The orphan nuclear receptor NR4A2 is part of a p53–microRNA-34 network

The interplay of NR4A receptors and the oncogene–tumor suppressor networks in cancer

(2015) Jordan A. Beard et al.   CELLULAR SIGNALLING

MicroRNA-132 promotes estradiol synthesis in ovarian granulosa cells via translational repression of Nurr1

(2015) Shaogen Wu et al.   Reproductive Biology and Endocrinology

A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression

(2014) N. Okada et al.   GENES & DEVELOPMENT

Therapeutic targeting of microRNAs: current status and future challenges

(2014) Zhonghan Li et al.   NATURE REVIEWS DRUG DISCOVERY

In-Depth Analysis Shows Synergy between Erlotinib and miR-34a

(2014) Jane Zhao et al.   PLoS One

Mir-34: A New Weapon Against Cancer?

(2014) Gabriella Misso et al.   Molecular Therapy-Nucleic Acids

Dichotomous roles for the orphan nuclear receptor NURR1 in breast cancer

(2013) Shawn Llopis et al.   BMC CANCER

Expression of orphan nuclear receptor NR4A2 in gastric cancer cells confers chemoresistance and predicts an unfavorable postoperative survival of gastric cancer patients with chemotherapy

(2013) Yifang Han et al.   CANCER

Nuclear orphan receptor NR4A2 confers chemoresistance and predicts unfavorable prognosis of colorectal carcinoma patients who received postoperative chemotherapy

(2013) Yifang Han et al.   EUROPEAN JOURNAL OF CANCER

NuMA Is Required for the Selective Induction of p53 Target Genes

(2013) H. Ohata et al.   MOLECULAR AND CELLULAR BIOLOGY

miR-137 regulates the constitutive androstane receptor and modulates doxorubicin sensitivity in parental and doxorubicin-resistant neuroblastoma cells

(2013) A A Takwi et al.   ONCOGENE

MicroRNA-34a Modulates Chemosensitivity of Breast Cancer Cells to Adriamycin by Targeting Notch1

(2012) Xiu-juan Li et al.   ARCHIVES OF MEDICAL RESEARCH

MiR-34b is associated with clinical outcome in triple-negative breast cancer patients

(2012) Marek Svoboda et al.   Diagnostic Pathology

Identification of microRNA-regulated gene networks by expression analysis of target genes

(2012) Vincenzo Alessandro Gennarino et al.   GENOME RESEARCH

miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression

(2012) D. Yang et al.   JOURNAL OF CELL SCIENCE

Intact p53-Dependent Responses in miR-34–Deficient Mice

(2012) Carla P. Concepcion et al.   PLoS Genetics

miR-34 – a microRNA replacement therapy is headed to the clinic

(2012) Andreas G. Bader   Frontiers in Genetics

A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation

(2011) Jane M Valentine et al.   BMC CANCER

DNA hypermethylation of microRNA-34b/c has prognostic value for stage Ⅰ non-small cell lung cancer

(2011) Zhen Wang et al.   CANCER BIOLOGY & THERAPY

PGE2 targets squamous cell carcinoma cell with the activated epidermal growth factor receptor family for survival against 5-fluorouracil through NR4A2 induction

(2011) Hideo Shigeishi et al.   CANCER LETTERS

Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair

(2011) M. Malewicz et al.   GENES & DEVELOPMENT

miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancy

(2011) Fumihiko Nakatani et al.   JOURNAL OF PATHOLOGY

Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer

(2011) G Mudduluru et al.   ONCOGENE

Regulation of NR4A nuclear receptor expression by oncogenic BRAF in melanoma cells

(2011) Aaron G. Smith et al.   Pigment Cell & Melanoma Research

Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells

(2010) Yukihiro Akao et al.   CANCER LETTERS

Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer

(2010) Dmitri Lodygin et al.   CELL CYCLE

Frequent Downregulation of miR-34 Family in Human Ovarian Cancers

(2010) D. C. Corney et al.   CLINICAL CANCER RESEARCH

Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elements †

(2010) Jean-François Millau et al.   NUCLEIC ACIDS RESEARCH

Targeting of mRNAs by multiple miRNAs: the next step

(2010) M E Peter   ONCOGENE

Cytoplasmic mislocalization of the orphan nuclear receptor Nurr1 is a prognostic factor in bladder cancer

(2009) Teruo Inamoto et al.   CANCER

miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer

(2009) Elena Gallardo et al.   CARCINOGENESIS

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

The miR-34 family in cancer and apoptosis

(2009) H Hermeking   CELL DEATH AND DIFFERENTIATION

Reduced levels of miR-34a in neuroblastoma are not caused by mutations in theTP53binding site

(2009) Galina Feinberg-Gorenshtein et al.   GENES CHROMOSOMES & CANCER

NGFI-B Nuclear Orphan Receptor Nurr1 Interacts with p53 and Suppresses Its Transcriptional Activity

(2009) T. Zhang et al.   MOLECULAR CANCER RESEARCH

A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

(2009) S. Sur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear receptor drug discovery

(2008) Taosheng Chen   CURRENT OPINION IN CHEMICAL BIOLOGY

A Functional Screen Identifies miR-34a as a Candidate Neuroblastoma Tumor Suppressor Gene

(2008) K. A. Cole et al.   MOLECULAR CANCER RESEARCH

1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth

(2008) T. Inamoto et al.   MOLECULAR CANCER THERAPEUTICS

Comprehensive Dissection of PDGF-PDGFR Signaling Pathways in PDGFR Genetically Defined Cells

(2008) Erxi Wu et al.   PLoS One

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA