Article
Neurosciences
Savitha Sridharan, Marta A. Gajowa, Mora B. Ogando, Uday K. Jagadisan, Lamiae Abdeladim, Masato Sadahiro, Hayley A. Bounds, William D. Hendricks, Toby S. Turney, Ian Tayler, Karthika Gopakumar, Ian Anton Oldenburg, Stephen G. Brohawn, Hillel Adesnik
Summary: Structure-guided mutagenesis has been used to engineer new optogenetic tools with high potency and fast kinetics, enabling precise control of population neural activity at a large scale, and temporally and spatially. These new tools have been extensively benchmarked and characterized, providing a resource for patterned optogenetics experiments. Furthermore, when combined with optimized procedures for holographic photostimulation, these new tools allow for the coactivation of hundreds of spatially defined neurons simultaneously with a single hologram.
Article
Physics, Fluids & Plasmas
Martin N. P. Nilsson, Henrik Jorntell
Summary: The Hodgkin and Huxley neuron model explains voltage spike propagation in axons, but falls short in explaining certain key features of the neural code. By analyzing channel current fluctuations in a trisection of the model, it was found that neuronal encoding can be conclusively described by a soft-thresholding function with just three parameters. This explanation provided excellent matches with in vivo recordings of cerebellar Purkinje neurons, supporting its validity.
Article
Multidisciplinary Sciences
Preeti F. Sareen, Li Yan McCurdy, Michael N. Nitabach
Summary: Feeding decisions in fruit flies are influenced by neural activity in a small population of neurons projecting to the fan-shaped body, integrating internal state, decision-relevant information, and previous experience. These neurons encode behavioral food choice and are inhibited by taste of the rejected food, highlighting the involvement of both taste quality and hunger state in decision-making.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Electrical & Electronic
Dechun Zhao, Shuyang Jiao, Huan Chen, Xiaorong Hou
Summary: The development of microelectrode arrays and multichannel recordings has allowed for high-precision detection in signal processing. The study of neuronal frontal potentials has become increasingly important in brain-computer interface and neuroscience research. Spike detection plays a crucial role in neuronal analysis, and the accuracy of this detection is influenced by feature extraction and classification. However, accurately detecting spike potentials in noisy signals poses a challenge. The authors propose a heuristic adaptive threshold spike-detection algorithm that effectively removes noise and achieves robust spike detection.
IET SIGNAL PROCESSING
(2023)
Article
Biochemistry & Molecular Biology
Nathan Harris, Samuel G. Bates, Zihao Zhuang, Matthew Bernstein, Jamie M. Stonemetz, Tyler J. Hill, Yanxun V. Yu, John A. Calarco, Piali Sengupta
Summary: Neurons modify their transcriptomes in response to an animal's experience, and specific experiences transduce to modulate gene expression and precisely tune neuronal functions. In this study, the molecular profile of a thermosensory neuron pair in C. elegans experiencing different temperature stimuli is described. The results reveal that distinct features of the temperature stimulus are encoded in the gene expression program in this single neuron type, and specific transcriptional dynamics of certain genes are essential for neuronal, behavioral, and developmental plasticity.
Article
Multidisciplinary Sciences
Yang Yiling, Katharine Shapcott, Alina Peter, Johanna Klon-Lipok, Huang Xuhui, Andreea Lazar, Wolf Singer
Summary: Parallel multisite recordings in the visual cortex of trained monkeys revealed that responses of spatially distributed neurons to natural scenes are ordered in sequences, and the rank order of these sequences is stimulus-specific and maintained even with modified absolute timing. The response sequences result from a matching operation between sensory evidence and priors stored in the cortical network, and they can be decoded to identify stimuli using shorter response intervals than rate vectors.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Tuan Pham, Christian Hansel
Summary: Activity-dependent changes in membrane excitability are a form of cell-autonomous plasticity that can affect learning and the resolution of input representation.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Engineering, Electrical & Electronic
Wei Lu, Junhong Zhang, Xianfeng Zhao, Weiming Zhang, Jiwu Huang
Summary: This paper proposes a secure robust JPEG steganographic scheme based on an autoencoder and adaptive BCH encoding to prevent secret messages from being damaged during transmission in social networks. The autoencoder is pretrained to fit the transformation relationship between JPEG images before and after compression, and the BCH encoding is adaptively utilized to decrease the error rate of secret message extraction. DCT coefficient adjustment based on practical JPEG channel characteristics further improves the robustness and statistical security of the proposed scheme, which outperforms prior state-of-the-art schemes in terms of robust performance and statistical security.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY
(2021)
Article
Biology
Kathryn E. Kistler, Trevor Bedford
Summary: Seasonal coronaviruses, including OC43 and 229E, are undergoing adaptive evolution in regions of the viral spike protein exposed to human immune response, potentially leading to reinfection. This adaptive change may require continual vaccine updates for effective protection against these viruses.
Article
Computer Science, Artificial Intelligence
Igor Kulachenko, Polina Kononova
Summary: In the oil and gas industry, auxiliary maintenance and storage buildings need to be constructed near exploration sites. Mobile drilling rigs travel from one site to another, drilling wells for construction. Work deviations from expected values are maximized while keeping traveling costs below a threshold. This research proposes a mathematical model and algorithm to solve the Drilling Rig Routing Problem with uncertainties.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Engineering, Aerospace
Qieqie Zhang, Luodi Zhao, Long Zhao
Summary: The paper introduces a two-step robust adaptive filtering algorithm that enhances the stability and reliability of positioning results by handling abnormal observations and model disturbances in two separate filtering steps.
CHINESE JOURNAL OF AERONAUTICS
(2021)
Article
Computer Science, Information Systems
A. Siyuan Su, B. Jian Wu, C. Hu Yan, D. Houbiao Liu
Summary: Depth completion is a fundamental method for autonomous vehicles and robotics to acquire precise depth maps. However, fusing multi-model features and restoring details are still two main challenges. In this study, we propose a fusion net composed of two-branch backbone and depth refinement module, achieving state-of-the-art performance in depth completion tasks.
Article
Chemistry, Multidisciplinary
Lu Xiao, Yong Woong Jun, Eric T. Kool
Summary: This study presents a novel TRAIL method for site-selective labeling and manipulation of mRNA through a DNA tiling strategy, which can be applied to various in vitro and in cell studies, including analysis of RNA-binding proteins, mRNA imaging in cells, and analysis and control of translation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Electrical & Electronic
Yingqi Liang, Junbo Zhao, Pierluigi Siano, Dipti Srinivasan
Summary: This paper proposes a new data-driven approach for estimating sparse voltage sensitivity in large-scale distribution systems with PVs. The approach effectively mitigates the impact of PV stochasticity and unknown measurement noise under different system operating conditions. The proposed method includes adaptively-weighted l(1) sparsity-promoting regularization, l(2) regularization, Huber loss function, and concomitant scale estimate, implemented in a fast recursive parallel computing framework. Simulation results demonstrate the robustness and efficiency of the proposed estimator compared to existing alternatives.
IEEE TRANSACTIONS ON POWER SYSTEMS
(2023)
Article
Computer Science, Artificial Intelligence
Qiang Yu, Yanli Yao, Longbiao Wang, Huajin Tang, Jianwu Dang, Kay Chen Tan
Summary: The article proposes a spike-based framework for environmental sound recognition, integrating sparse encoding, efficient learning, and robust readout. Experimental results demonstrate that the framework outperforms baseline approaches, with advantages such as early decision making, small dataset acquiring, and ongoing dynamic processing.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2021)
Editorial Material
Neurosciences
Koen Kole, Yiping Zhang, Eric J. R. Jansen, Terence Brouns, Ate Bijlsma, Niccolo Calcini, Xuan Yan, Angelica da Silva Lantyer, Tansu Celikel
NATURE NEUROSCIENCE
(2020)
Article
Neurosciences
Ashutosh Mishra, Bernhard Englitz, Michael X. Cohen
Article
Neurosciences
Abed Ghanbari, Naixin Ren, Christian Keine, Carl Stoelzel, Bernhard Englitz, Harvey A. Swadlow, Ian H. Stevenson
JOURNAL OF NEUROSCIENCE
(2020)
Article
Biochemical Research Methods
A. Ivanenko, P. Watkins, M. A. J. van Gerven, K. Hammerschmidt, B. Englitz
PLOS COMPUTATIONAL BIOLOGY
(2020)
Article
Neuroimaging
U. Gorska, A. Rupp, T. Celikel, B. Englitz
Summary: Utilizing complex acoustic stimuli to trigger EEG responses could potentially serve as an objective criterion for distinguishing levels of consciousness in clinical patients, providing a cost-effective tool for selecting appropriate treatments for non-responsive PDOC patients.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Michael X. Cohen, Bernhard Englitz, Arthur S. C. Franca
Summary: Neural activity is coordinated across multiple spatial and temporal scales, with patterns of coordination implicated in both healthy and impaired cognitive operations. A constellation of multidimensional, inter-regional networks was identified, reproducible within animals across different recording sessions but varied across different animals. The theta band networks showed several prominent features, including equal contribution from all regions and strong inter-network synchronization.
Article
Neurosciences
A. Mishra, N. Marzban, M. X. Cohen, B. Englitz
Summary: The study on rats revealed stable neural microstates within and across brain regions, showing rhythmic patterns of coactivations which may serve as an indicator of inter-regional synchronization. These rhythmic coactivation patterns of microstates were modulated by behavioral states such as movement and exploration.
JOURNAL OF NEUROSCIENCE
(2021)
Editorial Material
Neurosciences
Judith R. Homberg, Roger A. H. Adan, Natalia Alenina, Antonis Asiminas, Michael Bader, Tom Beckers, Denovan P. Begg, Arjan Blokland, Marilise E. Burger, Gertjan van Dijk, Ulrich L. M. Eisel, Ype Elgersma, Bernhard Englitz, Antonio Fernandez-Ruiz, Carlos P. Fitzsimons, Anne-Marie van Dam, Peter Gass, Joanes Grandjean, Robbert Havekes, Marloes J. A. G. Henckens, Christiane Herden, Roelof A. Hut, Wendy Jarrett, Kate Jeffrey, Daniela Jezova, Andries Kalsbeek, Maarten Kamermans, Martien J. Kas, Nael Nadif Kasri, Amanda J. Kiliaan, Sharon M. Kolk, Aniko Korosi, S. Mechiel Korte, Tamas Kozicz, Steven A. Kushner, Kirk Leech, Klaus-Peter Leech, Heidi Lesscher, Paul J. Lucassen, Anita Luthi, Liya Ma, Anne S. Mallien, Peter Meerlo, Jorge F. Mejias, Frank J. Meye, Anna S. Mitchell, Joram D. Mul, Umberto Olcese, Azahara Oliva Gonzalez, Jocelien D. A. Oliver, Massimo Pasqualetti, CyrielM. A. Pennartz, Piotr Popik, Jos Prickaerts, Liset M. de la Prida, Sidarta Ribeiro, Benn Roozendaal, Janine I. Rossato, Ali-Akbar Salari, Regien G. Schoemaker, August B. Smit, Tomonori Takeuchi, Rixt van der Veen, Marten P. Smidt, Vladyslav V. Vyazovskiy, Maximilian Wiesmann, Corette J. Wierenga, Bella Williams, Ingo Willuhn, Markus Woehr, Monique Wolvekamp, Eddy A. van der Zee, Lisa Genzel, Louk J. M. J. Vanderschuren
Summary: Policymakers are working towards promoting animal-free alternatives in scientific research and have implemented strict regulations for animal research. However, in the field of neuroscience research, it is argued that the use of animals should not be compromised until viable and translational alternatives are available and proven to be valuable.
Article
Computer Science, Interdisciplinary Applications
Chao Huang, Fleur Zeldenrust, Tansu Celikel
Summary: The study utilized a network model of cortical columns for simulations, finding that the simulated network replicated properties of touch representations and changes in synaptic strength. The simulations revealed the importance of the history of membrane potential in synaptic integration.
Article
Robotics
Yulia Sandamirskaya, Mohsen Kaboli, Jorg Conradt, Tansu Celikel
Summary: This viewpoint provides an overview of recent insights from neuroscience that could enhance signal processing in artificial neural networks on chip, unlocking innovative applications in robotics and autonomous intelligent systems.
Editorial Material
Neurosciences
Andre Rupp, Bernhard Englitz, Emili Balaguer-Ballester, Martin Andermann
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Biology
Thijs L. van der Plas, Jerome Tubiana, Guillaume Le Goc, Geoffrey Migault, Michael Kunst, Herwig Baier, Volker Bormuth, Bernhard Englitz, Georges Debregeas
Summary: In this study, the activity of 40,000 neurons in zebrafish larvae was recorded, and a data-driven generative model called the compositional Restricted Boltzmann Machine (cRBM) was able to accurately reproduce the mean activity and pairwise correlation statistics of their spontaneous activity. The cRBM model revealed the existence of 200 neural assemblies, which form successive brain states.
Article
Multidisciplinary Sciences
Gabriel Oliveira-Stahl, Soha Farboud, Max L. Sterling, Jesse J. Heckman, Bram van Raalte, Dionne Lenferink, Amber van der Stam, Cleo J. L. M. Smeets, Simon E. Fisher, Bernhard Englitz
Summary: Mice emit a variety of vocalizations during social interactions, especially during sexually motivated dyadic interactions. Accurately attributing these vocalizations to their emitter is important for understanding social vocal behaviors. This study introduces a novel algorithm, SLIM, which improves the accuracy of sound localization and allows reliable assignment of 84.3% of all ultrasonic vocalizations in the dataset. Applying SLIM to courtship interactions between mice reveals that vocalization behavior is dependent on the spatial relation between the interacting mice and the genotype. These findings enhance our understanding of social vocal behaviors.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Ana B. Lao-Rodriguez, Karol Przewrocki, David Perez-Gonzalez, Artoghrul Alishbayli, Evrim Yilmaz, Manuel S. Malmierca, Bernhard Englitz
Summary: Prediction is crucial for survival, and cognitive studies indicate that the brain can make multilevel predictions. However, neuronal evidence for predictions has been difficult to find due to the challenge of separating neural activity related to predictions from stimulus responses. In this study, we recorded single-neuron activity from auditory regions in both anesthetized and awake animals and observed reliable responses to omitted tones, providing empirical evidence for the implementation of predictive processes.
Correction
Biochemistry & Molecular Biology
Lisa Genzel, Roger Adan, Anton Berns, Jeroen J. J. P. van den Beucken, Arjan Blokland, Erik H. W. G. M. Boddeke, Willy M. Bogers, Ronald Bontrop, R. Bulthuis, Teun Bousema, Hans Clevers, Tineke C. J. J. Coenen, Anne-Marie van Dam, Peter M. T. Deen, K. W. van Dijk, Bart J. L. Eggen, Ype Elgersma, Izel Erdogan, Bernhard Englitz, J. Martje Fentener van Vlissingen, Susanne la Fleur, Ron Fouchier, Carlos P. Fitzsimons, Wilbert Frieling, Bart Haagmans, Balthasar A. Heesters, Marloes J. A. G. Henckens, Sander Herfst, Elly Hol, Daniel van den Hove, Marien I. de Jonge, Jos Jonkers, Leo A. B. Joosten, Andries Kalsbeek, Maarten Kamermans, Harm H. Kampinga, Martien J. Kas, Jaap Keijer, Sander Kersten, Amanda J. Kiliaan, Taco W. A. Kooij, Sander Kooijman, Werner J. H. Koopman, Aniko Korosi, Harm J. Krugers, Thijs Kuiken, Steven A. Kushner, Jan A. M. Langermans, Heidi M. B. Lesscher, Paul J. Lucassen, Esther Lutgens, Mihai G. Netea, Lucas P. J. J. Noldus, Jos W. M. van der Meer, Frank J. Meye, Joram D. Mul, Kees van Oers Jocelien D. A. Olivier, R. Jeroen Pasterkamp, Ingrid H. C. H. M. Philippens, Jos Prickaerts, B. J. A. Pollux, Patrick C. N. Rensen, Jacco van Rheenen, Ronald P. van Rij, Laila Ritsma, Barry. H. G. Rockx, Benno Roozendaal, Evert M. van Schothorst, K. Stittelaar, Norbert Stockhofe, Dick F. Swaab, Rik L. de Swart, Louk J. M. J. Vanderschuren, Taco J. de Vries, Femke de Vrij, Richard van Wezel, Corette J. Wierenga, Maximilian Wiesmann, Ingo Willuhn, Chris I. de Zeeuw, Judith R. Homberg