Article
Biochemistry & Molecular Biology
Sara Rodrigues, Marta Anglada-Huguet, Katja Hochgraefe, Senthilvelrajan Kaniyappan, Susanne Wegmann, Eva-Maria Mandelkow
Summary: The progression of Tau pathology in Alzheimer's disease is believed to be due to the spread of misfolded Tau proteins and their aggregation. This study investigates the correlation between Tau's aggregation propensity and its ability to spread across synapses. The findings suggest that the concentration of Tau in specific brain regions plays a role in its propagation, independent of its aggregation propensity. Additionally, the study highlights the role of Tau in synaptic toxicity and astrogliosis.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Yanxing Chen, Shuai Zhao, Ziqi Fan, Zheyu Li, Yueli Zhu, Ting Shen, Kaicheng Li, Yaping Yan, Jun Tian, Zhirong Liu, Baorong Zhang
Summary: The study uncovered a crosstalk between amyloid and NP tau pathology, where Aβ plaques promoted the aggregation of NP tau, and metformin enhanced microglial autophagy capability to promote the phagocytosis of pathological Aβ and tau proteins, reducing Aβ deposits and limiting the spreading of NP tau pathology.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Clinical Neurology
Emily J. Davis, Caroline W. Solsberg, Charles C. White, Elena Minones-Moyano, Marina Sirota, Lori Chibnik, David A. Bennett, Philip L. De Jager, Jennifer S. Yokoyama, Dena B. Dubal
Summary: This study found that X chromosome gene expression is associated with cognitive change and tau pathology in aging and AD in a sex-specific manner, with cognitive change related to X chromosome gene expression in women and tau pathology related to X chromosome gene expression in men.
Article
Psychology, Experimental
Sarah A. Wu, Tobias Gerstenberg
Summary: How replaceable a person is affects responsibility judgments. The counterfactual replacement model predicts that people are held more responsible if it would have been difficult to replace them. Three experiments using a quantitatively controlled paradigm support this model's predictions and show that it explains responsibility judgments better than alternative models based solely on what actually happened.
Article
Engineering, Civil
Christopher E. Ndehedehe, Vagner G. Ferreira, Nathan O. Agutu, Alex O. Onojeghuo, Onuwa Okwuashi, Habtamu Tilahun Kassahun, Ashraf Dewan
Summary: This study aims to evaluate the variability of hydrological stores and their response to drought intensity in semi-arid regions of Australia using multiple indicators. Results show the relationship between climate hotspots, climate modes, and the impact of indicators on agricultural systems. Additionally, extreme events such as droughts and floods affect the distribution of surface water.
JOURNAL OF HYDROLOGY
(2021)
Article
Neurosciences
M-A de Fisenne, Z. Yilmaz, R. De Decker, V Suain, L. Buee, K. Ando, J-P Brion, K. Leroy
Summary: Research suggests that there is a low risk of tau pathology transmission during eye surgery using AD tissue material, and that retinal ganglion cells exhibit a resistance to develop a tau pathology.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Neurosciences
Liara Rizzi, Marcio L. F. Balthazar
Summary: Suspected non-Alzheimer's disease pathophysiology (SNAP) is a concept based on biomarkers indicating a different biological basis or early stage of Alzheimer's disease. There is great research interest in understanding the pathological processes and biomarkers related to SNAP, but more clarification is needed.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Longfei Li, Ruirui Shi, Jianlan Gu, Yunn Chyn Tung, Yan Zhou, Dingwei Zhou, Ruozhen Wu, Dandan Chu, Nana Jin, Kevin Deng, Jiawei Xu, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
Summary: NFTs composed of hyperphosphorylated tau are a hallmark of AD, with different forms of tau in the brain showing prion-like activity and the ability to induce tau aggregation. This heterogeneity in tau pathology presents a major challenge in developing effective therapeutic treatments for AD.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Letter
Clinical Neurology
William O. Humphrey, Rachel Martindale, William W. Pendlebury, John C. DeWitt
Summary: The study shows that pathological changes of PART can occur earlier in the general autopsy population than previously thought, especially in women.
Article
Radiology, Nuclear Medicine & Medical Imaging
Colin Groot, Sylvia Villeneuve, Ruben Smith, Oskar Hansson, Rik Ossenkoppele
Summary: The introduction of PET ligands that bind tau pathology has allowed for the quantification and visualization of tau pathology in aging and Alzheimer's disease. While these ligands are effective in binding tau aggregates in advanced stages of AD, their binding in non-AD tauopathies is weaker and overlaps with known off-target binding regions. An increased neocortical tau PET signal holds important prognostic information, and tau PET shows great potential as a prognostic marker in symptomatic stages of AD. For differential diagnosis, tau PET is primarily useful in distinguishing AD dementia from other neurodegenerative diseases, but its performance decreases in the mild cognitive impairment stage of AD.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Management
Saoirse Caitlin O'Shea
Summary: The essay discusses the author's gender affirmation surgery and recovery process, highlighting the lack of discussion on surgery in organizational literature and oversimplification in popular accounts that fail to address the complexities of the somatic nature and issues surrounding surgery.
GENDER WORK AND ORGANIZATION
(2022)
Review
Pharmacology & Pharmacy
Ana R. Monteiro, Daniel J. Barbosa, Fernando Remiao, Renata Silva
Summary: Alzheimer's disease is a prevalent neurodegenerative disease that affects millions of people worldwide. It is characterized by cognitive decline and degeneration of cholinergic neurons. The available therapies are limited, and the disease's pathogenesis is complex, involving the presence of neurofibrillary tangles and amyloid-beta peptide aggregates. Innovative multitarget therapeutical compounds are being developed to delay disease progression and restore cell function, and research on new insights and emerging disease-modifying drugs is ongoing.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Clinical Neurology
Antonio Valencia, Veronica L. Reinhart Bieber, Bekim Bajrami, Galina Marsh, Stefan Hamann, Ru Wei, Karen Ling, Frank Rigo, H. Moore Arnold, Olga Golonzhka, Heike Hering
Summary: Acetylation of tau protein is dysregulated in Alzheimer's Disease. Despite knocking down HDAC6 protein, there was no observed increase in tau acetylation or changes in tau phosphorylation or aggregation in PS19 mice, indicating that HDAC6 does not impact tau pathology in this model.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xingrong Peng, Rongcan Luo, Xiaoqian Ran, Yarong Guo, Yong-Gang Yao, Minghua Qiu
Summary: Ganoapplins A and B (1 and 2) with a 6/6/6/5/6-fused pentacyclic skeleton containing an aromatic E ring were isolated from Ganoderma applanatum. Their structures were determined through spectroscopic analyses, quantum chemical calculations, and the study of their roles in autophagy activation. Cellular assays demonstrated that 1 and 2 can inhibit tau pathology by inducing autophagy, indicating their potential as a treatment for Alzheimer's disease (AD).
BIOORGANIC CHEMISTRY
(2023)
Review
Clinical Neurology
Sarah Houben, Megane Homa, Zehra Yilmaz, Karelle Leroy, Jean-Pierre Brion, Kunie Ando
Summary: AHN plays a critical role in sustaining hippocampal functions such as learning and memory, and impaired AHN in AD patients may contribute to cognitive deficits. NFTs and amyloid plaques are key neuropathological hallmarks of AD, with abnormal tau protein accumulation impacting AHN. Further research is needed to fully understand the relationship between tau pathology and AHN.
FRONTIERS IN NEUROLOGY
(2021)
