Article
Engineering, Biomedical
Ruonan Zhang, Ting Pan, Yu Xiang, Mingming Zhang, Han Xie, Zimao Liang, Bi Chen, Cong Xu, Jing Wang, Xingxing Huang, Qianru Zhu, Ziming Zhao, Quan Gao, Chengyong Wen, Wencheng Liu, Weirui Ma, Jiao Feng, Xueni Sun, Ting Duan, Elaine Lai-Han Leung, Tian Xie, Qibiao Wu, Xinbing Sui
Summary: Curcumenol has been found to induce cell death and inhibit cell proliferation in lung cancer cells. The study also reveals that the long non-coding RNA H19 (lncRNA H19) is downregulated in lung cancer cells treated with curcumenol, and its decreased expression enhances curcumenol-induced ferroptotic cell death through the miR-19b-3p/FTH1 axis.
BIOACTIVE MATERIALS
(2022)
Review
Cell Biology
Yuanyuan Sun, Qian Li, Hongxiu Guo, Quanwei He
Summary: This paper primarily summarizes the mechanism of ferroptosis after intracerebral hemorrhage (ICH), focusing on lipid peroxidation, the antioxidant system, iron metabolism, and other pathways. Although there has been progress in this field, there are still gaps in understanding non-heme iron entry into neurons, the mitochondrial role in ferroptosis, and the specific mechanism of lipid peroxidation-induced ferroptosis. Moreover, translating the inhibitory effects of drugs on ferroptosis into clinical trials is necessary.
Review
Biochemistry & Molecular Biology
Siying Ren, Yue Chen, Likun Wang, Guofeng Wu
Summary: Intracerebral hemorrhage is a devastating form of stroke that induces cell death responsible for secondary brain injury. Iron-dependent cell death, known as ferroptosis, plays a crucial role in the occurrence and progression of intracerebral hemorrhage. Understanding and targeting the regulators and signaling pathways of ferroptosis could lead to potential treatments for intracerebral hemorrhage.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Geriatrics & Gerontology
Chenxiao Lu, Changwu Tan, Hongfei Ouyang, Zhuohui Chen, Zhouyi Yan, Mengqi Zhang
Summary: Iron metabolism-related cell death mechanism called ferroptosis has become a topic of great interest among scientists. It interacts with other cell death pathways and plays a significant role in intracerebral hemorrhage (ICH). Understanding the role of ferroptosis in ICH opens new possibilities for future treatments and prevention of ICH and other intracerebral diseases.
Article
Pharmacology & Pharmacy
Lining Duan, Ying Zhang, Yuna Yang, Shiyu Su, Ligui Zhou, Po-Chieh Lo, Jiaying Cai, Yiqi Qiao, Min Li, Shuiqing Huang, Hong Wang, Yousheng Mo, Qi Wang
Summary: Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and disability rates, where ferroptosis plays a dominant role in its pathogenesis. Baicalin, a main active ingredient of Chinese herbal medicine, exhibits neuroprotective effects against ICH-induced brain injury by inhibiting ferroptosis and shows potential as a therapeutic drug for ICH treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Jian Wang, Fei Teng, Shuhan Liu, Xiaoqiang Pan, Bo Yang, Wei Wu
Summary: In this study, the effects of ICH-exos on HMC3 cells and the ceRNA network involving lncRNA SND1-IT1 were investigated. The results showed that ICH-exos delivered lncRNA SND1-IT1 to HMC3 cells, leading to decreased cell viability and increased apoptosis. The ceRNA network involving lncRNA SND1-IT1/miR-124-3p/MTF1 was found to play a role in regulating cell growth.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ying Kong, Shulin Li, Miao Zhang, Wenting Xu, Qiuxin Chen, Lihong Zheng, Peng Liu, Wei Zou
Summary: Baihui-penetrating-Qubin acupuncture may alleviate neuronal cell death, inflammation, and ferroptosis after intracerebral hemorrhage by down-regulating miR-23a-3p.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Julie Massart, Rasmus J. O. Sjogren, Brendan Egan, Christian Garde, Magnus Lindgren, Weifeng Gu, Duarte M. S. Ferreira, Mutsumi Katayama, Jorge L. Ruas, Romain Barres, Donal J. O'Gorman, Juleen R. Zierath, Anna Krook
Summary: Exercise training induces changes in miRNA expression in human skeletal muscle, with miR-19b-3p affecting insulin signaling, glucose uptake, and maximal oxygen consumption. Short-term aerobic exercise training regime leads to miRNA remodeling in skeletal muscle, influencing glucose metabolism.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Hui Chen, Lejia Ren, Wenbin Ma
Summary: This study investigated the role of SOX10 in ferroptosis of hippocampal neurons after intracerebral hemorrhage (ICH). The findings suggest that SOX10 overexpression improves cell viability, decreases reactive oxygen species and Fe2+ levels, and increases gluta-thione and glutathione peroxidase 4 levels in ICH models. Additionally, SOX10 increases miR-29a-3p expression, which limits ACSL4 transcription and promotes ferroptosis of hippocampal neurons after ICH.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Oncology
Rocio B. Duca, Cintia Massillo, Guillermo N. Dalton, Paula L. Farre, Karen D. Grana, Kevin Gardner, Adriana De Siervi
Summary: This research identified the association between a high fat diet and prostate cancer, pinpointing the potential importance of two miRNAs in the diagnosis and prognosis of prostate cancer. Further investigations revealed the significant relevance of these miRNAs in distinguishing tumor types and metastatic status.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Chemistry, Physical
Chunhui Sheng, Xiaodong Guo, Zhuqing Wan, Xiaoqiang Bai, Hao Liu, Xiao Zhang, Ping Zhang, Yunsong Liu, Wenyue Li, Yongsheng Zhou, Longwei Lv
Summary: This study investigated the potential of exosomes derived from human adipose-derived stem cells (hASCs) in promoting osteogenic differentiation for osteoporosis treatment. The study identified the key differentially expressed microRNA between two exosomes and their potential target gene. Results showed that exosomes from osteogenic induction medium had a better effect on promoting osteogenic differentiation than those from proliferation medium. Moreover, miR-335-3p inhibitor-optimized exosomes enhanced osteogenic differentiation in vitro and bone density in vivo, suggesting the potential of engineered exosomes in optimizing exosome-based therapy for osteoporosis.
Article
Genetics & Heredity
Chen Jiahui, Zheng Jiadai, Zheng Nan, Zhou Rui, Huang Lipin, He Jian, Zhu Wenzong, Zhang Riyuan
Summary: The purpose of this study was to investigate the role and mechanism of miR-19b-3p in regulating myocardial inflammation and injury in viral myocarditis induced by Coxsackievirus B3 (CVB3). The upregulation of miR-19b-3p was found to have a protective effect against CVB3-induced inflammation and myocardial injury by targeting PKNOX1 and regulating macrophage polarization.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Jing Sui, Qun Zhao, Yanqiu Zhang, Geyu Liang
Summary: The study found that LINC00961 is significantly downregulated in non-small cell lung cancer (NSCLC) tissues, and it inhibits the expression of miR-19a-3p/miR-19b-3p/miR-125b-5p through the PI3K-AKT/MAPK/mTOR signaling pathway, thereby suppressing tumor cell proliferation and migration while promoting apoptosis. This may provide potential biomarkers for the diagnosis and treatment of NSCLC.
DNA AND CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hang Zhai, Sisi Zhong, Runxin Wu, Zhaohong Mo, Shiyang Zheng, Jinhua Xue, Hongyu Meng, Maosheng Liu, Xianyu Chen, Guangquan Zhang, Xiyan Zheng, Fei Du, Ruixi Li, Boxuan Zhou
Summary: This study found that RBMS1 is involved in hepatocellular carcinoma (HCC) development and functions as a regulator of ferroptosis by attenuating the expression of GPX4. The circIDE/miR-19b-3p/RBMS1 axis was identified as a promising therapeutic target and prognostic factor in HCC.
Article
Cell Biology
Cristina Morsiani, Lucia Terlecki-Zaniewicz, Susanna Skalicky, Maria Giulia Bacalini, Salvatore Collura, Maria Conte, Federica Sevini, Paolo Garagnani, Stefano Salvioli, Matthias Hackl, Johannes Grillari, Claudio Franceschi, Miriam Capri
Summary: This study identified an age-related increase of plasma miR-19a/b-3p in old subjects but a decrease in centenarians. The decrease was more pronounced in healthy centenarians and confirmed by comparing healthy and unhealthy centenarians' isomiRs patterns. The findings suggest potential biomarkers for tracking aging and age-related diseases.