Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells

DDX3 regulates DNA damage-induced apoptosis and p53 stabilization

(2013) Mianen Sun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Death receptors as targets in cancer

(2013) O Micheau et al.   BRITISH JOURNAL OF PHARMACOLOGY

Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family

(2013) K Azijli et al.   CELL DEATH AND DIFFERENTIATION

Design of Glycogen Synthase Kinase-3 Inhibitors: An Overview on Recent Advancements

(2013) Minhajul Arfeen et al.   CURRENT PHARMACEUTICAL DESIGN

GSK-3α is a central regulator of age-related pathologies in mice

(2013) Jibin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Aberrant Glycogen Synthase Kinase 3β Is Involved in Pancreatic Cancer Cell Invasion and Resistance to Therapy

(2013) Ayako Kitano et al.   PLoS One

A New Alpha in Line Between KRAS and NF-κB Activation?

(2013) Chorom Pak et al.   Cancer Discovery

GSK-3α Promotes Oncogenic KRAS Function in Pancreatic Cancer via TAK1–TAB Stabilization and Regulation of Noncanonical NF-κB

(2013) Deepali Bang et al.   Cancer Discovery

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells

(2013) M Herreros-Villanueva et al.   Oncogenesis

Translating TRAIL-receptor targeting agents to the clinic

(2012) Martha W. den Hollander et al.   CANCER LETTERS

NF-κB as a target for pancreatic cancer therapy

(2012) Carmine Carbone et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Dimer-specific regulatory mechanisms within the NF-κB family of transcription factors

(2012) Stephen T. Smale   IMMUNOLOGICAL REVIEWS

GSK-3α and GSK-3β Proteins Are Involved in Early Stages of Chondrocyte Differentiation with Functional Redundancy through RelA Protein Phosphorylation

(2012) Shozo Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to TRAIL-Induced Apoptosis

(2012) Shadi Mamaghani et al.   PLoS One

Novel Reporter Alleles of GSK-3α and GSK-3β

(2012) William B. Barrell et al.   PLoS One

Regulation of protein stability by GSK3 mediated phosphorylation

(2011) Chong Xu et al.   CELL CYCLE

High Cell Surface Death Receptor Expression Determines Type IVersusType II Signaling

(2011) Xue Wei Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration

(2011) Jin-San Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding

(2011) Trevor Siggers et al.   NATURE IMMUNOLOGY

Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer

(2011) J-S Zhang et al.   ONCOGENE

Targeting apoptosis pathways in pancreatic cancer

(2010) Alexander Arlt et al.   CANCER LETTERS

TRAIL-Induced Apoptosis Is Preferentially Mediated via TRAIL Receptor 1 in Pancreatic Carcinoma Cells and Profoundly Enhanced by XIAP Inhibitors

(2010) D. Stadel et al.   CLINICAL CANCER RESEARCH

Impact of death receptor signaling on the malignancy of pancreatic ductal adenocarcinoma

(2010) Christian Röder et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Identification of c-FLIPL and c-FLIPS as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells

(2010) C. Haag et al.   GUT

New insights into apoptosis signaling by Apo2L/TRAIL

(2010) F Gonzalvez et al.   ONCOGENE

Small Molecule XIAP Inhibitors Enhance TRAIL-Induced Apoptosis and Antitumor Activity in Preclinical Models of Pancreatic Carcinoma

(2009) M. Vogler et al.   CANCER RESEARCH

Apoptosis pathways and their therapeutic exploitation in pancreatic cancer

(2009) Simone Fulda   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Regulatory Logic of the NF- B Signaling System

(2009) E. O'Dea et al.   Cold Spring Harbor Perspectives in Biology

TRAIL and cancer therapy

(2008) Frank A.E. Kruyt   CANCER LETTERS

Maintenance of Constitutive I B Kinase Activity by Glycogen Synthase Kinase-3 /  in Pancreatic Cancer

(2008) W. Wilson et al.   CANCER RESEARCH

Targeting XIAP Bypasses Bcl-2-Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo

(2008) M. Vogler et al.   CANCER RESEARCH

Targeting the extrinsic apoptosis pathway in cancer

(2008) Avi Ashkenazi   CYTOKINE & GROWTH FACTOR REVIEWS