Article
Engineering, Biomedical
Ruonan Zhang, Ting Pan, Yu Xiang, Mingming Zhang, Han Xie, Zimao Liang, Bi Chen, Cong Xu, Jing Wang, Xingxing Huang, Qianru Zhu, Ziming Zhao, Quan Gao, Chengyong Wen, Wencheng Liu, Weirui Ma, Jiao Feng, Xueni Sun, Ting Duan, Elaine Lai-Han Leung, Tian Xie, Qibiao Wu, Xinbing Sui
Summary: Curcumenol has been found to induce cell death and inhibit cell proliferation in lung cancer cells. The study also reveals that the long non-coding RNA H19 (lncRNA H19) is downregulated in lung cancer cells treated with curcumenol, and its decreased expression enhances curcumenol-induced ferroptotic cell death through the miR-19b-3p/FTH1 axis.
BIOACTIVE MATERIALS
(2022)
Article
Multidisciplinary Sciences
Julie Massart, Rasmus J. O. Sjogren, Brendan Egan, Christian Garde, Magnus Lindgren, Weifeng Gu, Duarte M. S. Ferreira, Mutsumi Katayama, Jorge L. Ruas, Romain Barres, Donal J. O'Gorman, Juleen R. Zierath, Anna Krook
Summary: Exercise training induces changes in miRNA expression in human skeletal muscle, with miR-19b-3p affecting insulin signaling, glucose uptake, and maximal oxygen consumption. Short-term aerobic exercise training regime leads to miRNA remodeling in skeletal muscle, influencing glucose metabolism.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Hao Zeng, Yu-Xia Chen
Summary: This study found that miR-19b-3p expression was down-regulated and SOX6 expression was up-regulated in patients with hypoxic-ischemic encephalopathy (HIE). Overexpression of miR-19b-3p could alleviate HIE cell injury by inhibiting SOX6 expression and activating the Wnt/β-catenin pathway.
NEUROCHEMICAL RESEARCH
(2023)
Article
Immunology
Misagh Rajabinejad, Gelayol Asadi, Sedigheh Ranjbar, Fatemeh Rezaei Varmaziar, Mojgan Karimi, Farhad Salari, Ali Gorgin Karaji, Alireza Rezaiemanesh, Leila Afshar Hezarkhani
Summary: The MALAT1-H19/miR-19b-3p axis may be involved in the development of DN, and these molecules could be useful biomarkers for DN. Dysregulated expression of SEMA4C, PLXNB2, and ATG16L1, targeted by miR-19b-3p and miR-125a-5p, showed that they probably play a role in the development of DN.
IMMUNOLOGY LETTERS
(2022)
Article
Medicine, Research & Experimental
Li Qian, Li Pi, Bai-Rong Fang, Xian-Xi Meng
Summary: This study demonstrates that the high expression of H19 in exosomes derived from adipose mesenchymal stem cells accelerates skin tissue wound healing by upregulating SOX9 via miR-19b.
LABORATORY INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Michela Simbula, Maria Francesca Manchinu, Maura Mingoia, Mauro Pala, Isadora Asunis, Cristian Antonio Caria, Lucia Perseu, Manan Shah, Merlin Crossley, Paolo Moi, Maria Serafina Ristaldi
Summary: This study identified a crucial BCL11A/miR-365-3p/SOX6 pathway in the regulation of HbF, providing new insights and potential therapeutic targets for treating 0-hemoglobinopathies.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Cell Biology
Feng Xu, Jia-Yu Zhong, Bei Guo, Xiao Lin, Feng Wu, Fu-Xing-Zi Li, Su-Kang Shan, Ming-Hui Zheng, Yi Wang, Qiu-Shuang Xu, Li-Min Lei, Chang-Ming Tan, Xiao-Bo Liao, Ling-Qing Yuan
Summary: The study found that H19 plays a promoting role in arterial medial calcification, functioning as a competing endogenous RNA for miR-140-5p and activating the ERK1/2 and p38MAPK signaling pathways induced by Satb2.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Hui Han, Tingyu Tian, Guoqian Huang, Dalu Li, Shimao Yang
Summary: The research indicates that melatonin regulates the osteogenic and adipogenic differentiation of bone mesenchymal stem cells through the H19/miR-541-3p/APN axis, providing a new insight for targeted therapy of osteoporosis.
Article
Neurosciences
Zhoujing Yang, Sheng Hu, Yinbin He, Ling Ji
Summary: In this study, it was found that BUP-induced neurotoxicity in human neural cells could be regulated by the epigenetic axis of LINC00665 / hsa-miR-34a-5p. By exploring the functional mechanism of LINC00665 in regulating BUP-induced neurotoxicity, the study provides insights into potential therapeutic targets for neurologic dysfunctions induced by excessive application of local anesthetics.
BRAIN RESEARCH BULLETIN
(2021)
Article
Genetics & Heredity
Chen Jiahui, Zheng Jiadai, Zheng Nan, Zhou Rui, Huang Lipin, He Jian, Zhu Wenzong, Zhang Riyuan
Summary: The purpose of this study was to investigate the role and mechanism of miR-19b-3p in regulating myocardial inflammation and injury in viral myocarditis induced by Coxsackievirus B3 (CVB3). The upregulation of miR-19b-3p was found to have a protective effect against CVB3-induced inflammation and myocardial injury by targeting PKNOX1 and regulating macrophage polarization.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Xia Yi, Xiangqi Tang
Summary: Exosomes from miR-19b-3p-modified ADSCs are able to inhibit ferroptosis and improve ICH damage when administered to ICH mice or cultured neurons.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yingchun Wu, Yan Yue, Sidong Xiong
Summary: This study found that miR-19a and miR-19b were significantly up-regulated in heart tissues of CVB3-infected mice, and they facilitated viral biosynthesis and replication by targeting the encoding region of RdRp. Treatment with miR-19b antagomir suppressed CVB3 replication and infection in cells and reduced the cardiac viral load of CVB3-infected mice, resulting in alleviation of myocarditis.
ANTIVIRAL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Rongkang Guo, Chaohan Wu, Fan Liu, Tianhua Dong, Tao Zhang
Summary: In this study, functional biomimetic composite hydrogels loaded with bone marrow mesenchymal stem cells (BMSCs) derived microRNA-19b-3p/WWP1 axis through extracellular vesicles (EVs) were constructed. The results showed that EVs could deliver miR-19b-3p to BMSCs, inhibit the expression of WWP1, and promote the osteogenic differentiation of BMSCs, ultimately promoting bone regeneration in rats with bone defects.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wei-Ping Xia, Xiang Chen, Feng Ru, Yao He, Pei-Hua Liu, Yu Gan, Bo Zhang, Yong Li, Guo-Yu Dai, Ze-Xiang Jiang, Zhi Chen
Summary: This study demonstrated that XIST and SOX6 were upregulated while miR-19b was downregulated in renal fibrosis. By regulating the XIST/miR-19b/SOX6 signal axis, apoptosis and inflammation responses in renal fibrosis can be inhibited.
MOLECULAR IMMUNOLOGY
(2021)
Article
Oncology
Rocio B. Duca, Cintia Massillo, Guillermo N. Dalton, Paula L. Farre, Karen D. Grana, Kevin Gardner, Adriana De Siervi
Summary: This research identified the association between a high fat diet and prostate cancer, pinpointing the potential importance of two miRNAs in the diagnosis and prognosis of prostate cancer. Further investigations revealed the significant relevance of these miRNAs in distinguishing tumor types and metastatic status.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)