Dynein disruption perturbs post-synaptic components and contributes to impaired MuSK clustering at the NMJ: implication in ALS

Postmitotic Expression of SOD1G93AGene Affects the Identity of Myogenic Cells and Inhibits Myoblasts Differentiation

(2015) Martina Martini et al.   MEDIATORS OF INFLAMMATION

N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy

(2014) S. Falcone et al.   EMBO Molecular Medicine

A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity

(2014) Peter I. Joyce et al.   HUMAN MOLECULAR GENETICS

Neuromuscular synaptogenesis: coordinating partners with multiple functions

(2014) Houssam Darabid et al.   NATURE REVIEWS NEUROSCIENCE

Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons

(2014) Vera van Dis et al.   Acta Neuropathologica Communications

Endosomal trafficking of the receptor tyrosine kinase MuSK proceeds via clathrin-dependent pathways, Arf6 and actin

(2013) Susan Luiskandl et al.   FEBS Journal

Dynein Interacts with the Neural Cell Adhesion Molecule (NCAM180) to Tether Dynamic Microtubules and Maintain Synaptic Density in Cortical Neurons

(2013) Eran Perlson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage

(2013) Jason Yi et al.   JOURNAL OF CELL BIOLOGY

Crystal clear insights into how the dynein motor moves

(2013) A. P. Carter   JOURNAL OF CELL SCIENCE

Dynein mutations associated with hereditary motor neuropathies impair mitochondrial morphology and function with age

(2013) Judith Eschbach et al.   NEUROBIOLOGY OF DISEASE

The Role of MuSK in Synapse Formation and Neuromuscular Disease

(2013) S. J. Burden et al.   Cold Spring Harbor Perspectives in Biology

Elevated PGC-1α Activity Sustains Mitochondrial Biogenesis and Muscle Function without Extending Survival in a Mouse Model of Inherited ALS

(2012) Sandrine Da Cruz et al.   Cell Metabolism

Initiation of synapse formation by Wnt-induced MuSK endocytosis

(2012) L. R. Gordon et al.   DEVELOPMENT

Muscle length and myonuclear position are independently regulated by distinct Dynein pathways

(2012) E. S. Folker et al.   DEVELOPMENT

Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3

(2012) Bruno Cadot et al.   EMBO REPORTS

Neuregulin-1 potentiates agrin-induced acetylcholine receptor clustering through muscle-specific kinase phosphorylation

(2012) S. T. Ngo et al.   JOURNAL OF CELL SCIENCE

Opposing microtubule motors drive robust nuclear dynamics in developing muscle cells

(2012) Meredith H. Wilson et al.   JOURNAL OF CELL SCIENCE

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

(2012) Ari J. Firestone et al.   NATURE

Increasing MuSK Activity Delays Denervation and Improves Motor Function in ALS Mice

(2012) María J. Pérez-García et al.   Cell Reports

Neuromuscular Junction Defects in Mice with Mutation of dynein heavy chain 1

(2011) Stephanie L. Courchesne et al.   PLoS One

Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport

(2010) Ping Shi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

To build a synapse: signaling pathways in neuromuscular junction assembly

(2010) H. Wu et al.   DEVELOPMENT

Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice

(2010) Margaret Wong et al.   HUMAN MOLECULAR GENETICS

Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes

(2010) Juliane P. Caviston et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease

(2010) Nobutaka Hirokawa et al.   NEURON

Dynein Dysfunction Induces Endocytic Pathology Accompanied by an Increase in Rab GTPases

(2009) Nobuyuki Kimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specificity of Cytoplasmic Dynein Subunits in Discrete Membrane-trafficking Steps

(2009) Krysten J. Palmer et al.   MOLECULAR BIOLOGY OF THE CELL

Rapsyn interacts with the muscle acetylcholine receptor via α-helical domains in the α, β, and ε subunit intracellular loops

(2009) Y. Lee et al.   NEUROSCIENCE

Muscle Mitochondrial Uncoupling Dismantles Neuromuscular Junction and Triggers Distal Degeneration of Motor Neurons

(2009) Luc Dupuis et al.   PLoS One

Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK

(2008) Natalie Kim et al.   CELL

Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

(2008) Gabriella Dobrowolny et al.   Cell Metabolism

Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin

(2008) E. S. Chevalier-Larsen et al.   HUMAN MOLECULAR GENETICS

Motor Neuron Disease Occurring in a Mutant Dynactin Mouse Model Is Characterized by Defects in Vesicular Trafficking

(2008) F. M. Laird et al.   JOURNAL OF NEUROSCIENCE

Neuron-Specific Expression of Mutant Superoxide Dismutase Is Sufficient to Induce Amyotrophic Lateral Sclerosis in Transgenic Mice

(2008) D. Jaarsma et al.   JOURNAL OF NEUROSCIENCE

LRP4 Serves as a Coreceptor of Agrin

(2008) Bin Zhang et al.   NEURON