Why Most Clinical Research Is Not Useful

Routinely collected data and comparative effectiveness evidence: promises and limitations

(2016) Lars G. Hemkens et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Agreement of treatment effects for mortality from routinely collected data and subsequent randomized trials: meta-epidemiological survey

(2016) Lars G Hemkens et al.   BMJ-British Medical Journal

Agreement of treatment effects for mortality from routinely collected data and subsequent randomized trials: meta-epidemiological survey

(2016) Lars G Hemkens et al.   BMJ-British Medical Journal

ISIS and the emergence of large, simple trials

(2015) Douglas G Altman   LANCET

Call to improve transparency of trials of non-regulated interventions

(2015) R. Dal-Re et al.   BMJ-British Medical Journal

Value of Information: A Tool to Improve Research Prioritization and Reduce Waste

(2015) Cosetta Minelli et al.   PLOS MEDICINE

Call to improve transparency of trials of non-regulated interventions

(2015) R. Dal-Re et al.   BMJ-British Medical Journal

An evaluation of the feasibility, cost and value of information of a multicentre randomised controlled trial of intravenous immunoglobulin for sepsis (severe sepsis and septic shock): incorporating a systematic review, meta-analysis and value of information analysis.

(2014) MO Soares et al.   HEALTH TECHNOLOGY ASSESSMENT

Ethics and Regulatory Complexities for Pragmatic Clinical Trials

(2014) Jeremy Sugarman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prevalence, Characteristics, and Publication of Discontinued Randomized Trials

(2014) Benjamin Kasenda et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Launching PCORnet, a national patient-centered clinical research network

(2014) R. L. Fleurence et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Reducing waste from incomplete or unusable reports of biomedical research

(2014) Paul Glasziou et al.   LANCET

Increasing value and reducing waste: addressing inaccessible research

(2014) An-Wen Chan et al.   LANCET

Biomedical research: increasing value, reducing waste

(2014) Malcolm R Macleod et al.   LANCET

Increasing value and reducing waste in research design, conduct, and analysis

(2014) John P A Ioannidis et al.   LANCET

PCORI at 3 Years — Progress, Lessons, and Plans

(2014) Joseph V. Selby et al.   NEW ENGLAND JOURNAL OF MEDICINE

Attention to Local Health Burden and the Global Disparity of Health Research

(2014) James A. Evans et al.   PLoS One

Estimates of the Continuously Publishing Core in the Scientific Workforce

(2014) John P. A. Ioannidis et al.   PLoS One

Patient-Centeredness in the Design of Clinical Trials

(2014) C. Daniel Mullins et al.   VALUE IN HEALTH

Discontinuation and non-publication of surgical randomised controlled trials: observational study

(2014) S. J. Chapman et al.   BMJ-British Medical Journal

Multisystem failure: the story of anti-influenza drugs

(2014) T. Jefferson et al.   BMJ-British Medical Journal

How to Make More Published Research True

(2014) John P. A. Ioannidis   PLOS MEDICINE

A Guide to Reading Health Care News Stories

(2014) Gary Schwitzer   JAMA Internal Medicine

Use of data from registered clinical trials to identify gaps in health research and development

(2013) Roderik F Viergever et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Mega-Trials for Blockbusters

(2013) John P. A. Ioannidis   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Observational studies often make clinical practice recommendations: an empirical evaluation of authors' attitudes

(2013) Vinay Prasad et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Randomized Clinical Trials — Removing Unnecessary Obstacles

(2013) Christina Reith et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Trial Registration in Physical Therapy Journals: A Cross-Sectional Study

(2013) A. S. Babu et al.   PHYSICAL THERAPY

Raw data from clinical trials: within reach?

(2013) Peter Doshi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Ensuring the integrity of clinical practice guidelines: a tool for protecting patients

(2013) Jeanne Lenzer et al.   BMJ-British Medical Journal

Should people at low risk of cardiovascular disease take a statin?

(2013) J. D. Abramson et al.   BMJ-British Medical Journal

"Hardly worth the effort"? Medical journals' policies and their editors' and publishers' views on trial registration and publication bias: quantitative and qualitative study

(2013) E. Wager et al.   BMJ-British Medical Journal

Perceived information gain from randomized trials correlates with publication in high–impact factor journals

(2012) Evangelos Evangelou et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Trial Registration Numbers Are Underreported in Biomedical Publications

(2012) Fleur T. van de Wetering et al.   PLoS One

The role of private industry in pragmatic comparative effectiveness trials

(2012) Don P Buesching et al.   Journal of Comparative Effectiveness Research

Magnitude of effects in clinical trials published in high-impact general medical journals

(2011) Konstantinos CM Siontis et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Minimal Modeling Approaches to Value of Information Analysis for Health Research

(2011) David O. Meltzer et al.   MEDICAL DECISION MAKING

Transparency of outcome reporting and trial registration of randomized controlled trials in top psychosomatic and behavioral health journals: A systematic review

(2010) Katherine Milette et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

Outcome Reporting in Industry-Sponsored Trials of Gabapentin for Off-Label Use

(2009) S. Swaroop Vedula et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sensible approaches for reducing clinical trial costs

(2008) Eric L Eisenstein et al.   Clinical Trials

Disease Mongering Is Now Part of the Global Health Debate

(2008) Ray Moynihan et al.   PLOS MEDICINE