Human Cortical Neural Stem Cells Expressing Insulin-Like Growth Factor-I: A Novel Cellular Therapy for Alzheimer's Disease

Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss

(2015) Rahasson R. Ager et al.   HIPPOCAMPUS

Human neural stem cells alleviate Alzheimer-like pathology in a mouse model

(2015) Il-Shin Lee et al.   Molecular Neurodegeneration

Autocrine Production of IGF-I Increases Stem Cell-Mediated Neuroprotection

(2015) J. Simon Lunn et al.   STEM CELLS

Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: Phase 1 trial outcomes

(2014) Eva L. Feldman et al.   ANNALS OF NEUROLOGY

ERK1/2 Pathway-Mediated Differentiation of IGF-1-Transfected Spinal Cord-Derived Neural Stem Cells into Oligodendrocytes

(2014) Bo Shi et al.   PLoS One

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Therapeutic effects of the transplantation of VEGF overexpressing bone marrow mesenchymal stem cells in the hippocampus of murine model of Alzheimer’s disease

(2014) Karina O. Garcia et al.   Frontiers in Aging Neuroscience

Insulin-Like Growth Factor Receptor Signaling is Necessary for Epidermal Growth Factor Mediated Proliferation of SVZ Neural Precursors in vitro Following Neonatal Hypoxia–Ischemia

(2014) Dhivyaa Alagappan et al.   Frontiers in Neurology

2013 Alzheimer's disease facts and figures

(2013)   Alzheimers & Dementia

Farnesyltransferase Haplodeficiency Reduces Neuropathology and Rescues Cognitive Function in a Mouse Model of Alzheimer Disease

(2013) Shaowu Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Central nervous system stem cell transplantation for children with neuronal ceroid lipofuscinosis

(2013) Nathan R. Selden et al.   Journal of Neurosurgery-Pediatrics

Further insights into Alzheimer disease pathogenesis

(2013) Michael W. Weiner   Nature Reviews Neurology

Systemic Transplantation of Human Umbilical Cord Derived Mesenchymal Stem Cells-Educated T Regulatory Cells Improved the Impaired Cognition in AβPPswe/PS1dE9 Transgenic Mice

(2013) Hongna Yang et al.   PLoS One

Evolution of the evidence on the effectiveness and cost-effectiveness of acetylcholinesterase inhibitors and memantine for Alzheimer's disease: systematic review and economic model†

(2012) Christopher Hyde et al.   AGE AND AGEING

Intraspinal transplantation of neurogenin-expressing stem cells generates spinal cord neural progenitors

(2012) J. Simon Lunn et al.   NEUROBIOLOGY OF DISEASE

Selective degeneration of septal and hippocampal GABAergic neurons in a mouse model of amyloidosis and tauopathy

(2012) Desirée Loreth et al.   NEUROBIOLOGY OF DISEASE

Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease

(2012) Robert Howard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human Neural Stem Cell Replacement Therapy for Amyotrophic Lateral Sclerosis by Spinal Transplantation

(2012) Michael P. Hefferan et al.   PLoS One

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Neural Stem Cell Engraftment and Myelination in the Human Brain

(2012) N. Gupta et al.   Science Translational Medicine

Stem cell technology for neurodegenerative diseases

(2011) J. Simon Lunn et al.   ANNALS OF NEUROLOGY

Cortical Neurons Develop Insulin Resistance and Blunted Akt Signaling: A Potential Mechanism Contributing to Enhanced Ischemic Injury in Diabetes

(2011) Bhumsoo Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

IGF-I ameliorates hippocampal neurodegeneration and protects against cognitive deficits in an animal model of temporal lobe epilepsy

(2011) Panagiota Miltiadous et al.   EXPERIMENTAL NEUROLOGY

Resveratrol improves cognitive function in mice by increasing production of insulin-like growth factor-I in the hippocampus

(2011) Naoaki Harada et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A pathophysiological framework of hippocampal dysfunction in ageing and disease

(2011) Scott A. Small et al.   NATURE REVIEWS NEUROSCIENCE

Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia

(2011) Lisa McGinley et al.   Stem Cell Research & Therapy

Alzheimer Disease

(2010) Rudy J. Castellani et al.   DM DISEASE-A-MONTH

Overexpression of Human Apolipoprotein A-I Preserves Cognitive Function and Attenuates Neuroinflammation and Cerebral Amyloid Angiopathy in a Mouse Model of Alzheimer Disease

(2010) Terry L. Lewis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lentivirus-mediated expression of insulin-like growth factor-I promotes neural stem/precursor cell proliferation and enhances their potential to generate neurons

(2010) Georgia Kouroupi et al.   JOURNAL OF NEUROCHEMISTRY

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

Cell-Mediated Neuroprotection in a Mouse Model of Human Tauopathy

(2010) D. W. Hampton et al.   JOURNAL OF NEUROSCIENCE

Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation

(2010) Hyun Ju Lee et al.   NEUROBIOLOGY OF AGING

The Pleotrophic Effects of Insulin-Like Growth Factor-I on Human Spinal Cord Neural Progenitor Cells

(2010) J. Simon Lunn et al.   STEM CELLS AND DEVELOPMENT

Transplantation of primed or unprimed mouse embryonic stem cell-derived neural precursor cells improves cognitive function in Alzheimerian rats

(2009) Farshad Homayouni Moghadam et al.   DIFFERENTIATION

IGF-I maintains calpastatin expression and attenuates apoptosis in several models of photoreceptor cell death

(2009) Ana I. Arroba et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Stem cells: comprehensive treatments for amyotrophic lateral sclerosis in conjunction with growth factor delivery

(2009) J. Simon Lunn et al.   GROWTH FACTORS

Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: Differentiation and structural integration into the segmental motor circuitry

(2009) Leyan Xu et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

(2009) M. Blurton-Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin-like Growth Factor 1, Insulin-like Growth Factor-Binding Protein 3, and Testicular Germ-Cell Tumor Risk

(2008) V. M. Chia et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Modulation of the microenvironment by growth factors regulates thein vivogrowth of skeletal myoblasts

(2008) Akihiro Yanagiuchi et al.   BJU INTERNATIONAL

Neural Stem Cells Improve Learning and Memory in Rats with Alzheimer’s Disease

(2008) Shuliang Wu et al.   PATHOBIOLOGY

Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis

(2008) Masatoshi Suzuki et al.   TRENDS IN NEUROSCIENCES

Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease

(2007) Allison D. Ebert et al.   EXPERIMENTAL NEUROLOGY