Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside

Mast cell stabilisers

(2016) Tao Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Intestinal Secretory Mechanisms in Irritable Bowel Syndrome–Diarrhea

(2015) Michael Camilleri   Clinical Gastroenterology and Hepatology

Successful treatment of mast cell activation syndrome with sunitinib

(2015) Lawrence B. Afrin et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Nerve Fiber Outgrowth Is Increased in the Intestinal Mucosa of Patients With Irritable Bowel Syndrome

(2015) Giovanni Dothel et al.   GASTROENTEROLOGY

The role of mast cells in functional GI disorders

(2015) Mira M Wouters et al.   GUT

An indoxyl compound 5-bromo-4-chloro-3-indolyl 1,3-diacetate, CAC-0982, suppresses activation of Fyn kinase in mast cells and IgE-mediated allergic responses in mice

(2015) Jun Ho Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mast Cell-dependent Mesenteric Afferent Activation by Mucosal Supernatant From Different Bowel Segments of Guinea Pigs With Post-infectious Irritable Bowel Syndrome

(2015) Jun Song et al.   Journal of Neurogastroenterology and Motility

Role of Corticotropin-releasing Factor Signaling in Stress-related Alterations of Colonic Motility and Hyperalgesia

(2015) Yvette Taché et al.   Journal of Neurogastroenterology and Motility

Epidemiology of Functional Gastrointestinal Disorders in Japan and in the World

(2015) Tadayuki Oshima et al.   Journal of Neurogastroenterology and Motility

520 Efficacy of Ibodutant, a Selective Antagonist of Neurokinin 2 Receptors, in Irritable Bowel Syndrome With Diarrhoea (IBS-D): The Results of a Double-Blind, Randomised, Placebo-Controlled, Parallel-Group Phase II Study (the IRIS-2)

(2015) Jan F. Tack et al.   GASTROENTEROLOGY

901 Effect of the H1-Receptor Antagonist Ebastin on Visceral Perception and Clinical Symptoms in IBS

(2015) Sander van Wanrooij et al.   GASTROENTEROLOGY

Commensal bacteria directly suppressin vitrodegranulation of mast cells in a MyD88-independent manner

(2014) Kazumi Kasakura et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Mast Cells in Irritable Bowel Syndrome and Ulcerative Colitis: Function Not Numbers Is What Makes All the Difference

(2014) Theoharis C. Theoharides   DIGESTIVE DISEASES AND SCIENCES

Developments in pathophysiology, diagnosis and management

(2014) Peter J. Whorwell   Nature Reviews Gastroenterology & Hepatology

Mast cell-derived serine proteinase regulates T helper 2 polarization

(2014) Zhi-Qiang Liu et al.   Scientific Reports

Regional Differences in Chronic Stress-induced Alterations in Mast Cell and Protease-activated Receptor-2-positive Cell Numbers in the Colon of Ws/Ws Rats

(2014) Yong Sung Kim et al.   Journal of Neurogastroenterology and Motility

Mast Cell Tryptase Reduces Junctional Adhesion Molecule-A (JAM-A) Expression in Intestinal Epithelial Cells: Implications for the Mechanisms of Barrier Dysfunction in Irritable Bowel Syndrome

(2013) Ewa M Wilcz-Villega et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Immune Activation in Irritable Bowel Syndrome: Can Neuroimmune Interactions Explain Symptoms?

(2013) Patrick A Hughes et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Development of Gut Microbiota in a Mouse Model of Ovalbumin-induced Allergic Diarrhea under Sub-barrier System

(2013) Juan-Hong Wang et al.   ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES

Colonic Mucosal Immune Activity in Irritable Bowel Syndrome: Comparison with Healthy Controls and Patients with Ulcerative Colitis

(2013) Ji Yong Ahn et al.   DIGESTIVE DISEASES AND SCIENCES

Mucosal innate immune cells regulate both gut homeostasis and intestinal inflammation

(2013) Yosuke Kurashima et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Current and future pharmacological treatments for diarrhea-predominant irritable bowel syndrome

(2013) Michael Camilleri   EXPERT OPINION ON PHARMACOTHERAPY

Functions and Imaging of Mast Cell and Neural Axis of the Gut

(2013) Michael Schemann et al.   GASTROENTEROLOGY

Impaired Emotional Learning and Involvement of the Corticotropin-Releasing Factor Signaling System in Patients With Irritable Bowel Syndrome

(2013) Jennifer S. Labus et al.   GASTROENTEROLOGY

Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism

(2013) Tim Vanuytsel et al.   GUT

Host immune response determines visceral hyperalgesia in a rat model of post-inflammatory irritable bowel syndrome

(2013) Birgit Adam et al.   JOURNAL OF GASTROENTEROLOGY

A focus on mast cells and pain

(2013) Anne Héron et al.   JOURNAL OF NEUROIMMUNOLOGY

Vasoactive intestinal polypeptide regulates barrier function via mast cells in human intestinal follicle-associated epithelium and during stress in rats

(2013) Å. V. Keita et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Stress-Induced Visceral Hypersensitivity in Maternally Separated Rats Can Be Reversed by Peripherally Restricted Histamine-1-Receptor Antagonists

(2013) Oana I. Stanisor et al.   PLoS One

Novel therapies for constipation

(2013) Sreedhari Thayalasekeran   WORLD JOURNAL OF GASTROENTEROLOGY

Mucosal Mast Cell Count Is Associated With Intestinal Permeability in Patients With Diarrhea Predominant Irritable Bowel Syndrome

(2013) Hyuk Lee et al.   Journal of Neurogastroenterology and Motility

Editorial: Irritable Bowel Syndrome and the Elusive Mast Cells

(2012) Theoharis C Theoharides et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Colonic mucosal mediators from patients with irritable bowel syndrome excite enteric cholinergic motor neurons

(2012) B. Balestra et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Novel insights in the role of peripheral corticotropin-releasing factor and mast cells in stress-induced visceral hypersensitivity

(2012) M. Larauche   NEUROGASTROENTEROLOGY AND MOTILITY

CRF Induces Intestinal Epithelial Barrier Injury via the Release of Mast Cell Proteases and TNF-α

(2012) Elizabeth L. Overman et al.   PLoS One

Colonic mast cells in controls and slow transit constipation patients

(2011) G. Bassotti et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Randomised clinical trial: the clinical effects of a novel neurokinin receptor antagonist, DNK333, in women with diarrhoea-predominant irritable bowel syndrome

(2011) S. Zakko et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Combination of Allergic Factors Can Worsen Diarrheic Irritable Bowel Syndrome: Role of Barrier Defects and Mast Cells

(2011) M Vivinus-Nébot et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Mast cell–nerve axis with a focus on the human gut

(2011) Sabine Buhner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Intestinal mast cells in gut inflammation and motility disturbances

(2011) Benedicte Y. De Winter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Association Between Early Adverse Life Events and Irritable Bowel Syndrome

(2011) Kara Bradford et al.   Clinical Gastroenterology and Hepatology

Visceral Pain: Spinal Afferents, Enteric Mast Cells, Enteric Nervous System and Stress

(2011) Jackie D. Wood   CURRENT PHARMACEUTICAL DESIGN

Germ-free status and altered caecal subdominant microbiota are associated with a high susceptibility to cow's milk allergy in mice

(2011) Bertrand Rodriguez et al.   FEMS MICROBIOLOGY ECOLOGY

The impact of bacterial infection on mast cell degranulation

(2011) Jordan Wesolowski et al.   IMMUNOLOGIC RESEARCH

Visceral hypersensitivity in irritable bowel syndrome

(2011) Motoyori Kanazawa et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Corticotropin-Releasing Factor Receptor 1 Antagonist Alters Regional Activation and Effective Connectivity in an Emotional-Arousal Circuit during Expectation of Abdominal Pain

(2011) C. S. Hubbard et al.   JOURNAL OF NEUROSCIENCE

The Immune System in Irritable Bowel Syndrome

(2011) Giovanni Barbara et al.   Journal of Neurogastroenterology and Motility

Aminosalicylates and Other Anti-Inflammatory Compounds for Irritable Bowel Syndrome

(2010) Giovanni Barbara et al.   DIGESTIVE DISEASES

The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome

(2010) T. K. Klooker et al.   GUT

Human visceral afferent recordings: preliminary report

(2010) M. Peiris et al.   GUT

Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions

(2010) Lena Öhman et al.   Nature Reviews Gastroenterology & Hepatology

Stress-induced barrier disruption of rat follicle-associated epithelium involves corticotropin-releasing hormone, acetylcholine, substance P, and mast cells

(2010) å. v. Keita et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The intestinal barrier and its regulation by neuroimmune factors

(2010) å. v. Keita et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Mucosal Immune Activation in Irritable Bowel Syndrome: Gender-Dependence and Association With Digestive Symptoms

(2009) Cesare Cremon et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Do corticotropin releasing factor-1 receptors influence colonic transit and bowel function in women with irritable bowel syndrome?

(2009) Seth Sweetser et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Stress-related modulation of inflammation in experimental models of bowel disease and post-infectious irritable bowel syndrome: Role of corticotropin-releasing factor receptors

(2009) Cornelia Kiank et al.   BRAIN BEHAVIOR AND IMMUNITY

Visceral pain hypersensitivity in functional gastrointestinal disorders

(2009) A. D. Farmer et al.   BRITISH MEDICAL BULLETIN

Activation of Human Enteric Neurons by Supernatants of Colonic Biopsy Specimens From Patients With Irritable Bowel Syndrome

(2009) Sabine Buhner et al.   GASTROENTEROLOGY

Unbalanced expression of protease-activated receptors-1 and -2 in the colon of diarrhea-predominant irritable bowel syndrome patients

(2009) Zhao Xiang Bian et al.   JOURNAL OF GASTROENTEROLOGY

A Bifidobacterium Probiotic Strain and Its Soluble Factors Alleviate Chloride Secretion by Human Intestinal Epithelial Cells

(2009) Elise Heuvelin et al.   JOURNAL OF NUTRITION

Synaptic Plasticity: The New Explanation of Visceral Hypersensitivity in Rats with Trichinella spiralis Infection?

(2008) Xiaojun Yang et al.   DIGESTIVE DISEASES AND SCIENCES