Streptococcus pneumoniae Endopeptidase O (PepO) Elicits a Strong Innate Immune Response in Mice via TLR2 and TLR4 Signaling Pathways

The Role of Innate Immunity Receptors in the Pathogenesis of Inflammatory Bowel Disease

(2015) Paula Peruzzi Elia et al.   MEDIATORS OF INFLAMMATION

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Experimental design approach in recombinant protein expression: determining medium composition and induction conditions for expression of pneumolysin from Streptococcus pneumoniae in Escherichia coli and preliminary purification process

(2014) Guillermo Marini et al.   BMC BIOTECHNOLOGY

How the Innate Immune System Senses Trouble and Causes Trouble

(2014) T. Hato et al.   Clinical Journal of the American Society of Nephrology

GHIP inStreptococcus pneumoniaeis involved in antibacterial resistance and elicits a strong innate immune response through TLR2 and JNK/p38MAPK

(2014) Jie Dong et al.   FEBS Journal

TLR5-Mediated Sensing of Gut Microbiota Is Necessary for Antibody Responses to Seasonal Influenza Vaccination

(2014) Jason Z. Oh et al.   IMMUNITY

Directing traffic: IL-17 and IL-22 coordinate pulmonary immune defense

(2014) Jeremy P. McAleer et al.   IMMUNOLOGICAL REVIEWS

Mucosal Immunization with Recombinant Fusion Protein DnaJ-ΔA146Ply Enhances Cross-Protective Immunity against Streptococcus pneumoniae Infection in Mice via Interleukin 17A

(2014) Yusi Liu et al.   INFECTION AND IMMUNITY

Binding ofStreptococcus pneumoniaeEndopeptidase O (PepO) to Complement Component C1q Modulates the Complement Attack and Promotes Host Cell Adherence

(2014) Vaibhav Agarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophils Counteract Autophagy-Mediated Anti-Inflammatory Mechanisms in Alveolar Macrophage: Role in Posthemorrhagic Shock Acute Lung Inflammation

(2014) Zongmei Wen et al.   JOURNAL OF IMMUNOLOGY

Type I interferon signaling contributes to the bias that Toll-like receptor 4 exhibits for signaling mediated by the adaptor protein TRIF

(2014) J. P. Kolb et al.   Science Signaling

Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation

(2014) M. A. Bewley et al.   mBio

Streptococcus pneumoniaeEndopeptidase O (PepO) Is a Multifunctional Plasminogen- and Fibronectin-binding Protein, Facilitating Evasion of Innate Immunity and Invasion of Host Cells

(2013) Vaibhav Agarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of a whole cell pneumococcal vaccine: BPL inactivation, cGMP production, and stability

(2013) Viviane M. Gonçalves et al.   VACCINE

Mycobacterium paratuberculosisCobT Activates Dendritic Cells via Engagement of Toll-like Receptor 4 Resulting in Th1 Cell Expansion

(2012) Eui-Hong Byun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like Receptor (TLR) 2 Mediates Inflammatory Responses to Oligomerized RrgA Pneumococcal Pilus Type 1 Protein

(2012) Alan Basset et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

(2012) Ezra Aksoy et al.   NATURE IMMUNOLOGY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Novel mucosal vaccines generated by genetic conjugation of heterologous proteins to pneumolysin (PLY) from Streptococcus pneumoniae

(2010) Gill Douce et al.   VACCINE

Mal connects TLR2 to PI3Kinase activation and phagocyte polarization

(2009) S Santos-Sierra et al.   EMBO JOURNAL

Pneumococcal Interaction with Human Dendritic Cells: Phagocytosis, Survival, and Induced Adaptive Immune Response Are Manipulated by PavA

(2009) N. Noske et al.   JOURNAL OF IMMUNOLOGY

Pathogenesis, treatment, and prevention of pneumococcal pneumonia

(2009) Tom van der Poll et al.   LANCET

Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates

(2009) Katherine L O'Brien et al.   LANCET

Pulsatile Stimulation Determines Timing and Specificity of NF- B-Dependent Transcription

(2009) L. Ashall et al.   SCIENCE

Molecular mechanisms of phagocytic uptake in mammalian cells

(2008) E. Groves et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Critical Involvement of Pneumolysin in Production of Interleukin-1  and Caspase-1-Dependent Cytokines in Infection with Streptococcus pneumoniae In Vitro: a Novel Function of Pneumolysin in Caspase-1 Activation

(2008) S. Shoma et al.   INFECTION AND IMMUNITY

Inhibition of pulmonary antibacterial defense by interferon-γ during recovery from influenza infection

(2008) Keer Sun et al.   NATURE MEDICINE

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease

(2008) Aras Kadioglu et al.   NATURE REVIEWS MICROBIOLOGY