Paradigm shift in activity assessment of IgA nephropathy – optimizing the next generation of diagnostic and therapeutic maneuvers via glycan targeting

Evidence-based Clinical Practice Guideline for CKD 2013

(2014)   Clinical and Experimental Nephrology

Serum levels of galactose-deficient immunoglobulin (Ig) A1 and related immune complex are associated with disease activity of IgA nephropathy

(2014) Yusuke Suzuki et al.   Clinical and Experimental Nephrology

Cytokines Alter IgA1O-Glycosylation by Dysregulating C1GalT1 and ST6GalNAc-II Enzymes

(2014) Hitoshi Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes in Nephritogenic Serum Galactose-Deficient IgA1 in IgA Nephropathy following Tonsillectomy and Steroid Therapy

(2014) Junichiro Nakata et al.   PLoS One

A Panel of Serum Biomarkers Differentiates IgA Nephropathy from Other Renal Diseases

(2014) Hiroyuki Yanagawa et al.   PLoS One

A Cancer-specific Monoclonal Antibody Recognizes the Aberrantly Glycosylated Podoplanin

(2014) Yukinari Kato et al.   Scientific Reports

Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010

(2013) Hitoshi Sugiyama et al.   Clinical and Experimental Nephrology

Elucidating heterogeneity of IgA1 hinge-region O-glycosylation by use of MALDI-TOF/TOF mass spectrometry: Role of cysteine alkylation during sample processing

(2013) Vojtěch Franc et al.   Journal of Proteomics

IgA Nephropathy

(2013) Robert J. Wyatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autoantibodies Targeting Galactose-Deficient IgA1 Associate with Progression of IgA Nephropathy

(2012) F. Berthoux et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression

(2012) Na Zhao et al.   KIDNEY INTERNATIONAL

The IgA1 immune complex–mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy

(2012) Houda Tamouza et al.   KIDNEY INTERNATIONAL

The KDIGO practice guideline on glomerulonephritis: reading between the (guide)lines—application to the individual patient

(2012) Jai Radhakrishnan et al.   KIDNEY INTERNATIONAL

Tonsillectomy has beneficial effects on remission and progression of IgA nephropathy independent of steroid therapy

(2012) Isseki Maeda et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Glycosylation of IgA1 and pathogenesis of IgA nephropathy

(2012) Jan Novak et al.   Seminars in Immunopathology

A treatment dilemma in adult immunoglobulin A nephropathy: what is the appropriate target, preservation of kidney function or induction of clinical remission?

(2011) Hirokazu Imai et al.   Clinical and Experimental Nephrology

Oxidative Stress and Galactose-Deficient IgA1 as Markers of Progression in IgA Nephropathy

(2011) R. Camilla et al.   Clinical Journal of the American Society of Nephrology

The pathogenesis of IgA nephropathy

(2011) Richard J Glassock   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Naturally Occurring Structural Isomers in Serum IgA1 O-Glycosylation

(2011) Kazuo Takahashi et al.   JOURNAL OF PROTEOME RESEARCH

The Pathophysiology of IgA Nephropathy

(2011) H. Suzuki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IgA1 immune complexes from pediatric patients with IgA nephropathy activate cultured human mesangial cells

(2011) Jan Novak et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Galactosylation of N- and O-linked carbohydrate moieties of IgA1 and IgG in IgA nephropathy

(2010) A. C. ALLEN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Production of Anti-carbohydrate Antibodies by Phage Display Technologies

(2010) Noriyuki Yuasa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxic regulation of glycosylation via the N-acetylglucosamine cycle

(2010) Ken Shirato et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

ClusteredO-Glycans of IgA1

(2010) Kazuo Takahashi et al.   MOLECULAR & CELLULAR PROTEOMICS

Influence of tonsillectomy on the progression of mesangioproliferative glomerulonephritis

(2010) A. Piccoli et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Slower Decline of Glomerular Filtration Rate in the Japanese General Population: A Longitudinal 10-Year Follow-Up Study

(2008) Enyu IMAI et al.   HYPERTENSION RESEARCH

Aberrant IgA1 Glycosylation Is Inherited in Familial and Sporadic IgA Nephropathy

(2008) A. G. Gharavi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Podocyte injury induced by mesangial-derived cytokines in IgA nephropathy

(2008) K. N. Lai et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Fucosylated haptoglobin is a novel marker for pancreatic cancer: Detailed analyses of oligosaccharide structures

(2008) Eiji Miyoshi et al.   PROTEOMICS