Metalloproteases Affecting Blood Coagulation, Fibrinolysis and Platelet Aggregation from Snake Venoms: Definition and Nomenclature of Interaction Sites

A novel fibrinolytic metalloproteinase, barnettlysin-I from Bothrops barnetti (barnett´s pitviper) snake venom with anti-platelet properties

(2016) Eladio Flores Sanchez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells

(2015) João Alfredo Moraes et al.   ATHEROSCLEROSIS

Biochemical characterization of a factor X activator protein purified from Walterinnesia aegyptia venom

(2015) Sami U. Khan et al.   BLOOD COAGULATION & FIBRINOLYSIS

Disintegrins from Snake Venoms and their Applications in Cancer Research and Therapy

(2015) Jessica Arruda Macedo et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Design of Highly Potent Urea-Based, Exosite-Binding Inhibitors Selective for Glutamate Carboxypeptidase II

(2015) Jan Tykvart et al.   JOURNAL OF MEDICINAL CHEMISTRY

New strategies for targeting matrix metalloproteinases

(2015) Gregg B. Fields   MATRIX BIOLOGY

Hematologic Effects and Complications of Snake Envenoming

(2015) Ingrid Berling et al.   TRANSFUSION MEDICINE REVIEWS

Probing BoNT/A Protease Exosites: Implications for Inhibitor Design and Light Chain Longevity

(2014) Song Xue et al.   BIOCHEMISTRY

Non-covalent and covalent modifications modulate the reactivity of monomeric mammalian globins

(2013) Paolo Ascenzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Applications of snake venom components to modulate integrin activities in cell–matrix interactions

(2013) Cezary Marcinkiewicz   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Unraveling Hidden Regulatory Sites in Structurally Homologous Metalloproteases

(2013) Yael Udi et al.   JOURNAL OF MOLECULAR BIOLOGY

Snake bites and hemostasis/thrombosis

(2013) Ryan J.R. McCleary et al.   THROMBOSIS RESEARCH

Crystal structure of a Trimeresurus mucrosquamatus venom metalloproteinase providing new insights into the inhibition by endogenous tripeptide inhibitors

(2013) Tsung-Lin Chou et al.   TOXICON

Hirudin and S18886 Maintain Luminal Patency After Thrombolysis With Alfimeprase

(2012) Jullia Y. Lee et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The long road of research on snake venom serine proteinases

(2012) Solange M.T. Serrano   TOXICON

The continuing saga of snake venom disintegrins

(2012) Juan J. Calvete   TOXICON

Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) Nonresponsiveness is not shared by platelet-derived growth factor: The selective role of integrins in IGF-1 signaling

(2011) Roger K Long et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Toxins in thrombosis and haemostasis: potential beyond imagination

(2011) R. M. KINI   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Non-RGD-containing snake venom disintegrins, functional and structural relations

(2011) Erin M. Walsh et al.   TOXICON

The metalloprotease, NN-PF3 from Naja naja venom inhibits platelet aggregation primarily by affecting α2β1 integrin

(2010) M. S. Kumar et al.   ANNALS OF HEMATOLOGY

Allostery in a monomeric protein: The case of human serum albumin

(2010) Paolo Ascenzi et al.   BIOPHYSICAL CHEMISTRY

Ligand binding assays at equilibrium: validation and interpretation

(2010) Edward C. Hulme et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nerve Growth Factor Inhibits Metalloproteinase-Disintegrins and Blocks Ectodomain Shedding of Platelet Glycoprotein VI

(2010) Lakshmi C. Wijeyewickrema et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High resolution analysis of snake venom metalloproteinase (SVMP) peptide bond cleavage specificity using proteome based peptide libraries and mass spectrometry

(2010) Adriana F. Paes Leme et al.   Journal of Proteomics

Vicrostatin – An Anti-Invasive Multi-Integrin Targeting Chimeric Disintegrin with Tumor Anti-Angiogenic and Pro-Apoptotic Activities

(2010) Radu O. Minea et al.   PLoS One

Different regions of the class P-III snake venom metalloproteinase jararhagin are involved in binding to α2β1 integrin and collagen

(2010) Isabelle Tanjoni et al.   TOXICON

Snake Venom Disintegrins and Cell Migration

(2010) Heloisa S. Selistre-de-Araujo et al.   Toxins

Fibrolase: Trials and Tribulations

(2010) Francis S. Markland et al.   Toxins

Structural basis of the autolysis of AaHIV suggests a novel target recognizing model for ADAM/reprolysin family proteins

(2009) Zhiqiang Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High-Resolution Crystal Structure of the Snake Venom Metalloproteinase BaP1 Complexed with a Peptidomimetic: Insight into Inhibitor Binding

(2009) Torsten Lingott et al.   BIOCHEMISTRY

VGD and MLD-motifs containing heterodimeric disintegrin viplebedin-2 from Vipera lebetina snake venom

(2009) Heiki Vija et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Integrins Contribute to Initial Morphological Development and Process Outgrowth in Rat Adult Hippocampal Progenitor Cells

(2009) Matthew M. Harper et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Determination of the Structure Form of the Fourth Ligand of Zinc in Acutolysin A Using Combined Quantum Mechanical and Molecular Mechanical Simulation

(2009) Emilia L. Wu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structures of two elapid snake venom metalloproteases with distinct activities highlight the disulfide patterns in the D domain of ADAMalysin family proteins

(2009) Hong-Hsiang Guan et al.   JOURNAL OF STRUCTURAL BIOLOGY

Leberagin-C, A disintegrin-like/cysteine-rich protein from Macrovipera lebetina transmediterranea venom, inhibits alphavbeta3 integrin-mediated cell adhesion

(2009) Inès Limam et al.   MATRIX BIOLOGY

Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms

(2009) Chung-Jung Tsai et al.   Molecular BioSystems

Structural studies of BmooMPα-I, a non-hemorrhagic metalloproteinase from Bothrops moojeni venom

(2009) P.K. Akao et al.   TOXICON

Structural requirements of KTS-disintegrins for inhibition of α1β1integrin

(2008) Meghan C. Brown et al.   BIOCHEMICAL JOURNAL

Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity

(2008) Jay W. Fox et al.   FEBS Journal

Disintegrins in health and disease

(2008) Mary Ann McLane   Frontiers in Bioscience-Landmark

Competitive Interactions of Collagen and a Jararhagin-derived Disintegrin Peptide with the Integrin α2-I Domain

(2008) Lester J. Lambert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming Growth Factor β1 Induces αvβ3 Integrin Expression in Human Lung Fibroblasts via a β3 Integrin-, c-Src-, and p38 MAPK-dependent Pathway

(2008) Dmitri V. Pechkovsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A snake venom metalloproteinase, kistomin, cleaves platelet glycoprotein VI and impairs platelet functions

(2008) C. C. Hsu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The three-dimensional structure of bothropasin, the main hemorrhagic factor from Bothrops jararaca venom: Insights for a new classification of snake venom metalloprotease subgroups

(2008) João R.C. Muniz et al.   TOXICON

Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities

(2003) Leandra Watanabe et al.   PROTEIN SCIENCE