Cryptococcus and Phagocytes: Complex Interactions that Influence Disease Outcome

Cryptococcal transmigration across a model brain blood-barrier: evidence of the Trojan horse mechanism and differences between Cryptococcus neoformans var. grubii strain H99 and Cryptococcus gattii strain R265

(2016) Tania C. Sorrell et al.   MICROBES AND INFECTION

Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex

(2015) Ferry Hagen et al.   FUNGAL GENETICS AND BIOLOGY

Real-Time Imaging of Interactions of Neutrophils with Cryptococcus neoformans Demonstrates a Crucial Role of Complement C5a-C5aR Signaling

(2015) Donglei Sun et al.   INFECTION AND IMMUNITY

Cryptococcus neoformans–Induced Macrophage Lysosome Damage Crucially Contributes to Fungal Virulence

(2015) Michael J. Davis et al.   JOURNAL OF IMMUNOLOGY

Cryptococcal Heat Shock Protein 70 Homolog Ssa1 Contributes to Pulmonary Expansion ofCryptococcus neoformansduring the Afferent Phase of the Immune Response by Promoting Macrophage M2 Polarization

(2015) Alison J. Eastman et al.   JOURNAL OF IMMUNOLOGY

Macrophage Mitochondrial and Stress Response to Ingestion ofCryptococcus neoformans

(2015) Carolina Coelho et al.   JOURNAL OF IMMUNOLOGY

Real-time in vivo imaging reveals the ability of neutrophils to remove Cryptococcus neoformans directly from the brain vasculature

(2015) M. Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Decreased TLR2 signal expression in peripheral blood mononuclear cell from patients with cryptococcal meningitis

(2015) Lei Zhang et al.   MICROBIOLOGY AND IMMUNOLOGY

Capsular polysaccharides from Cryptococcus neoformans modulate production of neutrophil extracellular traps (NETs) by human neutrophils

(2015) Juliana D. B. Rocha et al.   Scientific Reports

Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection

(2015) Darin L. Wiesner et al.   PLoS Pathogens

Is Development of a Vaccine against Cryptococcus neoformans Feasible?

(2015) Chrissy M. Leopold Wager et al.   PLoS Pathogens

Paradoxical Immune Responses in Non-HIV Cryptococcal Meningitis

(2015) Anil A. Panackal et al.   PLoS Pathogens

The fungal pathogenCryptococcus neoformansmanipulates macrophage phagosome maturation

(2014) Leanne M. Smith et al.   CELLULAR MICROBIOLOGY

Chitin Activates Parallel Immune Modules that Direct Distinct Inflammatory Responses via Innate Lymphoid Type 2 and γδ T Cells

(2014) Steven J. Van Dyken et al.   IMMUNITY

Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis

(2014) Wilber Sabiiti et al.   JOURNAL OF CLINICAL INVESTIGATION

CCR2 Mediates Conventional Dendritic Cell Recruitment and the Formation of Bronchovascular Mononuclear Cell Infiltrates in the Lungs of Mice Infected with Cryptococcus neoformans

(2014) J. J. Osterholzer et al.   JOURNAL OF IMMUNOLOGY

Deoxynucleic Acids from Cryptococcus neoformans Activate Myeloid Dendritic Cells via a TLR9-Dependent Pathway

(2014) K. Nakamura et al.   JOURNAL OF IMMUNOLOGY

Early or Late IL-10 Blockade Enhances Th1 and Th17 Effector Responses and Promotes Fungal Clearance in Mice with Cryptococcal Lung Infection

(2014) Benjamin J. Murdock et al.   JOURNAL OF IMMUNOLOGY

STAT1 Signaling Is Essential for Protection againstCryptococcus neoformansInfection in Mice

(2014) Chrissy M. Leopold Wager et al.   JOURNAL OF IMMUNOLOGY

Epigenetic Silencing of the Human NOS2 Gene: Rethinking the Role of Nitric Oxide in Human Macrophage Inflammatory Responses

(2014) T. J. Gross et al.   JOURNAL OF IMMUNOLOGY

Classical versus alternative macrophage activation: the Ying and the Yang in host defense against pulmonary fungal infections

(2014) C M Leopold Wager et al.   Mucosal Immunology

IL-4 Receptor-Alpha-Dependent Control of Cryptococcus neoformans in the Early Phase of Pulmonary Infection

(2014) Andreas Grahnert et al.   PLoS One

Vaccine-Mediated Immune Responses to Experimental Pulmonary Cryptococcus gattii Infection in Mice

(2014) Ashok K. Chaturvedi et al.   PLoS One

‘Division of labour’ in response to host oxidative burst drives a fatal Cryptococcus gattii outbreak

(2014) Kerstin Voelz et al.   Nature Communications

Cryptococcus neoformans and Cryptococcus gattii, the Etiologic Agents of Cryptococcosis

(2014) K. J. Kwon-Chung et al.   Cold Spring Harbor Perspectives in Medicine

Retrospective Study of the Epidemiology and Clinical Manifestations of Cryptococcus gattii Infections in Colombia from 1997–2011

(2014) Jairo Lizarazo et al.   PLoS Neglected Tropical Diseases

Characterization and Optimization of the Glucan Particle-Based Vaccine Platform

(2013) Haibin Huang et al.   Clinical and Vaccine Immunology

Development and function of group 2 innate lymphoid cells

(2013) Jennifer A Walker et al.   CURRENT OPINION IN IMMUNOLOGY

Cryptococcusantigens and immune responses: implications for a vaccine

(2013) Ashok K Chaturvedi et al.   Expert Review of Vaccines

Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms

(2013) J. T. Mattila et al.   JOURNAL OF IMMUNOLOGY

Cryptococcus gattii Is Killed by Dendritic Cells, but Evades Adaptive Immunity by Failing To Induce Dendritic Cell Maturation

(2013) S. M. Huston et al.   JOURNAL OF IMMUNOLOGY

Identification and characterization ofCryptococcus neoformansprotein fractions that induce protective immune responses

(2013) Ashok K. Chaturvedi et al.   PROTEOMICS

Depletion of neutrophils in a protective model of pulmonary cryptococcosis results in increased IL-17A production by gamma/delta T cells

(2012) Karen L Wozniak et al.   BMC IMMUNOLOGY

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

(2012) Jessica Quintin et al.   Cell Host & Microbe

Cryptococcusinteractions with macrophages: evasion and manipulation of the phagosome by a fungal pathogen

(2012) Simon A. Johnston et al.   CELLULAR MICROBIOLOGY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Early Induction of CCL7 Downstream of TLR9 Signaling Promotes the Development of Robust Immunity to Cryptococcal Infection

(2012) Y. Qiu et al.   JOURNAL OF IMMUNOLOGY

Relative Contributions of Dectin-1 and Complement to Immune Responses to Particulate  -Glucans

(2012) H. Huang et al.   JOURNAL OF IMMUNOLOGY

Protective Immunity against Pulmonary Cryptococcosis Is Associated with STAT1-Mediated Classical Macrophage Activation

(2012) S. E. Hardison et al.   JOURNAL OF IMMUNOLOGY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

C-type lectin receptors orchestrate antifungal immunity

(2012) Sarah E Hardison et al.   NATURE IMMUNOLOGY

Capsule Independent Uptake of the Fungal Pathogen Cryptococcus neoformans into Brain Microvascular Endothelial Cells

(2012) Wilber Sabiiti et al.   PLoS One

Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo

(2012) P. C. Cook et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Dendritic Cell Lysosomal Killing of Cryptococcus

(2012) Camaron R. Hole et al.   Scientific Reports

Molecular mechanisms of cryptococcal meningitis

(2012) Tong-Bao Liu et al.   Virulence

Vaccine and Immunotherapeutic Approaches for the Prevention of Cryptococcosis: Lessons Learned from Animal Models

(2012) Camaron R. Hole et al.   Frontiers in Microbiology

Protective Immunity against Experimental Pulmonary Cryptococcosis in T Cell-Depleted Mice

(2011) Karen L. Wozniak et al.   Clinical and Vaccine Immunology

Cryptococcus gattii Infection in Healthy Hosts: A Sentinel for Subclinical Immunodeficiency?

(2011) K. A. Marr et al.   CLINICAL INFECTIOUS DISEASES

Cryptococcus neoformanssuppresses the activation of bone marrow–derived dendritic cells stimulated with its own DNA, but not with DNA from other fungi

(2011) Hideki Yamamoto et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box

(2011) James W. Kronstad et al.   NATURE REVIEWS MICROBIOLOGY

Role of IL-17A on Resolution of Pulmonary C. neoformans Infection

(2011) Karen L. Wozniak et al.   PLoS One

Contributions of the MyD88-Dependent Receptors IL-18R, IL-1R, and TLR9 to Host Defenses following Pulmonary Challenge with Cryptococcus neoformans

(2011) Jennifer P. Wang et al.   PLoS One

Cryptococcus Neoformans Modulates Extracellular Killing by Neutrophils

(2011) Asfia Qureshi et al.   Frontiers in Microbiology

Pulmonary Infection with an Interferon-γ-Producing Cryptococcus neoformans Strain Results in Classical Macrophage Activation and Protection

(2010) Sarah E. Hardison et al.   AMERICAN JOURNAL OF PATHOLOGY

TLR9 Signaling Is Required for Generation of the Adaptive Immune Protection in Cryptococcus neoformans-Infected Lungs

(2010) Yanmei Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanisms of cryptococcal virulence and persistence

(2010) Michal A Olszewski et al.   Future Microbiology

Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease

(2010) Reiko M. Onishi et al.   IMMUNOLOGY

Extracellular Fibrils of Pathogenic Yeast Cryptococcus gattii Are Important for Ecological Niche, Murine Virulence and Human Neutrophil Interactions

(2010) Deborah J. Springer et al.   PLoS One

Role of Sphingomyelin Synthase in Controlling the Antimicrobial Activity of Neutrophils against Cryptococcus neoformans

(2010) Asfia Qureshi et al.   PLoS One

Robust Stimulation of Humoral and Cellular Immune Responses following Vaccination with Antigen-Loaded  -Glucan Particles

(2010) H. Huang et al.   mBio

The Human Fungal Pathogen Cryptococcus neoformans Escapes Macrophages by a Phagosome Emptying Mechanism That Is Inhibited by Arp2/3 Complex-Mediated Actin Polymerisation

(2010) Simon A. Johnston et al.   PLoS Pathogens

Cryptococcal Cell Morphology Affects Host Cell Interactions and Pathogenicity

(2010) Laura H. Okagaki et al.   PLoS Pathogens

Fungal Cell Gigantism during Mammalian Infection

(2010) Oscar Zaragoza et al.   PLoS Pathogens

Robust Th1 and Th17 Immunity Supports Pulmonary Clearance but Cannot Prevent Systemic Dissemination of Highly Virulent Cryptococcus neoformans H99

(2009) Yanmei Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Cryptococcal Urease Promotes the Accumulation of Immature Dendritic Cells and a Non-Protective T2 Immune Response within the Lung

(2009) John J. Osterholzer et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-4/IL-13-Dependent Alternative Activation of Macrophages but Not Microglial Cells Is Associated with Uncontrolled Cerebral Cryptococcosis

(2009) Werner Stenzel et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

How Sweet it is! Cell Wall Biogenesis and Polysaccharide Capsule Formation inCryptococcus neoformans

(2009) Tamara Lea Doering   Annual Review of Microbiology

TheCryptococcus neoformans cap10 andcap59 mutant strains, affected in glucuronoxylomannan synthesis, differentially activate human dendritic cells

(2009) Jan Grijpstra et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Distinct Patterns of Dendritic Cell Cytokine Release Stimulated by Fungal  -Glucans and Toll-Like Receptor Agonists

(2009) H. Huang et al.   INFECTION AND IMMUNITY

Administration of IL-23 engages innate and adaptive immune mechanisms during fungal infection

(2009) M. A. Kleinschek et al.   INTERNATIONAL IMMUNOLOGY

Insights into the Mechanisms of Protective Immunity against Cryptococcus neoformans Infection Using a Mouse Model of Pulmonary Cryptococcosis

(2009) Karen L. Wozniak et al.   PLoS One

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

Capsule enlargement inCryptococcus neoformansconfers resistance to oxidative stress suggesting a mechanism for intracellular survival

(2008) Oscar Zaragoza et al.   CELLULAR MICROBIOLOGY

Cryptococcus neoformans Enters the Endolysosomal Pathway of Dendritic Cells and Is Killed by Lysosomal Components

(2008) K. L. Wozniak et al.   INFECTION AND IMMUNITY

Cryptococcus neoformans inhibits nitric oxide synthesis caused by CpG-oligodeoxynucleotide-stimulated macrophages in a fashion independent of capsular polysaccharides

(2008) Gang Xiao et al.   MICROBIOLOGY AND IMMUNOLOGY

Cooperative Stimulation of Dendritic Cells by Cryptococcus neoformans Mannoproteins and CpG Oligodeoxynucleotides

(2008) Jennifer M. Dan et al.   PLoS One