Article
Clinical Neurology
Lisanne J. Dommershuijsen, Alis Heshmatollah, Francesco U. S. Mattace Raso, Peter J. Koudstaal, M. Arfan Ikram, M. Kamran Ikram
Summary: Orthostatic hypotension is common in patients with Parkinson's disease (PD), but our study found that it is not significantly associated with an increased risk of PD in the general population.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Yaping Liu, Jihui Zhang, Steven W. H. Chau, Mandy Wai Man Yu, Ngan Yin Chan, Joey W. Y. Chan, Shirley Xin Li, Bei Huang, Jing Wang, Hongliang Feng, Li Zhou, Vincent Mok, Yun Kwok Wing
Summary: This study found that pRBD has a predictive progression in both pathophysiology and neurodegenerative outcome. This has significant implications for the nosological status of pRBD, the current REM sleep-related EMG diagnostic criteria, spectrum concept of RBD, and future neuroprotective interventions.
Article
Clinical Neurology
Jiahao Zhao, Ying Wan, Lu Song, Na Wu, Zien Zhang, Zhenguo Liu, Jing Gan
Summary: A risk prediction model for the future onset of freezing of gait (FOG) in Parkinson's disease (PD) patients has been developed based on a multicenter cohort study in China. Duration of the disease, levodopa dosage, and severity of depressive symptoms were identified as the strongest predictors of future FOG onset.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Beata Lindholm, Christina Brogardh, Per Odin, Peter Hagell
Summary: The study identified predictors for falls/near falls in Parkinson’s disease, including history of falls, abnormal tandem gait, and lower MMSE scores. These factors not only affect the fall risk in the short term but also in the long term among patients with PD.
JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Camila Henriques de Aquino
Summary: Alzheimer's disease and Parkinson's disease are common neurodegenerative disorders with no approved disease-modifying therapies. Advances in biomarker research have improved early identification of individuals at risk and different disease stages. However, clinical trials at these early stages face challenges such as identifying eligible populations and selecting appropriate biomarkers.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Srishti Shrestha, Christine G. Parks, Marie Richards-Barber, Honglei Chen, Dale P. Sandler
Summary: In this retrospective PD case identification effort within the Agricultural Health Study, self-reported PD cases with information on motor symptoms or medication use may serve as a reasonable alternative when physician-based confirmation is not feasible. The majority of potential PD cases were confirmed as probable or possible PD through medical record review.
Article
Clinical Neurology
Sokratis Charisis, Eva Ntanasi, Maria Stamelou, Georgia Xiromerisiou, Maria Maraki, Aristidis S. Veskoukis, Mary Yannakoulia, Mary H. Kosmidis, Costas A. Anastasiou, Nikolaos Giagkou, Efthimios Dardiotis, Georgios Hadjigeorgiou, Paraskevi Sakka, Demetrios Kouretas, Leonidas Stefanis, Nikolaos Scarmeas
Summary: The study explores the potential role of plasma GSH as a risk/susceptibility biomarker for prodromal PD and finds that higher plasma GSH levels are associated with slower increases in pPD probability, potentially aiding in the identification of individuals likely to be diagnosed with pPD more rapidly.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Gaiyan Zhou, Jingru Ren, Danyan Rong, Hao Zhou, Houxu Ning, Hui Wang, Chenxi Pan, Yajie Wang, Ronggui Zhang, Zhiying Guo, Peiyu Huang, Weiguo Liu
Summary: The study investigated the changes of substantia nigra (SN) free water values in prodromal and clinical stages of Parkinson's disease (PD). The results showed that SN free water values increased in prodromal stages but decreased in early clinical stages. The study also found a positive correlation between SN free water values and motor symptoms. These findings suggest that SN free water may serve as a potential marker for diagnosing and monitoring PD.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Gaiyan Zhou, Jingru Ren, Danyan Rong, Hao Zhou, Houxu Ning, Hui Wang, Chenxi Pan, Yajie Wang, Ronggui Zhang, Zhiying Guo, Peiyu Huang, Weiguo Liu
Summary: The free water content in the substantia nigra (SN) is significantly different between the prodromal stage (pPD) and early clinical stage (dnPD) of Parkinson's disease. However, in the late disease stage, the trend of free water content may be reversed. These findings are important for the early diagnosis and monitoring of disease progression in Parkinson's disease.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Eva Schaeffer, Inken Toedt, Susanne Koehler, Annette Rogge, Daniela Berg
Summary: Significant progress has been made in understanding the prodromal phase of Parkinson's disease, leading to the development of disease prediction models. However, diagnostic uncertainty and lack of therapeutic options have raised ethical issues that need further attention. The differentiation between individuals with and without REM sleep behavior disorder (RBD) is crucial in prognostic counseling for prodromal PD.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Ming-Wei Sia, Jia-Nee Foo, Seyed-Ehsan Saffari, Aidan Sheng-Yong Wong, Chiea-Chuen Khor, Jian-Min Yuan, Eng-King Tan, Woon-Puay Koh, Louis Chew-Seng Tan
Summary: In a population-based Asian cohort study, a polygenic risk score (PRS) was found to be significantly associated with Parkinson's disease (PD) incidence. Participants with PRS in the top tertile and middle tertile were at higher risk of developing PD, as supported by Kaplan-Meier survival analysis results.
MOVEMENT DISORDERS
(2021)
Article
Geriatrics & Gerontology
Xiaoxia Zhou, Yaqin Xiang, Tingwei Song, Yuwen Zhao, Hongxu Pan, Qian Xu, Yase Chen, Qiying Sun, Xinyin Wu, Xinxiang Yan, Jifeng Guo, Beisha Tang, Lifang Lei, Zhenhua Liu
Summary: This study aimed to assess the prevalence, evolution, clinical characteristics, correlates and predictors of fatigue in Parkinson's disease (PD) patients, as well as investigate the influence of comorbid fatigue on longitudinal changes in motor and non-motor symptoms over a 2-year follow-up period. The study found that fatigue was present in 36.8% of PD patients and was associated with older age, longer disease duration, and higher baseline levodopa equivalent daily dose. PD patients with fatigue had more severe motor and non-motor symptoms compared to those without fatigue.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Joe Verghese, Pierfilippo De Sanctis, Emmeline Ayers
Summary: This study found that there are limitations in everyday function in the early clinical stages of cognitive decline, which can serve as warning signs for pre-MCI.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Stephen Joza, Michele T. Hu, Ki-Young Jung, Dieter Kunz, Ambra Stefani, Petr Dusek, Michele Terzaghi, Dario Arnaldi, Aleksandar Videnovic, Mya C. Schiess, Wiebke Hermann, Jee-Young Lee, Luigi Ferini-Strambi, Simon J. G. Lewis, Laurene Leclair-Visonneau, Wolfgang H. Oertel, Elena Antelmi, Friederike Sixel-Doering, Valerie Cochen De Cock, Claudio Liguori, Jun Liu, Federica Provini, Monica Puligheddu, Alessandra Nicoletti, Claudio L. A. Bassetti, Jitka Buskova, Yves Dauvilliers, Raffaele Ferri, Jacques Y. Montplaisir, Michael Lawton, Han-Joon Kim, Frederik Bes, Birgit Hoegl, Karel Sonka, Giuseppe Fiamingo, Pietro Mattioli, Maria Lorena Lavadia, Jessika Suescun, Kyung Ah Woo, Sara Marelli, Kaylena Ehgoetz Martens, Annette Janzen, Giuseppe Plazzi, Brit Mollenhauer, Mariana Fernandes, Yuanyuan Li, Pietro Cortelli, Michela Figorilli, Calogero Edoardo Cicero, Carolin Schaefer, Lily Guiraud, Giuseppe Lanza, Jean-Francois Gagnon, Jun-Sang Sunwoo, Abubaker Ibrahim, Nicola Girtler, Claudia Trenkwalder, Luca Baldelli, Amelie Pelletier, Ronald B. Postuma
Summary: The synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, have a long prodromal period with progressive subclinical symptoms. Idiopathic REM sleep behavior disorder is an early predictor of these diseases and provides an opportunity for intervention with neuroprotective therapy.
Review
Neurosciences
Thomas Koeglsperger, Svenja-Lotta Rumpf, Patricia Schliesser, Felix L. Struebing, Matthias Brendel, Johannes Levin, Claudia Trenkwalder, Guenter U. Hoeglinger, Jochen Herms
Summary: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons. Previous studies have identified cellular and molecular changes that occur before the appearance of Lewy bodies (LBs) in these neurons. Understanding these early pathological events may help in the development of therapeutic and diagnostic strategies for PD.
MOLECULAR NEURODEGENERATION
(2023)
Letter
Clinical Neurology
Jules M. Janssen Daalen, Jessica Hubbers, Mirmohsen Sharifi Bonab, Soania Mathur, Dick H. J. Thijssen, Bastiaan R. Bloem, Marjan J. Meinders
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Bastiaan R. Bloem, Erik Post, Deborah A. Hall
Summary: The Rune Labs Kinematics System, a smartwatch-based monitoring system, has been cleared by the FDA to remotely track motor impairments in Parkinson's disease. While this new digital approach shows promise, further validation studies are needed to determine its clinical significance and use in research.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Bernd Leplow, Daniela Renftle, Mareike Thomas, Katja Michaelis, Susanne Solbrig, Walter Maetzler, Daniela Berg, Inga Liepelt-Scarfone
Summary: Impulse control disorders (ICD) frequently occur in Parkinson's disease (PD), not always as a direct consequence of medication. This study investigated premorbid personality traits and behavioral characteristics in non-demented PD patients with self-reported symptoms of ICD (PD-srICD). It was found that patients with PD-srICD had similarities with substance use disorder patients, and thorough psychological diagnostics are recommended.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Neurosciences
Gabrielle Todd, Caroline D. Rae, Janet L. Taylor, Nigel C. Rogasch, Jane E. Butler, Michael Hayes, Robert A. Wilcox, Simon C. Gandevia, Karl Aoun, Adrian Esterman, Simon J. G. Lewis, Julie M. Hall, Elie Matar, Jana Godau, Daniela Berg, Christian Plewnia, Anna-Katharina Von Thaler, Clarence Chiang, Kay L. Double
Summary: Research has found that increased thickness of the substantia nigra in healthy older adults may be associated with changes in excitability of motor cortical circuitry. This finding has important implications for understanding brain changes in healthy older adults at risk of Parkinson's disease.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Clinical Neurology
Eva-Juliane Vollstedt, Susen Schaake, Katja Lohmann, Shalini Padmanabhan, Alexis Brice, Suzanne Lesage, Christelle Tesson, Marie Vidailhet, Isabel Wurster, Faycel Hentati, Anat Mirelman, Nir Giladi, Karen Marder, Cheryl Waters, Stanley Fahn, Meike Kasten, Norbert Bruggemann, Max Borsche, Tatiana Foroud, Eduardo Tolosa, Alicia Garrido, Grazia Annesi, Monica Gagliardi, Maria Bozi, Leonidas Stefanis, Joaquim J. Ferreira, Leonor Correia Guedes, Micol Avenali, Simona Petrucci, Lorraine Clark, Ekaterina Y. Fedotova, Natalya Y. Abramycheva, Victoria Alvarez, Manuel Menendez-Gonzalez, Silvia Jesus Maestre, Pilar Gomez-Garre, Pablo Mir, Andrea Carmine Belin, Caroline Ran, Chin-Hsien Lin, Ming-Che Kuo, David Crosiers, Zbigniew K. Wszolek, Owen A. Ross, Joseph Jankovic, Kenya Nishioka, Manabu Funayama, Jordi Clarimon, Caroline H. Williams-Gray, Marta Camacho, Mario Cornejo-Olivas, Luis Torres-Ramirez, Yih-Ru Wu, Guey-Jen Lee-Chen, Ana Morgadinho, Teeratorn Pulkes, Pichet Termsarasab, Daniela Berg, Gregor Kuhlenbaumer, Andrea A. Kuhn, Friederike Borngraeber, Giuseppe de Michele, Anna De Rosa, Alexander Zimprich, Andreas Puschmann, George D. Mellick, Jolanta Dorszewska, Jonathan Carr, Rosangela Ferese, Stefano Gambardella, Bruce Chase, Katerina Markopoulou, Wataru Satake, Tatsushi Toda, Malco Rossi, Marcelo Merello, Timothy Lynch, Diana A. Olszewska, Shen-Yang Lim, Azlina Ahmad-Annuar, Ai Huey Tan, Bashayer Al-Mubarak, Hasmet Hanagasi, Dariusz Koziorowski, Sibel Ertan, Gencer Genc, Patricia de Carvalho Aguiar, Melinda Barkhuizen, Marcia M. G. Pimentel, Rachel Saunders-Pullman, Bart van de Warrenburg, Susan Bressman, Mathias Toft, Silke Appel-Cresswell, Anthony E. Lang, Matej Skorvanek, Agnita J. W. Boon, Rejko Kruger, Esther M. Sammler, Vitor Tumas, Bao-Rong Zhang, Gaetan Garraux, Sun Ju Chung, Yun Joong Kim, Juliane Winkelmann, Carolyn M. Sue, Eng-King Tan, Joana Damasio, Peter Klivenyi, Vladimir S. Kostic, David Arkadir, Mika Martikainen, Vanderci Borges, Jens Michael Hertz, Laura Brighina, Mariana Spitz, Oksana Suchowersky, Olaf Riess, Parimal Das, Brit Mollenhauer, Emilia M. Gatto, Maria Skaalum Petersen, Nobutaka Hattori, Ruey-Meei Wu, Sergey N. Illarioshkin, Enza Maria Valente, Jan O. Aasly, Anna Aasly, Roy N. Alcalay, Avner Thaler, Matthew J. Farrer, Kathrin Brockmann, Jean-Christophe Corvol, Christine Klein
Summary: Through a worldwide online survey, we established an international cohort of individuals with PD-linked variants, providing harmonized and quality-controlled clinical and genetic data for each participant and promoting collaboration among researchers in the field of monogenic PD.
MOVEMENT DISORDERS
(2023)
Article
Chemistry, Analytical
Edoardo Bianchini, Bianca Calio, Marika Alborghetti, Domiziana Rinaldi, Clint Hansen, Nicolas Vuillerme, Walter Maetzler, Francesco E. Pontieri
Summary: Commercial smartwatches may not accurately count steps in Parkinson's disease patients, especially when they are in the OFF pharmacological state and worn on the most-affected body side. However, they show good performance in healthy subjects at a self-selected speed.
Article
Chemistry, Analytical
Clint Hansen, Baraah Chebil, John Cockroft, Edoardo Bianchini, Robbin Romijnders, Walter Maetzler
Summary: This study collected skeletal kinematics data from 21 healthy participants and 24 neurogeriatric participants using wearable sensors and an accelerometer-based functional calibration method. The study found that IMU-based parameters significantly correlated with the SPPB score and showed significant differences between SPPB subgroups. Lower limb range of motion and joint segment coordination were positively correlated with the SPPB score, while segment coordination variability was negatively correlated.
Article
Clinical Neurology
A. Scaravilli, M. Tranfa, G. Pontillo, F. Falco, C. Criscuolo, M. Moccia, S. Monti, R. Lanzillo, V. Brescia Morra, G. Palma, M. Petracca, E. Tedeschi, A. Elefante, A. Brunetti, S. Cocozza
Summary: This study aimed to evaluate the long-term impact of gadolinium retention in the dentate nuclei on motor and cognitive disability in patients with MS. The findings showed no significant association between gadolinium retention and long-term motor or cognitive outcomes in these patients.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Editorial Material
Medicine, Research & Experimental
Aleksander H. Erga, Guido Alves, Albert F. G. Leentjens
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2023)
Article
Clinical Neurology
Dijana Nuic, Sjors van de Weijer, Saoussen Cherif, Anna Skrzatek, Eline Zeeboer, Claire Olivier, Jean-Christophe Corvol, Pierre Foulon, Jenica Z. Pastor, Gregoire Mercier, Brian Lau, Bastiaan R. Bloem, Nienke M. De Vries, Marie-Laure Welter
Summary: This study aimed to evaluate the efficacy of a home-based training system using a tailored exergame for patients with Parkinson's disease (PD) to improve gait and balance disorders. The results showed that home-based training using a tailored exergame can be performed safely by PD patients and could potentially improve gait and balance disorders.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Psychology, Multidisciplinary
Lydia Kastner, Ulrike Suenkel, Gerhard W. Eschweiler, Theresa Dankowski, Anna-Katharina von Thaler, Christian Mychajliw, Kathrin Brockmann, Walter Maetzler, Daniela Berg, Andreas J. Fallgatter, Sebastian Heinzel, Ansgar Thiel
Summary: Older age is a major risk factor for severe COVID-19. In 2020, there was a broad political debate on whether older adults need special protection and isolation to minimize their risk of SARS-CoV-2 infection. However, isolation may also have indirect negative psychological or physical consequences depending on individual coping strategies and personality traits.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Medicine, General & Internal
Irene Goettgens, Linda Modderkolk, Paula Vermue, Sirwan K. L. Darweesh, Bastiaan R. Bloem, Sabine Oertelt-Prigione
Summary: This study explores the impact of gender norms and stereotypes on illness experiences of people with Parkinson's disease (PD) and provides recommendations for gender-sensitive PD care. The findings suggest that gendered stereotypes affect both the perception of the disease and the social environment of male and female patients. The study emphasizes the importance of considering the influence of gender roles and norms on coping strategies and access to care for individuals with diverse gender identities.
Letter
Clinical Neurology
Daniele Caliendo, Maria Carmela Grassia, Antonio Carotenuto, Maria Petracca, Roberta Lanzillo, Vincenzo Brescia Morra, Marcello Moccia
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2024)
Meeting Abstract
Clinical Neurology
R. Yilmaz, R. Wolke, N. Puls, M. Sorgun, G. Deuschl, D. Berg, N. Margraf
MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Benjamin Roeben, Lena Zeltner, Gisela E. Hagberg, Klaus Scheffler, Ludger Schoels, Benjamin Bender
MOVEMENT DISORDERS
(2023)