Review
Ophthalmology
Young Hyun Kim, Thien C. Nguyen, Meng C. Lin, Cheng-Chun J. Peng, Clayton J. Radke
Summary: Hyperosmotic tears can stimulate the cornea and cause dry eye symptoms, but the use of soft contact lenses can protect the cornea from these effects. Current measurement methods for tear osmolarity during lens wear do not accurately reflect the osmolarity of the tear film that covers the cornea. Dry eye patients can benefit from contact lenses with low salt diffusivity to reduce their tear osmolarity to normal levels.
PROGRESS IN RETINAL AND EYE RESEARCH
(2022)
Article
Ophthalmology
Mark Willcox, Nancy Keir, Vinod Maseedupally, Simin Masoudi, Alison McDermott, Rabia Mobeen, Christine Purslow, Jacinto Santodomingo-Rubido, Silvia Tavazzi, Fabrizio Zeri, Lyndon Jones
Summary: Contact lens materials have undergone significant changes in the past 20 years with the introduction of silicone hydrogel materials. However, research is still needed to improve comfort, as the association between contact lens wettability and comfort is not clear. The interactions between lens materials, tear film, and disinfection solution play an important role in biocompatibility, but whether this can be altered to improve comfort remains debatable.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Ophthalmology
Young Hyun Kim, Meng C. Lin, Cheng-Chun Peng, Clayton J. Radke
Summary: The study demonstrates that wearing soft contact lenses can effectively protect the cornea from localized spikes of hyperosmolarity on the pre-lens tear film, reducing resulting pain sensations. Lower salt diffusivities increase this protective effect.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Ophthalmology
Gulnoza Azieva, Dimitra Makrynioti, Reynolds Kwame Ablordeppey, Carol Lin, Alexandra Benavente-Perez
Summary: This study aimed to develop a novel protocol to assess the ocular surface in a non-human primate model (common marmoset) and compare the changes in central corneal thickness, tear osmolarity, blink rate, and tear meniscus height in untreated marmosets and marmosets treated with contact lenses. The findings showed that marmosets treated with contact lenses experienced an increase in blink rate, central corneal thickness, and tear meniscus height, along with a decrease in tear osmolarity within the first few months of contact lens treatment.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Yangzhi Zhu, Rohollah Nasiri, Elham Davoodi, Shiming Zhang, Sourav Saha, Matthew Linn, Lu Jiang, Reihaneh Haghniaz, Martin C. Hartel, Vadim Jucaud, Mehmet R. Dokmeci, Anna Herland, Ehsan Toyserkani, Ali Khademhosseini
Summary: The study investigates the use of contact lenses with microchannels to enhance tear flow from the pre-lens tear film to the post-lens ocular surface. The results demonstrate that the tear transport can be enhanced by an artificial eyelid motion in a pressure range similar to human eyelid pressure. This research shows the feasibility of developing microfluidic contact lenses to prevent or minimize contact lens-induced dry eye and discomfort.
Article
Veterinary Sciences
Sunjun Jung, Shin Ae Park
Summary: This study reports a case of a diabetic dog with eye symptoms. The corneal epithelial defect was successfully treated with a contact lens and corneal protection, but an unusual pattern of intracorneal hemorrhage was observed. The hemorrhage was resolved after the removal of the contact lens.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Ophthalmology
Katsuhide Yamasaki, Yohei Mizuno, Yoshiyuki Kitamura, David J. McCanna, William Ngo, Lyndon W. Jones
Summary: All three solutions significantly reduced P. aeruginosa on direct-contact surfaces. The PVP-I system was more effective against P. aeruginosa on non-contact surfaces than the hydrogen peroxide system or the chemical multipurpose system, and capable of inhibiting regrowth of P. aeruginosa for at least 7 days post-disinfection.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Multidisciplinary Sciences
Francois-Mael Robert, Bernard Abiven, Maina Sinou, Kevin Heggarty, Laure Adam, Vincent Nourrit, Jean-Louis de Bougrenet de la Tocnaye
Summary: In this paper, an infrared laser pointer is introduced, which is composed of a vertical-cavity surface-emitting laser (VCSEL) and a diffractive optical element (DOE), encapsulated into a scleral contact lens (SCL). The VCSEL is powered remotely by inductive coupling from a primary antenna embedded into an eyewear frame. The DOE is used to collimate the laser beam or project a pattern image. The article discusses the manufacturing and assembly of the SCL components, emphasizing the technological challenges of encapsulating them in the reduced volume of the SCL while keeping the pupil free. The operational performance and efficient applications of the laser pointer in visual assistance and augmented reality are also described.
SCIENTIFIC REPORTS
(2023)
Article
Materials Science, Multidisciplinary
Yuji Ohkubo, Daiki Fukuoka, Yosuke Seto, Misa Nishino, Katsuyoshi Endo, Kazuya Yamamura
Summary: A platinum (Pt)-free manganese oxide (MnOx) catalyst film was prepared on an aluminum (Al) substrate (MnOx/Al) using a hydrothermal impregnation method. The catalyst showed high catalytic activity for H2O2 decomposition, but further improvements were needed. By roughening the Al substrate, an MnOx catalyst film (MnOx/ roughened-Al) with enhanced activity and durability was obtained, which could potentially replace conventional Pt plating catalyst films.
Article
Ophthalmology
Nicole Carnt, Darwin C. Minassian, John K. G. Dart
Summary: This study aims to identify the risk factors for Acanthamoeba keratitis (AK) in daily disposable (DD) contact lens users compared to daily wear (DW) reusable lens users and specific risks for DD users. It is important because CL use is the main cause of microbial keratitis in many major economies, with AK accounting for approximately 50% of sight loss cases. Determining these AK risks informs practitioner advice and consumer behavior.
Article
Ophthalmology
Sabrina Mukhtar, Sarah Atta, Asad Durrani, Chandrashan Perera, Regis Kowalski, Vishal Jhanji
Summary: The degree of microbiological agreement between corneal scrapings and contact lens cultures in cases of contact lens-associated keratitis was investigated. The results showed that although there was disagreement in the microbiological yield, contact lens cultures were useful in managing patients and achieved similar outcomes to corneal scrapings.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Huazhen An, Shuai Wang, Dawei Li, Zhilong Peng, Shaohua Chen
Summary: The study showed that the self-cleaning efficiency of micropillar-arrayed surfaces increases with the size of microparticles. For large and small microparticles, the self-cleaning efficiency also increases with an increase in preload. However, for medium microparticles, the self-cleaning efficiency first increases and then decreases as the preload increases. The mechanical mechanism underlying such self-cleaning performance is mainly attributed to the competition among various energy factors like elastic energy, interfacial adhesion energy, and contact states between microparticles and micropillars.
Article
Astronomy & Astrophysics
Austin H. Dymont, Xinting Yu, Kazumasa Ohno, Xi Zhang, Jonathan J. Fortney, Daniel Thorngren, Connor Dickinson
Summary: The study suggests that haziness in warm exoplanets is not simply controlled by any single planetary/stellar parameter. Parameters such as planet gravity, atmospheric scale height, planet density, orbital eccentricity, and age of the star may have tentative correlations with the haziness. More observations and laboratory experiments are needed to fully understand the complex physics and chemistry involved in creating hazy warm exoplanets.
ASTROPHYSICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Gang Heng, Jiasi Zhang, Yi Dong, Jiankun Jia, Benqi Huang, Yanbing Shen, Dan Wang, Zhen Lan, Jianxin Zhang, Tao Fu, Weidong Jin
Summary: This study found that serum osmolarity disorder is significantly associated with increased 28-day mortality in septic shock patients. The relatively higher mortality in patients with hypo-osmolarity and hyper-osmolarity compared to normal osmolarity was observed even after propensity score matching. However, transforming hyper-osmolarity into normal osmolarity through fluid therapy on day 2 and 3 can decrease this mortality.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Yangyang Xu, Zhiqiang Xu, Xupeng Shu, Qiaoli Liu, Yuzhou Wang, Jiahui Xia, Yong Li, Jia Qu, Liang Hu
Summary: The study investigated the dynamic changes in ocular surface indicators in first-time contact lens wearers and identified the most influential factors in contact lens discomfort. The results showed that the first week of contact lens wear was the main period for the appearance of ocular surface clinical signs, and the first month was the main period for the activation of subclinical inflammation. Corneal staining and conjunctival microvascular response were found to be the main factors affecting contact lens discomfort.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Horlando Carlota da Silva, Aurelio de Oliveira Monteiro, Francisco Wagner de Queiroz Almeida-Neto, Emanuelle Machado Marinho, Maria Kueirislene Amancio Ferreira, Francisco Rogenio da Silva Mendes, Emmanuel Silva Marinho, Marcia Machado Marinho, Lucas Lima Bezerra, Matheus Nunes da Rocha, Jane Eire Silva Alencar de Menezes, Alexandre Magno Rodrigues Teixeira, Antonio Wlisses da Silva, Emanuela de Lima Reboucas, Francisco das Chagas Lima Pinto, Helcio Silva dos Santos, Gilvandete Maria Pinheiro Santiago
Summary: Diabetes mellitus is a chronic metabolic disorder that has been increasing drastically worldwide. The study found that fisetinidol, a compound obtained from plants, has potential hypoglycemic and hepatoprotective effects, and shares the same inhibitory mechanisms as existing antidiabetic drugs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Obstetrics & Gynecology
Victor Blasco, Francisco M. Pinto, Ainhoa Fernandez-Atucha, Nicolas Prados Dodd, Manuel Fernandez-Sanchez, Luz Candenas
Summary: Neurokinin B and its receptors have a significant role in the regulation of female reproduction. Abnormal expression of these molecules may be associated with decreased fertility in women with infertility, providing new insights for diagnosis and treatment.
REPRODUCTIVE SCIENCES
(2023)
Article
Ophthalmology
Elena Martinez-Plaza, Alberto Lopez-de la Rosa, Eleni Papadatou, Nabil E. Habib, Antonio J. Del Aguila-Carrasco, Alberto Lopez-Miguel, Miguel J. Maldonado, Phillip J. Buckhurst
Summary: This study investigated the influence of decentration and tilt of an intraocular lens on visual acuity and higher-order aberrations, and analyzed the agreement between different reference systems for assessing the decentration and tilt of the lens.
Article
Engineering, Biomedical
Elena Martinez-Plaza, Alberto Lopez-de la Rosa, Alberto Lopez-Miguel, Alfredo Holgueras, Miguel J. Maldonado
Summary: This article provides an overview of the EVO and EVO+ Visian Implantable Collamer Lenses (ICL) for correcting refractive error. It discusses the visual performance, subjective perception, safety, and potential complications associated with these lenses. Overall, the study highlights the excellent outcomes and safety of central hole ICL lenses, while also suggesting areas for future research.
EXPERT REVIEW OF MEDICAL DEVICES
(2023)
Article
Ophthalmology
Elena Martinez-Plaza, Mario Marcos, Alberto Lopez-de la Rosa, Alberto Lopez-Miguel, Miguel J. Maldonado
Summary: This study assessed the repeatability and agreement of Cartesian coordinates and the length of apparent chord mu and pupil diameter measurements between Galilei G4 and Topolyzer Vario. The results showed consistent measurements between the two devices, but they are not interchangeable.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2023)
Review
Clinical Neurology
Susana Lopez-Ortiz, Simone Lista, Pedro L. Valenzuela, Jose Pinto-Fraga, Ricardo Carmona, Filippo Caraci, Giuseppe Caruso, Nicola Toschi, Enzo Emanuele, Audrey Gabelle, Robert Nistico, Francesco Garaci, Alejandro Lucia, Alejandro Santos-Lozano
Summary: The study summarizes the relationship between physical activity and the development of Alzheimer's disease, as well as the impact of exercise on patients with Alzheimer's disease. The findings suggest that physical activity can lower the risk of Alzheimer's disease and exercise has positive effects on cognitive function, physical performance, and functional independence.
JOURNAL OF NEUROLOGY
(2023)
Article
Ophthalmology
Cecilia Diez-Montero, Alberto Lopez-de la Rosa, Alberto Lopez-Miguel, Miguel J. Maldonado
Summary: The relationship between anterior chamber depth (ACD) and lens thickness (LT), as well as its three main components, in cataractous and non-cataractous eyes was assessed in this study. The presence of cataracts does not modify the inverse relationship of the LT, anterior and posterior cortex, and nucleus with ACD, and this relationship does not seem to depend importantly on axial length (AxL). The possible differences in LT, anterior and posterior cortex, and nucleus between cataractous and non-cataractous eyes may not be caused by lens opacification, but possibly by the progressive lens growth due to aging.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Saul Penin-Grandes, Susana Lopez-Ortiz, Sergio Maroto-Izquierdo, Hector Menendez, Jose Pinto-Fraga, Juan Martin-Hernandez, Simone Lista, Alejandro Lucia, Alejandro Santos-Lozano
Summary: This systematic review evaluates the effects of regular exercise in patients with peripheral arterial disease (PAD) by summarizing published meta-analyses. The review finds that exercise has a positive impact on functional parameters and health-related quality of life in PAD patients. Supervised aerobic exercise is particularly effective in improving walking-related outcomes and pain, while resistance exercise is more effective for improving lower limb strength.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Ophthalmology
Elena Martinez-Plaza, Alberto Lopez-de la Rosa, Carolina Ossa-Calderon, Francisco Blazquez-Arauzo, Alberto Lopez-Miguel, Miguel J. Maldonado
Summary: This study evaluated the effect of EVO+ Visian Implantable Collamer Lens (ICL) implantation on iridocorneal angle pigmentation and structures. The results showed that EVO+ ICL implantation did not have a clinically significant effect on iridocorneal angle pigmentation and/or structures during a short-medium follow-up using gonioscopy assessment.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Laura Valencia-Nieto, Alberto Lopez-de la Rosa, Maria J. Gonzalez-Garcia, Alberto Lopez-Miguel
Summary: This study assessed the reliability and agreement of NIBUT in symptomatic and asymptomatic contact lens wearers. The objective assessment using the CA-800 device provided more reliable measurements compared to the subjective assessment using the EasyTear device. However, the objective method indicated shorter NIBUT values.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Ophthalmology
Elena Martinez-Plaza, Alberto Lopez-Miguel, Alberto Lopez-de la Rosa, Miguel J. Maldonado
Summary: This study aimed to assess whether the postoperative outcomes of one eye implanted with an EVO+ implantable collamer lens (ICL) can predict the vault of the fellow eye, and to evaluate the changes in vault of both eyes after the implantation. The results showed that the vault of the first implanted eye at one day postoperatively can predict the vault of the second eye. The vault tended to decrease during the follow-up period.
INTERNATIONAL OPHTHALMOLOGY
(2023)
