasculogenesis via Vascular Endothelial Growth Factor and Stromal-Derived Factor 1

(2009) C. Folkins et al.   CANCER RESEARCH

Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells

(2009) Yoshinori Yoshida et al.   Cell Stem Cell

Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens

(2009) Steven M. Pollard et al.   Cell Stem Cell

Autocrine TGF-β Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors

(2009) Hiroaki Ikushima et al.   Cell Stem Cell

CD133+ and nestin+ tumor-initiating cells dominate in N29 and N32 experimental gliomas

(2009) Daniel Bexell et al.   INTERNATIONAL JOURNAL OF CANCER

Ionizing Radiation Shifts the PAI-1/ID-1 Balance and Activates Notch Signaling in Endothelial Cells

(2009) Marion Scharpfenecker et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

FM19G11, a New Hypoxia-inducible Factor (HIF) Modulator, Affects Stem Cell Differentiation Status

(2009) Victoria Moreno-Manzano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Integrated Approach for Experimental Target Identification of Hypoxia-induced miR-210

(2009) Pasquale Fasanaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flow cytometry and in vitro analysis of human glioma–associated macrophages

(2009) Ian F. Parney et al.   JOURNAL OF NEUROSURGERY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α

(2009) A Soeda et al.   ONCOGENE

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

Gliosarcoma Stem Cells Undergo Glial and Mesenchymal Differentiation In Vivo

(2009) Ana C. deCarvalho et al.   STEM CELLS

Targeting Interleukin 6 Signaling Suppresses Glioma Stem Cell Survival and Tumor Growth

(2009) Hui Wang et al.   STEM CELLS

Notch Promotes Radioresistance of Glioma Stem Cells

(2009) Jialiang Wang et al.   STEM CELLS

STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells

(2009) Maureen M. Sherry et al.   STEM CELLS

Notch Pathway Blockade Depletes CD133-Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts

(2009) Xing Fan et al.   STEM CELLS

MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells

(2008) Hilah Gal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glioma stem cells are more aggressive in recurrent tumors with malignant progression than in the primary tumor, and both can be maintained long-term in vitro

(2008) Qiang Huang et al.   BMC CANCER

Epigenetic-Mediated Dysfunction of the Bone Morphogenetic Protein Pathway Inhibits Differentiation of Glioblastoma-Initiating Cells

(2008) Jeongwu Lee et al.   CANCER CELL

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

CXCR4 mediates the proliferation of glioblastoma progenitor cells

(2008) Moneeb Ehtesham et al.   CANCER LETTERS

Gli Activity Correlates with Tumor Grade in Platelet-Derived Growth Factor-Induced Gliomas

(2008) O. J. Becher et al.   CANCER RESEARCH

Adult SVZ Stem Cells Lie in a Vascular Niche: A Quantitative Analysis of Niche Cell-Cell Interactions

(2008) Qin Shen et al.   Cell Stem Cell

Cancer Stem Cell Analysis and Clinical Outcome in Patients with Glioblastoma Multiforme

(2008) R. Pallini et al.   CLINICAL CANCER RESEARCH

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

(2008) D. Hambardzumyan et al.   GENES & DEVELOPMENT

Nestin and CD133: valuable stem cell-specific markers for determining clinical outcome of glioma patients

(2008) Mingyu Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas

(2008) Kyeung Min Joo et al.   LABORATORY INVESTIGATION

Presence of pluripotent CD133+ cells correlates with malignancy of gliomas

(2008) Niklas Thon et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumours

(2008) V. Häyry et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

SOX2Silencing in Glioblastoma Tumor-Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity

(2008) Rosaria Maria Rita Gangemi et al.   STEM CELLS