Article
Chemistry, Multidisciplinary
Zhong-fang Shi, Qing Fang, Ye Chen, Li-xin Xu, Min Wu, Mei Jia, Yi Lu, Xiao-xuan Wang, Yu-jiao Wang, Xu Yan, Li-ping Dong, Fang Yuan
Summary: Methylene blue attenuates brain edema by inhibiting AQP4 expression via the ERK1/2 pathway, suggesting its potential as a treatment option for brain edema.
ACTA PHARMACOLOGICA SINICA
(2021)
Review
Cell Biology
Terese A. Garcia, Carrie R. Jonak, Devin K. Binder
Summary: Edema formation following traumatic spinal cord injury (SCI) worsens secondary injury and is correlated with worse neurological outcome. The aquaporin-4 (AQP4) water channel plays an important role in water homeostasis and has the potential to modulate edema resolution and functional recovery after SCI. Further research is needed to understand the expression and subcellular localization of AQP4 during specific phases after SCI for therapeutic optimization.
Review
Clinical Neurology
Shufen Zhang, Deshu Shang, Han Shi, Weiyu Teng, Li Tian
Summary: Astrocytes play crucial roles in ischemic stroke, closely related to factors such as blood-brain barrier, growth factors, gap junctions, AQP4, and glial scars. The latest literature has summarized the potential roles of astrocytes after ischemic stroke.
EUROPEAN NEUROLOGY
(2021)
Article
Clinical Neurology
Wolfgang Haupt, Lukas Meyer, Maximilian Wagner, Rosalie McDonough, Sarah Elsayed, Matthias Bechstein, Gerhard Schoen, Helge Kniep, Andre Kemmling, Jens Fiehler, Uta Hanning, Gabriel Broocks
Summary: This study suggests that the reduction of relative cerebral blood volume (rCBV) is predictive of irreversible tissue injury and functional outcome in patients with ischemic stroke, particularly in those with core volumes > 50 ml. Thus, analyzing rCBV reduction within ischemic lesions may provide additional information for acute stroke management.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qi Lu, Jun Xiong, Yuan Yuan, Zhanwei Ruan, Yu Zhang, Bo Chai, Lei Li, Shufang Cai, Jian Xiao, Yanqing Wu, Peng Huang, Hongyu Zhang
Summary: This study demonstrates that minocycline can improve the functional recovery of traumatic brain injury (TBI) by reducing the levels of aquaporin-4 (AQP4). Minocycline treatment effectively reduces neuronal apoptosis, ameliorates brain edema and blood-brain barrier disruption in TBI. The expression of tight junction proteins and the morphology of astrocytes are also optimized by minocycline administration. AQP4 may be an important therapeutic target for minocycline treatment of TBI.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Felix C. Ng, Leonid Churilov, Nawaf Yassi, Timothy J. Kleinig, Vincent Thijs, Teddy Y. Wu, Darshan Shah, Helen M. Dewey, Gagan Sharma, Patricia M. Desmond, Bernard Yan, Mark W. Parsons, Geoffrey A. Donnan, Stephen M. Davis, Peter J. Mitchell, Bruce Cv Campbell
Summary: The relationship between reperfusion and edema in ischemic stroke patients with large vessel occlusion is complex. Core volume on pre-treatment CT-Perfusion is positively associated with edema, while mismatch volume has a significant interaction with reperfusion in influencing edema outcomes. Reperfusion appears to have a beneficial effect in reducing edema in patients with large mismatch volume but not in those with smaller mismatch volume.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Eun-Hye Kim, Eun-Sun Kim, Donggeun Shin, Donghyun Kim, Sungbin Choi, Young-Jun Shin, Kyeong-A Kim, Dabi Noh, Ahmet B. Caglayan, G. K. Rajanikant, Arshad Majid, Ok-Nam Bae
Summary: The study found that carnosine inhibits MMP activity by chelating zinc, resulting in the reduction of edema and brain injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Cloe Moelo, Alicia Quillevere, Lucas Le Roy, Serge Timsit
Summary: Cerebral edema is a deadly complication of ischemic stroke for which there is no current pharmaceutical treatment. This study found that the cyclin-dependent kinase inhibitor (S)-roscovitine was able to reduce cerebral edema and modulate the interaction between Aquaporin-4 (AQP4) and alpha 1-syntrophin, suggesting its potential as a treatment for cerebral edema in ischemic stroke and other neurological diseases.
Article
Neurosciences
Caihong Ji, Xing Yu, Weilin Xu, Cameron Lenahan, Sheng Tu, Anwen Shao
Summary: The glymphatic system plays a crucial role in the formation of cerebral edema after ischemic stroke, but there is no definite conclusion on its role in the influx of cerebrospinal fluid and interstitial fluid clearance. AQP4, as a key component of the glymphatic system, has a complex bimodal effect on cerebral edema after ischemic stroke, making it a potential target for treatment strategies.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Noel van Horn, Jeremy J. Heit, Reza Kabiri, Gabriel Broocks, Soren Christensen, Michael Mlynash, Lukas Meyer, Michael H. Schoenfeld, Maarten G. Lansberg, Gregory W. Albers, Jens Fiehler, Max Wintermark, Tobias D. Faizy
Summary: In patients with acute ischemic stroke due to large vessel occlusion, a study investigated the correlation between robust cortical venous outflow profiles and early edema progression rate (EPR), as well as functional outcomes. The study found that favorable venous outflow profiles were associated with reduced EPR and good long-term functional outcomes.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Neurosciences
Xiaohong Li, Xiaoli Tan, Qian Zhou, Zhuoxi Xie, Weiting Meng, Yeyu Pang, Lizhen Huang, Zhihao Ding, Yuanhong Hu, Ruhua Li, Guilan Huang, Hao Li
Summary: This study investigated the changes in the glymphatic system after cerebral ischemia-reperfusion injury and found that limb remote ischemic postconditioning (LRIP) can improve glymphatic function to protect the brain.
Article
Endocrinology & Metabolism
Lukas Meyer, Michael Schoenfeld, Matthias Bechstein, Uta Hanning, Bastian Cheng, Goetz Thomalla, Gerhard Schoen, Andre Kemmling, Jens Fiehler, Gabriel Broocks
Summary: This study found that age is a significant factor in influencing brain edema formation after thrombectomy for LVO stroke. Younger patients showed higher edema formation on follow-up, while older patients had relatively lower levels. Successful recanalization reduced edema progression, but younger age remained independently associated with higher edema formation.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Oncology
Maria J. Contreras-Zarate, Karen L. F. Alvarez-Eraso, Jenny A. Jaramillo-Gomez, Zachary Littrell, Nikki Tsuji, D. Ryan Ormond, Sana D. Karam, Peter Kabos, Diana M. Cittelly
Summary: This study aimed to determine whether radiation-associated treatment of breast-cancer brain metastases (BCBM) induces cytotoxic edema and the consequences of blocking the edema. The results showed that astrocytic swelling and upregulation of AQP4 occurred within 24 hours following radiation. Using anti-epileptic drugs that block AQP4 function can prevent radiation-induced cytotoxic edema.
Review
Cell Biology
Ying-Jie Wang, Yan-Rong Sun, Yan-Hong Pei, Hao-Wen Ma, Ya-Kun Mu, Li-Hua Qin, Jun-Hao Yan
Summary: Recent studies have explored the roles of three lymphatic drainage systems in the brain, namely the glymphatic system, intramural periarterial drainage pathway, and meningeal lymphatic vessels, in various neurological diseases. Impairment of these systems can result in cerebral edema, accumulation of toxic factors, and activation of neuroinflammation after ischemic stroke, while restoration of their normal functions can improve neurological outcomes. This review summarizes the basic concepts of these drainage systems, including drainage routes, physiological functions, regulatory mechanisms, and detection technologies, and highlights recent advances in therapeutic strategies targeting these drainage systems.
NEURAL REGENERATION RESEARCH
(2023)
Review
Neurosciences
Jenny I. Szu, Devin K. Binder
Summary: This review evaluates the role of AQP4 dysregulation and mislocalization in epilepsy, highlighting their significant impact on neuronal hyperexcitability. Research has shown that the mislocalization of AQP4 can greatly affect the excitability of neurons, playing a crucial role in the development of epilepsy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Immunology
Ping Wang, Hai-Peng Yang, Shujun Tian, Liwei Wang, Stephani C. Wang, Fengmin Zhang, Yu-Feng Wang
JOURNAL OF NEUROIMMUNOLOGY
(2015)
Editorial Material
Cardiac & Cardiovascular Systems
Charles T. Bakhos, Stephani C. Wang, Karen L. Tedesco, Arsyl D. DeJesus, Sahar Nozad, Harry J. Depan
ANNALS OF THORACIC SURGERY
(2016)
Editorial Material
Cardiac & Cardiovascular Systems
Stephani C. Wang, Walter W. Scott
ANNALS OF THORACIC SURGERY
(2016)
Review
Neurosciences
Shu-Wei Jia, Xiao-Yu Liu, Stephani C. Wang, Yu-Feng Wang
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2016)
Editorial Material
Cardiac & Cardiovascular Systems
Stephani C. Wang, ChrisW. Pan
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Stephani C. Wang, Jack Guccione, Cy Kim, Pranav M. Patel
Editorial Material
Cardiac & Cardiovascular Systems
Stephani C. Wang, Mark Lee, Elvis Cami, Morton Kern
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Review
Surgery
Stephani C. Wang, Tejinder P. Singh
JOURNAL OF ROBOTIC SURGERY
(2017)
Letter
Rheumatology
Stephani Wang, Sabeen Habib, Sarwat Umer, Lewis Reisman, Vidya Raman
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Ping Wang, Puneet Kumar, Chang Wang, Kathryn A. DeFea
BIOCHEMICAL JOURNAL
(2007)