Systematic analysis of thePTEN5′ leader identifies a major AUU initiated proteoform

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity

(2015) G. R. Masson et al.   BIOCHEMICAL JOURNAL

Conformational Stability and Catalytic Activity of PTEN Variants Linked to Cancers and Autism Spectrum Disorders

(2015) Sean B. Johnston et al.   BIOCHEMISTRY

Identification of intrinsically disordered regions in PTEN and delineation of its function via a network approach

(2015) Prerna Malaney et al.   METHODS

Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex

(2015) Jose L. Llácer et al.   MOLECULAR CELL

Ribosome Structure Reveals Preservation of Active Sites in the Presence of a P-Site Wobble Mismatch

(2015) Egor Svidritskiy et al.   STRUCTURE

Translation of 5′ leaders is pervasive in genes resistant to eIF2 repression

(2015) Dmitry E Andreev et al.   eLife

Catalysis by the Tumor-Suppressor Enzymes PTEN and PTEN-L

(2015) Sean B. Johnston et al.   PLoS One

Relevance and Therapeutic Possibility of PTEN-Long in Renal Cell Carcinoma

(2015) Hui Wang et al.   PLoS One

The Scanning Mechanism of Eukaryotic Translation Initiation

(2014) Alan G. Hinnebusch   Annual Review of Biochemistry

Computational approach for calculating the probability of eukaryotic translation initiation from ribo-seq data that takes into account leaky scanning

(2014) Audrey M Michel et al.   BMC BIOINFORMATICS

Structural Changes Enable Start Codon Recognition by the Eukaryotic Translation Initiation Complex

(2014) Tanweer Hussain et al.   CELL

Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function

(2014) Antonella Papa et al.   CELL

PTENα, a PTEN Isoform Translated through Alternative Initiation, Regulates Mitochondrial Function and Energy Metabolism

(2014) Hui Liang et al.   Cell Metabolism

N-terminal Proteomics and Ribosome Profiling Provide a Comprehensive View of the Alternative Translation Initiation Landscape in Mice and Men

(2014) Petra Van Damme et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative analysis of mammalian translation initiation sites by FACS-seq

(2014) W. L. Noderer et al.   Molecular Systems Biology

A Unified Nomenclature and Amino Acid Numbering for Human PTEN

(2014) R. Pulido et al.   Science Signaling

Imaging of neurosphere oxygenation with phosphorescent probes

(2013) Ruslan I. Dmitriev et al.   BIOMATERIALS

TOR and S6K1 promote translation reinitiation of uORF-containing mRNAs via phosphorylation of eIF3h

(2013) Mikhail Schepetilnikov et al.   EMBO JOURNAL

The PTEN Long N-tail is intrinsically disordered: increased viability for PTEN therapy

(2013) Prerna Malaney et al.   Molecular BioSystems

GWIPS-viz: development of a ribo-seq genome browser

(2013) Audrey M. Michel et al.   NUCLEIC ACIDS RESEARCH

Regulation of the Tumor Suppressor PTEN through Exosomes: A Diagnostic Potential for Prostate Cancer

(2013) Kathleen Gabriel et al.   PLoS One

A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival

(2013) B. D. Hopkins et al.   SCIENCE

Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting

(2012) C. Fritsch et al.   GENOME RESEARCH

Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution

(2012) S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leucine-tRNA Initiates at CUG Start Codons for Protein Synthesis and Presentation by MHC Class I

(2012) S. R. Starck et al.   SCIENCE

The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

(2012) U. Putz et al.   Science Signaling

Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes

(2011) Nicholas T. Ingolia et al.   CELL

Functional Elements in Initiation Factors 1, 1A, and 2  Discriminate against Poor AUG Context and Non-AUG Start Codons

(2011) P. Martin-Marcos et al.   MOLECULAR AND CELLULAR BIOLOGY

Stringency of start codon selection modulates autoregulation of translation initiation factor eIF5

(2011) Gary Loughran et al.   NUCLEIC ACIDS RESEARCH

Identification of evolutionarily conserved non-AUG-initiated N-terminal extensions in human coding sequences

(2011) Ivaylo P. Ivanov et al.   NUCLEIC ACIDS RESEARCH

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Update of the FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation

(2010) H. Kawaji et al.   NUCLEIC ACIDS RESEARCH

Initiation context modulates autoregulation of eukaryotic translation initiation factor 1 (eIF1)

(2010) I. P. Ivanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly

(2009) Elizabeth A Varga et al.   GENETICS IN MEDICINE

eIF1 Controls Multiple Steps in Start Codon Recognition during Eukaryotic Translation Initiation

(2009) Jagpreet S. Nanda et al.   JOURNAL OF MOLECULAR BIOLOGY

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans

(2009) S. E. Calvo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

Should I Stay or Should I Go? Eukaryotic Translation Initiation Factors 1 and 1A Control Start Codon Recognition

(2008) Sarah F. Mitchell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the 30S translation initiation complex

(2008) Angelita Simonetti et al.   NATURE