Article
Immunology
Muqiu Zhang, Dong Cui, Huixia Yang
Summary: The study found increased distribution of M2 macrophages in the chorionic villi of pregnant women with uncontrolled T2DM, while the subsets of M2 macrophages in the placental decidua were similar between uncontrolled T2DM pregnant women and normal groups.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Salvatore Vaiasicca, Gianmarco Melone, David W. James, Marcos Quintela, Alessandra Preziuso, Richard H. Finnell, Robert Steven Conlan, Lewis W. Francis, Bruna Corradetti
Summary: Study using mesenchymal stem cells from chorionic villi reveals complex molecular mechanisms in Down syndrome, with genes located on chromosomes other than 21 playing key roles in cell cycle regulation and immune response pathways, highlighting the potential for personalized interventions.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Honglei Zhu, Huayan Li, Kunjie Gao, Yi Huang, Yuru Liao, Weichu Hu, Feng Chen, Haoyuan Jiang, Xiaomei Liang, Haonan Song, Yuxin Wang, Hanrong Huang, Yifan Wang, Fan Liu, Hao Huang, Qian Wang, Xiao Yi
Summary: We developed CV-derived nanofibers to enhance the secretion and bioactivity of EVs from MSCs. We constructed a CV-nanofiber bionic culture system for large-scale cultivation of MSCs to collect high-concentration EVs. Additionally, encapsulating EVs with CV-nanofibers formed EVs-ECM aggregates, which effectively promoted endometrium regeneration. This study provides new insights for enhancing EV secretion and bioactivity, and offers a cell-free therapy for treating IUA.
Review
Biology
Gina D. Kusuma, Harry M. Georgiou, Anthony Perkins, Mohamed H. Abumaree, Shaun P. Brennecke, Bill Kalionis
Summary: Preeclampsia is a serious disorder of pregnancy that can lead to hypertension and proteinuria. Abnormal placental growth and perfusion cause oxidative stress and secretion of abnormal levels of pro-angiogenic and anti-angiogenic factors by the placenta, resulting in damage to the maternal vascular endothelium and the clinical features of preeclampsia. Current treatments for preeclampsia are limited. The decidua is a major source of reactive oxygen species, and the role of decidua-derived MSC in normal and pathological placental development is poorly understood. MSC have the ability to respond to oxidative stress, but this response is compromised in preeclampsia.
YALE JOURNAL OF BIOLOGY AND MEDICINE
(2022)
Article
Cell & Tissue Engineering
Mario A. Gomez-Salazar, Yiyun Wang, Neelima Thottappillil, Reef W. Hardy, Manon Alexandre, Fabian Holler, Niall Martin, Zaniah N. Gonzalez-Galofre, Dorota Stefancova, Daniele Medici, Aaron W. James, Bruno Peault
Summary: This study found that innate mesenchymal stem cells with multilineage differentiation and tissue (re)generative or pathogenic properties reside in perivascular niches. The activity of aldehyde dehydrogenase was evaluated in human adipose tissue perivascular areas and found to mark the high potential mesenchymal stem cells. The main isoform in this cell fraction is ALDH1A1.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Livia Rosa-Fernandes, Carla Bandeira, Shahab Zaki Pour, Viviane de Fatima Benedetti, Daniel Ferreira, Aline R. Lorenzon, Jusciele B. Moreli, Claudio Romero Farias Marinho, Martin R. Larsen, Paolo Zanotto, Giuseppe Palmisano, Estela Bevilacqua
Summary: The study utilized quantitative proteomics analysis to investigate the impact of ZIKV infection on placental cells, revealing altered levels of proteins involved in cell proliferation, apoptosis, and inflammatory processes. The findings suggest that antibody-opsonized ZIKV particles may play a pivotal role in determining infection outcomes and the role of mixed infections, providing valuable insights for infection control strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Obstetrics & Gynecology
Maria Teresa Bruno, Salvatore Caruso, Francesca Bica, Giulia Arcidiacono, Sara Boemi
Summary: This study demonstrates that papillomavirus DNA can infect the placenta and that placental HPV infection can occur as early as the first trimester of pregnancy.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Cell Biology
Yoon Young Go, Sung-won Chae, Jae-Jun Song
Summary: Human chorionic membrane extracts (CME) enhance osteogenesis by providing an osteoconductive environment for osteoblasts. CME contains various osteogenesis-related stimulators and triggers osteogenic differentiation through specific cellular signaling pathways.
CELL PROLIFERATION
(2022)
Article
Medicine, General & Internal
Sophia Indira Romberg, Nina-Naomi Kreis, Alexandra Friemel, Susanne Roth, Alice Steglich Souto, Samira Catharina Hoock, Kyra Fischer, Thorsten Nowak, Christine Solbach, Frank Louwen, Andreas Ritter, Juping Yuan
Summary: This study found that the functionality of hCV-MSCs is dependent on primary cilia and that primary cilia are impaired in hCV-MSCs from preeclamptic placentas.
Article
Cell Biology
Zhongzhen Liu, Man Zhai, Qingqing Zhang, Tingyu Yang, Zunmin Wan, Jianlin Li, Xiaofeng Liu, Bo Xu, Libei Du, Rachel W. S. Chan, Li Zhang, William S. B. Yeung, Ka Wang Cheung, Philip C. N. Chiu, Wen-Jing Wang, Cheuk-Lun Lee, Ya Gao
Summary: This study described the landscape of spatial transcriptome of human placental villi and identified the main cell types and regulatory pathways. The results provide valuable insights for further investigation of placenta development, physiology, and pathology in a spatial context.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Microscopy
Arash Rabbani, Masoud Babaei, Masoumeh Gharib
Summary: This study presents a novel method of data augmentation for segmenting placental histological images with limited labeled data. The method generates new realizations of the placenta morphology while preserving the general textures and orientations. The results show that the method leads to a significant decrease in the binary cross-entropy loss and provides more accurate morphological characterization of the placental intervillous space.
Article
Immunology
Jing Yang, Lili Gong, Qiming Liu, Huanqiang Zhao, Zekun Wang, Xiaotian Li, Weidong Tian, Qiongjie Zhou
Summary: Preeclampsia (PE) is a major cause of complications and deaths in pregnant women and fetuses. This study investigates the molecular mechanism of PE by analyzing single-cell transcriptomes of placenta and decidua from patients with late-onset PE (LOPE) and normal pregnant women. The findings suggest that LOPE is associated with deficient development of trophoblasts and impaired invasion of extravillous trophoblasts (EVT) in the placenta, as well as insufficient decidualization of decidual stromal cells (DSC) and suppressed regulatory functions of decidual immune cells in the decidua.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Huiyuan Pang, Di Lei, Yuping Guo, Ying Yu, Tingting Liu, Yujie Liu, Tingting Chen, Cuifang Fan
Summary: This article explores the close link between pregnancy and cancer, and suggests the potential of utilizing pregnancy as a clue for cancer treatment from the perspectives of cells, microenvironment, and metabolism.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xia Chen, Qianwen Zheng, Li Ji, Yanyan Zhuang, Hao Yu, Xinmeng Cheng, Yun Han, Jinxing Lv, Bo Zheng, Yanli Zheng, Jun Yu
Summary: This study identified molecular signaling pathways related to missed abortion (MA) using a quantitative proteomics approach. They found that COX6C played a critical role in MA and its down-regulated expression may contribute to the pathophysiology of MA. The study helps to understand the pathophysiological mechanisms of MA.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell & Tissue Engineering
Hiroshi Takahashi, Taku Nakashima, Takeshi Masuda, Masashi Namba, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Summary: The study reveals that lung-resident ALDH(br) cells play a crucial role in pulmonary fibrosis, as transferring these cells can ameliorate fibrosis and the decrease in ALDH(br) cells is more significant in aged mice.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Nutrition & Dietetics
Claire Hogan, Anthony V. Perkins
Summary: Selenium is an essential trace element for human health, and deficiency can lead to various diseases. Selenium is incorporated into selenoproteins, which play important roles in antioxidant defense, signaling, hormone production, DNA synthesis, and protein response. This review highlights the importance of selenium for a healthy pregnancy and the role of placental selenoproteins in early life development.
Article
Multidisciplinary Sciences
Paulina Pruszkowska-Przybylska, Shaun Brennecke, Eric K. Moses, Phillip E. Melton
Summary: Advanced biological aging, assessed through DNA methylation markers, is associated with complex diseases. This study found that maternal DNA methylation age acceleration is increased in women with preeclampsia. Further investigation into differential DNA methylation in preeclampsia is important.
SCIENTIFIC REPORTS
(2022)
Article
Obstetrics & Gynecology
Natalie Suff, Vicky X. Xu, Giorgia Dalla Valle, Jenny Carter, Shaun Brennecke, Andrew Shennan
Summary: This study investigated the risk of recurrent spontaneous preterm birth (sPTB) in women with a prior term birth and a subsequent sPTB. The results showed that women with a previous term birth had a higher risk of recurrent sPTB compared to women with only a history of sPTB. The etiology of sPTB may differ in this subgroup of women and further research is needed to identify and treat them effectively.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Natalie Suff, Vicky X. Xu, Agnieszka Glazewska-Hallin, Jenny Carter, Shaun Brennecke, Andrew Shennan
Summary: In women who have had a previous term caesarean section (EmCS) and have risk factors for preterm birth, the risk of a recurrent preterm birth is higher than in women without a previous EmCS. Furthermore, both first and second stage EmCS are associated with an increased risk of recurrent preterm birth.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Nutrition & Dietetics
Pierre Hofstee, Anthony V. Perkins, James S. M. Cuffe
Summary: Selenium deficiency during the perinatal period reduces exercise behavior and leads to glucose intolerance in offspring. Exercise may not be the optimal intervention for metabolic disease in offspring affected by selenium deficiency in early life.
Review
Obstetrics & Gynecology
Stefan Verlohren, Shaun P. Brennecke, Alberto Galindo, S. Ananth Karumanchi, Ljiljana B. Mirkovic, Dietmar Schlembach, Holger Stepan, Manu Vatish, Harald Zeisler, Sarosh Rana
Summary: Preeclampsia poses significant morbidity and mortality risks for both mother and baby. The discovery of circulating angiogenic factors in preeclampsia pathogenesis has advanced diagnosis and prognosis, but there is currently no consensus or clear guidance on their practical use in routine clinical practice.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Developmental Biology
C. Perera, S. Zheng, M. I. Kokkinos, H. M. Georgiou, M. Schoppet, P. F. James, S. P. Brennecke, B. Kalionis
Summary: In preeclampsia, the presence of PE-DMSCs in the vascular niche contributes to endothelial cell dysfunction due to increased release of ENG. Conversely, in normotensive pregnancies, DMSC secretion of ENG likely has a beneficial effect on endothelial cells.
Review
Genetics & Heredity
Molly Johnston, Chanelle Warton, Mark D. Pertile, Michelle Taylor-Sands, Martin B. Delatycki, Lisa Hui, Julian Savulescu, Catherine Mills
Summary: This paper discusses the ethical issues surrounding NIPT for SCAs, along with current guidelines and management protocols. Careful consideration is needed regarding what information is provided to users.
PRENATAL DIAGNOSIS
(2023)
Article
Genetics & Heredity
Katrina L. L. Scarff, Nicola Flowers, Clare J. J. Love, Alison D. D. Archibald, Clare E. E. Hunt, Olivia Giouzeppos, Justine Elliott, Martin B. B. Delatycki, Mark D. D. Pertile
Summary: This study evaluated the performance of cell-free DNA (cfDNA) screening for common fetal aneuploidies, choice of prenatal procedure, and chromosome conditions identified during pregnancy after low-risk cfDNA screening. The results showed that cfDNA screening had high accuracy, but some chromosome conditions were still undetectable and required ultrasound examination and prenatal diagnostic testing for identification.
PRENATAL DIAGNOSIS
(2023)
Review
Obstetrics & Gynecology
Kelly Hughes, Heather Ford, Shakila Thangaratinam, Shaun Brennecke, Ben W. Mol, Rui Wang
Summary: This study conducted a systematic review of 14 papers and found that cervical length is associated with the risk of preterm birth. However, most of the systematic reviews analyzed the diagnostic test accuracy of cervical length rather than its predictive ability. It is recommended to perform individual participant data meta-analysis to better quantify the predictive capacity of transvaginal ultrasonographic cervical length for preterm birth.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Genetics & Heredity
Marta Cifuentes Ochoa, Nicola Jane Flowers, Mark Domenic Pertile, Alison Dalton Archibald
Summary: This study explores the lived experience of reciprocal translocation carriers and their partners. It reveals that carrier status has long-term emotional and reproductive impacts, causing uncertainty and fear during pregnancy. Access to accurate information, peer support, and hope are crucial for adaptation to this new reality. Knowing the carrier status of their children is valued by couples. The complex impacts of carrying a reciprocal translocation emphasize the importance of specialist genetic counseling services in supporting couples.
JOURNAL OF GENETIC COUNSELING
(2023)
Editorial Material
Genetics & Heredity
Lisa Hui, Katie Ellis, Dora Mayen, Mark D. D. Pertile, Rebecca Reimers, Luming Sun, Joris Vermeesch, Neeta L. L. Vora, Lyn S. S. Chitty, SPD Board of Directors
PRENATAL DIAGNOSIS
(2023)
Meeting Abstract
Obstetrics & Gynecology
C. Siepen, S. Brennecke
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Meeting Abstract
Obstetrics & Gynecology
S. Corker, T. Cade, S. Brennecke
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Review
Biology
Gina D. Kusuma, Harry M. Georgiou, Anthony Perkins, Mohamed H. Abumaree, Shaun P. Brennecke, Bill Kalionis
Summary: Preeclampsia is a serious disorder of pregnancy that can lead to hypertension and proteinuria. Abnormal placental growth and perfusion cause oxidative stress and secretion of abnormal levels of pro-angiogenic and anti-angiogenic factors by the placenta, resulting in damage to the maternal vascular endothelium and the clinical features of preeclampsia. Current treatments for preeclampsia are limited. The decidua is a major source of reactive oxygen species, and the role of decidua-derived MSC in normal and pathological placental development is poorly understood. MSC have the ability to respond to oxidative stress, but this response is compromised in preeclampsia.
YALE JOURNAL OF BIOLOGY AND MEDICINE
(2022)