Experimental Models of Foamy Macrophages and Approaches for Dissecting the Mechanisms of Lipid Accumulation and Consumption during Dormancy and Reactivation of Tuberculosis

Triacylglycerol and wax ester-accumulating machinery in prokaryotes

(2016) Héctor M. Alvarez   BIOCHIMIE

Human Xenobiotic Nuclear Receptor PXR AugmentsMycobacterium tuberculosisSurvival

(2016) Ella Bhagyaraj et al.   JOURNAL OF IMMUNOLOGY

MAB_3551cencodes the primary triacylglycerol synthase involved in lipid accumulation inMycobacterium abscessus

(2016) Albertus Viljoen et al.   MOLECULAR MICROBIOLOGY

The perilipin-like PPE15 protein inMycobacterium tuberculosisis required for triacylglycerol accumulation under dormancy-inducing conditions

(2016) Jaiyanth Daniel et al.   MOLECULAR MICROBIOLOGY

Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis

(2016) Amanda J. Martinot et al.   PLoS Pathogens

MUSASHI-Mediated Expression of JMJD3, a H3K27me3 Demethylase, Is Involved in Foamy Macrophage Generation during Mycobacterial Infection

(2016) Sahana Holla et al.   PLoS Pathogens

Lipid droplet dynamics at early stages ofMycobacterium marinuminfection inDictyostelium

(2015) Caroline Barisch et al.   CELLULAR MICROBIOLOGY

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis

(2015) S. M. Irwin et al.   Disease Models & Mechanisms

Mycobacterium tuberculosis infection of the ‘non-classical immune cell’

(2015) Philippa J Randall et al.   IMMUNOLOGY AND CELL BIOLOGY

Lack of the Transcription Factor Hypoxia-Inducible Factor 1α (HIF-1α) in Macrophages Accelerates the Necrosis of Mycobacterium avium-Induced Granulomas

(2015) Marcos S. Cardoso et al.   INFECTION AND IMMUNITY

Characterization of Host and Microbial Determinants in Individuals with Latent Tuberculosis Infection Using a Human Granuloma Model

(2015) Evelyn Guirado et al.   mBio

M. tuberculosis Secretory Protein ESAT-6 Induces Metabolic Flux Perturbations to Drive Foamy Macrophage Differentiation

(2015) Varshneya Singh et al.   Scientific Reports

Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria

(2015) Louis S. Ates et al.   PLoS Genetics

Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites

(2014) Albert Pol et al.   JOURNAL OF CELL BIOLOGY

Mycobacterium tuberculosis Keto-Mycolic Acid and Macrophage Nuclear Receptor TR4 Modulate Foamy Biogenesis in Granulomas: A Case of a Heterologous and Noncanonical Ligand-Receptor Pair

(2014) H. K. Dkhar et al.   JOURNAL OF IMMUNOLOGY

Platelets Direct Monocyte Differentiation Into Epithelioid-Like Multinucleated Giant Foam Cells With Suppressive Capacity Upon Mycobacterial Stimulation

(2014) Yonghong Feng et al.   JOURNAL OF INFECTIOUS DISEASES

Mycobacterium tuberculosis persistence in various adipose depots of infected mice and the effect of anti-tubercular therapy

(2014) Pooja Agarwal et al.   MICROBES AND INFECTION

Genomic insights into tuberculosis

(2014) James E. Galagan   NATURE REVIEWS GENETICS

An Acyl-CoA Synthetase in Mycobacterium tuberculosis Involved in Triacylglycerol Accumulation during Dormancy

(2014) Jaiyanth Daniel et al.   PLoS One

Phosphorylation of KasB Regulates Virulence and Acid-Fastness in Mycobacterium tuberculosis

(2014) Catherine Vilchèze et al.   PLoS Pathogens

Dictyostelium Lipid Droplets Host Novel Proteins

(2013) Xiaoli Du et al.   EUKARYOTIC CELL

Reversible Lipid Accumulation and Associated Division Arrest of Mycobacterium avium in Lipoprotein-Induced Foamy Macrophages May Resemble Key Events during Latency and Reactivation of Tuberculosis

(2013) Irène Caire-Brändli et al.   INFECTION AND IMMUNITY

IntracellularMycobacterium tuberculosisExploits Host-derived Fatty Acids to Limit Metabolic Stress

(2013) Wonsik Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains

(2013) Adam Kassan et al.   JOURNAL OF CELL BIOLOGY

Wnt6 Is Expressed in Granulomatous Lesions of Mycobacterium tuberculosis-Infected Mice and Is Involved in Macrophage Differentiation and Proliferation

(2013) K. Schaale et al.   JOURNAL OF IMMUNOLOGY

Human Granuloma In Vitro Model, for TB Dormancy and Resuscitation

(2013) Nidhi Kapoor et al.   PLoS One

Modeling the Mycobacterium tuberculosis Granuloma – the Critical Battlefield in Host Immunity and Disease

(2013) Evelyn Guirado et al.   Frontiers in Immunology

Evaluation of a Mouse Model of Necrotic Granuloma Formation Using C3HeB/FeJ Mice for Testing of Drugs against Mycobacterium tuberculosis

(2012) Emily R. Driver et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mycobacterial lipolytic enzymes: A gold mine for tuberculosis research

(2012) L. Dedieu et al.   BIOCHIMIE

Mycobacterium tuberculosis-Driven Targeted Recalibration of Macrophage Lipid Homeostasis Promotes the Foamy Phenotype

(2012) Varshneya Singh et al.   Cell Host & Microbe

Infection of macrophages withMycobacterium tuberculosisinduces global modifications to phagosomal function

(2012) Maria Podinovskaia et al.   CELLULAR MICROBIOLOGY

Controlling the size of lipid droplets: lipid and protein factors

(2012) Hongyuan Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Mycobacterium tuberculosis Modulates Macrophage Lipid-Sensing Nuclear Receptors PPAR  and TR4 for Survival

(2012) S. Mahajan et al.   JOURNAL OF IMMUNOLOGY

MmPPOX Inhibits Mycobacterium tuberculosis Lipolytic Enzymes Belonging to the Hormone-Sensitive Lipase Family and Alters Mycobacterial Growth

(2012) Vincent Delorme et al.   PLoS One

Emerging Roles for Lipid Droplets in Immunity and Host-Pathogen Interactions

(2011) Hector Alex Saka et al.   Annual Review of Cell and Developmental Biology

Watching intracellular lipolysis in mycobacteria using time lapse fluorescence microscopy

(2011) Rabeb Dhouib et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Redox homeostasis in mycobacteria: the key to tuberculosis control?

(2011) Ashwani Kumar et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Latent tuberculosis: what the host “sees”?

(2011) Hannah P. Gideon et al.   IMMUNOLOGIC RESEARCH

DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes

(2011) Charles A. Harris et al.   JOURNAL OF LIPID RESEARCH

Differential immune response of adipocytes to virulent and attenuated Mycobacterium tuberculosis

(2011) Jong-Seok Kim et al.   MICROBES AND INFECTION

Metabolic Regulation of Mycobacterial Growth and Antibiotic Sensitivity

(2011) Seung-Hun Baek et al.   PLOS BIOLOGY

Mycobacterium tuberculosis Uses Host Triacylglycerol to Accumulate Lipid Droplets and Acquires a Dormancy-Like Phenotype in Lipid-Loaded Macrophages

(2011) Jaiyanth Daniel et al.   PLoS Pathogens

Evidence for the cytotoxic effects of Mycobacterium tuberculosis phospholipase C towards macrophages

(2010) J.C. Bakala N'Goma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: a putative mechanism for host lipid acquisition and bacterial survival in phagosomes

(2010) Katherine A. Mattos et al.   CELLULAR MICROBIOLOGY

Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism

(2010) Mi-Jeong Kim et al.   EMBO Molecular Medicine

Two cutinase-like proteins secreted by Mycobacterium tuberculosis show very different lipolytic activities reflecting their physiological function

(2010) Mathieu Schué et al.   FASEB JOURNAL

A Monoacylglycerol Lipase from Mycobacterium smegmatis Involved in Bacterial Cell Interaction

(2010) R. Dhouib et al.   JOURNAL OF BACTERIOLOGY

Lipid Droplet-associated Proteins Are Involved in the Biosynthesis and Hydrolysis of Triacylglycerol inMycobacterium bovisBacillus Calmette-Guérin

(2010) Kai Leng Low et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

(2010) Jan F. C. Glatz et al.   PHYSIOLOGICAL REVIEWS

Dominant Role of the sst1 Locus in Pathogenesis of Necrotizing Lung Granulomas during Chronic Tuberculosis Infection and Reactivation in Genetically Resistant Hosts

(2009) Alexander V. Pichugin et al.   AMERICAN JOURNAL OF PATHOLOGY

Triacylglycerol Utilization Is Required for Regrowth of In Vitro Hypoxic Nonreplicating Mycobacterium bovis Bacillus Calmette-Guerin

(2009) K. L. Low et al.   JOURNAL OF BACTERIOLOGY

Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis

(2009) K. A. Mattos et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Foamy macrophages and the progression of the human tuberculosis granuloma

(2009) David G Russell et al.   NATURE IMMUNOLOGY

Biogenesis of cytoplasmic lipid droplets: From the lipid ester globule in the membrane to the visible structure

(2008) Yuki Ohsaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

(2008) L. E. Via et al.   INFECTION AND IMMUNITY

Evolution of foamy macrophages in the pulmonary granulomas of experimental tuberculosis models

(2008) Neus Cáceres et al.   TUBERCULOSIS

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

(2008) Pascale Peyron et al.   PLoS Pathogens