Article
Clinical Neurology
Lisanne J. Dommershuijsen, Alis Heshmatollah, Francesco U. S. Mattace Raso, Peter J. Koudstaal, M. Arfan Ikram, M. Kamran Ikram
Summary: Orthostatic hypotension is common in patients with Parkinson's disease (PD), but our study found that it is not significantly associated with an increased risk of PD in the general population.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Yaping Liu, Jihui Zhang, Steven W. H. Chau, Mandy Wai Man Yu, Ngan Yin Chan, Joey W. Y. Chan, Shirley Xin Li, Bei Huang, Jing Wang, Hongliang Feng, Li Zhou, Vincent Mok, Yun Kwok Wing
Summary: This study found that pRBD has a predictive progression in both pathophysiology and neurodegenerative outcome. This has significant implications for the nosological status of pRBD, the current REM sleep-related EMG diagnostic criteria, spectrum concept of RBD, and future neuroprotective interventions.
Article
Clinical Neurology
Jiahao Zhao, Ying Wan, Lu Song, Na Wu, Zien Zhang, Zhenguo Liu, Jing Gan
Summary: A risk prediction model for the future onset of freezing of gait (FOG) in Parkinson's disease (PD) patients has been developed based on a multicenter cohort study in China. Duration of the disease, levodopa dosage, and severity of depressive symptoms were identified as the strongest predictors of future FOG onset.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Beata Lindholm, Christina Brogardh, Per Odin, Peter Hagell
Summary: The study identified predictors for falls/near falls in Parkinson’s disease, including history of falls, abnormal tandem gait, and lower MMSE scores. These factors not only affect the fall risk in the short term but also in the long term among patients with PD.
JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Camila Henriques de Aquino
Summary: Alzheimer's disease and Parkinson's disease are common neurodegenerative disorders with no approved disease-modifying therapies. Advances in biomarker research have improved early identification of individuals at risk and different disease stages. However, clinical trials at these early stages face challenges such as identifying eligible populations and selecting appropriate biomarkers.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Srishti Shrestha, Christine G. Parks, Marie Richards-Barber, Honglei Chen, Dale P. Sandler
Summary: In this retrospective PD case identification effort within the Agricultural Health Study, self-reported PD cases with information on motor symptoms or medication use may serve as a reasonable alternative when physician-based confirmation is not feasible. The majority of potential PD cases were confirmed as probable or possible PD through medical record review.
Article
Clinical Neurology
Sokratis Charisis, Eva Ntanasi, Maria Stamelou, Georgia Xiromerisiou, Maria Maraki, Aristidis S. Veskoukis, Mary Yannakoulia, Mary H. Kosmidis, Costas A. Anastasiou, Nikolaos Giagkou, Efthimios Dardiotis, Georgios Hadjigeorgiou, Paraskevi Sakka, Demetrios Kouretas, Leonidas Stefanis, Nikolaos Scarmeas
Summary: The study explores the potential role of plasma GSH as a risk/susceptibility biomarker for prodromal PD and finds that higher plasma GSH levels are associated with slower increases in pPD probability, potentially aiding in the identification of individuals likely to be diagnosed with pPD more rapidly.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Gaiyan Zhou, Jingru Ren, Danyan Rong, Hao Zhou, Houxu Ning, Hui Wang, Chenxi Pan, Yajie Wang, Ronggui Zhang, Zhiying Guo, Peiyu Huang, Weiguo Liu
Summary: The study investigated the changes of substantia nigra (SN) free water values in prodromal and clinical stages of Parkinson's disease (PD). The results showed that SN free water values increased in prodromal stages but decreased in early clinical stages. The study also found a positive correlation between SN free water values and motor symptoms. These findings suggest that SN free water may serve as a potential marker for diagnosing and monitoring PD.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Gaiyan Zhou, Jingru Ren, Danyan Rong, Hao Zhou, Houxu Ning, Hui Wang, Chenxi Pan, Yajie Wang, Ronggui Zhang, Zhiying Guo, Peiyu Huang, Weiguo Liu
Summary: The free water content in the substantia nigra (SN) is significantly different between the prodromal stage (pPD) and early clinical stage (dnPD) of Parkinson's disease. However, in the late disease stage, the trend of free water content may be reversed. These findings are important for the early diagnosis and monitoring of disease progression in Parkinson's disease.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Eva Schaeffer, Inken Toedt, Susanne Koehler, Annette Rogge, Daniela Berg
Summary: Significant progress has been made in understanding the prodromal phase of Parkinson's disease, leading to the development of disease prediction models. However, diagnostic uncertainty and lack of therapeutic options have raised ethical issues that need further attention. The differentiation between individuals with and without REM sleep behavior disorder (RBD) is crucial in prognostic counseling for prodromal PD.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Ming-Wei Sia, Jia-Nee Foo, Seyed-Ehsan Saffari, Aidan Sheng-Yong Wong, Chiea-Chuen Khor, Jian-Min Yuan, Eng-King Tan, Woon-Puay Koh, Louis Chew-Seng Tan
Summary: In a population-based Asian cohort study, a polygenic risk score (PRS) was found to be significantly associated with Parkinson's disease (PD) incidence. Participants with PRS in the top tertile and middle tertile were at higher risk of developing PD, as supported by Kaplan-Meier survival analysis results.
MOVEMENT DISORDERS
(2021)
Article
Geriatrics & Gerontology
Xiaoxia Zhou, Yaqin Xiang, Tingwei Song, Yuwen Zhao, Hongxu Pan, Qian Xu, Yase Chen, Qiying Sun, Xinyin Wu, Xinxiang Yan, Jifeng Guo, Beisha Tang, Lifang Lei, Zhenhua Liu
Summary: This study aimed to assess the prevalence, evolution, clinical characteristics, correlates and predictors of fatigue in Parkinson's disease (PD) patients, as well as investigate the influence of comorbid fatigue on longitudinal changes in motor and non-motor symptoms over a 2-year follow-up period. The study found that fatigue was present in 36.8% of PD patients and was associated with older age, longer disease duration, and higher baseline levodopa equivalent daily dose. PD patients with fatigue had more severe motor and non-motor symptoms compared to those without fatigue.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Joe Verghese, Pierfilippo De Sanctis, Emmeline Ayers
Summary: This study found that there are limitations in everyday function in the early clinical stages of cognitive decline, which can serve as warning signs for pre-MCI.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Stephen Joza, Michele T. Hu, Ki-Young Jung, Dieter Kunz, Ambra Stefani, Petr Dusek, Michele Terzaghi, Dario Arnaldi, Aleksandar Videnovic, Mya C. Schiess, Wiebke Hermann, Jee-Young Lee, Luigi Ferini-Strambi, Simon J. G. Lewis, Laurene Leclair-Visonneau, Wolfgang H. Oertel, Elena Antelmi, Friederike Sixel-Doering, Valerie Cochen De Cock, Claudio Liguori, Jun Liu, Federica Provini, Monica Puligheddu, Alessandra Nicoletti, Claudio L. A. Bassetti, Jitka Buskova, Yves Dauvilliers, Raffaele Ferri, Jacques Y. Montplaisir, Michael Lawton, Han-Joon Kim, Frederik Bes, Birgit Hoegl, Karel Sonka, Giuseppe Fiamingo, Pietro Mattioli, Maria Lorena Lavadia, Jessika Suescun, Kyung Ah Woo, Sara Marelli, Kaylena Ehgoetz Martens, Annette Janzen, Giuseppe Plazzi, Brit Mollenhauer, Mariana Fernandes, Yuanyuan Li, Pietro Cortelli, Michela Figorilli, Calogero Edoardo Cicero, Carolin Schaefer, Lily Guiraud, Giuseppe Lanza, Jean-Francois Gagnon, Jun-Sang Sunwoo, Abubaker Ibrahim, Nicola Girtler, Claudia Trenkwalder, Luca Baldelli, Amelie Pelletier, Ronald B. Postuma
Summary: The synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, have a long prodromal period with progressive subclinical symptoms. Idiopathic REM sleep behavior disorder is an early predictor of these diseases and provides an opportunity for intervention with neuroprotective therapy.
Review
Neurosciences
Thomas Koeglsperger, Svenja-Lotta Rumpf, Patricia Schliesser, Felix L. Struebing, Matthias Brendel, Johannes Levin, Claudia Trenkwalder, Guenter U. Hoeglinger, Jochen Herms
Summary: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons. Previous studies have identified cellular and molecular changes that occur before the appearance of Lewy bodies (LBs) in these neurons. Understanding these early pathological events may help in the development of therapeutic and diagnostic strategies for PD.
MOLECULAR NEURODEGENERATION
(2023)
Article
Medicine, Research & Experimental
Zi H. Su, Salil Patel, Bronwyn Gavine, Tim Buchanan, Marko Bogdanovic, Nagaraja Sarangmat, Alexander L. Green, Bastiaan R. Bloem, James J. FitzGerald, Chrystalina A. Antoniades
Summary: This study compared the effects of dopaminergic medication and subthalamic nucleus deep brain stimulation (STN DBS) on gait variability in Parkinson disease patients. The results showed that STN DBS reduced short-term variability in lower limb gait parameters, while medication did not have this effect. In addition, STN DBS had no effect on arm swing and trunk motion variability, while medication increased them.
Article
Clinical Neurology
Henrieke L. Frequin, Jason Schouten, Constant V. M. Verschuur, Sven R. Suwijn, Judith A. Boel, Bart Post, Bastiaan R. Bloem, Johannes J. van Hilten, Teus van Laar, Gerrit Tissingh, Alexander G. Munts, Joke M. Dijk, Gunther Deuschl, Anthony Lang, Marcel G. W. Dijkgraaf, Rob J. de Haan, Rob M. A. de Bie
Summary: The study found that levodopa had similar effects on bradykinesia, rigidity, and tremor in patients with early Parkinson's disease. The improvements in symptoms were larger at 22 weeks compared to 4 weeks. At 80 weeks, fewer patients in the early-start group experienced motor response fluctuations.
Article
Gastroenterology & Hepatology
Denis Revskij, Jakob Runst, Camilla Umstaetter, Luise Ehlers, Sarah Rohde, Dietmar Zechner, Manuela Bastian, Brigitte Mueller-Hilke, Georg Fuellen, Larissa Henze, Hugo Murua Escobar, Christian Junghanss, Axel Kowald, Uwe Walter, Ruediger Koehling, Olaf Wolkenhauer, Robert Jaster
Summary: This study investigates the relationship between Ucp2 and the microenvironment of pancreatic ductal adenocarcinoma (PDAC) using a model of accelerated aging. The results suggest that Ucp2 promotes tumor growth and is associated with the stromal response in the tumor microenvironment.
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2023)
Article
Clinical Neurology
Ulf Jensen-Kondering, Nils G. Margraf, Caroline Weiler, Walter Maetzler, Justina Dargvainiene, Kim Falk, Sarah Philippen, Thorsten Bartsch, Charlotte Flueh, Christoph Roecken, Bettina Moeller, Georg Royl, Alexander Neumann, Norbert Brueggemann, Benjamin Roeben, Claudia Schulte, Benjamin Bender, Daniela Berg, Gregor Kuhlenbaeumer
Summary: This study compared the clinical, radiological, and cerebrospinal fluid marker data of patients with CAA, MLH, AD, and healthy controls. The results showed that cSS was more common in CAA, and MLH with cSS was associated with ICH. The concentrations of cerebrospinal fluid markers differed among the groups.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Bernd Leplow, Daniela Renftle, Mareike Thomas, Katja Michaelis, Susanne Solbrig, Walter Maetzler, Daniela Berg, Inga Liepelt-Scarfone
Summary: Impulse control disorders (ICD) frequently occur in Parkinson's disease (PD), not always as a direct consequence of medication. This study investigated premorbid personality traits and behavioral characteristics in non-demented PD patients with self-reported symptoms of ICD (PD-srICD). It was found that patients with PD-srICD had similarities with substance use disorder patients, and thorough psychological diagnostics are recommended.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Editorial Material
Clinical Neurology
Milan Beckers, Bastiaan R. Bloem, Rick C. Helmich
JOURNAL OF MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Guenther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
MOVEMENT DISORDERS
(2023)
Article
Multidisciplinary Sciences
Meemansa Sood, Ulrike Suenkel, Anna-Katharina von Thaler, Helena U. U. Zacharias, Kathrin Brockmann, Gerhard W. Eschweiler, Walter Maetzler, Daniela Berg, Holger Froehlich, Sebastian Heinzel
Summary: Parkinson's disease (PD) has a long prodromal phase with many markers indicating an increased risk prior to clinical diagnosis. Current prediction models lack consideration of interdependencies between predictors and differentiation by subtypes, and may be limited by confounding factors and restricted data access. Using AI and a Bayesian network, we analyzed data from 1178 healthy individuals and 24 incident PD cases to quantify marker interdependencies and generate synthetic profiles. We identified robust interdependencies and demonstrated the usefulness of AI in modeling and understanding PD markers.
Article
Neurosciences
Odette Fruendt, Anne-Marie Hanff, Annika Moehl, Tobias Mai, Christiane Kirchner, Ali Amouzandeh, Carsten Buhmann, Rejko Kruger, Martin Suedmeyer
Summary: Data on the use of device-aided therapies (DATs) in people with Parkinson's disease (PwP) are scarce. German DAT application rate is rather low, indicating a need for precise identification of symptoms and implementation in future treatment strategies.
Review
Clinical Neurology
Anneli Langbroek-Amersfoort, Sabine Schootemeijer, Lars Bouten, Bastiaan R. Bloem, Nienke M. De Vries
Summary: There is increasing evidence supporting the positive effects of community-based exercise for individuals with Parkinson's disease. However, the studies on this topic vary greatly in terms of exercise types, study designs, and outcome measures. While this review acknowledges the feasibility and potential benefits of community-based exercise, it also emphasizes the need for improvement in the overall quality of these studies.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2023)
Article
Neurosciences
Cameron Kirk, Rana Zia Ur Rehman, Brook Galna, Lisa Alcock, Saverio Ranciati, Luca Palmerini, Judith Garcia-Aymerich, Clint Hansen, Eva Schaeffer, Daniela Berg, Walter Maetzler, Lynn Rochester, Silvia Del Din, Alison J. Yarnall
Summary: This study aimed to explore the differences in real-world walking speed (RWS) between Parkinson's disease (PD) patients and older adults (OAs) cross-sectionally and longitudinally, as well as its relationship with motor disease severity. The results showed that PD patients had significantly lower RWS compared to OAs, and the decline in RWS over time was more rapid in PD. Furthermore, there was a significant negative relationship between RWS and the MDS-UPDRS III only at a specific walking bout threshold.
JOURNAL OF PARKINSONS DISEASE
(2023)
Review
Clinical Neurology
Carlo Alberto Artusi, Christian Geroin, Jorik Nonnekes, Camila Aquino, Divyani Garg, Marian L. Dale, Darbe Schlosser, Yijie Lai, Mohammad Al-Wardat, Mehri Salari, Robin Wolke, Valery Tsinda Labou, Gabriele Imbalzano, Serena Camozzi, Marcelo Merello, Bastiaan R. Bloem, Tamine Capato, Ruth Djaldetti, Karen Doherty, Alfonso Fasano, Houyam Tibar, Leonardo Lopiano, Nils G. Margraf, Caroline Moreau, Yoshikazu Ugawa, Roongroj Bhidayasiri, Michele Tinazzi
Summary: Axial postural abnormalities are common in patients with Parkinson's disease and atypical parkinsonism, and have a significant impact on the patients' quality of life. However, there is limited understanding of the pathophysiology and clinical predictors of these symptoms, highlighting the need for further research in this area.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Editorial Material
Clinical Neurology
Tessa F. Peerbolte, Rozanne J. A. van Diggelen, Marjan J. Meinders, Bastiaan R. Bloem, Sanne W. van den Berg
PRACTICAL NEUROLOGY
(2023)
Review
Medicine, General & Internal
Felix Klawitter, Uwe Walter, Hubertus Axer, Robert Patejdl, Johannes Ehler
Summary: Intensive care unit-acquired weakness (ICUAW) is a common cause of muscle atrophy and functional disability in critically ill patients. Evaluating ICUAW is challenging due to sedation, delirium, and cognitive impairment. While invasive methods like muscle biopsies and nerve conduction studies have been attempted, they are impractical for daily use in intensive care medicine. Non-invasive neuromuscular ultrasound (NMUS) shows promise in detecting and monitoring muscle and nerve alterations in ICUAW, with potential for predicting patient outcome. This review highlights the current state and future opportunities of NMUS in ICUAW.
MEDICINA-LITHUANIA
(2023)
Letter
Clinical Neurology
Daniele Caliendo, Maria Carmela Grassia, Antonio Carotenuto, Maria Petracca, Roberta Lanzillo, Vincenzo Brescia Morra, Marcello Moccia
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)