Article
Chemistry, Physical
Muhammad Qamar, Ghulam Abbas, Muhammad Afzaal, Muhammad Y. Naz, Abdul Ghuffar, Muhammad Irfan, Stanislaw Legutko, Jerzy Jozwik, Magdalena Zawada-Michalowska, Abdulnour Ali Jazem Ghanim, Saifur Rahman, Usama M. Niazi, Mohammed Jalalah, Fahad Salem Alkahtani, Mohammad K. A. Khan, Ewelina Kosicka
Summary: This study investigated the optical properties and electric field enhancement of gold nanorods, and found that they have high efficiency in targeted drug delivery. The experimental results also revealed the potential of gold nanorods in anticancer applications.
Article
Oncology
Noor Essa, Fiona O'Connell, Adriele Prina-Mello, Jacintha O'Sullivan, Simone Marcone
Summary: The relationship between obesity and cancer has been well characterized, but the biological mechanisms in obese cancer patients are still unclear. The obese tumor microenvironment provides additional benefits to tumor cells against anticancer therapies by altering the extracellular matrix composition and immune cell profile, while nanotechnology, particularly gold nanoparticles, is being researched for cancer treatment due to their sensitizing abilities for cancer cells and enhancement of drug delivery.
Review
Nanoscience & Nanotechnology
Anseo Choi, Kaila Javius-Jones, Seungpyo Hong, Hansoo Park
Summary: Nanoparticle-based drug delivery systems have limitations in tumor targeting and therapeutic outcomes. Cell-based drug delivery systems, using blood cells, immune cells, and stem cells with natural tumor tropism and low immunogenicity, provide a solution to these problems. In this review, we discuss the benefits and drawbacks of cell-based therapies, as well as their mechanisms in tumor microenvironments. Additionally, we summarize different strategies for loading therapeutic agents onto or inside circulating cells, and their current applications in disease treatments.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Wenzhao Han, Junfeng Ke, Feng Guo, Fanwei Meng, Hui Li, Liping Wang
Summary: An innovative nano-drug delivery system was designed to efficiently release drugs in the tumor microenvironment, showing low cytotoxicity and promising anti-tumor properties.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Nanoscience & Nanotechnology
Zhengting Jiang, Wenjie Zhang, Jie Zhang, Tian Liu, Juan Xing, Huan Zhang, Dong Tang
Summary: Cancer immunotherapy has made significant progress in treating tumors, but challenges in the tumor microenvironment hinder its effectiveness. Nanomaterial-based drug delivery systems have shown promise in overcoming these obstacles and improving treatment outcomes for cancer patients.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Pharmacology & Pharmacy
Giorgiana Negrea, Valentin-Florian Rauca, Marta Szilvia Meszaros, Laura Patras, Lavinia Luput, Emilia Licarete, Vlad-Alexandru Toma, Alina Porfire, Dana Muntean, Alina Sesarman, Manuela Banciu
Summary: This study proposes a novel combination therapy that selectively targets both tumor-associated macrophages and melanoma cells, leading to strong inhibition of tumor growth and modulation of the tumor-immune microenvironment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Physical
Xiaodong Jing, Hao Hu, Yanzhen Sun, Bing Yu, Hailin Cong, Youqing Shen
Summary: The tumor microenvironment contains abnormal biochemical indicators that accelerate tumor heterogeneity. However, these indicators also provide opportunities for designing intelligent drug delivery systems, potentially improving the effectiveness of chemotherapy and reducing side effects.
Review
Nanoscience & Nanotechnology
Ruixin Jia, Lesheng Teng, Lingyu Gao, Ting Su, Lu Fu, Zhidong Qiu, Ye Bi
Summary: Nanomedicines offer unique advantages in tumor therapy, but traditional nanomedicines are hindered by complex physiological fluids and tumor microenvironments. Stimuli-responsive drug-delivery systems have emerged as a promising tool to overcome these barriers and deliver therapeutic agents to target sites effectively.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Yongzhuo Huang
Summary: There is a close relationship between cancer metabolism and immunity. Targeting cancer metabolism shows promise as a therapeutic approach for cancer immunotherapy. The Warburg effect, characterized by abnormal glucose metabolism, can modify cancer cells and create a suppressive immune microenvironment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Ziwan Xu, Wenyao Zhen, Caroline McCleary, Taokun Luo, Xiaomin Jiang, Cheng Peng, Ralph R. Weichselbaum, Wenbin Lin
Summary: In this study, a novel nanoscale metal-organic framework (nMOF) Hf-TP-SN, containing an X-ray-triggerable 7-ethyl-10-hydroxycamptothecin (SN38) prodrug, was designed for synergistic radiotherapy and chemotherapy. Upon X-ray irradiation, Hf-12 secondary building units served as radiosensitizers to enhance the generation of hydroxyl radicals, leading to the on-demand release of SN38. The Hf-TP-SN showed 5-fold higher release of SN38 compared to its molecular counterpart, resulting in significant cytotoxicity to cancer cells and efficient tumor growth inhibition in colon and breast cancer mouse models.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Qimeng Wu, Yang Hu, Bing Yu, Hao Hu, Fu-Jian Xu
Summary: This article comprehensively reviews the classification and design strategies of polysaccharide-based tumor microenvironment (TME) responsive drug delivery systems (DDSs). It summarizes the advantages and challenges of current DDSs and foresees the future directions of development. Polysaccharide-based DDSs are expected to provide new strategies and solutions for cancer therapy, making important contributions to the realization of precision medicine.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Applied
Jaya R. Lakkakula, Pratik Gujarathi, Prachi Pansare, Swastika Tripathi
Summary: Combining alginate with other materials as a drug delivery system can effectively enhance the targeted therapeutic effects of doxorubicin on cancer, showing great potential for widespread applications.
CARBOHYDRATE POLYMERS
(2021)
Article
Acoustics
Bharat Bhargawa, Varsha Sharma, Munuswamy-Ramanujam Ganesh, Francesca Cavalieri, Muthupandian Ashokkumar, Bernaurdshaw Neppolian, Anandhakumar Sundaramurthy
Summary: We present a novel approach using gold nanorods to encapsulate and release an anticancer drug, 5-fluorouracil, in lysozyme microspheres. The drug release from the encapsulated microspheres was enhanced under ultrasound irradiation, resulting in excellent anticancer activity.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Yan Ting Liu, Shreya Goel, Megumi Kai, Jose Alberto Moran Guerrero, Thao Nguyen, Junhua Mai, Haifa Shen, Arturas Ziemys, Kenji Yokoi
Summary: Our study showed that tumors derived from different seed and soil sources exhibited varying responses to immunotherapy, with differences in PD-L1 expression, therapeutic delivery, immune cell accumulation, and tumor coagulation. This highlights the importance of understanding organ-specific heterogeneity in the delivery and response to immunotherapy in polyclonal tumors.
Article
Chemistry, Multidisciplinary
Mohammad Irani, Sina Mohammadrezaei Nodeh
Summary: This study investigates the capability of composite and core-shell nanofibers for targeted delivery of anticancer drugs in lung cancer treatment. The results demonstrate that the simultaneous loading of CMPT and PTX anticancer drugs and Au nanoparticles in core-shell nanofibers is more beneficial for lung cancer treatment.
Article
Chemistry, Multidisciplinary
Changlong Wang, Xiaojun Wang, Wei Zhang, Ding Ma, Feng Li, Rongrong Jia, Min Shi, Yugang Wang, Guanghui Ma, Wei Wei
Summary: The study demonstrates that shielding Fn with a CaP shell can enhance delivery performance by reducing interception in the liver and re-exposing it in acidic tumors, potentially leading to therapeutic effects.
ADVANCED MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Changlong Wang, Wei Zhang, Yanjie He, Zirui Gao, Liyuan Liu, Siyao Yu, Yuxing Hu, Shuang Wang, Chaochao Zhao, Hui Li, Jinan Shi, Wu Zhou, Feng Li, Hua Yue, Yuhua Li, Wei Wei, Guanghui Ma, Ding Ma
Summary: Trivalent arsenic (As-III) is effective in treating acute promyelocytic leukemia, but its limitations include low effective concentrations in leukemia cells and off-target cytotoxicity. Researchers designed a ferritin-based As nanomedicine, As@Fn, that targets leukemia cells expressing CD71 with high affinity, demonstrating improved efficacy in different leukemia types in animal models.
NATURE NANOTECHNOLOGY
(2021)
Review
Materials Science, Biomaterials
Yuan Deng, Wei Wei, Peifu Tang
Summary: With the rapidly aging population, osteoporosis has become a global public health problem. Calcium-based nanomaterials (CBNMs) have unique advantages in osteoporosis treatment and can be applied locally or systemically. Local CBNMs for bone regeneration develop faster, while innovations are being made in the construction strategies and preparation methods of systemically administered CBNMs. Research into systemically administered CBNMs for antiosteoporosis treatment has more development prospects.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Biotechnology & Applied Microbiology
Jiale Zou, Shuang Wang, Ningli Chai, Hua Yue, Peng Ye, Peilin Guo, Feng Li, Bo Wei, Guanghui Ma, Wei Wei, Enqiang Linghu
Summary: This study demonstrates the reliability of gastric cancer PDOs as tools for predicting the efficacy of nanoformulations. It found that liposomal PTX achieved better killing effect of PDOs compared to albumin-bound PTX, and revealed the underlying mechanisms through which they exerted their distinct effects. These findings were further validated in a patient-derived xenograft model.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Shuping Li, Hua Yue, Shuang Wang, Xin Li, Xiaojun Wang, Peilin Guo, Guanghui Ma, Wei Wei
Summary: This review summarizes the research on using natural bacteria to regulate the tumor microenvironment (TME), including the strategies of bacterial carriers and the clinical trials of bacteria-mediated cancer therapy. The challenges and prospects for the design of bacteria-based carriers are also discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Yajie Liu, Xilin Bai, Chengliang Lyu, Jing Fang, Fan Zhang, Wen-Hao Wu, Wei Wei, Wen-Bin Zhang
Summary: In this study, a novel mechano-bioconjugation strategy was developed to synthesize a fusion protein with a catenane topology using a cascade of post-translational events. The resulting conjugate not only retained the activity of the individual proteins, but also exhibited improved aggregation resistance and prolonged circulation time. In a mouse xenograft model, the fusion protein showed potent inhibition of tumor growth. Mechano-bioconjugation offers an alternative pathway for developing advanced protein therapeutics.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Liwen Huang, Xiao Zhang, Zhaowen Ding, Yilin Qi, Wenjing Wang, Xihan Xu, Hua Yue, Lihuan Bai, Heping Wang, Leyan Feng, Jing Ren, Xue Yang, Guanghui Ma, Wei Wei, Xue Xue
Summary: Research on nano-bio interfaces has shown that 2D nanomaterials can interact with biological membranes to form impactful structures. This interaction can lead to changes in membrane phospholipids, potentially alleviating neurodegenerative disorders. In this study, PEGylated 2D nanomaterials were found to alleviate behavioral and neuronal degeneration in Parkinson's disease. The interaction between these nanomaterials and phosphatidylinositol-4,5-bisphosphate was identified, and the underlying mechanism was revealed to involve a shift in the orientation of the lipid within the membrane, preventing cleavage-mediated inositol 1,4,5-trisphosphate and reducing endoplasmic reticulum stress. These findings suggest that P-sheet nanomaterials could be a drug-free treatment option for neurodegenerative disorders.
Review
Multidisciplinary Sciences
Wei Yang, Hua Yue, Guihong Lu, Wenjing Wang, Yuan Deng, Guanghui Ma, Wei Wei
Summary: This article reviews the delivery systems for modulation of oxidative levels and explores the applications of antioxidants and ROS inducers. Antioxidants can be used for treating inflammatory diseases, while ROS inducers can be utilized for killing tumor cells.
Article
Chemistry, Multidisciplinary
Zhaowen Ding, Xiao Zhang, Yan Wang, Kenji Ogino, Yuanbin Wu, Hua Yue, Zhouguang Jiao, Cui Song, Guihong Lu, Shuang Wang, Xiaoyong Gao, Yongjun Gao, Min Shi, Yugang Wang, Guanghui Ma, Wei Wei
Summary: The interaction between vascular endothelial cells (VECs) and nanomaterials is crucial for the safe and efficient application of nanomedicine. Researchers have discovered that two-dimensional PEGylated lamellar materials (PLMs) can significantly stimulate VECs by interacting with membrane lipids and inducing changes in calcium ion channels. In vivo studies have shown that PLMs-stimulated VECs have diverse impacts on atherosclerosis and tumor-associated nanomedicine accumulation. This study not only enhances our understanding of the mechanism by which specific proteins on VEC membranes are stimulated by PLMs but also provides guidance for the rational use of promising PLMs in nanomedicine.
Review
Chemistry, Multidisciplinary
Peilin Guo, Shuang Wang, Hua Yue, Xiao Zhang, Guanghui Ma, Xin Li, Wei Wei
Summary: The use of bacteria and their biotic components as therapeutics has shown great potential in disease treatment. Oral delivery of bacteria is preferred due to improved patient compliance, but the harsh gastrointestinal environment reduces their viability and therapeutic efficacy. Recent advances in synthetic biology and nanotechnology have enabled the engineering of bacteria for improved survival and treatment in the gastrointestinal tract.
Article
Materials Science, Biomaterials
Haixin Wang, Xiao-Dong Gao, Hua Yue
Summary: We designed a convertible material polylactic acid with controlled release of lentinan (LNT@Mic) to reprogram the immunosuppressive tumor microenvironment (TME) and enhance the efficacy of immunotherapy. LNT@Mic exhibited effective biocompatibility and controlled long-term release of LNT, showing substantial antitumor activity in the MC38 tumor model and enhancing the efficacy of anti-programmed death-ligand 1 therapy against the 'cold' 4T1 tumor model.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Chemistry, Multidisciplinary
Yanhui Hu, Yuyuan Xing, Hua Yue, Tong Chen, Yanyan Diao, Wei Wei, Suojiang Zhang
Summary: This review provides a comprehensive survey on the utilization of ionic liquids (ILs) in the biomedical field. It highlights the diverse structures and properties of ILs and their relevance in various biomedical applications. The mechanisms of ILs as potential drug candidates and their applications as extractants and catalysts in pharmaceutical engineering are summarized. The review also thoroughly examines and analyzes the applications of ILs in disease diagnosis and delivery systems.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Xiaojun Wang, Hui Ding, Zongyang Li, Yaonan Peng, Hui Tan, Changlong Wang, Guodong Huang, Weiping Li, Guanghui Ma, Wei Wei
Summary: The researchers successfully developed M1-like macrophage-derived extracellular vesicles (M1EVs) for the treatment of glioblastoma multiforme (GBM). These M1EVs achieved synergistic immunomodulation, chemiexcited photodynamic therapy (CDT), and hypoxia-activated chemotherapy in GBM, leading to a potent therapeutic effect. The results demonstrated the excellent efficacy of CCA-M1EVs against GBM in cell-derived and patient-derived xenograft models.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)