GHIP inStreptococcus pneumoniaeis involved in antibacterial resistance and elicits a strong innate immune response through TLR2 and JNK/p38MAPK

Experimental design approach in recombinant protein expression: determining medium composition and induction conditions for expression of pneumolysin from Streptococcus pneumoniae in Escherichia coli and preliminary purification process

(2014) Guillermo Marini et al.   BMC BIOTECHNOLOGY

Mucosal Immunization with Recombinant Fusion Protein DnaJ-ΔA146Ply Enhances Cross-Protective Immunity against Streptococcus pneumoniae Infection in Mice via Interleukin 17A

(2014) Yusi Liu et al.   INFECTION AND IMMUNITY

Neutrophil-Toxin Interactions Promote Antigen Delivery and Mucosal Clearance of Streptococcus pneumoniae

(2014) Kathryn A. Matthias et al.   JOURNAL OF IMMUNOLOGY

Structural Basis of the Novel S. pneumoniae Virulence Factor, GHIP, a Glycosyl Hydrolase 25 Participating in Host-Cell Invasion

(2013) Siqiang Niu et al.   PLoS One

Development of a whole cell pneumococcal vaccine: BPL inactivation, cGMP production, and stability

(2013) Viviane M. Gonçalves et al.   VACCINE

The function of TLR2 during staphylococcal diseases

(2013) Bénédicte Fournier   Frontiers in Cellular and Infection Microbiology

Daily Exposure to Dust Alters Innate Immunity

(2012) Karin Sahlander et al.   PLoS One

Safety and immunogenicity of a pneumococcal histidine triad protein D vaccine candidate in adults

(2012) Michael Seiberling et al.   VACCINE

The Role of TLR2 in Infection and Immunity

(2012) Laura Oliveira-Nascimento et al.   Frontiers in Immunology

Green tea polyphenol epigallocatechin-3-gallate inhibits TLR2 signaling induced by peptidoglycan through the polyphenol sensing molecule 67-kDa laminin receptor

(2011) Eui-Hong Byun et al.   FEBS LETTERS

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

The NLRP3 Inflammasome Is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia

(2011) M. Witzenrath et al.   JOURNAL OF IMMUNOLOGY

The Integrins Mac-1 and  4 1 Perform Crucial Roles in Neutrophil and T Cell Recruitment to Lungs during Streptococcus pneumoniae Infection

(2011) A. Kadioglu et al.   JOURNAL OF IMMUNOLOGY

Purification, crystallization and preliminary X-ray studies of the putative lysozyme SP0987 fromStreptococcus pneumoniae

(2010) Siqiang Niu et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Pneumolysin-induced CXCL8 production by nasopharyngeal epithelial cells is dependent on calcium flux and MAPK activation via Toll-like receptor 4

(2010) Semih Dogan et al.   MICROBES AND INFECTION

Streptococcus pneumoniae Autolysis Prevents Phagocytosis and Production of Phagocyte-Activating Cytokines

(2009) A. Martner et al.   INFECTION AND IMMUNITY

Immunization with a Combination of Three Pneumococcal Proteins Confers Additive and Broad Protection against Streptococcus pneumoniae Infections in Mice

(2009) K. Wu et al.   INFECTION AND IMMUNITY

Interleukin-6 is essential for zwitterionic polysaccharide-mediated abscess formation

(2009) Sonja Meemboor et al.   Innate Immunity

Characterization of N-terminal Structure of TLR2-activating Lipoprotein inStaphylococcus aureus

(2009) Kazuki Tawaratsumida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM-1 Activation Alters the Dynamics of Pulmonary IRAK-M Expression In Vivo and Improves Host Defense during Pneumococcal Pneumonia

(2009) H. Lagler et al.   JOURNAL OF IMMUNOLOGY

Pneumococcal Interaction with Human Dendritic Cells: Phagocytosis, Survival, and Induced Adaptive Immune Response Are Manipulated by PavA

(2009) N. Noske et al.   JOURNAL OF IMMUNOLOGY

Human Neutrophils Kill Streptococcus pneumoniae via Serine Proteases

(2009) A. J. Standish et al.   JOURNAL OF IMMUNOLOGY

EstA protein, a novel virulence factor of Streptococcus pneumoniae, induces nitric oxide and pro-inflammatory cytokine production in RAW 264.7 macrophages through NF-κB/MAPK

(2009) Eun Hee Kang et al.   MICROBIAL PATHOGENESIS

Cellular localization of choline-utilization proteins inStreptococcus pneumoniaeusing novel fluorescent reporter systems

(2009) Alice Eberhardt et al.   MOLECULAR MICROBIOLOGY

Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis

(2009) J. C. Alves-Filho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical Involvement of Pneumolysin in Production of Interleukin-1  and Caspase-1-Dependent Cytokines in Infection with Streptococcus pneumoniae In Vitro: a Novel Function of Pneumolysin in Caspase-1 Activation

(2008) S. Shoma et al.   INFECTION AND IMMUNITY

Induction of CC and CXC Chemokines in Human Antigen‐Presenting Dendritic Cells by the Pneumococcal Proteins Pneumolysin and CbpA, and the Role Played by Toll‐Like Receptor 4, NF‐κB, and Mitogen‐Activated Protein Kinases

(2008) Jolanta Bernatoniene et al.   JOURNAL OF INFECTIOUS DISEASES

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease

(2008) Aras Kadioglu et al.   NATURE REVIEWS MICROBIOLOGY

H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

(2008) Lucy A. Perrone et al.   PLoS Pathogens

Emergence of Invasive Pneumococcal Disease Caused by Nonvaccine Serotypes in the Era of 7-Valent Conjugate Vaccine

(2007) C. Munoz-Almagro et al.   CLINICAL INFECTIOUS DISEASES