G i -Biased β 2 AR Signaling Links GRK2 Upregulation to Heart Failure

Cardiac pressure overload hypertrophy is differentially regulated by β-adrenergic receptor subtypes

(2011) Mingming Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

RGS2 is a primary terminator of β2-adrenergic receptor-mediated Gi signaling

(2011) Khalid Chakir et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Executive Summary: Heart Disease and Stroke Statistics—2010 Update

(2010) et al.   CIRCULATION

Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms

(2010) Henriette Brinks et al.   CIRCULATION RESEARCH

Reduction of Sympathetic Activity via Adrenal-targeted GRK2 Gene Deletion Attenuates Heart Failure Progression and Improves Cardiac Function after Myocardial Infarction

(2010) Anastasios Lymperopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Agonist Dose-dependent Phosphorylation by Protein Kinase A and G Protein-coupled Receptor Kinase Regulates β2Adrenoceptor Coupling to GiProteins in Cardiomyocytes

(2009) Ruijie Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GRK mythology: G-protein receptor kinases in cardiovascular disease

(2009) Gerald W. Dorn   JOURNAL OF MOLECULAR MEDICINE-JMM

Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway  2-adrenergic receptor physiologic signaling

(2009) W. C. H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Inhibition of Cardiomyocyte Gi Signaling Enhances Susceptibility to Apoptotic Cell Death in Response to Ischemic Stress

(2008) Brent R. DeGeorge et al.   CIRCULATION

Inotropes and Vasopressors

(2008) Christopher B. Overgaard et al.   CIRCULATION

Cardioprotective and Survival Benefits of Long-Term Combined Therapy with  2 Adrenoreceptor (AR) Agonist and  1 AR Blocker in Dilated Cardiomyopathy Postmyocardial Infarction

(2008) I. Ahmet et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS