Article
Chemistry, Multidisciplinary
Zhong-fang Shi, Qing Fang, Ye Chen, Li-xin Xu, Min Wu, Mei Jia, Yi Lu, Xiao-xuan Wang, Yu-jiao Wang, Xu Yan, Li-ping Dong, Fang Yuan
Summary: Methylene blue attenuates brain edema by inhibiting AQP4 expression via the ERK1/2 pathway, suggesting its potential as a treatment option for brain edema.
ACTA PHARMACOLOGICA SINICA
(2021)
Review
Cell Biology
Terese A. Garcia, Carrie R. Jonak, Devin K. Binder
Summary: Edema formation following traumatic spinal cord injury (SCI) worsens secondary injury and is correlated with worse neurological outcome. The aquaporin-4 (AQP4) water channel plays an important role in water homeostasis and has the potential to modulate edema resolution and functional recovery after SCI. Further research is needed to understand the expression and subcellular localization of AQP4 during specific phases after SCI for therapeutic optimization.
Review
Clinical Neurology
Shufen Zhang, Deshu Shang, Han Shi, Weiyu Teng, Li Tian
Summary: Astrocytes play crucial roles in ischemic stroke, closely related to factors such as blood-brain barrier, growth factors, gap junctions, AQP4, and glial scars. The latest literature has summarized the potential roles of astrocytes after ischemic stroke.
EUROPEAN NEUROLOGY
(2021)
Article
Clinical Neurology
Wolfgang Haupt, Lukas Meyer, Maximilian Wagner, Rosalie McDonough, Sarah Elsayed, Matthias Bechstein, Gerhard Schoen, Helge Kniep, Andre Kemmling, Jens Fiehler, Uta Hanning, Gabriel Broocks
Summary: This study suggests that the reduction of relative cerebral blood volume (rCBV) is predictive of irreversible tissue injury and functional outcome in patients with ischemic stroke, particularly in those with core volumes > 50 ml. Thus, analyzing rCBV reduction within ischemic lesions may provide additional information for acute stroke management.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qi Lu, Jun Xiong, Yuan Yuan, Zhanwei Ruan, Yu Zhang, Bo Chai, Lei Li, Shufang Cai, Jian Xiao, Yanqing Wu, Peng Huang, Hongyu Zhang
Summary: This study demonstrates that minocycline can improve the functional recovery of traumatic brain injury (TBI) by reducing the levels of aquaporin-4 (AQP4). Minocycline treatment effectively reduces neuronal apoptosis, ameliorates brain edema and blood-brain barrier disruption in TBI. The expression of tight junction proteins and the morphology of astrocytes are also optimized by minocycline administration. AQP4 may be an important therapeutic target for minocycline treatment of TBI.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Felix C. Ng, Leonid Churilov, Nawaf Yassi, Timothy J. Kleinig, Vincent Thijs, Teddy Y. Wu, Darshan Shah, Helen M. Dewey, Gagan Sharma, Patricia M. Desmond, Bernard Yan, Mark W. Parsons, Geoffrey A. Donnan, Stephen M. Davis, Peter J. Mitchell, Bruce Cv Campbell
Summary: The relationship between reperfusion and edema in ischemic stroke patients with large vessel occlusion is complex. Core volume on pre-treatment CT-Perfusion is positively associated with edema, while mismatch volume has a significant interaction with reperfusion in influencing edema outcomes. Reperfusion appears to have a beneficial effect in reducing edema in patients with large mismatch volume but not in those with smaller mismatch volume.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Eun-Hye Kim, Eun-Sun Kim, Donggeun Shin, Donghyun Kim, Sungbin Choi, Young-Jun Shin, Kyeong-A Kim, Dabi Noh, Ahmet B. Caglayan, G. K. Rajanikant, Arshad Majid, Ok-Nam Bae
Summary: The study found that carnosine inhibits MMP activity by chelating zinc, resulting in the reduction of edema and brain injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Cloe Moelo, Alicia Quillevere, Lucas Le Roy, Serge Timsit
Summary: Cerebral edema is a deadly complication of ischemic stroke for which there is no current pharmaceutical treatment. This study found that the cyclin-dependent kinase inhibitor (S)-roscovitine was able to reduce cerebral edema and modulate the interaction between Aquaporin-4 (AQP4) and alpha 1-syntrophin, suggesting its potential as a treatment for cerebral edema in ischemic stroke and other neurological diseases.
Article
Neurosciences
Caihong Ji, Xing Yu, Weilin Xu, Cameron Lenahan, Sheng Tu, Anwen Shao
Summary: The glymphatic system plays a crucial role in the formation of cerebral edema after ischemic stroke, but there is no definite conclusion on its role in the influx of cerebrospinal fluid and interstitial fluid clearance. AQP4, as a key component of the glymphatic system, has a complex bimodal effect on cerebral edema after ischemic stroke, making it a potential target for treatment strategies.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Noel van Horn, Jeremy J. Heit, Reza Kabiri, Gabriel Broocks, Soren Christensen, Michael Mlynash, Lukas Meyer, Michael H. Schoenfeld, Maarten G. Lansberg, Gregory W. Albers, Jens Fiehler, Max Wintermark, Tobias D. Faizy
Summary: In patients with acute ischemic stroke due to large vessel occlusion, a study investigated the correlation between robust cortical venous outflow profiles and early edema progression rate (EPR), as well as functional outcomes. The study found that favorable venous outflow profiles were associated with reduced EPR and good long-term functional outcomes.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Neurosciences
Xiaohong Li, Xiaoli Tan, Qian Zhou, Zhuoxi Xie, Weiting Meng, Yeyu Pang, Lizhen Huang, Zhihao Ding, Yuanhong Hu, Ruhua Li, Guilan Huang, Hao Li
Summary: This study investigated the changes in the glymphatic system after cerebral ischemia-reperfusion injury and found that limb remote ischemic postconditioning (LRIP) can improve glymphatic function to protect the brain.
Article
Endocrinology & Metabolism
Lukas Meyer, Michael Schoenfeld, Matthias Bechstein, Uta Hanning, Bastian Cheng, Goetz Thomalla, Gerhard Schoen, Andre Kemmling, Jens Fiehler, Gabriel Broocks
Summary: This study found that age is a significant factor in influencing brain edema formation after thrombectomy for LVO stroke. Younger patients showed higher edema formation on follow-up, while older patients had relatively lower levels. Successful recanalization reduced edema progression, but younger age remained independently associated with higher edema formation.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Oncology
Maria J. Contreras-Zarate, Karen L. F. Alvarez-Eraso, Jenny A. Jaramillo-Gomez, Zachary Littrell, Nikki Tsuji, D. Ryan Ormond, Sana D. Karam, Peter Kabos, Diana M. Cittelly
Summary: This study aimed to determine whether radiation-associated treatment of breast-cancer brain metastases (BCBM) induces cytotoxic edema and the consequences of blocking the edema. The results showed that astrocytic swelling and upregulation of AQP4 occurred within 24 hours following radiation. Using anti-epileptic drugs that block AQP4 function can prevent radiation-induced cytotoxic edema.
Review
Cell Biology
Ying-Jie Wang, Yan-Rong Sun, Yan-Hong Pei, Hao-Wen Ma, Ya-Kun Mu, Li-Hua Qin, Jun-Hao Yan
Summary: Recent studies have explored the roles of three lymphatic drainage systems in the brain, namely the glymphatic system, intramural periarterial drainage pathway, and meningeal lymphatic vessels, in various neurological diseases. Impairment of these systems can result in cerebral edema, accumulation of toxic factors, and activation of neuroinflammation after ischemic stroke, while restoration of their normal functions can improve neurological outcomes. This review summarizes the basic concepts of these drainage systems, including drainage routes, physiological functions, regulatory mechanisms, and detection technologies, and highlights recent advances in therapeutic strategies targeting these drainage systems.
NEURAL REGENERATION RESEARCH
(2023)
Review
Neurosciences
Jenny I. Szu, Devin K. Binder
Summary: This review evaluates the role of AQP4 dysregulation and mislocalization in epilepsy, highlighting their significant impact on neuronal hyperexcitability. Research has shown that the mislocalization of AQP4 can greatly affect the excitability of neurons, playing a crucial role in the development of epilepsy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Immunology
Ping Wang, Hai-Peng Yang, Shujun Tian, Liwei Wang, Stephani C. Wang, Fengmin Zhang, Yu-Feng Wang
JOURNAL OF NEUROIMMUNOLOGY
(2015)
Editorial Material
Cardiac & Cardiovascular Systems
Charles T. Bakhos, Stephani C. Wang, Karen L. Tedesco, Arsyl D. DeJesus, Sahar Nozad, Harry J. Depan
ANNALS OF THORACIC SURGERY
(2016)
Editorial Material
Cardiac & Cardiovascular Systems
Stephani C. Wang, Walter W. Scott
ANNALS OF THORACIC SURGERY
(2016)
Review
Neurosciences
Shu-Wei Jia, Xiao-Yu Liu, Stephani C. Wang, Yu-Feng Wang
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2016)
Editorial Material
Cardiac & Cardiovascular Systems
Stephani C. Wang, ChrisW. Pan
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Stephani C. Wang, Jack Guccione, Cy Kim, Pranav M. Patel
Editorial Material
Cardiac & Cardiovascular Systems
Stephani C. Wang, Mark Lee, Elvis Cami, Morton Kern
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Review
Surgery
Stephani C. Wang, Tejinder P. Singh
JOURNAL OF ROBOTIC SURGERY
(2017)
Letter
Rheumatology
Stephani Wang, Sabeen Habib, Sarwat Umer, Lewis Reisman, Vidya Raman
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Ping Wang, Puneet Kumar, Chang Wang, Kathryn A. DeFea
BIOCHEMICAL JOURNAL
(2007)
Article
Neurosciences
Adam Vacek, Grant Mair, Philip White, Philip M. Bath, Keith W. Muir, Rustam Al-Shahi Salman, Chloe Martin, David Dye, Francesca M. Chappell, Ruediger von Kummer, Malcolm Macleod, Nikola Sprigg, Joanna M. Wardlaw
Summary: This study evaluated the performance of e-ASPECTS software in delineating the extent of intracranial hemorrhage (ICH) on brain CT scans. The results showed that the software achieved excellent or good delineation of ICH extent in 71% of cases. However, it was more likely to over- or under-estimate the extent when ICH was more extensive, intraventricular, or extra-axial.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Mathias Jacobsen Bach, Audrone Jakubauskaite, Ian Law, Otto Molby Henriksen, Inger Havsteen, Alexander Cuculiza Henriksen, Sverre Rosenbaum, Lisbeth Marner
Summary: This study found that the rCBFacz value after ACZ challenge can serve as an important indicator for predicting future cerebrovascular events, with high accuracy and prognostic value.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Tak Kyu Oh, Saeyeon Kim, In-Ae Song
Summary: The study found that many survivors of nontraumatic intracranial hemorrhage in South Korea experience unemployment, decreased household income, and newly acquired disability after intensive care unit admission. However, these changes are not associated with 2-year all-cause mortality.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Eduardo Sousa de Melo, Rodrigo de Paiva Bezerra, Arthur Cesario de Holanda, Maria Junia Lira e Silva, Paloma Peter Travassos, Tayne Fernanda Lemos da Silva, Genova Maria de Azevedo Oliveira, Silvia Marinho Martins Alves, Carolina de Araujo Medeiros, Maria das Neves Dantas da Silveira Barros, Wilson Alves de Oliveira, Gisele Sampaio Silva, Luciana Patrizia Alves de Andrade Valenca
Summary: Cardiac involvement has been found to be the predominant factor correlated with stroke in Chagas disease. While atherosclerosis-related risk factors are prevalent, their influence on ischemic stroke in Chagas disease appears limited.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Pingping Zheng, Ning Zhang, Zixi Chen
Summary: This case presents a rare infectious cause of stroke and air embolism involving a pulmonary abscess and pulmonary vein thrombosis. Early detection, diagnosis, and appropriate treatment of infected systemic embolism in young patients are crucial to prevent serious complications.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Filippo Luca Gurgoglione, Luigi Vignali, Maria Alberta Cattabiani, Emilia Solinas, Giorgio Benatti, Iacopo Tadonio, Federico Barocelli, Chiara Dizdari, Domenico Tuttolomondo, Diego Ardissino, Francesco Nicolini, Giampaolo Niccoli
Summary: The incidence of recurrent ischemic neurological events after transcatheter patent foramen ovale closure is relatively low. Obesity, Risk of Paradoxical Embolism score < 7, and migraine are independent positive predictors of recurrent stroke or transient ischemic attack.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Angelo Cascio Rizzo, Ghil Schwarz, Amedeo Cervo, Giuditta Giussani, Chiara Ceresa, Antonella Gatti, Fausto De Angeli, Cristina Motto, Angelo Guccione, Rachele Tortorella, Giuseppe Granata, Claudia Rollo, Antonio Macera, Mariangela Piano, Guglielmo Pero, Elio Clemente Agostoni
Summary: This study aimed to evaluate the efficacy and safety of endovascular treatment (EVT) in primary and EVT-induced secondary medium-vessel occlusions (MeVO). The results showed that primary MeVO had poorer outcomes in terms of complications, EVT efficacy, and the proportion of patients with a modified Rankin Scale (mRS) of 0-2 at 3 months compared to exclusive large-vessel occlusion (LVO). However, EVT-induced secondary MeVO showed similar safety and efficacy outcomes as exclusive LVO and had better outcomes in terms of mRS 0-2 compared to primary MeVO.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jing Zhang, Chenming Wei, Jian Wu
Summary: This case report describes a patient with Bloom syndrome who developed acute cerebral infarction along with elevated antiphospholipid antibodies, suggesting a possible association between immune and coagulation abnormalities caused by Bloom syndrome and the development of acute cerebral infarction.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Yunxia Zhou, Shenglan He, Yanhong Hu
Summary: Compared with clopidogrel, DAPT with ticagrelor plus aspirin was associated with significantly lower thromboembolic events without an increase in hemorrhagic events in the treatment of intracranial aneurysms, according to the one-year clinical outcome analysis. However, larger upcoming trials are needed to confirm the effectiveness and safety of ticagrelor-associated DAPT.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Edvania Andrade de Moura Silva, Ludmilla Ribeiro Batista, Marcela Aline Fernandes Braga, Luci Fuscaldi Teixeira-Salmela, Christina Danielli Coelho de Morais Faria, Iza Faria-Fortini
Summary: The study found that stroke severity is the best predictor of self-perceived manual ability at both three and six months after stroke. Age, although significant, contributes little to the prediction of manual ability.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Sidarrth Prasad, Erica M. Jones, Mehari Gebreyohanns, Veronica Aguilera, DaiWai M. Olson, Jane A. Anderson, Sean I. Savitz, Salvador C. Flores, Steven J. Warach, Charlotte E. Rhodes, Mark P. Goldberg, Nneka L. Ifejika
Summary: This study identified the barriers and facilitators to adopting tenecteplase (TNK) as a thrombolytic treatment for acute ischemic stroke (AIS) by conducting qualitative research with stroke clinicians in Texas. The findings suggest that providing evidence and identifying key change processes can help clinicians achieve consensus on adopting TNK for AIS treatment.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Jeshma Jayan, Sunil K. Narayan, Yasmin Nesha Haniffa, Navin Kumar
Summary: This study investigated the effects of transcranial electrical and magnetic stimulation on somatosensory evoked potentials in chronic ischemic stroke patients, finding that the real tDCS and rTMS combination results in significant improvement and is safe for use.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Phoebe M. Tran, Cenjing Zhu, William T. Harris II, Sajeesh K. Kamala Raghavan, Agricola Odoi, Liem Tran
Summary: This study assessed the geographic accessibility of stroke rehabilitation facilities in Tennessee. The study found that rural counties had significantly longer travel distances and times compared to urban counties. Counties with high and medium stroke prevalence also had higher travel times and distances compared to low stroke prevalence counties. Therefore, addressing transportation barriers and implementing tele-rehabilitation are crucial for improving access to stroke aftercare in these areas.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Lili Xu, Shuaiyu Chen, Jing Xu, Yanyan Shi, Zhihang Huang, Meng Wang, Ziqiao Wei, Hui Cao, Junshan Zhou, Wei Wang, Mingyang Du
Summary: This study found that the Chinese Visceral Adiposity Index (CVAI) is positively correlated with 90-day poor outcome in Chinese ischemic stroke patients after endovascular thrombectomy (EVT).
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)
Article
Neurosciences
Guangying Wu, Shuhua Li, Min Luo, Xiaotian Li, Xinghua Zhu, Junhuai Zhang, Qian He, Qian Yang, Guojiang Zhao, Shasha Luo, Zhijie Yang
Summary: The study aimed to investigate the relationship between serum alkaline phosphatase (ALP) levels and the severity and prognosis of intracerebral hemorrhage (ICH). The results showed that serum ALP levels in ICH patients were significantly elevated and correlated with hematoma volume and Glasgow coma scale (GCS) score. High serum ALP levels may serve as a potential predictor for the severity and unfavorable prognosis of ICH.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2024)