Journal
CANCER LETTERS
Volume 380, Issue 2, Pages 561-567Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2015.05.010
Keywords
Vascular niches; Tumor microenvironment; Cancer stem cells; Endothelial cells; Therapeutic significance
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Funding
- National Natural Science Foundation of China (NSFC) [81230062, 81370071]
- Natural Science Foundation Project of CQ CSTC [CSTC2013JCYJYS10001]
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Cancer stem cells (CSCs) locate in and interact with particular vascular niches to maintain their stemness. CSCs induce, remodel and participate in the formation of microenvironmental niches to facilitate survival, sternness and escape from radio-/chemo-/bio-therapies. Neovasculature in tumor is often basement membrane-deficient and enriched with CSC-derived endothelial cells (ECs) and other mural cells, which may promote tumor invasion and metastasis. The aim of this review is to summarize recent findings about the crosstalk between CSCs and their vascular niches and discuss the potential therapeutic significance. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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