Hypericin in the Light and in the Dark: Two Sides of the Same Coin

Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, which Generates Vaccine for Cancer Therapy

(2016) Yuanhong Zheng et al.   International Journal of Biological Sciences

Interspecific variation in localization of hypericins and phloroglucinols in the genusHypericumas revealed by desorption electrospray ionization mass spectrometry imaging

(2016) Andrea Kucharíková et al.   PHYSIOLOGIA PLANTARUM

Extracellular ATP and P2X7 receptor exert context-specific immunogenic effects after immunogenic cancer cell death

(2016) A D Garg et al.   Cell Death & Disease

Spatial chemo-profiling of hypericin and related phytochemicals in Hypericum species using MALDI-HRMS imaging

(2015) Souvik Kusari et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Antimicrobial photodynamic activity of hypericin against methicillin-susceptible and resistant Staphylococcus aureus biofilms

(2015) Isabel García et al.   Future Microbiology

Topical PDT in the Treatment of Benign Skin Diseases: Principles and New Applications

(2015) Miri Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biodistribution and anti-tumor efficacy of intratumorally injected necrosis-avid theranostic agent radioiodinated hypericin in rodent tumor models

(2015) Wei Liu et al.   JOURNAL OF DRUG TARGETING

A Phase IIA Dose-Finding Study of PVP-Hypericin Fluorescence Cystoscopy for Detection of Nonmuscle-Invasive Bladder Cancer

(2015) Michael Straub et al.   JOURNAL OF ENDOUROLOGY

Red and far-red fluorescent dyes for the characterization of head and neck cancer at the cellular level

(2015) Muriel Abbaci et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Potentiation of hypericin-mediated photodynamic therapy cytotoxicity by MK-886: Focus on ABC transporters, GDF-15 and redox status

(2015) Barbora Kuchárová et al.   Photodiagnosis and Photodynamic Therapy

The role of ABA in the freezing injury avoidance in two Hypericum species differing in frost tolerance and potential to synthesize hypericins

(2015) Katarína Bruňáková et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Necrosis targeted radiotherapy with iodine-131-labeled hypericin to improve anticancer efficacy of vascular disrupting treatment in rabbit VX2 tumor models

(2015) Haibo Shao et al.   Oncotarget

Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal

(2015) Abhishek D. Garg et al.   Oncotarget

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

(2015) Abhishek D. Garg et al.   Frontiers in Immunology

Antiangiogenesis agents avastin and erbitux enhance the efficacy of photodynamic therapy in a murine bladder tumor model

(2015) Ramaswamy Bhuvaneswari et al.   LASERS IN SURGERY AND MEDICINE

Classification of current anticancer immunotherapies

(2015) Lorenzo Galluzzi et al.   Oncotarget

In Vitro Fungicidal Photodynamic Effect of Hypericin on Trichophyton spp

(2014) Manuel Pablo Paz-Cristobal et al.   MYCOPATHOLOGIA

Exploration of the mechanism underlying the tumor necrosis avidity of hypericin

(2014) Marie Van de Putte et al.   ONCOLOGY REPORTS

Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model

(2014) Marie Van de Putte et al.   ONCOLOGY REPORTS

ER stress, autophagy and immunogenic cell death in photodynamic therapy-induced anti-cancer immune responses

(2014) Abhishek D. Garg et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

St John's Wort (Hypericum perforatum L.) Photomedicine: Hypericin-Photodynamic Therapy Induces Metastatic Melanoma Cell Death

(2014) Britta Kleemann et al.   PLoS One

Successful in vivo tumor visualization using fluorescence laparoscopy in a mouse model of disseminated alveolar rhabdomyosarcoma

(2014) Cristian Urla et al.   SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

Single pre-treatment with hypericin, a St. John’s wort secondary metabolite, attenuates cisplatin- and mitoxantrone-induced cell death in A2780, A2780cis and HL-60 cells

(2014) Zuzana Jendželovská et al.   TOXICOLOGY IN VITRO

The Effect of St John’s Wort on the Pharmacokinetics of Docetaxel

(2013) Andrew K. L. Goey et al.   CLINICAL PHARMACOKINETICS

Conjunction of glutathione level, NAD(P)H/FAD redox status and hypericin content as a potential factor affecting colon cancer cell resistance to photodynamic therapy with hypericin

(2013) Lucia Mikešová et al.   Photodiagnosis and Photodynamic Therapy

Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model

(2013) Susan Noell et al.   Photodiagnosis and Photodynamic Therapy

Topical Application of St. Johnʼs Wort (Hypericum perforatum)

(2013) Ute Wölfle et al.   PLANTA MEDICA

Sequential Systemic Administrations of Combretastatin A4 Phosphate and Radioiodinated Hypericin Exert Synergistic Targeted Theranostic Effects with Prolonged Survival on SCID Mice Carrying Bifocal Tumor Xenografts

(2013) Junjie Li et al.   Theranostics

Mechanisms and insights into drug resistance in cancer

(2013) Hiba Zahreddine et al.   Frontiers in Pharmacology

Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species

(2012) Noemi Rubio et al.   Autophagy

Hypericin for visualization of high grade gliomas: First clinical experience

(2012) R. Ritz et al.   EJSO

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

Toward real-time virtual biopsy of oral lesions using confocal laser endomicroscopy interfaced with embedded computing

(2012) Patricia S. P. Thong et al.   JOURNAL OF BIOMEDICAL OPTICS

Effects of hypericin and a chlorin based photosensitizer alone or in combination in squamous cell carcinoma cells in the dark

(2012) Emina Besic Gyenge et al.   Photodiagnosis and Photodynamic Therapy

Photodynamic effect of hypericin on the microorganisms and primary human fibroblasts

(2012) Nasim Kashef et al.   Photodiagnosis and Photodynamic Therapy

Exploring Theranostic Potentials of Radioiodinated Hypericin in Rodent Necrosis Models

(2012) Junjie Li et al.   Theranostics

Photodynamic therapy of cancer: An update

(2011) Patrizia Agostinis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas

(2011) William T. Couldwell et al.   CANCER

Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin

(2011) Abhishek D. Garg et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Radiolabeled iodohypericin as tumor necrosis avid tracer: diagnostic and therapeutic potential

(2011) Marie Van de Putte et al.   INTERNATIONAL JOURNAL OF CANCER

Selective enrichment of hypericin in malignant glioma: Pioneering in vivo results

(2011) Ritz   INTERNATIONAL JOURNAL OF ONCOLOGY

Small-Animal PET of Tumor Damage Induced by Photothermal Ablation with 64Cu-Bis-DOTA-Hypericin

(2011) S. Song et al.   JOURNAL OF NUCLEAR MEDICINE

Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin

(2011) Jaromír Mikeš et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

In Vitro Fungicidal Photodynamic Effect of Hypericin on Candida Species†

(2011) Antonio Rezusta et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Low dose hypericin-PDT induces complete tumor regression in BALB/c mice bearing CT26 colon carcinoma

(2011) Renata Sanovic et al.   Photodiagnosis and Photodynamic Therapy

A Dual-targeting Anticancer Approach: Soil and Seed Principle

(2011) Junjie Li et al.   RADIOLOGY

Biodistribution of PVP-hypericin and hexaminolevulinate-induced PpIX in normal and orthotopic tumor-bearing rat urinary bladder

(2010) Joachim Vandepitte et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression

(2010) Siegfried Kasper et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Evaluation of hypericin-mediated photodynamic therapy in combination with angiogenesis inhibitor bevacizumab using in vivo fluorescence confocal endomicroscopy

(2010) Ramaswamy Bhuvaneswari et al.   JOURNAL OF BIOMEDICAL OPTICS

Comparative in vitro study on the characteristics of different photosensitizers employed in PDT

(2010) Juergen Berlanda et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Photodynamic therapy using topically applied hypericin: Comparative effect with methyl-aminolevulinic acid on UV induced skin tumours

(2010) A. Boiy et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

A phase II placebo-controlled study of photodynamic therapy with topical hypericin and visible light irradiation in the treatment of cutaneous T-cell lymphoma and psoriasis

(2010) Alain H. Rook et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Clinical application of fluorescence endoscopic imaging using hypericin for the diagnosis of human oral cavity lesions

(2009) P S P Thong et al.   BRITISH JOURNAL OF CANCER

Light-Independent Metabolomics of EndophyticThielavia subthermophilaProvides Insight into Microbial Hypericin Biosynthesis

(2009) Souvik Kusari et al.   JOURNAL OF NATURAL PRODUCTS

The Multifaceted Photocytotoxic Profile of Hypericin

(2009) Theodossis A. Theodossiou et al.   MOLECULAR PHARMACEUTICS

The role of p53 in the efficiency of photodynamic therapy with hypericin and subsequent long-term survival of colon cancer cells

(2009) Jaromír Mikeš et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells

(2009) Rastislav Jendželovský et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Degradation of HER2 Receptor Through Hypericin-mediated Photodynamic Therapy

(2009) Ján Kovaľ et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Genotoxicity and antigenotoxicity evaluation of non-photoactivated hypericin

(2009) Eva Miadokova et al.   PHYTOTHERAPY RESEARCH

Characterization of hairy root-phenotype in transgenic Hypericum perforatum L. clones

(2008) Jana Koperdáková et al.   ACTA PHYSIOLOGIAE PLANTARUM

An Endophytic Fungus fromHypericum perforatumthat Produces Hypericin

(2008) Souvik Kusari et al.   JOURNAL OF NATURAL PRODUCTS

Hypericin-mediated photodynamic therapy of pituitary tumors: preclinical study in a GH4C1 rat tumor model

(2008) Chad D. Cole et al.   JOURNAL OF NEURO-ONCOLOGY

Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy

(2008) Ramaswamy Bhuvaneswari et al.   Molecular Cancer

Photodynamic Therapy of Nonmelanoma Skin Cancer with Topical Hypericum perforatum Extract—A Pilot Study

(2008) Denisa Kacerovská et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Fluorescence Diagnosis of Bladder Cancer with New Water Soluble Hypericin Bound to Polyvinylpyrrolidone: PVP-Hypericin

(2008) Andreas Kubin et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Interactive Transport, Subcellular Relocation and Enhanced Phototoxicity of Hypericin Encapsulated in Guanidinylated LiposomesviaMolecular Recognition

(2008) Maria C. Galanou et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Hypericin as a Marker for Determination of Tissue Viability After Intratumoral Ethanol Injection in a Murine Liver Tumor Model

(2007) Marie Van de Putte et al.   ACADEMIC RADIOLOGY