Article
Immunology
Abrar Ul Haq Khan, Saeedah Musaed Almutairi, Alaa Kassim Ali, Rosalba Salcedo, C. Andrew Stewart, Lisheng Wang, Seung-Hwan Lee
Summary: Natural killer (NK) cells modify their metabolism to support high energy demands during infection, with interleukin-1 family members critical in activating NK cells. Upregulation of nutrient transporters on NK cells can occur through multiple pathways, with MyD88 playing an imperative role in NK cell metabolism during infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Xiuqin Tang, Meijun Yang, Jiaxin Liu, Libing Zheng, Dongdong Xu, Changfeng Chi, Zhenming Lv, Huihui Liu
Summary: A novel isoform of MyD88, NaMyD88, was identified and functionally characterized in Nibea albiflora. This protein shared high identity with known MyD88 and was found to interact with NaTLR9 in the cytoplasm. Expression of NaMyD88 was detected in various tissues and up-regulated after infection, indicating its involvement in the immune response of N.albiflora.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Shaoshuai Tang, Xinlan Xu, Dapeng Yu, Meng Long, Hongli Xia, Yishan Lu, Zhen Gan
Summary: This study characterizes the immune functions of amphibian MyD88 and reveals the functional conservation of MyD88 in early tetrapods.
Review
Immunology
Yudan Cui, Jingshan Cai, Wenxin Wang, Shengjun Wang
Summary: HDACIs are antitumor drugs that enhance gene transcription via epigenetic regulation, with cytotoxic properties against tumor cells. The effects of HDACIs on immunocytes in the tumor microenvironment, specifically MDSCs, are still not fully understood.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Umut Can Kucuksezer, Esin Aktas Cetin, Fehim Esen, Ilhan Tahrali, Nilgun Akdeniz, Metin Yusuf Gelmez, Gunnur Deniz
Summary: NK cells are a subset of innate lymphoid cells that play important roles in anti-tumor immune responses and immune regulation, with different subgroups showing cytotoxic functions or cytokine production. Their activation is influenced by a variety of factors, including cell surface receptors and cytokines, and their dysregulation can contribute to various immune-mediated diseases. Further research on NK cell biology and their potential therapeutic applications is necessary for better understanding and treatment of inflammatory disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Cristina Zalfa, Silke Paust
Summary: In the tumor microenvironment, myeloid-derived suppressor cells play a crucial role in regulating NK cell function, impacting the antitumor immune response. Strategies targeting MDSC-mediated immunosuppression can enhance the cytotoxic antitumor activity of NK cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Roman M. Mueller-Heck, Bjoern Boesken, Ivo Michiels, Marcel Dudda, Marcus Jaeger, Stefanie B. Flohe
Summary: This study investigated the impact of invasive spine surgery on the relationship between monocytes and NK cells in response to Staphylococcus aureus. The findings showed that NK cells continuously lost their ability to produce IFN-gamma during the first week after surgery independently from monocyte-derived IL-12 secretion. Additionally, pre-operative levels of GDF-15 in the serum were associated with the extent of NK cell suppression and hospitalization.
Article
Cell Biology
Alessandra Zecca, Valeria Barili, Danila Rizzo, Andrea Olivani, Elisabetta Biasini, Diletta Laccabue, Raffaele Dalla Valle, Carlo Ferrari, Elisabetta Cariani, Gabriele Missale
Summary: The study identified different subsets of NK cells infiltrating HCC, including non-liver-resident cells that coexpressed CD49a and Eomes, showing reduced cytotoxic potential. This NK cell subset likely plays a regulatory role in proangiogenic function.
Article
Oncology
Rui Zhang, Qingxi Liu, Sa Zhou, Hongpeng He, Mingfeng Zhao, Wenjian Ma
Summary: In this study, a genetically modified bifunctional CAR-NK cell therapy was developed for the treatment of acute myeloid leukemia (AML). The bifunctional CD33/B16 CAR-NK cells showed superior killing efficiency towards AML cells compared to CAR-NK cells targeting CD33 only. In vivo studies also demonstrated effective clearance of leukemic cells and improved survival. These findings suggest a promising CAR-NK approach for AML treatment and potentially other tumors.
Article
Immunology
Jie Shen, Mengyu Zhang, Ke Zhang, Yahan Qin, Meifang Liu, Shujuan Liang, Daquan Chen, Meiyu Peng
Summary: This study found that Angelica polysaccharide (APS) promoted the proliferation, differentiation, and immunosuppressive function of myeloid-derived suppressor cells (MDSC) through the STAT1 and STAT3 signaling pathways. In vivo, APS increased the proportion of MDSC in mice, suggesting that its clinical application should consider the possible side effects of increasing MDSC quantity and function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Sigrid P. Dubois, Milos D. Miljkovic, Thomas A. Fleisher, Stefania Pittaluga, Jennifer Hsu-Albert, Bonita R. Bryant, Michael N. Petrus, Liyanage P. Perera, Jurgen R. Muller, Joanna H. Shih, Thomas A. Waldmann, Kevin C. Conlon
Summary: The study demonstrated that administering IL-15 as CIV-5 significantly expanded NK cells with increased cytotoxic functions. There were no dose-limiting toxicities in the CIV-5 regimen, and a substantial increase in CD8(+) T cells was observed.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Chemistry, Multidisciplinary
Donghe Li, Yuyin Zhang, Qingsong Qiu, Jinzeng Wang, Xuemei Zhao, Bo Jiao, Xiuli Zhang, Shanhe Yu, Pengfei Xu, Yuqing Dan, Xinhua Xiao, Peihong Wang, Mingzhu Liu, Zhizhou Xia, Zhangsen Huang, Ruihong Zhang, Jiaoyang Li, Xi Xie, Yan Zhang, Chenxuan Liu, Ping Liu, Ruibao Ren
Summary: IRF8 deficiency leads to a decrease in the number of LT-HSCs in mice, but an increase in the repopulation capacity of individual HSCs. The regulation of TLR9 signaling in diverse innate immune cells by IRF8 influences HSCs.
Review
Biochemistry & Molecular Biology
Hammad Ahmed, Mahtab Ahmad Khan, Ulf Dietrich Kahlert, Mika Niemela, Daniel Haenggi, Shafqat Rasul Chaudhry, Sajjad Muhammad
Summary: MyD88 is an inflammatory adaptor protein in the Toll-like receptor 4 signaling pathway, playing a crucial role in SAH-related neuroinflammation. Research suggests that inhibition of MyD88 can reduce inflammation caused by SAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Lea Katharina Picard, Elisabeth Littwitz-Salomon, Herbert Waldmann, Carsten Watzl
Summary: Inhibition of glucose uptake can prevent NK cell proliferation and reduce stimulation-dependent IFN-gamma production, but does not affect cytotoxicity and serial killing activity.
Article
Immunology
Minna Sivonen, Katja A. Sirvio, Sara Wojciechowski, Anssi Kailaanmaki, Satu Kaipainen, Aubrey Bailey, Martin Villalba, Tuija Kekarainen
Summary: In this study, we aimed to identify the optimal activation and expansion protocol for cytotoxic NK cells against glioblastoma in vitro. The results showed that the ex vivo proliferation capacity and functionality of NK cells were affected by multiple factors, including the donor, composition of starting material, cytokine combination, and the activation protocol. These findings could be utilized for upscaling clinical NK cell manufacturing.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Critical Care Medicine
Marcin F. Osuchowski, Federico Aletti, Jean-Marc Cavaillon, Stefanie B. Flohe, Evangelos J. Giamarellos-Bourboulis, Markus Huber-Lang, Borna Relja, Tomasz Skirecki, Andrea Szabo, Marc Maegele
Article
Biochemistry & Molecular Biology
Wiebke Hansen, Sina Luppus, Romy Barthel, Dae-In Chang, Julia Broemstrup, Thomas Zwarg, Jo Shibata, Astrid M. Westendorf, Jan Buer, Norbert Scherbaum
Summary: Heroin addiction can suppress adaptive immune responses, leading to increased inhibitory Tregs and impaired proliferative activity in CD4(+) T cells. Structured treatments like HAT and MMT can reduce elevated Tregs levels in heroin-addicted patients, while chronic heroin use directly affects the proliferative activity and cytokine production of CD4(+) T cells.
Article
Immunology
Vittoria Palmieri, Jana-Fabienne Ebel, Nhi Ngo Thi Phuong, Robert Klopfleisch, Vivian Pham Vu, Alexandra Adamczyk, Julia Zoller, Christian Riedel, Jan Buer, Philippe Krebs, Wiebke Hansen, Eva Pastille, Astrid M. Westendorf
Summary: IL-33 signaling pathway plays a critical role in regulating the immune response to enteric pathogens, affecting the colitis caused by microbial invasion. Deficiency of IL-33 can attenuate bacterial-induced colitis, while boosting its pathway can exacerbate the inflammatory response.
MUCOSAL IMMUNOLOGY
(2021)
Article
Oncology
Alexandra Adamczyk, Eva Pastille, Jan Kehrmann, Vivian P. Vu, Robert Geffers, Marie-Helene Wasmer, Stefan Kasper, Martin Schuler, Christian M. Lange, Beat Muggli, Tilman T. Rau, Diana Klein, Wiebke Hansen, Philippe Krebs, Jan Buer, Astrid M. Westendorf
Summary: Colorectal cancer is a common malignancy with a need for novel antitumor therapies, particularly in advanced cases. Recent studies have shown that tumor-associated Tregs from thymic origin with specific migratory properties play a key role in colorectal cancer, and targeting GPR15 as a novel potential therapy can enhance antitumoral immunity in colorectal cancer.
Article
Immunology
Hanna Abberger, Romy Barthel, Jasmin Bahr, Jacqueline Thiel, Sina Luppus, Jan Buer, Astrid M. Westendorf, Wiebke Hansen
Summary: The study found that in activated CD4(+) non-Tregs, Nrp-1 expression has an activating role, while in CD4(+) non-Tregs from naive mice, Nrp-1 expression leads to dysfunction.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Bettina Budeus, Artur Kibler, Martina Brauser, Ekaterina Homp, Kevin Bronischewski, J. Alexander Ross, Andre Gorgens, Marc A. Weniger, Josefine Dunst, Taras Kreslavsky, Symone Vitoriano da Conceicao Castro, Florian Murke, Christopher C. Oakes, Peter Rusch, Dimitrios Andrikos, Peter Kern, Angela Koeninger, Monika Lindemann, Patricia Johansson, Wiebke Hansen, Anna-Carin Lundell, Anna Rudin, Jan Duerig, Bernd Giebel, Daniel Hoffmann, Ralf Kueppers, Marc Seifert
Summary: Umbilical cord blood B cells exhibit a mature phenotype similar to adult B cells, with diverse yet conserved Ig repertoire and accelerated responsiveness. This suggests that UCB B cells are not immature but differ in their response dynamics compared to adult B cells.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Nhi Ngo Thi Phuong, Vittoria Palmieri, Alexandra Adamczyk, Robert Klopfleisch, Jost Langhorst, Wiebke Hansen, Astrid M. Westendorf, Eva Pastille
Summary: The IL-33/ST2 pathway plays a crucial protective role in colitis by modulating the numbers of ILC2 and Treg cells, highlighting its potential as a novel therapeutic target in inflammatory bowel disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Camilla Wilk, Laura Effenberg, Hanna Abberger, Laura Steenpass, Wiebke Hansen, Michael Zeschnigk, Carsten Kirschning, Jan Buer, Jan Kehrmann
Summary: Demethylation of FOXP3-TSDR is crucial for the stable differentiation and suppressive function of regulatory T cells. This study demonstrates that transfection of specific plasmids can decrease FOXP3-TSDR methylation and increase FOXP3 mRNA expression in Jurkat cells, potentially enabling the programming of primary T cells into regulatory T cells.
CELLULAR IMMUNOLOGY
(2022)
Article
Clinical Neurology
Lucia Beckmann, Stefanie Obst, Nicole Labusek, Hanna Abberger, Christian Koester, Ludger Klein-Hitpass, Sven Schumann, Christoph Kleinschnitz, Dirk M. Hermann, Ursula Felderhoff-Mueser, Ivo Bendix, Wiebke Hansen, Josephine Herz
Summary: Clinical and experimental studies suggest sexual dimorphism in neonatal brain injury and therapy responses caused by hypoxia-ischemia (HI). This study found that regulatory T cells (Tregs) from neonatal female mice provide neuroprotection, while Tregs from male mice increase secondary neurodegeneration, which may be associated with intrinsic transcriptional differences between sexes. There is an urgent need for sex-stratified clinical and preclinical analyses.
Article
Endocrinology & Metabolism
Svenja Philipp, Mareike Horstmann, Matthias Hose, Anke Daser, Gina-Eva Goertz, Christoph Jesenek, Ulrich Floegel, Wiebke Hansen, Nikolaos Bechrakis, Jasvinder Paul S. Banga, Anja Eckstein, Utta Berchner-Pfannschmidt
Summary: This study revealed early infiltration of macrophages in the orbital region and induction of pathogenic anti-TSHR antibodies during disease onset in the model. This was followed subsequently by influx of CD8(+) T cells specific for TSHR coupled with reduction in Tregs and substantial increase in brown adipose tissue.
Article
Cell Biology
Ekaterina Pylaeva, Georg Korschunow, Ilona Spyra, Sharareh Bordbari, Elena Siakaeva, Irem Ozel, Maksim Domnich, Anthony Squire, Anja Hasenberg, Kruthika Thangavelu, Timon Hussain, Moritz Goetz, Karl S. Lang, Matthias Gunzer, Wiebke Hansen, Jan Buer, Agnes Bankfalvi, Stephan Lang, Jadwiga Jablonska
Summary: In this study, researchers found that tumor-associated neutrophils migrate to lymph nodes during head and neck cancer progression and play a dual role in shaping anti-tumor responses. In metastasis-free stages, neutrophils stimulate T cells, while in metastatic stages, they suppress T cell responses. The accumulation of neutrophils in lymph nodes can predict the survival rate of head and neck cancer patients.
Article
Biology
Anne Gunther, Matthias Hose, Hanna Abberger, Fabian Schumacher, Ylva Veith, Burkhard Kleuser, Kai Matuschewski, Karl Sebastian Lang, Erich Gulbins, Jan Buer, Astrid M. Westendorf, Wiebke Hansen
Summary: This study demonstrates the involvement of acid ceramidase and ceramide in controlling P. yoelii infection, with a mechanism involving regulation of red blood cell development.
Article
Virology
Philip Podschwadt, Anna Malyshkina, Sonja Windmann, Tanja Werner, Wiebke Hansen, Wibke Bayer
Summary: The study reveals the different roles and IL-10 expression capabilities of SFFV- and F-MuLV-infected cells during FV infection. The pathogenic SFFV may contribute to immune suppression.
Article
Biology
Matthias Hose, Anne Guenther, Eyad Naser, Fabian Schumacher, Tina Schoenberger, Julia Falkenstein, Athanasios Papadamakis, Burkhard Kleuser, Katrin Anne Becker, Erich Gulbins, Adriana Haimovitz-Friedman, Jan Buer, Astrid M. Westendorf, Wiebke Hansen
Summary: Modulation of ceramide levels by interfering with Asm or Ac activity affects T cell differentiation and function, representing a potential novel therapeutic strategy for T cell-dependent diseases such as tumorigenesis.
Article
Immunology
Philip Podschwadt, Anna Malyshkina, Sonja Windmann, Athanasios Papadamakis, Leonie Kerkmann, Dennis Lapuente, Matthias Tenbusch, Mengji Lu, Michael Schindler, Karl Sebastian Lang, Wiebke Hansen, Wibke Bayer
Summary: The envelope protein of retroviruses has been found to have immunosuppressive properties. This study demonstrates that CD4(+) T cells producing interleukin-10 (IL-10) play a mechanistic role in the envelope protein-induced suppression of CD8(+) T-cell responses. The study also shows that the degree of CD8(+) T-cell response inhibition varies with different immunogens and that the immunosuppression phenomenon is observed in both co-immunization experiments and immune control of tumor growth.
FRONTIERS IN IMMUNOLOGY
(2022)