Breaking the Spell: Combating Multidrug Resistant ‘Superbugs’

Bactericidal Activity of Lactoferrin and Its Amidated and Pepsin-Digested Derivatives against Pseudomonas fluorescens in Ground Beef and Meat Fractions

(2016) ANA del OLMO et al.   JOURNAL OF FOOD PROTECTION

Current Progress in Developing Subunit Vaccines against Enterotoxigenic Escherichia coli-Associated Diarrhea

(2015) Weiping Zhang et al.   Clinical and Vaccine Immunology

Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection againstStaphylococcus aureus

(2015) Fabio Bagnoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsic Antimicrobial Resistance Determinants in the Superbug Pseudomonas aeruginosa

(2015) Justine L. Murray et al.   mBio

Bacterial Resistance to Leucyl-tRNA Synthetase Inhibitor GSK2251052 Develops during Treatment of Complicated Urinary Tract Infections

(2014) Karen O'Dwyer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibacterial resistance: an emerging ‘zoonosis’?

(2014) Marie-Thérèse Labro et al.   Expert Review of Anti-Infective Therapy

Immunization with Lipopolysaccharide-Deficient Whole Cells Provides Protective Immunity in an Experimental Mouse Model of Acinetobacter baumannii Infection

(2014) Meritxell García-Quintanilla et al.   PLoS One

ComparativeIn VitroActivities of GSK2251052, a Novel Boron-Containing Leucyl-tRNA Synthetase Inhibitor, against 916 Anaerobic Organisms

(2013) Ellie J. C. Goldstein et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibacterial Activity of Eravacycline (TP-434), a Novel Fluorocycline, against Hospital and Community Pathogens

(2013) J. A. Sutcliffe et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Potency and Spectrum of Activity of AN3365, a Novel Boron-Containing Protein Synthesis Inhibitor, Tested against Clinical Isolates of Enterobacteriaceae and Nonfermentative Gram-Negative Bacilli

(2013) Rodrigo E. Mendes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Strategies and molecular tools to fight antimicrobial resistance: resistome, transcriptome, and antimicrobial peptides

(2013) Letícia S. Tavares et al.   Frontiers in Microbiology

A brief multi-disciplinary review on antimicrobial resistance in medicine and its linkage to the global environmental microbiota

(2013) L. Cantas et al.   Frontiers in Microbiology

Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance

(2013) Fernanda Guilhelmelli et al.   Frontiers in Microbiology

Th17-stimulating Protein Vaccines Confer Protection againstPseudomonas aeruginosaPneumonia

(2012) Weihui Wu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Target- and Resistance-Based Mechanistic Studies with TP-434, a Novel Fluorocycline Antibiotic

(2012) Trudy H. Grossman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug resistance and real-time tracking

(2012) Jin-Ming Li et al.   BIOMATERIALS

Drug discovery enters a new era with multi-target intervention strategy

(2012) Xiao-ying Tian et al.   Chinese Journal of Integrative Medicine

Combining imaging and pathway profiling: an alternative approach to cancer drug discovery

(2012) Neil O. Carragher et al.   DRUG DISCOVERY TODAY

Prokaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37

(2012) Yong Hai Nan et al.   PEPTIDES

Spread of carbapenemase NDM-1 producers: The situation in India and what may be proposed

(2012) Asad U. Khan et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

Carbapenem resistance in Enterobacteriaceae: here is the storm!

(2012) Patrice Nordmann et al.   TRENDS IN MOLECULAR MEDICINE

Contributions of capsule, lipoproteins and duration of colonisation towards the protective immunity of prior Streptococcus pneumoniae nasopharyngeal colonisation

(2012) Jonathan M. Cohen et al.   VACCINE

Analytical chemiluminescence and bioluminescence: latest achievements and new horizons

(2011) Aldo Roda et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Antibiotics in development targeting protein synthesis

(2011) Joyce A. Sutcliffe   Annals of the New York Academy of Sciences

A Decade of the Human Genome Sequence-How Does the Medicinal Chemist Benefit?

(2011) Andreas Brunschweiger et al.   ChemMedChem

Luminescent nanoparticles and their use forin vitroandin vivodiagnostics

(2011) Jörn Probst et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Global spread of drug-resistantAcinetobacter baumannii: molecular epidemiology and management of antimicrobial resistance

(2011) Emanuele Durante-Mangoni et al.   Future Microbiology

Molecular and cellular mechanisms of DNA vaccines

(2011) Cevayir Coban et al.   Human vaccines & immunotherapeutics

Activity of ACHN-490 against meticillin-resistant Staphylococcus aureus (MRSA) isolates from patients in US hospitals

(2011) Fred C. Tenover et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Rapid Detection of Bacteria by Carbon Quantum Dots

(2011) Tapas K. Mandal et al.   Journal of Biomedical Nanotechnology

NDM-1-producing Enterobacter cloacae and Klebsiella pneumoniae from diabetic foot ulcers in India

(2011) A. U. Khan et al.   JOURNAL OF MEDICAL MICROBIOLOGY

p53 Independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia

(2011) K P Ng et al.   LEUKEMIA

Designing antimicrobial peptides: form follows function

(2011) Christopher D. Fjell et al.   NATURE REVIEWS DRUG DISCOVERY

The emerging NDM carbapenemases

(2011) Patrice Nordmann et al.   TRENDS IN MICROBIOLOGY

Nanoparticles as fluorescent labels for optical imaging and sensing in genomics and proteomics

(2010) Ana María Coto-García et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Challenges of antibacterial discovery revisited

(2010) Michael N. Gwynn et al.   Annals of the New York Academy of Sciences

The Genomic Enzymology of Antibiotic Resistance

(2010) Mariya Morar et al.   Annual Review of Genetics

Synthesis and Spectrum of the Neoglycoside ACHN-490

(2010) J. B. Aggen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Improved network performance via antagonism: From synthetic rescues to multi-drug combinations

(2010) Adilson E. Motter   BIOESSAYS

Tethering antimicrobial peptides: Current status and potential challenges

(2010) Sagheer A. Onaizi et al.   BIOTECHNOLOGY ADVANCES

Combating evolution with intelligent design: the neoglycoside ACHN-490

(2010) Eliana S Armstrong et al.   CURRENT OPINION IN MICROBIOLOGY

Novel targeted immunotherapy approaches for staphylococcal infection

(2010) Michael Otto   EXPERT OPINION ON BIOLOGICAL THERAPY

Conformational Analysis of a Synthetic Antimicrobial Peptide in Water and Membrane-Mimicking Solvents: A Molecular Dynamics Simulation Study

(2010) Sandro L. Fornili et al.   International Journal of Peptide Research and Therapeutics

Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates

(2010) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Antisense Phosphorodiamidate Morpholino Oligomers Targeted to an Essential Gene InhibitBurkholderia cepaciaComplex

(2010) David E. Greenberg et al.   JOURNAL OF INFECTIOUS DISEASES

Pharmacogenomic strategies against microbial resistance: from bright to bleak to innovative

(2010) Thomas Dandekar et al.   PHARMACOGENOMICS

Tracking Acquired Antibiotic Resistance in Commensal Bacteria of Galápagos Land Iguanas: No Man, No Resistance

(2010) Maria Cristina Thaller et al.   PLoS One

Molecular Characterisation of Trimethoprim Resistance in Escherichia coli and Klebsiella pneumoniae during a Two Year Intervention on Trimethoprim Use

(2010) Alma Brolund et al.   PLoS One

Resistance Plasmid Families in Enterobacteriaceae

(2009) A. Carattoli   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Safety and tolerability of the antimicrobial peptide human lactoferrin 1-11 (hLF1-11)

(2009) Walter JFM van der Velden et al.   BMC Medicine

Making Sense of Antisense in Antibiotic Drug Discovery

(2009) Gerard D. Wright   Cell Host & Microbe

Antimicrobial use: risk driver of multidrug resistant microorganisms in healthcare settings

(2009) Evelina Tacconelli   CURRENT OPINION IN INFECTIOUS DISEASES

Functional relationship between bacterial cell density and the efficacy of antibiotics

(2009) K. I. Udekwu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Quantum Dots for In Vivo Small-Animal Imaging

(2009) L. A. Bentolila et al.   JOURNAL OF NUCLEAR MEDICINE

Genetic Architecture of Intrinsic Antibiotic Susceptibility

(2009) Hany S. Girgis et al.   PLoS One

Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning

(2009) Thouis R. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Characterization of the Antibiotic Resistance Reservoir in the Human Microflora

(2009) M. O. A. Sommer et al.   SCIENCE

Quantum dot probes for bacteria distinguish Escherichia coli mutants and permit in vivo imaging

(2008) W. Matthew Leevy et al.   CHEMICAL COMMUNICATIONS

Topical versus Systemic Antimicrobial Therapy for Treating Mildly Infected Diabetic Foot Ulcers: A Randomized, Controlled, Double‐Blinded, Multicenter Trial of Pexiganan Cream

(2008) Benjamin A. Lipsky et al.   CLINICAL INFECTIOUS DISEASES

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Extended-spectrum β-lactamase-producing Enterobacteriaceae: an emerging public-health concern

(2008) Johann DD Pitout et al.   LANCET INFECTIOUS DISEASES

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

The Neglected Intrinsic Resistome of Bacterial Pathogens

(2008) Alicia Fajardo et al.   PLoS One