Morphologic Spectrum of Neuroendocrine Tumors of the Prostate An Updated Review

Context.-The incidence of neuroendocrine tumors of the prostate increases after hormonal therapy. Neuroendocrine tumors possess a broad spectrum of morphologic features and pose challenges in the pathologic diagnosis and clinical management of patients. Objective.-To present a brief updated summary of neuroendocrine tumors of the prostate with an overview of their histopathologic and immunohistochemical profiles and differential diagnoses. Data Sources.-Literature review, personal experience in the daily practice of pathologic diagnosis, and laboratory research. Conclusions.-Our understanding of neuroendocrine tumors of the prostate classification and diagnosis continues to evolve. These advances benefit the risk stratification and management of prostate cancer.