Article
Biochemistry & Molecular Biology
Fang Wang, Kexin Huang, Ziqi Xu, Fengna Shi, Cheng Chen
Summary: In this study, two nanocomposite polysaccharide hydrogels were developed using a simple mixing method. The hydrogels exhibited improved tensile strength, fatigue resistance, and self-healing ability due to the presence of dynamic bonds. Additionally, the drug-loaded nanocomposite hydrogels showed sustained release and increased release under acidic conditions, making them promising candidates for drug delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Dingding Wang, Weibo Wang, Ping Wang, Chuang Wang, Juntao Niu, Yang Liu, Yuzhou Chen
Summary: This paper summarizes the physiological factors of colonic drug delivery, the pathological characteristics of common colonic diseases, and the latest advances in the design, preparation, and characterization of natural polysaccharide hydrogels. It is expected to provide new references for colon-targeted oral hydrogel systems using natural polysaccharides as raw materials.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Materials Science, Biomaterials
Kartik Sahajpal, Shashank Shekhar, Amit Kumar, Bhasha Sharma, Mahendra Kumar Meena, Ajay Kumar Bhagi, Shreya Sharma
Summary: Stimuli-responsive biopolymer hydrogels have promising applications in biomedicine due to their excellent hydrophilicity, biocompatibility, and dynamic responsiveness to various stimuli. Schiff base-linked protein and polypeptide hydrogels, which exhibit structural dynamic behaviors, such as shape memory, self-healing properties, and dynamic mechanical resilience, can be developed for in vivo therapy. Natural proteins and synthetic polypeptides are ideal candidates for fabricating such hydrogels.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Xiang Li, Huijun Zhang, Lingyan Liu, Chunyan Cao, Peng Wei, Xin Yi, Yifeng Zhou, Qingyang Lv, Dongfang Zhou, Tao Yi
Summary: This article introduces a new peptide-based hydrogelator Fmoc-FFRRVR, which is easier to form a hydrogel under mild conditions compared to the traditional Fmoc-FF, with a gelation time of only 2 seconds. Fmoc-FFRRVR self-assembles into organized arrays of beta-sheets in nanofibers, displaying elasticity, reversibility, and injectability, making it suitable for biomedical applications such as drug carriers.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Polymer Science
Bahareh Farasati Far, Mohammad Reza Naimi-Jamal, Maryam Safaei, Kimia Zarei, Marzieh Moradi, Hamed Yazdani Nezhad
Summary: Natural polymer-based hydrogels have shown great potential and applications in drug delivery systems. Polysaccharides can cross-link with other molecules to form hydrogels, enabling targeted drug delivery. Hydrogels, as adjustable biomedical devices, have wide applications in the field of pharmaceuticals and biomedical engineering.
Article
Chemistry, Multidisciplinary
Payel Dowari, Shalini Roy, Saurav Das, Sumit Chowdhuri, Ritvika Kushwaha, Basab K. Das, Anindita Ukil, Debapratim Das
Summary: A mannose-containing composite hydrogel was prepared by combining a self-aggregating short peptide and a mannose-containing non-aggregating peptide. The hydrogel showed stability, biodegradability, non-cytotoxicity, and efficient drug delivery to kill the parasite.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Wei Liu, Xiaoge Wang, Danyang Zhou, Xiangze Fan, Jinhua Zhu, Xiuhua Liu
Summary: A novel hydrogel was designed and prepared based on a three-component reaction. The hydrogel exhibited dual responsiveness to glucose and pH, enabling controllable release of insulin. It also showed a synergistic effect in protecting hepatocytes from oxidative stress. These findings suggest potential clinical applications for treating insulin deficiency in diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Zijia Wang, Xinyue Zhai, Ming Fan, Huaping Tan, Yong Chen
Summary: In this study, magnetic microspheres based on chitosan derivatives were developed and a thermal-reversible, self-healing hydrogel was prepared by incorporating these microspheres. The hybrid scaffolds synthesized with the magnetic microspheres showed controllable shape and mobility under magnetic force. The scaffolds exhibited good morphology, dispersity, and stability in physical environment.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Zhenghao Zhang, Sifan Ai, Zhimou Yang, Xingyi Li
Summary: Peptide-based supramolecular hydrogels have shown great promise as drug delivery systems due to their excellent biocompatibility, response to external stimuli, and ability to self-assemble into specific nanostructures in different environments. Utilizing inherent biological microenvironment as stimuli can provide spatiotemporal controllability for transporting therapeutics more accurately. These materials formed by weak non-covalent interactions exhibit shear-thinning and immediate recovery behavior, making them injectable and ideal for drug delivery.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Yuanfen Liu, Yingchun Ran, Yu Ge, Faisal Raza, Shasha Li, Hajra Zafar, Yiqun Wu, Ana Claudia Paiva-Santos, Chenyang Yu, Meng Sun, Ying Zhu, Fei Li
Summary: This study designed a pH-responsive peptide hydrogel as a carrier for the antitumor drugs gemcitabine and paclitaxel. The results showed that the hydrogel had different release effects at different pH values and was highly sensitive to pH, enabling slow and continuous drug release at the tumor site.
Article
Polymer Science
Alexandra Croitoriu, Loredana Elena Nita, Alina Gabriela Rusu, Alina Ghilan, Maria Bercea, Aurica P. Chiriac
Summary: This study focuses on the preparation of a bionic hydrogel stabilized with a physiologically occurring, bifunctional biomolecule, L-lysine, co-assembled with other amino acids or peptides. The co-assembled supramolecular structure shows good rheological characteristics and has the potential to support tissue repair.
Article
Chemistry, Multidisciplinary
Han Wang, Hao Su, Tian Xu, Honggang Cui
Summary: Non-ionic hydrogels are of interest for long-term therapeutic implantation due to their low immunogenicity. This study reports the formation of non-ionic supramolecular polymer hydrogels triggered by salt. The hydrogels exhibit sustained release of an anticancer drug and potent activity against cancer cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biotechnology & Applied Microbiology
Xuejiao Yang, Honglei Lu, Yinghua Tao, Hongyue Zhang, Huaimin Wang
Summary: This study reports a method to control the fiber alignment, chirality, and stiffness of aromatic peptide hydrogels through heterodimerization of enantiomeric mixtures. The relative ratio of L and D enantiomers can also regulate the adhesion and morphology of mammalian cells. This work provides a new strategy for controlling supramolecular chirality in materials science.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ayaz Mahmood, Dev Patel, Brandon Hickson, John DesRochers, Xiao Hu
Summary: Hydrogels from biopolymers have various characteristics and find wide applications in biomedicine, contributing to patient treatments and outcomes. Different types of biopolymer hydrogels can be synthesized for specific purposes, such as cell delivery and drug delivery, in the field of biomedicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Kwadwo Mfoafo, Yadollah Omidi, Hossein Omidian
Summary: Thermoresponsive polymers have been widely used for the development of stimuli-responsive drug formulations in various routes of administration. However, their use has been limited by obstacles such as high polymer concentration, wide gelation temperature, low gel strength, poor mucoadhesiveness, and short retention. In-situ thermoresponsive mucoadhesive hydrogel blends or hybrids have been suggested as a solution to improve drug bioavailability and efficacy. This article highlights the development and assessment of such hydrogels in different administration routes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Physical
Hui Yuan, Laura L. E. Mears, Yuefei Wang, Rongxin Su, Wei Qi, Zhimin He, Markus Valtiner
Summary: Osteoarthritis, a common degenerative joint disease, causes serious pain due to the progressive loss and destruction of articular cartilage. Restoring joint lubrication is crucial for its treatment, and various lubricants have been developed to reduce friction and promote cartilage repair. This review discusses the recent progress in natural, bioinspired, and alternative lubricants for osteoarthritis treatment, as well as their structural characterization and lubrication properties.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Qing Li, Yuefei Wang, Gong Zhang, Rongxin Su, Wei Qi
Summary: Biomimetic science has attracted significant interest in various fields, including chemistry, biology, materials science, and energy. Biomimetic mineralization involves the synthesis of inorganic minerals under the control of organic molecules or biomolecules, with peptides playing a crucial role as building blocks. Peptides can precisely control the morphology, size, and composition of mineralized materials, and also provide templates for the nucleation and growth of inorganic nanomaterials, offering potential for high catalytic efficiency, selectivity, and biotherapeutic functions.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Environmental Sciences
Mingda Che, Cancan Shan, Wenjie Zhang, Yanyi Duan, Renliang Huang, Mei Cui, Wei Qi, Rongxin Su
Summary: A novel heterogenous Fenton-like process utilizing arbutin-modified cellulose nanocrystals (AT-CNC) activated persulfate was proposed to remove the harmful algal blooms (HABs) Phaeocystis globosa from seawater. The results showed that the removal efficiency of P. globosa reached high levels under certain additive conditions. Therefore, this method has the potential to be an efficient option for controlling HABs.
Article
Chemistry, Multidisciplinary
Jiayu Liu, Jiaxing Zhang, Liwei Zhang, Yuefei Wang, Hao Wei, Yuhe Shen, Jiwei Min, Xi Rong, Wei Qi, Rongxin Su, Zhimin He
Summary: This study reports the coordination assembly of ferrocene-diphenylalanine (Fc-FF) with divalent copper ions (Cu2+), resulting in the formation of metal-peptide assemblies (MPAs) with hierarchical spiral architectures. The MPAs consist of helically organized nanofibers that resemble logarithmic spirals. These MPAs exhibit hierarchically porous structures with abundant Fc and Cu2+ active sites, displaying significantly higher catalytic activity than natural laccase in decolorization reactions. Furthermore, the temperature and enantiomeric excess (ee) can be controlled to synthesize a series of hierarchical structures for MPAs. Peptide enantiomers with higher ee values self-assemble into highly complex and ordered structures, which exhibit higher surface area and porosity and thus enhanced catalytic activity compared to those assembled by peptides with lower ee values. These findings provide new insights into the crucial role of chirality in directing the self-assembly of biomolecules into highly ordered complex functional structures.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Qing Li, Jiaxing Zhang, Yuefei Wang, Jiwei Min, Yuhe Shen, Wei Liu, Xuefeng Liu, Rongxin Su, Wei Qi
Summary: This study presents a dual-functional nanozyme of Au/Cu hierarchically organized particles (Hops) with excellent polyphenol oxidase-like (PPO-like) and peroxidase-like (POD-like) activities, which can rapidly oxidize toxic phenolic pollutants and serve as a sensitive tool to detect energy-supplying substances.
SCIENCE CHINA-MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Heng Chang, Vahid Adibnia, Wei Qi, Rongxin Su, Xavier Banquy
Summary: Recent studies have shown that synergistic interactions between Dopa, cationic residues, and aromatic rings enhance the underwater adhesion strength of mussel foot proteins. This study provides the first evidence of a cation-catechol-benzene ternary synergy in adhesive peptides. The peptide (KY*F)2 demonstrates the strongest underwater cohesion energy and more bonding interactions compared to other peptides, offering insights on designing Dopa-containing underwater adhesives.
ACS APPLIED BIO MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Chang Liu, Xiaoyue Zhang, Yu Zhou, Lin Zhu, Chengyu Zhang, Xiaohui Yan, Shengping You, Wei Qi, Rongxin Su
Summary: A leakage-proof Zr-based metal-organic framework (MOF) carrier, UiO-66NH2(30), was constructed to immobilize laccase (Lac) and enhance antibiotic biodegradation. The Lac was fixed inside the carrier with a high loading amount (275.96 mg/g) and recovery (618%). The immobilized Lac@UiO-66-NH2(30) exhibited excellent reusability and stability, achieving almost complete degradation of rifampicin and lincomycin within 6 minutes and 6 hours, respectively.
BIOCHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Yanyi Duan, Jiangjiexing Wu, Wei Qi, Rongxin Su
Summary: A nanocomposite superhydrophobic coating was fabricated using natural sourced nanomaterials (cellulose nanocrystals, CNCs) as nanofillers via a simple sol-gel synthesis method. The coating with 20 wt% CNCs (CNC20) showed the best antifouling performance, reducing fouling by 82% compared to the control group in a 90-day marine field test. This biomimetic study provides a novel strategy for the development of environmentally friendly coatings with CNCs nanofillers.
CARBOHYDRATE POLYMERS
(2023)
Article
Biotechnology & Applied Microbiology
Feifei Song, Tao Gu, Lin Zhang, Jiaxing Zhang, Shengping You, Wei Qi, Rongxin Su
Summary: This study improved the catalytic activity of L-Trp-TPH1-BH4 by rational design and obtained the S337A/F318Y beneficial mutant, which increased the yield of 5-HTP and produced 0.91 g/L of 5-HTP, offering the prospect of green production of 5-HTP.
ENZYME AND MICROBIAL TECHNOLOGY
(2023)
Article
Chemistry, Physical
Heng Chang, Vahid Adibnia, Rongxin Su, Wei Qi, Xavier Banquy
Summary: This study introduces new adhesive materials that use cation-p interactions for specific cohesive interaction in water. These materials are short peptides based on the FKF motif with different side groups. By controlling the composition of the side group, the strength and specificity of the cohesive and adhesive energies of the peptides can be finely tuned. The interfacial properties of the adhesive peptides depend on the deposition solvent, and using DMSO as the solvent results in higher cohesive and adhesive energies. The supramolecular structure of the peptide film, specifically needle-like structures, significantly enhance the adhesion of the material. Overall, cation-p interaction can be effectively utilized to create adhesive materials with features found in underwater adhesives, such as solvent displacement activation, as well as new properties like specificity and supramolecular structure enhanced adhesion.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Xiaoxuan Ji, Qing Li, Rongxin Su, Yuefei Wang, Wei Qi
Summary: In this study, hierarchically organized gold nanoparticles (Au HOPs-X) with peroxidase-like catalytic activity were synthesized by reducing Au-thiolate hierarchically organized particles (Au HOPs) in situ. The Au HOPs-X exhibited enhanced catalytic activity compared to the initial Au HOPs due to the reduction of Au-thiolate complexes into Au nanoparticles and increased specific surface area. The highly catalytic Au HOPs-10 was combined with glucose oxidase to establish a standard curve for rapid detection of glucose through visual determination of solution saturation captured by mobile phone photos.
Article
Green & Sustainable Science & Technology
Jiri Jaromir Klemes, Aoife Foley, Fengqi You, Kathleen Aviso, Rongxin Su, Awais Bokhari
Summary: This article highlights the importance of renewable and sustainable energy and circular economy in achieving sustainable development. It emphasizes the need for a portfolio of technologies and strategies to reduce the carbon emissions intensity of the energy sector and utilize renewable energy sources. The article also addresses the development of more sustainable and renewable energy devices and the establishment of infrastructure to improve energy efficiency. Lastly, it suggests the development of optimization models considering temporal and geographical constraints for the proper deployment of these strategies.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2023)
Article
Chemistry, Applied
Yuhe Shen, Dongshuang Jia, Yuefei Wang, Tao Yu, Xiaojian Xu, Heng Chang, Qing Li, Rongxin Su, Wei Qi
Summary: In this study, we designed an asymmetric reaction system of tyrosine derivatives and demonstrated that the substrate molecular chirality can affect the reaction rate, intermolecular forces, and arrangement during assembly, thereby influencing the morphology, structure, and properties of biomimetic pigment materials. We also discovered that L + D-tyrosine derivatives can be oxidized and deposited on hair surfaces to achieve black and red-brown color effects, providing a green and safe biological hair dyeing method. Compared to previous studies, this approach offers faster coloring speed, higher color saturation, stronger color fixation stability, good mechanical strength, and biocompatibility, suggesting its potential for the manufacture of chiral-inspired advanced materials with bio-nanotechnology applications.
Article
Engineering, Chemical
Haoyu Wang, Jinghui Wang, Mei Cui, Rongxin Su, Renliang Huang
Summary: A novel antifouling and superhydrophobic polyurethane sponge was successfully prepared, which showed excellent antifouling properties and super-hydrophobicity. It exhibited a high absorption capacity for trichloromethane and maintained a high absorption rate even after 50 cycles. It also demonstrated exceptional oil-water separation performance with high separation fluxes and efficiency. Therefore, this sponge is a promising and applicable material for long-term oil/water separation and cleanup of oil spills in marine environments.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
