Distinct Prion Domain Sequences Ensure Efficient Amyloid Propagation by Promoting Chaperone Binding or Processing In Vivo

RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils

(2015) N. Zaarur et al.   EMBO JOURNAL

The Hsp104 N-Terminal Domain Enables Disaggregase Plasticity and Potentiation

(2015) Elizabeth A. Sweeny et al.   MOLECULAR CELL

Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils

(2015) Xuechao Gao et al.   MOLECULAR CELL

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

(2014) Xin Cai et al.   CELL

Yeast prions and human prion-like proteins: sequence features and prediction methods

(2014) Sean M. Cascarina et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Defining the limits: Protein aggregation and toxicityin vivo

(2014) William M. Holmes et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Distinct Amino Acid Compositional Requirements for Formation and Maintenance of the [PSI+] Prion in Yeast

(2014) Kyle S. MacLea et al.   MOLECULAR AND CELLULAR BIOLOGY

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of amino-terminal acetylation suppresses a prion phenotype by modulating global protein folding

(2014) William M. Holmes et al.   Nature Communications

Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing

(2014) Courtney L Klaips et al.   eLife

Effect of Charged Residues in the N-domain of Sup35 Protein on Prion [PSI+] Stability and Propagation

(2013) Stanislav A. Bondarev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequence- and Species-Dependence of Proteasomal Processivity

(2012) Daniel A. Kraut et al.   ACS Chemical Biology

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation

(2012) Juliane Winkler et al.   JOURNAL OF CELL BIOLOGY

The Effects of Amino Acid Composition of Glutamine-Rich Domains on Amyloid Formation and Fragmentation

(2012) Alexander I. Alexandrov et al.   PLoS One

Clinical Characterization of a Kindred With a Novel 12-Octapeptide Repeat Insertion in the Prion Protein Gene

(2011) Neeraj Kumar   ARCHIVES OF NEUROLOGY

Insight into Molecular Basis of Curing of [PSI+] Prion by Overexpression of 104-kDa Heat Shock Protein (Hsp104)

(2011) Christopher W. Helsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Destabilization and Recovery of a Yeast Prion after Mild Heat Shock

(2011) Gary P. Newnam et al.   JOURNAL OF MOLECULAR BIOLOGY

Strain conformation, primary structure and the propagation of the yeast prion [PSI+]

(2011) Katherine J Verges et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dominant prion mutants induce curing through pathways that promote chaperone-mediated disaggregation

(2011) Susanne DiSalvo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

[PSI+] Maintenance Is Dependent on the Composition, Not Primary Sequence, of the Oligopeptide Repeat Domain

(2011) James A. Toombs et al.   PLoS One

Aplysia CPEB Can Form Prion-like Multimers in Sensory Neurons that Contribute to Long-Term Facilitation

(2010) Kausik Si et al.   CELL

The prion hypothesis: from biological anomaly to basic regulatory mechanism

(2010) Mick F. Tuite et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular strategies for controlling protein aggregation

(2010) Jens Tyedmers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Optical trapping with high forces reveals unexpected behaviors of prion fibrils

(2010) Jijun Dong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Size Threshold Limits Prion Transmission and Establishes Phenotypic Diversity

(2010) Aaron Derdowski et al.   SCIENCE

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

ATP-dependent Proteases Differ Substantially in Their Ability to Unfold Globular Proteins

(2009) Prakash Koodathingal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequestration of essential proteins causes prion associated toxicity in yeast

(2009) Namitha Vishveshwara et al.   MOLECULAR MICROBIOLOGY

Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI +]

(2009) Peter M Tessier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Accurate Prediction of DnaK-Peptide Binding via Homology Modelling and Experimental Data

(2009) Joost Van Durme et al.   PLoS Computational Biology

Appearance and Propagation of Polyglutamine-based Amyloids in Yeast

(2008) Ilya M. Alexandrov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NatA Acetyltransferase Couples Sup35 Prion Complexes to the [PSI+] Phenotype

(2008) John A. Pezza et al.   MOLECULAR BIOLOGY OF THE CELL

In Vivo Monitoring of the Prion Replication Cycle Reveals a Critical Role for Sis1 in Delivering Substrates to Hsp104

(2008) Kimberly A. Tipton et al.   MOLECULAR CELL

Specificity of the J-protein Sis1 in the propagation of 3 yeast prions

(2008) T. Higurashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strain-specific sequences required for yeast [PSI+] prion propagation

(2008) H.-Y. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA