Review
Biochemistry & Molecular Biology
Tatiane Senna Bialves, Claudio L. Q. Bastos, Marcos Freitas Cordeiro, Robert Tew Boyle
Summary: Despite advances in melanoma treatment, there are still challenges. Snake venom proteins/peptides show potential for binding and inhibiting melanoma cell proliferation. Combining these compounds with current therapies could lead to more effective treatments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biotechnology & Applied Microbiology
Lijun Zhong, Lin Tang, Xiaoxia He
Summary: It has been discovered that ANGPTL3 plays an oncogenic role in several types of human malignancies. This study found that ANGPTL3 is highly expressed in cervical cancer cells and silencing ANGPTL3 can inhibit cell proliferation, migration, invasion, and angiogenesis. The inhibitory effect of ANGPTL3 can be offset by upregulating the expression of alpha v beta 3, which also promotes blood vessel formation and the secretion of VEGF and VEGFR2 in cervical cancer cells.
Article
Oncology
Anna Galicka, Lukasz Szoka, Iwona Radziejewska, Cezary Marcinkiewicz
Summary: The study evaluated the effect of the disintegrin VLO4 on glioblastoma cells. VLO4 showed pro-adhesive properties and inhibition of cell migration. It also had different cytotoxicity and pro-apoptotic effects on different cell lines.
Article
Biochemistry & Molecular Biology
Maram Morjen, Ons Zakraoui, Zaineb Abdelkafi-Koubaa, Najet Srairi-Abid, Naziha Marrakchi, Khadija Essafi-Benkhadir, Jed Jebali
Summary: Inflammation is closely related to various diseases, including cancer. This study investigated the anti-inflammatory effect of two disintegrin isoforms (CC5 and CC8) from snake venom on LPS-stimulated macrophages. The results showed that CC5 and CC8 reduced the adherence of macrophages to fibrinogen and vitronectin, decreased the levels of pro-inflammatory cytokines, and increased the secretion of an anti-inflammatory cytokine. In addition, both molecules exhibited an anti-inflammatory effect in a rat model. These findings suggest that CC5 and CC8 could be potential candidates for treating inflammatory-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bruna C. Casali, Larissa T. Gozzer, Matheus P. Baptista, Wanessa F. Altei, Heloisa S. Selistre-de-Araujo
Summary: Breast cancer in a hypoxic microenvironment is associated with cell metastatic behavior. Blocking the ocv beta 3 integrin with DisBa-01 may affect cell migration, but the impact varies with different assays and oxygen levels. These findings add complexity to the role of the ocv beta 3 integrin in tumor progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ewa Brzozowska, Sameer Deshmukh
Summary: Integrins are crucial for cell adhesion, migration, and positioning. Studies have shown that the expression levels of Integrin αVβ6 are closely related to malignant diseases and patient prognosis. It plays a significant role in cancer progression and the activation of transforming growth factor β(TGF-β). While essential for normal function in healthy individuals, it can also be a target for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Shelby S. Szteiter, Ilse N. Diego, Jonathan Ortegon, Eliana M. Salinas, Abcde Cirilo, Armando Reyes, Oscar Sanchez, Montamas Suntravat, Emelyn Salazar, Elda E. Sanchez, Jacob A. Galan
Summary: Snake envenomation can cause severe systemic effects, but the use of commercial antivenom may have limitations. This study explored the neutralization ability of anti-disintegrin polyclonal antibodies, showing potential in neutralizing disintegrins and SVMPs.
Article
Oncology
Guixi Zheng, Hakim Bouamar, Matyas Cserhati, Carla R. Zeballos, Isha Mehta, Habil Zare, Larry Broome, Ruolei Hu, Zhao Lai, Yidong Chen, Francis E. Sharkey, Meenakshi Rani, Glenn A. Halff, Francisco G. Cigarroa, Lu-Zhe Sun
Summary: The study found that ITGA6 is upregulated in HCC tumors and has a malignant promoting role in HCC cells through integrin alpha 6 beta 4 complex. Thus, integrin alpha 6 beta 4 may be a therapeutic target for treating HCC patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Jingyi Zhu, Wenjuan Li, Jian Jing
Summary: Tumor tissues exhibit unique integrin receptor presentation during development, which can be targeted for antitumor therapy. A novel fusion protein called Echistatin-Annexin V (EAV) was developed, which showed strong inhibitory effects on melanoma tumor cells and angiogenesis in mouse models. The unique biological effects of EAV are based on its high selectivity for specific integrin receptors and its ability to bind to phosphatidylserine molecules. EAV-mediated tumor suppression provides a possible mechanism for the treatment of melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Sophie Ayama-Canden, Rodolfo Tondo, Liliana Pineros, Noelle Ninane, Catherine Demazy, Marc Dieu, Antoine Fattaccioli, Tijani Tabarrant, Stephane Lucas, Davide Bonifazi, Carine Michiels
Summary: In the context of breast cancer metastasis study, the study investigated the regulation mechanism of cell migration and found that the IGDQ fibronectin motif activates integrin and influences cell migration. Integrins α5 and αv are related to cell migration, and they control cell migration by regulating the expression and function of ITGA5 and ITGB3.
Article
Multidisciplinary Sciences
Dan-yang Guo, Zhong-hua Chen, Yi-fei Fu, Yue-yue Li, Meng-nan Chen, Jun-jie Wu, Zheng-dong Yuan, Jun-Xing Ye, Xia Li, Feng-lai Yuan
Summary: By blocking the signaling pathway of integrin alpha(v)beta(3), cilengitide effectively inhibits the functionality and formation of osteoclasts, resulting in diminished adhesion and bone resorption. The expression of key signaling molecules associated with the osteoclast cytoskeleton are downregulated by cilengitide.
Article
Oncology
Marius Kemper, Alina Schiecke, Hanna Maar, Sergey Nikulin, Andrey Poloznikov, Vladimir Galatenko, Michael Tachezy, Florian Gebauer, Tobias Lange, Kristoffer Riecken, Alexander Tonevitsky, Achim Aigner, Jakob Izbicki, Udo Schumacher, Daniel Wicklein
Summary: The knockdown of ITGAV in PDA cells significantly reduces primary tumor growth, peritoneal carcinomatosis, and spontaneous pulmonary metastasis. ITGAV activates latent TGF-beta and drives epithelial-mesenchymal transition. Combined depletion of ITGAV on tumor cells and E- and P-selectins in the tumor-host almost abolishes intraperitoneal spread.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Mark Sutherland, Andrew Gordon, Fatemah O. F. O. Al-Shammari, Adam Throup, Amy Cilia La Corte, Helen Philippou, Steven D. Shnyder, Laurence H. Patterson, Helen M. Sheldrake
Summary: This study presents a new ligand-mimetic beta 3 integrin antagonist that exhibits high activity against alpha v beta 3 and moderate affinity for alpha IIb beta 3, suggesting a new approach to integrin targeting in cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Liang Zhao, Xuejun Wen, Weizhi Xu, Yizhen Pang, Long Sun, Xiaoming Wu, Pengfei Xu, Jingjing Zhang, Zhide Guo, Qin Lin, Xiaoyuan Chen, Haojun Chen
Summary: This study evaluated the radiolabeled FAPI-RGD heterodimer using Ga-68 for imaging in cancer patients. The results showed that Ga-68-FAPI-RGD had improved tumor uptake and tumor-to-background ratio compared to F-18-FDG and Ga-68-FAPI PET/CT. The study concluded that Ga-68-FAPI-RGD PET/CT is safe and clinically feasible for imaging various types of cancer.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Immunology
Yan Jiang, Qiming Gong, Jinmei Huang, Yuanxun Gong, Qiang Tang, Dalong Wei, Qianli Tang, Jingjie Zhao, Jian Song, Lingzhang Meng
Summary: This study reveals the regulatory role of ADAM-10 in LPS-induced inflammation in macrophages, showing that ADAM-10 positively regulates MMP-12 to participate in the inflammatory process.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Cell Biology
Rafael S. Amendola, Ana Carolina B. M. Martin, Heloisa S. Selistre-de-Araujo, Heitor A. Paula-Neto, Roberta Saldanha-Gama, Christina Barja-Fidalgo
JOURNAL OF LEUKOCYTE BIOLOGY
(2015)
Article
Oncology
Rachel Zoe Carter, Kelli Cristina Micocci, Anthony Natoli, Richard Paul Redvers, Sophie Paquet-Fifield, Ana Carolina Baptista Moreno Martin, Delphine Denoyer, Xiawei Ling, Soo-Hyun Kim, Rebeka Tomasin, Heloisa Selistre-de-Araujo, Robin Lesley Anderson, Normand Pouliot
JOURNAL OF PATHOLOGY
(2015)
Article
Cell Biology
Ana Carolina Baptista Moreno Martin, Ana Carolina Ferreira Cardoso, Heloisa Sobreiro Selistre-de-Araujo, Marcia Regina Cominetti
CELL ADHESION & MIGRATION
(2015)
Article
Oncology
Ana Carolina B. M. Martin, Angelina M. Fuzer, Amanda B. Becceneri, James Almada da Silva, Rebeka Tomasin, Delphine Denoyer, Soo-Hyun Kim, Katherine A. McIntyre, Helen B. Pearson, Belinda Yeo, Aadya Nagpal, Xiawei Ling, Heloisa S. Selistre-de-Araujo, Paulo Cezar Vieira, Marcia R. Cominetti, Normand Pouliot
Article
Cell Biology
Soo-Hyun Kim, Richard P. Redvers, Lap Hing Chi, Xiawei Ling, Andrew J. Lucke, Robert C. Reid, David P. Fairlie, Ana Carolina Baptista Moreno Martin, Robin L. Anderson, Delphine Denoyer, Normand Pouliot
DISEASE MODELS & MECHANISMS
(2018)
Article
Oncology
Angelina M. Fuzer, Ana C. B. M. Martin, Amanda B. Becceneri, James A. da Silva, Paulo C. Vieira, Marcia R. Cominetti
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2019)
Review
Geriatrics & Gerontology
Rebeka Tomasin, Ana Carolina Baptista Moreno Martin, Marcia Regina Cominetti
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2019)
Article
Oncology
Ana Carolina Baptista Moreno Martin, Rebeka Tomasin, Liany Luna-Dulcey, Angelica Elen Graminha, Marina Araujo Naves, Ramon Handerson Gomes Teles, Vinicius Duval da Silva, James Almada da Silva, Paulo Cezar Vieira, Borhane Annabi, Marcia Regina Cominetti
Article
Pharmacology & Pharmacy
Ideli Zanesco-Fontes, Ana Carolina Lopes Silva, Patricia Bento da Silva, Jonatas Lobato Duarte, Leonardo Delello Di Filippo, Marlus Chorilli, Marcia Regina Cominetti, Ana Carolina Baptista Moreno Martin
Summary: A [10]-gingerol-loaded nanoemulsion was created to enhance stability and solubility, showing cytotoxic and apoptotic effects on murine and human TNBC cell lines, with improved apoptotic function on murine tumor cells. These results suggest a promising drug-delivery approach for [10]-gingerol in TNBC treatment.
Article
Biochemistry & Molecular Biology
Rafael Luis Luporini, Joice M. de A. Rodolpho, Lauro Tatsuo Kubota, Ana Carolina Baptista Moreno Martin, Marcia R. Cominetti, Fernanda de Freitas Anibal, Henrique Pott-Junior
Summary: This study aimed to assess inflammatory cytokines in adult COVID-19 patients, finding that IL-6 and IL-10 levels were higher in patients aged 65 and over. IL-10 was independently associated with age and disease severity, while IL-6 was associated with comorbidity index among older adults.
Article
Chemistry, Inorganic & Nuclear
Celisnolia M. Leite, Joao Honorato, Ana Carolina B. M. Martin, Rafael G. Silveira, Felippe M. Colombari, Jessica C. Amaral, Analu R. Costa, Marcia R. Cominetti, Ana M. Plutin, Debora de Aguiar, Boniek G. Vaz, Alzir A. Batista
Summary: The study synthesized and characterized six copper(I) complexes, which exhibited cytotoxicity towards three tumor cell lines, with one complex showing significant effects on the cytoskeleton and induction of apoptosis in TNBC cells.
INORGANIC CHEMISTRY
(2022)
Article
Veterinary Sciences
Silvia A. Teixeira, Mayara de Cassia Luzzi, Ana Carolina Baptista Moreno Martin, Terence Teixeira Duarte, Monica de Oliveira Leal, Gustavo Ramos Teixeira, Monise Tadin Reis, Carlos Roberto Almeida Junior, Karina Santos, Matias Eliseo Melendez, Diego da Cunha Silveira Alves da Silva, Priscila Neves Bernecule, Higor Vinicius Lourenco Firmino, Ana Laura Vieira Alves, Denise Peixoto Guimaraes, Joao Vitor Borduqui, Ana Carolina Laus, Bruna Minniti Mancano, Rui Manuel Reis
Summary: This study presents a unique animal facility in Brazil dedicated to cancer research, which has established various cancer models including conventional mouse models, genetically modified mouse models, and patient-derived xenograft models. These models have helped enhance our understanding of cancer biology and identify potential therapeutic targets for personalized therapy.
VETERINARY SCIENCES
(2022)
Meeting Abstract
Oncology
Ana Carolina Baptista Moreno Martin, Terence Duarte, Gustavo Teixeira, Renato Jose Da Silva Oliveira, Bruna Mancano, Carlos Almeida Junior, Rui Reis, Silvia Teixeira
PEDIATRIC BLOOD & CANCER
(2022)
Meeting Abstract
Oncology
Ana Carolina Baptista Moreno Martin, Rebeka Tomasin, Angelica Graminha, Marina Naves, Liany Luna Dulcey, Ramon Telles, Marcia Cominetti
CLINICAL & EXPERIMENTAL METASTASIS
(2017)
Meeting Abstract
Oncology
Ana Carolina B. Moreno Martin, Rebeka Tomasin, Phoebe Ling, James Almada da Silva, Paulo Cezar Vieira, Joao Batista Fernandes, Normand Pouliot, Heloisa S. S. de Araujo, Marcia R. Cominetti
CLINICAL & EXPERIMENTAL METASTASIS
(2015)
