Review
Oncology
Jinjing Xu, Kuiyang Zhu, Yali Wang, Jing Chen
Summary: This review summarizes the dual role of the heme/HO-1/Bach1 axis and their mutual dependence in carcinogenesis and anti-carcinogenesis intersection.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cole A. Guggisberg, Juyoung Kim, Jaekwon Lee, Xiaoli Chen, Moon-Suhn Ryu
Summary: Macrophages recycle iron from erythrocytes and NCOA4 regulates ferritinophagy and iron release. NCOA4 has functional association with immune response.
Article
Plant Sciences
Shuo Sun, Jiamei Zhu, Runze Guo, James Whelan, Huixia Shou
Summary: This study identified widespread hypermethylation in rice seedlings under Fe-deficient conditions, particularly in the CHH context. Integrative analysis revealed a negative correlation between transcript abundance of Fe-deficiency-induced genes and nearby TEs, and a positive correlation with 24-nucleotide siRNAs. Both pharmacological and genetic manipulation of DNA methylation demonstrated a crucial role of specific methylation patterns, directed by siRNAs, in acclimation of rice to Fe-deficient conditions. Comparisons with other reports suggest that this may be a universal mechanism for plants to adapt to limited nutrient availability.
Article
Biochemistry & Molecular Biology
Edina Pandur, Ramona Pap, Gergely Janosa, Adrienn Horvath, Katalin Sipos
Summary: Iron plays a crucial role in the human body, especially in endometrial receptivity and embryo implantation. Disturbances in iron homeostasis, such as iron deficiency, can lead to adverse pregnancy outcomes. Fractalkine (FKN) is a chemokine that is involved in the communication between the mother and the fetus, and it also regulates iron metabolism. This study found that FKN enhances the expression of iron metabolism-related genes, modifies iron uptake and release, and contributes to the redistribution of intracellular iron content, potentially improving the effect of iron deficiency on endometrial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Blair Tupta, Eric Stuehr, Mamta P. Sumi, Elizabeth A. Sweeny, Brandon Smith, Dennis J. Stuehr, Arnab Ghosh
Summary: This study reveals the important role of GAPDH in the maturation of myoglobin and hemoglobins by regulating the formation of sGC alpha1 beta1 heterodimer, iron provision, and the expression of GAPDH. These findings provide insights into the mechanisms of heme-maturation in globins.
Article
Cell Biology
Eva Fige, Judi Szendrei, Laszlo Sos, Izabela Kraszewska, Laszlo Potor, Jozsef Balla, Zsuzsa Szondy
Summary: HO-1 plays a crucial role in the engulfment of heme-containing cells and is essential for regulating internal signaling pathways and anti-inflammatory responses during efferocytosis. The uptake of apoptotic cells and eryptotic red blood cells may involve different mechanisms, but both pathways are controlled by HO-1.
Article
Nutrition & Dietetics
Amanda de Araujo Lima, Laudilse de Morais Souza, Gabriel Soares Badue, Alcides da Silva Diniz, Luiz Gonzaga Ribeiro Silva-Neto, Nassib Bezerra Bueno, Joao Araujo Barros-Neto, Daniel da Silva Vasconcelos, Nathalya da Silva Severino, Vanessa Amorim Peixoto, Karla Emanuelle Pereira de Vasconcelos, Terezinha da Rocha Ataide
Summary: This study aims to evaluate the availability of iron in the meals of the Municipal Centers of Early Childhood Education in Maceio. The results show that the amount of iron available in the meals does not meet the nutritional recommendations on most school days, highlighting the need to increase the availability of iron in school meals.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Immunology
Yongqing Cai, Bin Li, Dan Peng, Xianfeng Wang, Pan Li, Mingchun Huang, Haiyan Xing, Jianhong Chen
Summary: This study revealed that Hyp can protect the liver from oxidative damage by promoting Bach1 nuclear export and enhancing Nrf2 binding to ARE. Furthermore, this protective effect is achieved by enhancing Crm1 expression and ERK1/2 activity.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Liang Liu, Mitsuyo Matsumoto, Miki Matsui-Watanabe, Kyoko Ochiai, Bert K. K. Callens, Long Chi Nguyen, Yushi Kozuki, Miho Tanaka, Hironari Nishizawa, Kazuhiko Igarashi
Summary: The TBK1-BACH1 pathway promotes cancer cell metastasis by increasing labile iron within cells.
Article
Biochemistry & Molecular Biology
Linfei Jiao, Zichan He, Shengchen Wang, Chunli Sun, Shiwen Xu
Summary: This study revealed that selenium deficiency in pig cerebellum can induce necroptosis and inflammation by deregulating the miR-130-CYLD axis, activating the TNF-alpha pathway and necroptosis-related genes, and upregulating the expression of inflammatory cytokines.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Review
Nutrition & Dietetics
Edouard Charlebois, Kostas Pantopoulos
Summary: Dietary iron is crucial for health, but its absorption and metabolism are tightly regulated to prevent toxicity. Hepcidin deficiency causes hereditary hemochromatosis, an iron overload disorder. High intake of heme iron, found in meat products, is associated with metabolic syndrome, cardiovascular diseases, and cancers. Cohort studies provide epidemiological data, but further research is needed to establish causality and understand molecular mechanisms.
Article
Biochemistry & Molecular Biology
Chukwuma A. Chukwu, Helen Gilbody, Olivia Wickens, Craig Carroll, Sunil Bhandari, Philip A. Kalra
Summary: This study aimed to investigate the factors affecting the erythropoietic response to parenteral iron in iron-deficient anaemic patients. It found that the nature of iron deficiency, rather than the severity of CKD, has a greater impact on Hb response to intravenous iron, with a diminished response seen in patients with functional iron deficiency regardless of the degree of renal impairment.
Article
Plant Sciences
Estefania Mancini, Antoni Garcia-Molina
Summary: This study investigated the effect of alternative splicing (AS) on the transcriptome of rosette leaves under single and simultaneous copper (Cu) and iron (Fe) deficiency. It was found that differentially spliced genes (DSGs) and differentially expressed genes (DEGs) showed minimal overlap in number, indicating distinct responses to the double deficiency. Furthermore, it was observed that AS might act as a regulatory mechanism to modify the stability and/or functionality of enzymes involved in amino acid production during the combinatorial response to simultaneous Cu and Fe deficiency.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Microbiology
Caiyun Huo, Lijiao Jiao, Guiping Li, Donghai Li, Wutong Lin, Yingjian Sun, Huiling Sun
Summary: This study provides in-depth insight into the essential roles of HutZ in iron homeostasis and pathogenesis of Av. paragallinarum. Mutation of HutZ significantly affects bacterial growth and iron acquisition, as well as compromises tolerance to acid stress. Moreover, the mutation of HutZ weakens the ability of bacteria to invade and reproduce in host cells, resulting in decreased bacterial virulence in chickens.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Caiyun Huo, Lijiao Jiao, Guiping Li, Donghai Li, Wutong Lin, Yingjian Sun, Huiling Sun
Summary: This study provides insights into the essential roles of HutZ in iron homeostasis and pathogenesis of Av. paragallinarum, and suggests its potential as a therapeutic target for the development of prophylactic vaccines against this pathogen.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Teppei Inatomi, Shigeru Matsuda, Takashi Ishiuchi, Yura Do, Masunari Nakayama, Shusaku Abe, Kazutoshi Kasho, Sjoerd Wanrooij, Kazuto Nakada, Kenji Ichiyanagi, Hiroyuki Sasaki, Takehiro Yasukawa, Dongchon Kang
Summary: TFB2M and POLRMT are crucial for the maintenance of mitochondrial DNA (mtDNA) in human cells, playing vital roles not only in strand-asynchronous replication but also in strand-coupled replication initiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Hironari Nishizawa, Mie Yamanaka, Kazuhiko Igarashi
Summary: Ferroptosis is a form of cell death triggered by intracellular peroxidation of cell membrane phospholipids. It is regulated by transcription factors NRF2 and BACH1, which control various pathways and processes involved in ferroptosis.
Article
Genetics & Heredity
Kenji Ichiyanagi, Kuniaki Saito
Summary: The fifth Japanese meeting on host-transposon interactions focused on the diverse roles of transposable elements in genome function and evolution, as well as host defense systems against TE mobility through chromatin and RNA modifications and protein-protein interactions.
Article
Biology
Kei Fukuda, Yoshinori Makino, Satoru Kaneko, Chikako Shimura, Yuki Okada, Kenji Ichiyanagi, Yoichi Shinkai
Summary: The Kruppel-associated box domain zinc finger proteins are associated with DNA methylation of retroelements in human primordial germ cells, and during human spermatogenesis, the hominoid-specific retroelement SINE-VNTR-Alus (SVA) may undergo transcription-directed de novo DNA methylation, leading to significant inter-individual epigenetic variation in sperm.
Article
Cell Biology
Masaki Kawase, Kenji Ichiyanagi
Summary: In mammals, germ cells produce small regulatory RNAs called piRNAs, which have different characteristics and expression dynamics during development. The length of piRNAs is correlated with PIWI-like proteins, and retrotransposon-derived piRNAs are abundantly produced but decline in abundance as development proceeds.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Liang Liu, Mitsuyo Matsumoto, Miki Matsui-Watanabe, Kyoko Ochiai, Bert K. K. Callens, Long Chi Nguyen, Yushi Kozuki, Miho Tanaka, Hironari Nishizawa, Kazuhiko Igarashi
Summary: The TBK1-BACH1 pathway promotes cancer cell metastasis by increasing labile iron within cells.
Article
Chemistry, Multidisciplinary
Mizuki Sawata, Hiroki Shima, Kazutaka Murayama, Toshitaka Matsui, Kazuhiko Igarashi, Kazumasa Funabashi, Kenji Ite, Kenji Kizawa, Hidenari Takahara, Masaki Unno
Summary: This study demonstrates that PAD3 has autocitrullination capacity and identifies autocitrullination sites. The number of autocitrullination sites increases with the concentration of calcium ions and reaction time, and most of the sites are located near the substrate-binding site. High calcium ion concentration may cause slight structural changes in PAD3, leading to its transformation from an active form to an inactive form.
Review
Biochemistry & Molecular Biology
Manuj Ahuja, Navneet Ammal Kaidery, Debashis Dutta, Otis C. Attucks, Eliot H. Kazakov, Irina Gazaryan, Mitsuyo Matsumoto, Kazuhiko Igarashi, Sudarshana M. Sharma, Bobby Thomas
Summary: Parkinson's disease is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons. Although the exact cause is unclear, oxidative stress, mitochondrial dysfunction, neuroinflammation, and disruption of calcium homeostasis have been proposed as contributing factors. While drugs targeting these pathways have shown promise in preclinical models, a more effective therapeutic approach involving the activation of the Nrf2/Bach1 signaling pathway is being explored. This review discusses the potential benefits of simultaneously inhibiting Bach1 and stabilizing Nrf2 for the treatment of Parkinson's disease.
Article
Hematology
Masatoshi Ikeda, Hiroki Kato, Hiroki Shima, Mitsuyo Matsumoto, Eijiro Furukawa, Yan Yan, Ruiqi Liao, Jian Xu, Akihiko Muto, Tohru Fujiwara, Hideo Harigae, Emery H. Bresnick, Kazuhiko Igarashi
Summary: Iron deficiency promotes mitochondrial retention in red blood cells, while heme promotes mitochondrial clearance and erythroblast differentiation. The transcription factor GATA1 regulates autophagy and induces mitophagy through a heme-dependent mechanism. This mechanism provides a molecular framework for understanding this important cell biological process.
EXPERIMENTAL HEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chie Suzuki, Tohru Fujiwara, Hiroki Shima, Koya Ono, Kei Saito, Hiroki Kato, Koichi Onodera, Satoshi Ichikawa, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Yukio Nakamura, Kazuhiko Igarashi, Hideo Harigae
Summary: The study revealed that FAM210B protein plays a crucial role in erythroid differentiation by regulating mitochondrial energy metabolism, providing new insights into the mechanism of erythroid differentiation.
MOLECULAR AND CELLULAR BIOLOGY
(2022)
Article
Hematology
Koki Nagai, Tetsuya Niihori, Akihiko Muto, Yoshikazu Hayashi, Taiki Abe, Kazuhiko Igarashi, Yoko Aoki
Summary: Radioulnar synostosis with amegakaryocytic thrombocytopenia (RUSAT) is an inherited bone marrow failure syndrome caused by missense mutations in the MECOM gene. Knockin mice harboring RUSAT-associated MECOM mutations recapitulate the bone marrow dysfunction observed in RUSAT patients.
Review
Immunology
Kyoko Ochiai, Kazuhiko Igarashi
Summary: BACH2 is a transcriptional repressor that regulates gene expression in B cells, promoting antibody class switch and affinity maturation while repressing plasma-cell differentiation. Recent studies suggest that BACH2 may have diverse functions, including gene activation. Understanding these new functions could provide insights into preventing human immune deficiencies.
INTERNATIONAL IMMUNOLOGY
(2023)
Meeting Abstract
Hematology
Koya Ono, Tohru Fujiwara, Hiroki Shima, Hironari Nishizawa, Chie Suzuki, Noriyuki Takahashi, Hiroki Kato, Koichi Onodera, Satoshi Ichikawa, Noriko Fukuhara, Yasushi Onishi, Hisayuki Yokoyama, Yukio Nakamura, Kazuhiko Igarashi, Hideo Harigae
Editorial Material
Biochemistry & Molecular Biology
Kenji Ichiyanagi
GENES & GENETIC SYSTEMS
(2022)