Journal
NUTRIENTS
Volume 14, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/nu14030628
Keywords
selenium; pregnancy; placenta; selenoproteins
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Selenium is an essential trace element for human health, and deficiency can lead to various diseases. Selenium is incorporated into selenoproteins, which play important roles in antioxidant defense, signaling, hormone production, DNA synthesis, and protein response. This review highlights the importance of selenium for a healthy pregnancy and the role of placental selenoproteins in early life development.
Selenium is an essential trace element required for human health, and selenium deficiency has been associated with many diseases. The daily recommended intake of selenium is 60 mu g/day for adults, which increases to 65 mu g/day for women when pregnant. Selenium is incorporated into the 21st amino acid, selenocysteine (sec), a critical component of selenoproteins that plays an important role in a variety of biological responses such as antioxidant defence, reactive oxygen species (ROS) signalling, formation of thyroid hormones, DNA synthesis and the unfolded protein response in the endoplasmic reticulum (ER). Although 25 selenoproteins have been identified, the role of many of these is yet to be fully characterised. This review summarises the current evidence demonstrating that selenium is essential for a healthy pregnancy and that poor selenium status leads to gestational disorders. In particular, we focus on the importance of the placental selenoproteome, and the role these proteins may play in a healthy start to life.
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