A Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein

Environmental Temperature Differentially Modulates C. elegans Longevity through a Thermosensitive TRP Channel

(2015) Bi Zhang et al.   Cell Reports

Co-chaperone p23 Regulates C. elegans Lifespan in Response to Temperature

(2015) Makoto Horikawa et al.   PLoS Genetics

Chemosensation of Bacterial Secondary Metabolites Modulates Neuroendocrine Signaling and Behavior of C. elegans

(2014) Joshua D. Meisel et al.   CELL

ATF6 Activation Reduces the Secretion and Extracellular Aggregation of Destabilized Variants of an Amyloidogenic Protein

(2014) John J. Chen et al.   CHEMISTRY & BIOLOGY

A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication

(2014) W. L. Hung et al.   DEVELOPMENT

Brain Injection of  -Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker

(2014) A. N. Sacino et al.   JOURNAL OF NEUROSCIENCE

Protein Disulfide Isomerase A6 Controls the Decay of IRE1α Signaling via Disulfide-Dependent Association

(2014) Davide Eletto et al.   MOLECULAR CELL

Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer

(2014) Tamar Hashimshony et al.   NATURE

Regulation of Extracellular Matrix Organization by BMP Signaling in Caenorhabditis elegans

(2014) Robbie D. Schultz et al.   PLoS One

Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition

(2014) A. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Germline stem cell arrest inhibits the collapse of somatic proteostasis early inCaenorhabditis elegansadulthood

(2013) Netta Shemesh et al.   AGING CELL

Orchestration of secretory protein folding by ER chaperones

(2013) Tali Gidalevitz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

The Unfolded Protein Response in a Pair of Sensory Neurons Promotes Entry of C. elegans into Dauer Diapause

(2013) Warakorn Kulalert et al.   CURRENT BIOLOGY

Effect of Genetic Variation in a Drosophila Model of Diabetes-Associated Misfolded Human Proinsulin

(2013) B. Z. He et al.   GENETICS

Genetic Complexity in a Drosophila Model of Diabetes-Associated Misfolded Human Proinsulin

(2013) S.-Y. Park et al.   GENETICS

Complex expression dynamics and robustness in C. elegans insulin networks

(2013) A. D. Ritter et al.   GENOME RESEARCH

Cytosolic proteins lose solubility as amyloid deposits in a transgenic mouse model of Alzheimer-type amyloidosis

(2013) Guilian Xu et al.   HUMAN MOLECULAR GENETICS

Endoplasmic Reticulum Oxidoreductin-1α (Ero1α) Improves Folding and Secretion of Mutant Proinsulin and Limits Mutant Proinsulin-induced Endoplasmic Reticulum Stress

(2013) Jordan Wright et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aggregation of Human S100A8 and S100A9 Amyloidogenic Proteins Perturbs Proteostasis in a Yeast Model

(2013) Ekaterina Eremenko et al.   PLoS One

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

Identification of Proteins Sensitive to Thermal Stress in Human Neuroblastoma and Glioma Cell Lines

(2012) Guilian Xu et al.   PLoS One

Repression of a Potassium Channel by Nuclear Hormone Receptor and TGF-β Signaling Modulates Insulin Signaling in Caenorhabditis elegans

(2012) Donha Park et al.   PLoS Genetics

A SEL1L Mutation Links a Canine Progressive Early-Onset Cerebellar Ataxia to the Endoplasmic Reticulum–Associated Protein Degradation (ERAD) Machinery

(2012) Kaisa Kyöstilä et al.   PLoS Genetics

Specific insulin-like peptides encode sensory information to regulate distinct developmental processes

(2011) A. Cornils et al.   DEVELOPMENT

Degeneracy and Neuromodulation among Thermosensory Neurons Contribute to Robust Thermosensory Behaviors in Caenorhabditis elegans

(2011) M. Beverly et al.   JOURNAL OF NEUROSCIENCE

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway

(2011) G. Thibault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Superfolder GFP Is Fluorescent in Oxidizing Environments When Targeted via the Sec Translocon

(2011) Deborah E. Aronson et al.   TRAFFIC

Optogenetic analysis of synaptic transmission in the central nervous system of the nematode Caenorhabditis elegans

(2011) Theodore H. Lindsay et al.   Nature Communications

Quality and quantity control at the endoplasmic reticulum

(2010) Ramanujan S Hegde et al.   CURRENT OPINION IN CELL BIOLOGY

PERK (EIF2AK3) Regulates Proinsulin Trafficking and Quality Control in the Secretory Pathway

(2010) Sounak Gupta et al.   DIABETES

ERO1-β, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis

(2010) Ester Zito et al.   JOURNAL OF CELL BIOLOGY

Mutant INS-Gene Induced Diabetes of Youth: Proinsulin Cysteine Residues Impose Dominant-Negative Inhibition on Wild-Type Proinsulin Transport

(2010) Ming Liu et al.   PLoS One

In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes

(2009) Sindhu Rajan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Misfolded Proinsulin Affects Bystander Proinsulin in Neonatal Diabetes

(2009) Israel Hodish et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chaperone Activity of GRP94 Toward Insulin-like Growth Factor II Is Necessary for the Stress Response to Serum Deprivation

(2009) Olga Ostrovsky et al.   MOLECULAR BIOLOGY OF THE CELL

Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity

(2009) Tali Gidalevitz et al.   PLoS Genetics

Insulin, cGMP, and TGF-β Signals Regulate Food Intake and Quiescence in C. elegans: A Model for Satiety

(2008) Young-jai You et al.   Cell Metabolism

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

(2008) Konstanze F Winklhofer et al.   EMBO JOURNAL

Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats inDrosophila melanogaster

(2008) An-Chi Tien et al.   JOURNAL OF CELL BIOLOGY

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE