Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies

Cajal bodies are linked to genome conformation

(2016) Qiuyan Wang et al.   Nature Communications

Human telomerase: biogenesis, trafficking, recruitment, and activation

(2015) Jens C. Schmidt et al.   GENES & DEVELOPMENT

Dynamics of Human Telomerase Holoenzyme Assembly and Subunit Exchange across the Cell Cycle

(2015) Jacob M. Vogan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis of telomere dysfunction in human genetic diseases

(2015) Grzegorz Sarek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Coilin: The first 25 years

(2015) Martin Machyna et al.   RNA Biology

Molecular basis of telomere dysfunction in human genetic diseases

(2015) Grzegorz Sarek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cancer-associated TERT promoter mutations abrogate telomerase silencing

(2015) Kunitoshi Chiba et al.   eLife

Single-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexes

(2015) Robert Alexander Wu et al.   eLife

On the road with WRAP53β: guardian of Cajal bodies and genome integrity

(2015) Sofia Henriksson et al.   Frontiers in Genetics

Human telomerase specialization for repeat synthesis by unique handling of primer-template duplex

(2014) R. A. Wu et al.   EMBO JOURNAL

Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

(2014) Alec N. Sexton et al.   GENES & DEVELOPMENT

Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix

(2014) Jessica A Brown et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human cells lacking coilin and Cajal bodies are proficient in telomerase assembly, trafficking and telomere maintenance

(2014) Yanlian Chen et al.   NUCLEIC ACIDS RESEARCH

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends

(2012) Franklin L. Zhong et al.   CELL

An Enhanced H/ACA RNP Assembly Mechanism for Human Telomerase RNA

(2012) E. D. Egan et al.   MOLECULAR AND CELLULAR BIOLOGY

Telomerase Recruitment Requires both TCAB1 and Cajal Bodies Independently

(2012) J. L. Stern et al.   MOLECULAR AND CELLULAR BIOLOGY

The telomere syndromes

(2012) Mary Armanios et al.   NATURE REVIEWS GENETICS

Formation of triple-helical structures by the 3'-end sequences of MALAT1 and MEN  noncoding RNAs

(2012) J. A. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biogenesis of telomerase ribonucleoproteins

(2012) E. D. Egan et al.   RNA

Cajal bodies: where form meets function

(2012) Martin Machyna et al.   Wiley Interdisciplinary Reviews-RNA

Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita

(2011) F. Zhong et al.   GENES & DEVELOPMENT

Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells

(2011) Luis F. Z. Batista et al.   NATURE

Architecture of human telomerase RNA

(2011) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biogenesis and function of nuclear bodies

(2011) Yuntao S. Mao et al.   TRENDS IN GENETICS

A Cajal body-independent pathway for telomerase trafficking in mice

(2010) Rebecca L. Tomlinson et al.   EXPERIMENTAL CELL RESEARCH

The 5' Guanosine Tracts of Human Telomerase RNA Are Recognized by the G-Quadruplex Binding Domain of the RNA Helicase DHX36 and Function To Increase RNA Accumulation

(2010) A. N. Sexton et al.   MOLECULAR AND CELLULAR BIOLOGY

Box H/ACA Small Ribonucleoproteins

(2010) Tamás Kiss et al.   MOLECULAR CELL

The Cajal Body and Histone Locus Body

(2010) Z. Nizami et al.   Cold Spring Harbor Perspectives in Biology

Telomerase: An RNP Enzyme Synthesizes DNA

(2010) E. H. Blackburn et al.   Cold Spring Harbor Perspectives in Biology

WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies

(2010) Salah Mahmoudi et al.   PLOS BIOLOGY

A Conserved WD40 Protein Binds the Cajal Body Localization Signal of scaRNP Particles

(2009) Kazimierz T. Tycowski et al.   MOLECULAR CELL

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

(2009) Dirk Hockemeyer et al.   NATURE BIOTECHNOLOGY

A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis

(2009) A. S. Venteicher et al.   SCIENCE