Article
Cell Biology
Daojuan Wang, Zhengquan Zhu, Yu Fu, Qiong Zhang, Yi Zhang, Tingyu Wang, Yajing Weng, Yanting Wen, Wangsen Cao, Gaojian Tao, Yong Wang
Summary: This study found that the upregulation of BRD4 and the resulting AR transcriptional activation constitute an important regulatory pathway that promotes ovarian fibrosis in PCOS.
Article
Cell Biology
Yi Liu, Hejing Liu, Miaomiao Ye, Mengying Jiang, Xin Chen, Gendi Song, Huihui Ji, Zhi-wei Wang, Xueqiong Zhu
Summary: This study reveals that BRD4, a member of the BET protein family, is asymmetrically methylated by PRMT1 in ovarian cancer. The overexpression of PRMT1 is associated with poor prognosis in ovarian cancer patients. Silencing PRMT1 inhibits ovarian cancer proliferation, migration, and invasion. PRMT1-mediated BRD4 methylation promotes BRD4 phosphorylation and is involved in ovarian cancer metastasis.
CELL DEATH & DISEASE
(2023)
Article
Plant Sciences
Jin-Xing Zhou, Ping Du, Zhang-Wei Liu, Chao Feng, Xue-Wei Cai, Xin-Jian He
Summary: The study discovered the interaction between SUVH9 and FVE, showing that FVE promotes the association of Pol V with chromatin and contributes to DNA methylation at a subset of RdDM target loci. The FVE-dependent RdDM target loci are more abundant in gene-rich chromosome arms compared to FVE-independent ones.
Article
Oncology
Xiaohua Zhu, YingYing Xie, Wenyan Huang, Zigui Chen, SuiQun Guo
Summary: Our data demonstrated that NAP1L1 could act as a prognostic biomarker in OC and can interact with HDGF to mediate the proliferation of OC, and this process of triggered proliferation may contribute to the activation of HDGF/C-JUN signaling in OC cells.
Article
Oncology
Geng G. Tian, Changliang Hou, Jing Li, Ji Wu
Summary: This study investigated the three-dimensional structure of chromatin during the development of female germline stem cells (FGSCs) using high-throughput chromosome conformation capture technique. The results showed significant reorganization of the global 3D genome during FGSC development, with specific changes observed in the chromatin structure of topologically associating domains. The study also identified conserved chromatin structures between FGSC development and early embryonic development.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Yunfeng Jin, Li Chen, Li Li, Guoqin Huang, Hua Huang, Chunhui Tang
Summary: This study revealed the regulatory mechanism of SNAI2 in ovarian cancer and its correlation with ferroptosis. Elevated expression of SNAI2 and occurrence of ferroptosis were observed in ovarian cancer cells. Knockdown of SNAI2 suppressed cell viability, migration, invasion, and promoted cell apoptosis in SKOV3 cells, similar to the effects of erastin. SNAI2 was found to directly bind to the promoter of SLC7A11. Mice injected with SKOV3 cells showed that erastin had an anti-tumor effect, which was weakened by SNAI2 overexpression.
Article
Multidisciplinary Sciences
Zachary A. Hing, Janek S. Walker, Ethan C. Whipp, Lindsey Brinton, Matthew Cannon, Pu Zhang, Steven Sher, Casey B. Cempre, Fiona Brown, Porsha L. Smith, Claudio Agostinelli, Stefano A. Pileri, Jordan N. Skinner, Katie Williams, Hannah Phillips, Jami Shaffer, Larry P. Beaver, Alexander Pan, Kyle Shin, Charles T. Gregory, Gulcin H. Ozer, Selen A. Yilmaz, Bonnie K. Harrington, Amy M. Lehman, Lianbo Yu, Vincenzo Coppola, Pearlly Yan, Peggy Scherle, Min Wang, Philip Pitis, Chaoyi Xu, Kris Vaddi, Selina Chen-Kiang, Jennifer Woyach, James S. Blachly, Lapo Alinari, Yiping Yang, John C. Byrd, Robert A. Baiocchi, Bradley W. Blaser, Rosa Lapalombella
Summary: PRMT5 plays an important role in the progression of CLL to Richter transformation, and the PRMT5 inhibitor PRT382 shows potential therapeutic value.
NATURE COMMUNICATIONS
(2023)
Article
Developmental Biology
Mingjie Xu, Jie Yao, Yingchao Shi, Huijuan Yi, Wukui Zhao, Xinhua Lin, Zhongzhou Yang
Summary: The study identified a crucial role of the SRCAP chromatin remodeling complex in mitochondrial maturation and oxidative metabolism during heart development in mice. The complex functions through H2A.Z deposition to activate transcription of metabolic genes, shedding new light on the transcriptional regulation of ubiquinone biosynthesis.
Article
Cardiac & Cardiovascular Systems
Alessandro Bertero, Manuel Rosa-Garrido
Summary: Recent technological advancements in chromatin biology have revealed that chromatin folding in 3D space is non-random, hierarchical, and complex. While 3D chromatin structure is partially encoded in the primary sequence, a substantial portion of the genome appears to be dynamic. Additionally, evidence suggests that some 3D chromatin structure is functionally linked to gene regulation, influenced by various nuclear processes. This has led to investigations on the role of 3D chromatin topology dynamics in heart development and disease.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Cell Biology
Ruirui Wang, Fujing Huang, Wei Wei, Yu Zhou, Zi Ye, Liya Yu, Junyuan Hu, Cheguo Cai
Summary: PD-L1 is widely expressed in various human tumors and plays an essential role in mammary basal cells and stem cells, promoting mammary gland development and regeneration. Its expression is induced by continuous activation of the Wnt/ss-β-catenin signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yilin Fan, Marielle S. Koberlin, Nalin Ratnayeke, Chad Liu, Madhura Deshpande, Jeannine Gerhardt, Tobias Meyer
Summary: Lack of LRR1 in human cells leads to failure in unloading replisomes, accumulation of replisome components, and reduction in DNA replication rate during S phase. Continued binding of CMG helicases to chromatin blocks mitosis by activating a G2/M checkpoint.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Baowen Zhuo, Qifan Zhang, Tingyan Xie, Yidan Wang, Zhengliang Chen, Daming Zuo, Bo Guo
Summary: Regulatory T (Treg) cells in human tumors exhibit more potent immunosuppressive activity than peripheral blood Treg cells (PBTRs), which impairs the induction of effective antitumor immunity. This study explores the epigenetic profiles of tumor-infiltrating Treg cells (TITRs) and identifies functional regulatory elements. The researchers found global differences in chromatin accessibility and enhancer landscapes between TITRs and PBTRs, as well as two types of active enhancer formation in TITRs. They also discovered that the AP-1 family motifs are enriched at the enhancer regions of TITRs and validated the role of c-Jun in regulating signature genes of TITRs and Treg cell activation. The findings provide insights into the mechanism of AP-1-mediated activation of TITRs and may contribute to the development of new therapeutic strategies for liver cancer treatment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cell Biology
Yixuan Cen, Yifeng Fang, Yan Ren, Shiyuan Hong, Weiguo Lu, Junfen Xu
Summary: This study explored the characteristics of extrachromosomal circular DNAs (eccDNAs) in high grade serous ovarian cancer (HGSOC) and identified DNMT1(circle10302690-10302961) as the most significantly down-regulated eccDNA in metastatic tumors of HGSOC. The lower expression of DNMT1(circle10302690-10302961) was associated with worse prognosis of HGSOC.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Orlandric Miree, Sanjeev Kumar Srivastava, Mohammad Aslam Khan, Fnu Sameeta, Srijan Acharya, Harrison Ndetan, Karan Pal Singh, Kate Louise Hertweck, Santanu Dasgupta, Luciana Madeira da Silva, Rodney Paul Rocconi, James Elliot Carter, Seema Singh, Ajay Pratap Singh
Summary: The study found that aberrant MYB expression in ovarian cancer is positively correlated with tumor grades and stages, and has race-specific prognostic value for African American patients, but not for Caucasian American patients. High levels of MYB transcripts in epithelial ovarian cancer subtypes are associated with poor survival in African American patients, highlighting MYB as a potentially useful clinical biomarker for prognosis in this population.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Yang Shu, He Zhang, Jinqiu Li, Yanhong Shan
Summary: The study identified LINC00494 as a novel oncogenic lncRNA in ovarian cancer, which promotes cancer progression by modulating FBXO32 through binding with NF kappa B1. This provides new insights into the pathogenesis of ovarian cancer and suggests potential therapeutic targets.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Irina Lojkin, Tami Rubinek, Sandra Orsulic, Omer Schwarzmann, Beth Y. Karlan, Shikha Bose, Ido Wolf
Review
Genetics & Heredity
Omer Schwartzman, Amos Tanay
NATURE REVIEWS GENETICS
(2015)
Article
Multidisciplinary Sciences
Pedro Olivares-Chauvet, Zohar Mukamel, Aviezer Lifshitz, Omer Schwartzman, Noa Oded Elkayam, Yaniv Lubling, Gintaras Deikus, Robert P. Sebra, Amos Tanay
Article
Biochemical Research Methods
Omer Schwartzman, Zohar Mukamel, Noa Oded-Elkayam, Pedro Olivares-Chauvet, Yaniv Lubling, Gilad Landan, Shai Izraeli, Amos Tanay
Article
Multidisciplinary Sciences
Omer Schwartzman, Angela Maria Savino, Michael Gombert, Chiara Palmi, Gunnar Cario, Martin Schrappe, Cornelia Eckert, Arend von Stackelberg, Jin-Yan Huang, Michal Hameiri-Grossman, Smadar Avigad, Geertruy te Kronnie, Ifat Geron, Yehudit Birger, Avigail Rein, Giulia Zarfati, Ute Fischer, Zohar Mukamel, Martin Stanulla, Andrea Biondi, Giovanni Cazzaniga, Amedeo Vetere, Bridget K. Wagner, Zhu Chen, Sai-Juan Chen, Amos Tanay, Arndt Borkhardt, Shai Izraeli
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Hematology
Lital Shaham, Elena Vendramini, Yubin Ge, Yaron Goren, Yehudit Birger, Marloes R. Tijssen, Maureen McNulty, Ifat Geron, Omer Schwartzman, Liat Goldberg, Stella T. Chou, Holly Pitman, Mitchell J. Weiss, Shulamit Michaeli, Benjamin Sredni, Berthold Goettgens, John D. Crispino, Jeffrey W. Taub, Shai Izraeli
Article
Biochemistry & Molecular Biology
Netta Mendelson Cohen, Omer Schwartzman, Ram Jaschek, Aviezer Lifshitz, Michael Hoichman, Ran Balicer, Liran Shlush, Gabi Barbash, Amos Tanay
Summary: A new approach based on machine learning integrates a large amount of laboratory test data to stratify and predict the risk of future diseases, providing a multivariate model for quantitative patient evaluation.
Article
Biochemistry & Molecular Biology
Saifeng Cheng, Markus Mittnenzweig, Yoav Mayshar, Aviezer Lifshitz, Marko Dunjic, Yoach Rais, Raz Ben-Yair, Stephanie Gehrs, Elad Chomsky, Zohar Mukamel, Hernan Rubinstein, Katharina Schlereth, Netta Reines, Ayelet-Hashahar Orenbuch, Amos Tanay, Yonatan Stelzer
Summary: By using temporal single-cell atlases, this study reveals that the loss of TET genes in mice leads to embryonic developmental failure. Tet-mutant cells can retain near-complete differentiation potential when developing within a wild-type embryo, but embryos solely composed of mutant cells exhibit defects in epiblast to ectoderm transition and degenerated mesoderm potential.
Article
Biochemistry & Molecular Biology
Zohar Mukamel, Aviezer Lifshitz, Markus Mittnenzweig, Elad Chomsky, Omer Schwartzman, Oren Ben-Kiki, Mirie Zerbib, Amos Tanay
Summary: In mammalian embryos, the differential regulation of DNMT3A and DNMT3B and their distinct methylation kinetics play an important role in the process of differentiation and transcriptional regulation.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2022)