Diplomatic Assistance: Can Helminth-Modulated Macrophages Act as Treatment for Inflammatory Disease?

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

(2016) Ido Amit et al.   NATURE IMMUNOLOGY

Chronic helminth infection and helminth-derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice

(2015) Leonie Hussaarts et al.   FASEB JOURNAL

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

(2015) Mario M. Zaiss et al.   IMMUNITY

Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease

(2015) John Croese et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

(2015) Justyna Rzepecka et al.   JOURNAL OF AUTOIMMUNITY

DUSP3 Genetic Deletion Confers M2-like Macrophage–Dependent Tolerance to Septic Shock

(2015) Pratibha Singh et al.   JOURNAL OF IMMUNOLOGY

Treatment with RecombinantTrichinella spiralisCathepsin B–like Protein Ameliorates Intestinal Ischemia/Reperfusion Injury in Mice by Promoting a Switch from M1 to M2 Macrophages

(2015) Wei-Feng Liu et al.   JOURNAL OF IMMUNOLOGY

A Novel Regulatory Macrophage Induced by a Helminth Molecule Instructs IL-10 in CD4+T Cells and Protects against Mucosal Inflammation

(2015) Thomas Ziegler et al.   JOURNAL OF IMMUNOLOGY

Fasciola hepaticaFatty Acid Binding Protein Inhibits TLR4 Activation and Suppresses the Inflammatory Cytokines Induced by Lipopolysaccharide In Vitro and In Vivo

(2015) Ivelisse Martin et al.   JOURNAL OF IMMUNOLOGY

Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect

(2015) A Voldsgaard et al.   Multiple Sclerosis Journal

Identifying the immunomodulatory components of helminths

(2015) C. Shepherd et al.   PARASITE IMMUNOLOGY

A transcriptional perspective on human macrophage biology

(2015) Joachim L. Schultze et al.   SEMINARS IN IMMUNOLOGY

Chronic Filarial Infection Provides Protection against Bacterial Sepsis by Functionally Reprogramming Macrophages

(2015) Fabian Gondorf et al.   PLoS Pathogens

Immune Antibodies and Helminth Products Drive CXCR2-Dependent Macrophage-Myofibroblast Crosstalk to Promote Intestinal Repair

(2015) Julia Esser-von Bieren et al.   PLoS Pathogens

Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect

(2015) A Voldsgaard et al.   Multiple Sclerosis Journal

Therapeutic potential of larval excretory/secretory proteins of the pig whipwormTrichuris suisin allergic disease

(2014) F. Ebner et al.   ALLERGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Macrophages in intestinal homeostasis and inflammation

(2014) Calum C. Bain et al.   IMMUNOLOGICAL REVIEWS

A Helminth Immunomodulator Reduces Allergic and Inflammatory Responses by Induction of IL-10-Producing Macrophages

(2014) C. Schnoeller et al.   JOURNAL OF IMMUNOLOGY

A Transgenic Probiotic Secreting a Parasite Immunomodulator for Site-Directed Treatment of Gut Inflammation

(2014) Rose A Whelan et al.   MOLECULAR THERAPY

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

Brugia malayi Microfilariae Induce a Regulatory Monocyte/Macrophage Phenotype That Suppresses Innate and Adaptive Immune Responses

(2014) Noëlle Louise O'Regan et al.   PLoS Neglected Tropical Diseases

Inflammatory Monocytes Recruited to Allergic Skin Acquire an Anti-inflammatory M2 Phenotype via Basophil-Derived Interleukin-4

(2013) Mayumi Egawa et al.   IMMUNITY

Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of interleukin-10-producing B cells and reduced plasma cell infiltration of the joints

(2013) David T. Rodgers et al.   IMMUNOLOGY

Immunomodulation by helminth parasites: Defining mechanisms and mediators

(2013) Henry J. McSorley et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Lung-resident tissue macrophages generate Foxp3+regulatory T cells and promote airway tolerance

(2013) Pejman Soroosh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Parasite Infections in Multiple Sclerosis Modulate Immune Responses through a Retinoic Acid-Dependent Pathway

(2013) J. Correale et al.   JOURNAL OF IMMUNOLOGY

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Decreased prevalence of sepsis but not mild or severe P. falciparum malaria is associated with pre-existing filarial infection

(2013) Madhumita Panda et al.   Parasites & Vectors

Small Intestinal Nematode Infection of Mice Is Associated with Increased Enterobacterial Loads alongside the Intestinal Tract

(2013) Sebastian Rausch et al.   PLoS One

Modeling the heterogeneity of multiple sclerosis in animals

(2013) Sarah B. Simmons et al.   TRENDS IN IMMUNOLOGY

Helminth-host immunological interactions: prevention and control of immune-mediated diseases

(2012) David E. Elliott et al.   Annals of the New York Academy of Sciences

The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites

(2012) Miguel A. Pineda et al.   ARTHRITIS AND RHEUMATISM

Trichuris suisova therapy for allergic rhinitis does not affect allergen-specific cytokine responses despite a parasite-specific cytokine response

(2012) C. D. Bourke et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Screening, prevention, and treatment for hyperinfection syndrome and disseminated infections caused by Strongyloides stercoralis

(2012) Rojelio Mejia et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Adoptive Transfer of Immunomodulatory M2 Macrophages Prevents Type 1 Diabetes in NOD Mice

(2012) R. Parsa et al.   DIABETES

A nematode immunomodulator suppresses grass pollen-specific allergic responses by controlling excessive Th2 inflammation

(2012) Emilia Daniłowicz-Luebert et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

IFN-γ-induced iNOS Expression in Mouse Regulatory Macrophages Prolongs Allograft Survival in Fully Immunocompetent Recipients

(2012) Paloma Riquelme et al.   MOLECULAR THERAPY

An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection

(2012) Fei Chen et al.   NATURE MEDICINE

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation

(2012) H. Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Managing Macrophages in Rheumatoid Arthritis by Reform or Removal

(2012) Jun Li et al.   Current Rheumatology Reports

Immune modulation by Lacto-N-fucopentaose III in experimental autoimmune encephalomyelitis

(2011) Bing Zhu et al.   CLINICAL IMMUNOLOGY

Functional and Phenotypic Characteristics of Alternative Activation Induced in Human Monocytes by Interleukin-4 or the Parasitic Nematode Brugia malayi

(2011) Roshanak Tolouei Semnani et al.   INFECTION AND IMMUNITY

Modulation of Specific and Allergy-Related Immune Responses by Helminths

(2011) Emilia Daniłowicz-Luebert et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Cutting Edge: Immunological Consequences and Trafficking of Human Regulatory Macrophages Administered to Renal Transplant Recipients

(2011) J. A. Hutchinson et al.   JOURNAL OF IMMUNOLOGY

SHIP-deficient, alternatively activated macrophages protect mice during DSS-induced colitis

(2011) Shelley B. Weisser et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The impact of parasite infections on the course of multiple sclerosis

(2011) Jorge Correale et al.   JOURNAL OF NEUROIMMUNOLOGY

Probiotic helminth administration in relapsing–remitting multiple sclerosis: a phase 1 study

(2011) JO Fleming et al.   Multiple Sclerosis Journal

Symptoms after Ingestion of Pig Whipworm Trichuris suis Eggs in a Randomized Placebo-Controlled Double-Blind Clinical Trial

(2011) Peter Bager et al.   PLoS One

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Management of gut inflammation through the manipulation of intestinal dendritic cells and macrophages?

(2011) Liat Bar-On et al.   SEMINARS IN IMMUNOLOGY

Monocyte trafficking in acute and chronic inflammation

(2011) Molly A. Ingersoll et al.   TRENDS IN IMMUNOLOGY

A Helminth Immunomodulator Exploits Host Signaling Events to Regulate Cytokine Production in Macrophages

(2011) Christian Klotz et al.   PLoS Pathogens

Decreased Prevalence of Lymphatic Filariasis Among Subjects with Type-1 Diabetes

(2010) Vivekanandhan Aravindhan et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Experimental hookworm infection: a randomized placebo-controlled trial in asthma

(2010) J. R. Feary et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Chronic Helminth Infections Protect Against Allergic Diseases by Active Regulatory Processes

(2010) Hermelijn H. Smits et al.   CURRENT ALLERGY AND ASTHMA REPORTS

In Vitro-Derived Alternatively Activated Macrophages Reduce Colonic Inflammation in Mice

(2010) Meaghan M. Hunter et al.   GASTROENTEROLOGY

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Taenia crassicepsInfection Attenuates Multiple Low-Dose Streptozotocin-Induced Diabetes

(2010) Arlett Espinoza-Jiménez et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Immune Modulation bySchistosoma mansoniAntigens in NOD Mice: Effects on Both Innate and Adaptive Immune Systems

(2010) Paola Zaccone et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Arginase I Suppresses IL-12/IL-23p40-Driven Intestinal Inflammation during Acute Schistosomiasis

(2010) D. R. Herbert et al.   JOURNAL OF IMMUNOLOGY

Schistosoma mansoniegg antigens induce Treg that participate in diabetes prevention in NOD mice

(2009) Paola Zaccone et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Helminth Infection Can Reduce Insulitis and Type 1 Diabetes through CD25- and IL-10-Independent Mechanisms

(2009) Q. Liu et al.   INFECTION AND IMMUNITY

Extracts of the Rat Tapeworm, Hymenolepis diminuta, Suppress Macrophage Activation In Vitro and Alleviate Chemically Induced Colitis in Mice

(2009) M. J. G. Johnston et al.   INFECTION AND IMMUNITY

Trichuris suis ova therapy for allergic rhinitis: A randomized, double-blind, placebo-controlled clinical trial

(2009) Peter Bager et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Alternatively Activated and Immunoregulatory Monocytes in Human Filarial Infections

(2009) Subash Babu et al.   JOURNAL OF INFECTIOUS DISEASES

Regulation of type 1 diabetes, tuberculosis, and asthma by parasites

(2009) Zhugong Liu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Th2 Cytokine-Induced Alterations in Intestinal Smooth Muscle Function Depend on Alternatively Activated Macrophages

(2008) Aiping Zhao et al.   GASTROENTEROLOGY

Type II-activated macrophages suppress the development of experimental autoimmune encephalomyelitis

(2008) Joanna B Tierney et al.   IMMUNOLOGY AND CELL BIOLOGY

Helminths and the IBD hygiene hypothesis

(2008) Joel V. Weinstock et al.   INFLAMMATORY BOWEL DISEASES

Soluble egg antigen from Schistosoma japonicum modulates the progression of chronic progressive experimental autoimmune encephalomyelitis via Th2-shift response

(2008) Xueping Zheng et al.   JOURNAL OF NEUROIMMUNOLOGY