Review
Biochemistry & Molecular Biology
Senxiang Chen, Da Liu, Zimo Zhou, Sen Qin
Summary: Research on the targeting of lncRNA H19 in the treatment of osteoporosis shows promising prospects due to its effects on osteogenic differentiation processes. This review summarizes the molecular pathways and mechanisms of lncRNA H19 in the pathogenesis of osteoporosis and the progress of research on targeting H19 as a treatment option, indicating emerging possibilities for more effective treatments for bone metabolism diseases with molecular targets.
MOLECULAR MEDICINE
(2021)
Review
Cell & Tissue Engineering
Zimo Zhou, Mohammad Showkat Hossain, Da Liu
Summary: The long noncoding RNA H19 plays a vital role in osteogenic differentiation and is recognized as a novel target for promoting bone regeneration.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Jingting Wang, Xiao Ma, Hai Si, Zhongjun Ma, Yan Ma, Jing Wang, Bangwei Cao
Summary: The resistance to therapy in digestive system cancers is closely associated with Long non-coding RNA (LncRNA) H19, which regulates the abnormal expression of genes and plays a key role in the development and treatment resistance of various digestive system cancers. Identifying and targeting LncRNA H19 could be a potential novel therapeutic approach to improve cancer therapy resistance.
MOLECULAR MEDICINE
(2021)
Review
Cell Biology
Lingfeng Li, Xu Zhang, Nian Liu, Xiang Chen, Cong Peng
Summary: LINC00473, an oncogenic lncRNA, is upregulated in various human malignancies and associated with poor clinical outcomes. Its overexpression can promote cell proliferation, migration, and invasion, suggesting it as a potential prognostic biomarker and therapeutic target for human cancers.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ba Da Yun, Ye Ji Choi, Seung Wan Son, Gabriel Adelman Cipolla, Fernanda Costa Brandao Berti, Danielle Malheiros, Tae-Jin Oh, Hyo Jeong Kuh, Soo Young Choi, Jong Kook Park
Summary: Circular RNAs and long noncoding RNAs are differentially expressed in gastrointestinal cancers. They regulate cellular activities by interacting with microRNAs and proteins, and are transported in exosomes to facilitate cell-cell communication within the cancer microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Livia Fratini, Mariane Jaeger, Caroline Brunetto de Farias, Andre T. Brunetto, Algemir L. Brunetto, Lisa Shaw, Rafael Roesler
Summary: The transcription factor ZEB1 plays a critical role in cell function and embryonic development, with its activities regulated by interactions with miRNAs and lncRNAs. While the exact role of ZEB1 in pediatric cancer is still unclear, emerging evidence suggests its involvement in regulating solid tumors in children.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Seung Wan Son, Ba Da Yun, Mun Gyu Song, Jin Kyeong Lee, Soo Young Choi, Hyo Jeong Kuh, Jong Kook Park
Summary: Hypoxia, regulated by HIFs, influences cancer hallmarks and therapeutic resistance, with dysregulated lncRNAs being considered as potential candidates for cancer control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jue Wang, Bin Cao, Yan Gao, Yu-Hua Chen, Juan Feng
Summary: In this study, the researchers investigated the role of lncRNA H19 in insulin-like growth factor-1 regulation in ischemic stroke. They found that plasma exosomal lncRNA H19 was negatively associated with blood levels of insulin-like growth factor-1 in patients with cerebral ischemic stroke. Furthermore, they discovered that lncRNA H19 could be transported from neurons to astrocytes via exosomes and induce downregulation of insulin-like growth factor-1 through the H19/let-7a/insulin-like growth factor-1 receptor axis.
NEURAL REGENERATION RESEARCH
(2023)
Review
Pathology
Jin He, Zhuo Wang, Yongfeng Wang, Fangyu Liu, Liangyin Fu, Xianglai Jiang, Pingan Wang, Huan Chen, Ming Hu, Hui Cai
Summary: This study found that the aberrant expression of LINC00963 is associated with clinical prognosis and immune infiltration in various cancers. It also discovered correlations between LINC00963 expression and MSI, TMB, DNMTs, immune checkpoint biomarkers, and MMR in malignancies. LINC00963 may serve as a prognostic biomarker and a therapeutic target for cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Archittapon Nokkeaw, Pannathon Thamjamrassri, Naphat Chantaravisoot, Pisit Tangkijvanich, Chaiyaboot Ariyachet
Summary: The long non-coding RNA H19 plays a significant role in hepatocellular carcinoma (HCC), promoting cell growth and cell cycle progression by acting as a molecular sponge for miR-107 to upregulate CDK6 expression.
Review
Biotechnology & Applied Microbiology
Xinzhi Miao, Fang Wang, Tianyun Wang, Siti Razila Abdul Razak, Muhammad Amir Yunus, Ida Shazrina Ismail
Summary: Long noncoding RNAs play important roles in cellular processes and are implicated in cancers with different expressions. As competitive endogenous RNA, they interact with microRNA to affect the expression of target genes.
Article
Endocrinology & Metabolism
Pijun Yu, Jian Guo, Junjie Li, Xiao Shi, Ning Xu, Yongkang Jiang, Wei Chen, Qin Hu
Summary: In this study, it was found that PDGFR alpha(+) fibroblast-expressing lncRNA-H19 plays an important role in promoting wound healing. This lncRNA accelerates wound healing by promoting dermal fibroblast proliferation and macrophage infiltration, and it does so by inhibiting p53 activity and GDF15 releasement.
Article
Genetics & Heredity
Yongfeng Wang, Xianglai Jiang, Dongzhi Zhang, Yuanbin Zhao, Xiaoyong Han, Lihui Zhu, Jingyao Ren, Yubin Liu, Jiarong You, Haolan Wang, Hui Cai
Summary: The overexpression of DUXAP8 is associated with poor overall survival in malignant cancers and is linked to tumor mutational burden, microsatellite instability, and mismatch repair-related genes, suggesting it may serve as a prognostic biomarker and therapeutic target.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Wei Liu, Qin-Peng Wang, Jia Guo
Summary: This meta-analysis evaluated the prognostic value of lncRNA DANCR expression in cancer and found that high lncRNA DANCR expression was significantly associated with shorter overall survival and disease-free survival in cancer patients, as well as predicting more aggressive clinical features.
BIOSCIENCE REPORTS
(2021)
Review
Pharmacology & Pharmacy
Leiqi Zhu, Yuanyang Li, Fangqi Xia, Mengzhen Xue, Yaqi Wang, Dengke Jia, Yan Gao, Luoying Li, Yue Shi, Silong Chen, Guangfu Xu, Chengfu Yuan
Summary: This review explores the functions and mechanisms of long noncoding RNA H19 in diabetes mellitus and diabetic complications and highlights its potential as an instructive marker for the treatment of diabetes mellitus.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Cell & Tissue Engineering
Xiaohu Meng, Min Chen, Wenjie Su, Xuan Tao, Mingyang Sun, Xiaoping Zou, Rongchao Ying, Wei Wei, Baolin Wang
STEM CELL RESEARCH & THERAPY
(2018)
Article
Cell & Tissue Engineering
Xuan Tao, Mingyang Sun, Min Chen, Rongchao Ying, Wenjie Su, Jian Zhang, Xiaodong Xie, Wei Wei, Xiaohu Meng
STEM CELL RESEARCH & THERAPY
(2019)
